Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells

Molecular Endocrinology

Volumn 26, Issue 5, 2012, Pages 833-845

  El Shewy, Hesham M ^a   Sohn, Mimi ^a   Wilson, Parker ^a   Lee, Mi Hye ^a   Hammad, Samar M ^a   Luttrell, Louis M ^a   Jaffa, Ayad A ^b,c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^c AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (3 OCTYLPHENYLCARBAMOYL)ETHYL PHOSPHATE; CONNECTIVE TISSUE GROWTH FACTOR; GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; LOW DENSITY LIPOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N,N DIMETHYLSPHINGOSINE; PERTUSSIS TOXIN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIABETIC ANGIOPATHY; HUMAN; HUMAN CELL; KIDNEY INJURY; LIPID METABOLISM; LIPOPROTEIN METABOLISM; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; CONNECTIVE TISSUE GROWTH FACTOR; DIABETIC NEPHROPATHIES; DYSLIPIDEMIAS; GENE SILENCING; HUMANS; LIPOPROTEINS, LDL; LYSOPHOSPHOLIPIDS; MAP KINASE SIGNALING SYSTEM; MESANGIAL CELLS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN ISOFORMS; PROTEIN TRANSPORT; RATS; RECEPTORS, LYSOSPHINGOLIPID; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; SPHINGOSINE; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84860333970     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2011-1261     Document Type: Article

References (62)

