Increased expression and activation of stress-activated protein kinases/c-Jun NH2-terminal protein kinases in atherosclerotic lesions coincide with p53

American Journal of Pathology

Volumn 156, Issue 6, 2000, Pages 1875-1886

  Metzler, Bernhard ^a   Hu, Yanhua ^b   Dietrich, Hermann ^b   Xu, Qingbo ^c  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b MEDICAL UNIVERSITY OF INNSBRUCK   (Austria)

^c ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SMOOTH MUSCLE FIBER;

EID: 0033888287     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65061-4     Document Type: Article

References (65)

1. Stress-activated protein kinases in cardiovascular disease
2. Signal transduction in arteriosclerosis: Mechanical stress-activated MAP kinases in vascular smooth muscle cells
3. 'Stress-responsive' mitogen-activated protein kinases (c-Jun N- terminal kinases and p38 MAP kinases) in the myocardium
4. Acute hypertension activates mitogen-activated protein kinases in arterial wall
5. Activation of mitogen-activated protein kinases (ERK/JNK) and AP-1 transcription factor in rat carotid arteries after balloon injury
6. Activation of JNK/SAPK and ERK by mechanical strain in vascular smooth muscle cells depends on extracellular matrix composition
7. Stretch activates Jun N-terminal kinase/stress-activated protein kinase in vascular smooth muscle cells through mechanisms involving autocrine ATP stimulation of purinoceptors
8. Decline of shear stress-induced activation of extracellular signal- regulated kinases, but not stress-activated protein kinases, in in vitro propagated endothelial cells
9. Carvedilol inhibits activation of stress-activated protein kinase and reduces reperfusion injury in perfused rabbit heart
10. Transcriptional activation of scavenger receptor expression in human smooth muscle cells requires AP-1/c-Jun and C/EBPbeta: Both AP-1 binding and JNK activation are induced by phorbol esters and oxidative stress
11. 2-terminal protein kinases in tissues of heat-stressed mice
12. Endothelial cell inflammatory responses to tumor necrosis factor alpha. Ceramide-dependent and -independent mitogen-activated protein kinase cascades
13. The mitogen-activated protein kinase signal transduction pathway
14. The MAPK signaling cascade
15. Parallel signal processing among mammalian MAPKs
16. The stress-activated protein kinase subfamily of c-Jun kinases
17. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
18. Identification of an oncoprotein- and UV-responsive protein kinases that bind and potentiate the c-Jun activation domain
19. Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases
20. Transcription factor ATF2 regulation by the JNK signal transduction pathway
21. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors
22. MEKK1/JNK signaling stabilizes and activates p53
23. JNK targets p53 ubiquitination and degradation in nonstressed cells
24. Immunology of atherosclerosis: Cellular composition and major histocompatibility complex class II antigen expression in aortic intima, fatty streaks, and atherosclerotic plaques in young and aged human specimens
25. The pathogenesis of atherosclerosis: A perspective for the 1990s
26. Lipoproteins induce expression of the early growth response gene-1 in vascular smooth muscle cells from rat
27. Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent
28. Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms
29. Ox-LDL induces apoptosis in human coronary artery endothelial cells: Role of PKC, PTK, bcl-2, and Fas
30. Evidence for apoptosis in advanced human atheroma: Colocalization with interleukin-1 beta-converting enzyme
31. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques
32. Apoptosis in human atherosclerosis and restenosis
33. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model
34. Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65
35. Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65
36. Induction of mitogen-activated protein kinase phosphatase-1 by arachidonic acid in vascular smooth muscle cells
37. Smooth muscle cells in culture
38. Nitric oxide induces heat-shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1
39. Promotion of lymphocyte growth by high density lipoproteins (HDL): Physiological significance of the HDL binding site
40. Lipid utilization by human lymphocytes is correlated with high- density-lipoprotein binding site activity
41. Co-expression of ICAM-1, VCAM-1, ELAM-1 and Hsp60 in human arterial venous endothelial cells in response to cytokines and oxidized low density lipoproteins
42. Microsomal lipid peroxidation
43. Topographical association between the cyclin-dependent kinases inhibitor p21, p53 accumulation, and cellular proliferation in human atherosclerotic tissue
44. Co-expression of p53 and MDM2 in human atherosclerosis: Implications for the regulation of cellularity of atherosclerotic lesions
45. Bcl-2/Bax: A rheostat that regulates an anti-oxidant pathway and cell death
46. Potential role for ceramide in mitogen-activated protein kinase activation and proliferation of vascular smooth muscle cells induced by oxidized low density lipoprotein
47. Oxidized LDL stimulates the expression of TGF-beta and fibronectin in human glomerular epithelial cells
48. Oxidized LDL mediates the release of fibroblast growth factor-1
49. A receptor-mediated pathway for cholesterol homeostasis
50. Stimulation of mitogen activated protein kinase by LDL and oxLDL in human U-937 macrophage-like cells
51. Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages
52. The growth-promoting effect of low-density lipoprotein may be mediated by a pertussis toxin-sensitive mitogen-activated protein kinase pathway
53. LDL stimulates mitogen-activated protein kinase phosphatase-1 expression, independent of LDL receptors, in vascular smooth muscle cells
54. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man
55. Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein(a)
56. CD36 is a receptor for oxidized low density lipoprotein
57. CD36, a novel receptor for oxidized low-density lipoproteins, is highly expressed on lipid-laden macrophages in human atherosclerotic aorta
58. Oxidized LDL and atherogenesis
59. The carboxyl-terminal cytoplasmic domain of CD36 is required for oxidized low-density lipoprotein modulation of NF-kappaB activity by tumor necrosis factor-alpha
60. The regulation of AP-1 activity by mitogen-activated protein kinases
61. Apoptosis of vascular smooth muscle cells in atherosclerosis
62. Apoptosis: Basic mechanisms and implications for cardiovascular disease
63. Biomechanical stress-induced apoptosis in vein grafts involves p38 mitogen-activated protein kinases
64. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
65. Requirement for ceramide-initiated SAPK/JNK signaling in stress- induced apoptosis