1. Klahr S, Schreiner G, Ichikawa I 1988 The progression of renal disease. N Engl J Med 318:1657-1666
2. Drummond K, Mauer M, for the International Diabetic Nephropathy Study Group 2002 The early natural history of nephropathy in type 1 diabetes: early renal structural changes in type 1 diabetes. Diabetes 51:1580-1587
3. Chiarelli F, Gaspari S, Marcovecchio ML 2009 Role of growth factors in diabetic kidney disease. Horm Metab Res 41:585-593
4. Brigstock DR 2003 The CCN family: a new stimulus package. J Endocrinol 178:169-175
5. Frazier K, Williams S, Kothapalli D, Klapper H, Grotendorst GR 1996 Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol 107:404-411
6. Moussad EE, Brigstock DR 2000 Connective tissue growth factor: what's in a name? Mol Genet Metab 71:276-292
7. Twigg SM, Chen MM, Joly AH, Chakrapani SD, Tsubaki J, Kim HS, Oh Y, Rosenfeld RG 2001 Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: a potential mechanism for expansion of extracellular matrix in diabetes mellitus. Endocrinology 142:1760-1769
8. Igarashi A, Hayashi N, Nashiro K, Takehara K 1998 Differential expression of connective tissue growth factor gene in cutaneous fibrohistiocytic and vascular tumors. J Cutan Pathol 25:143-148
9. Liu BC, Chen Q, Luo DD, Sun J, Phillips AO, Ruan XZ, Liu NF 2003 Mechanisms of irbesartan in prevention of renal lesion in streptozotocin-induced diabetic rats. Acta Pharmacol Sin 24:67-73
10. Riser BL, Denichilo M, Cortes P, Baker C, Grondin JM, Yee J, Narins RG 2000 Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. J Am Soc Nephrol 11:25-38
11. Wahab NA, Yevdokimova N, Weston BS, Roberts T, Li XJ, Brinkman H, Mason RM 2001 Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy. Biochem J 359:77-87
12. Blom IE, van Dijk AJ, Wieten L, Duran K, Ito Y, Kleij L, deNichilo M, Rabelink TJ, Weening JJ, Aten J, Goldschmeding R 2001 In vitro evidence for differential involvement of CTGF, TGFβ, and PDGF-BB in mesangial response to injury. Nephrol Dial Transplant 16:1139-1148
13. Heusinger-Ribeiro J, Eberlein M, Wahab NA, Goppelt-Struebe M 2001 Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP. J AmSoc Nephrol 12:1853-1861
14. Wang S, Denichilo M, Brubaker C, Hirschberg R 2001 Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy. Kidney Int 60:96-105
15. Wang S, Hirschberg R 2003 BMP7 antagonizes TGF-beta -dependent fibrogenesis in mesangial cells. Am J Physiol Renal Physiol 284:F1006-F1013
16. Jaffa AA, Usinger WR, McHenry MB, Jaffa MA, Lipstiz SR, Lackland D, Lopes-Virella M, Luttrell LM, Wilson PW; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Group 2008 Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes. J Clin Endocrinol Metab 93:1893-1900
17. Jerums G, Premaratne E, Panagiotopoulos S, Clarke S, Power DA, MacIsaac RJ 2008 New and old markers of progression of diabetic nephropathy. Diabetes Res Clin Pract 82(Suppl):S30-S37
18. Murphy M, Godson C, Cannon S, Kato S, Mackenzie HS, Martin F, Brady HR 1999 Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem 274:5830-5834
19. Twigg SM, Joly AH, Chen MM, Tsubaki J, Kim HS, Hwa V, Oh Y, Rosenfeld RG 2002 Connective tissue growth factor/IGF-binding protein-related protein-2 is a mediator in the induction of fibronectin by advanced glycosylation end-products in human dermal fibroblasts. Endocrinology 143:1260-1269
20. Park SK, Kim J, Seomun Y, Choi J, Kim DH, Han IO, Lee EH, Chung SK, Joo CK 2001 Hydrogen peroxide is a novel inducer of connective tissue growth factor. Biochem Biophys Res Commun 284:966-971
21. Katsuma S, Ruike Y, Yano T, Kimura M, Hirasawa A, Tsujimoto G 2005 Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells. FEBS Lett 579:2576-2582
22. Muehlich S, Schneider N, Hinkmann F, Garlichs CD, Goppelt- Struebe M 2004 Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine- 1-phosphate, and platelets. Atherosclerosis 175:261-268
23. Sohn M, Tan Y, Wang B, Klein RL, Trojanowska M, Jaffa AA 2006 Mechanisms of low-density lipoprotein-induced expression of connective tissue growth factor in human aortic endothelial cells. Am J Physiol Heart Circ Physiol 290:H1624-H1634
24. Li MH, Sanchez T, Pappalardo A, Lynch KR, Hla T, Ferrer F 2008 Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Mol Cancer Res 6:1649-1656
25. Sohn M, Tan Y, Klein RL, Jaffa AA 2005 Evidence for low-density lipoprotein-induced expression of connective tissue growth factor in mesangial cells. Kidney Int 67:1286-1296
26. Jenkins AJ, Velarde V, Klein RL, Joyce KC, Philips D, Mayfield RK, Lyons TJ, Jaffa AA 2000 Native and modified LDL activate extracellular signal-regulated kinases in mesangial cells. Diabetes 49: 2160-2169
27. Maceyka M, Payne SG, Milstien S, Spiegel S 2002 Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta 1585:193-201
28. Spiegel S, Milstien S 2000 Sphingosine-1-phosphate: signaling inside and out. FEBS Lett 476:55-57
29. Katsuma S, Hada Y, Shiojima S, Hirasawa A, Tanoue A, Takagaki K, Ohgi T, Yano J, Tsujimoto G 2003 Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation. Biochem Biophys Res Commun 300: 577-584
30. Chowdhury I, Chaqour B 2004 Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells. Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics. Eur J Biochem 271: 4436-4450
31. Xin C, Ren S, Eberhardt W, Pfeilschifter J, Huwiler A 2006 The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells. Br J Pharmacol 147:164-174
32. Estrada R, Wang L, Jala VR, Lee JF, Lin CY, Gray RD, Haribabu B, Lee MJ 2009 Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells. Histochem Cell Biol 131:239-249
33. Gouni-Berthold I, Seewald S, Hescheler J, Sachinidis A 2004 Regulation of mitogen-activated protein kinase cascades by low density lipoprotein and lysophosphatidic acid. Cell Physiol Biochem 14: 167-176
34. Chang PY, Luo S, Jiang T, Lee YT, Lu SC, Henry PD, Chen CH 2001 Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids. Circulation 104:588-593
35. Taha TA, Argraves KM, ObeidLM2004 Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim Biophys Acta 1682:48-55
36. Watterson KR, Johnston E, Chalmers C, Pronin A, Cook SJ, Benovic JL, Palmer TM 2002 Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase2. J Biol Chem 277:5767-5777
37. Taha TA, Mullen TD, Obeid LM 2006 A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochim Biophys Acta 1758:2027-2036
38. El-Shewy HM, Johnson KR, Lee MH, Jaffa AA, Obeid LM, Luttrell LM 2006 Insulin-like growth factors mediate heterotrimeric G protein- dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. J Biol Chem 281:31399-31407
39. Johnson KR, Becker KP, Facchinetti MM, Hannun YA, Obeid LM 2002 PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine- 1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem 277:35257-35262
40. Anelli V, Gault CR, Snider AJ, Obeid LM 2010 Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro. FASEB J 24:2727-2738
41. Gáborik Z, Hunyady L 2004 Intracellular trafficking of hormone receptors. Trends Endocrinol Metab 15:286-293
42. Kamanna VS 2002 Low density lipoproteins and mitogenic signal transduction processes: role in the pathogenesis of renal disease. Histol Histopathol 17:497-505
43. Metzler B, Hu Y, Dietrich H, Xu Q 2000 Increased expression and activation of stress-activated protein kinases/c-Jun NH(2)-terminal protein kinases in atherosclerotic lesions coincide with p53. Am J Pathol 156:1875-1886
44. Zhao M, Liu Y, Wang X, New L, Han J, Brunk UT 2002 Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL. APMIS 110:458-468
45. Zhu Y, Liao H, Wang N, Ma KS, Verna LK, Shyy JY, Chien S, Stemerman MB 2001 LDL-activated p38 in endothelial cells is mediated by Ras. Arterioscler Thromb Vasc Biol 21:1159-1164
46. Velarde V, Jenkins AJ, Christopher J, Lyons TJ, Jaffa AA 2001 Activation of MAPK by low-density lipoproteins in vascular smooth muscle cells. J Appl Physiol 91:1412-1420
47. Kyriakis JM, Avruch J 2001 Mammalian MAPK signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-869
48. Schaeffer HJ, Weber MJ 1999 Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol 19: 2435-2444
49. Wetzker R, Böhmer FD 2003 Transactivation joins multiple tracks to the ERK/MAPK cascade. Nat Mol Cell Biol 4:651-657
50. Kimura T, Sato K, Kuwabara A, Tomura H, Ishiwara M, Kobayashi I, Ui M, Okajima F 2001 2001 Sphingosine 1 phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human unbilical vein endothelial cells. J Biol Chem 276:31780-31785
51. Murata N, Sato K, Kon J, Tomura H, Yanagita M, Kuwabara A, Ui M, Okajima F 2000 Interactions of sphingosine 1 phosphate with plasma components including lipoproteins, regulates the lipid receptor- mediated actions. Biochem J 352:809-815
52. Yatomi Y, Ohmori T, Rile G, Kazama F, Okamato H, Sano T, Satoh K, Kume S, Tigyi G, Igaaarashi Y, Ozaki Y 2000 Sphingosine 1 phosphate is a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells. Blood 96:3431-3438
53. Zhang B, Tomura H, Kuwabara A, Kimura T, Miura S, Noda K, Okajima F, Saku K 2005 Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins. Atherosclerosis 178:199-205
54. Hammad SM, Pierce JS, Soodavar F, Smith KJ, Al Gadban MM, Rembiesa B, Klein RL, Hannun YA, Bielawski J, Bielawska A 2010 Blood sphingolipidomics in healthy humans: impact of sample collection methodology. J Lipid Res 51:3074-3087
55. Yamanaka M, Shegogue D, Pei H, Bu S, Bielawska A, Bielawski J, Pettus B, Hannun YA, Obeid L, Trojanowska M 2004 Sphingosine kinase 1 is induced by TGF-β and mediates TIMP-1 up-regulation. J Biol Chem 279:53994-54001
56. Xin C, Ren S, Kleuser B, Shabahang S, Eberhardt W, Radeke H, Schafer-Korting M, Pfeilschifter J, Huwiler A 2004 Sphingosine 1 phosphate cross-activates the Smad signaling cascade and mimics TGF- β induced cell response. J Biol Chem 279:35255-35262
57. Spiegel S, Milstien S 2003 Sphingosine-1-phosphate and enigmatic signaling lipid. Nat Rev Mol Cell Biol 4:397-407
58. Katsuma S, Hada Y, Ueda T, Shiojima S, Hirasawa A, Tanoue A, Takagaki K, Ohgi T, Yano J, Tsujimoto G 2002 signaling mechanisms in sphingosine 1 phosphate promoted mesangial cell proliferation. Genes to Cells 7:1217-1230
59. Lee MJ, Van Brocklyn JR, Thangada S, Liu CH, Hand AR, Menzeleev R, Spiegel S, Hla T 1998 Sphingosine1 phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 279:1552-1555
60. Oemar BS, Werner A, Garnier JM, Do DD, Godoy N, Nauck M, Mä rz W, Rupp J, Pech M, Lü scher TF 1997 Human connective tissue growth factor is expressed in advanced atherosclerotic lesions. Circulation 95:831-839
61. Lovett DH, Sterzel RB, Kashgarian M, Ryan JL 1983 Neutral proteinase activity produced in vitro by cells of the glomerular mesangium. Kidney Int 23:342-349
62. Bielawski J, Szule ZM, Hannun YA, Bielawska A 2006 Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods 39:8.2-91