Lidamycin induces neural differentiation of mouse embryonic carcinoma cells through down-regulation of transcription factor Oct4

Biochemical and Biophysical Research Communications

Volumn 421, Issue 1, 2012, Pages 44-50

  Zhen, Hong Ying ^a   He, Qi Hua ^a   Li, Ying ^b   Zhou, Juan ^b   Yao, Cheng ^b   Liu, Yi Nan ^a   Ma, Li Jun ^c  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^c Shanghai St Luke's Hospital   (China)

Author keywords

Embryonic carcinoma (EC) cell; Lidamycin; Neural differentiation; Oct4; P21

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; LIDAMYCIN; MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN P21; RETINOIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; DOWN REGULATION; DRUG MECHANISM; EMBRYONAL CARCINOMA; GENE OVEREXPRESSION; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION;

AMINOGLYCOSIDES; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CARCINOMA, EMBRYONAL; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; ENEDIYNES; GENE KNOCKDOWN TECHNIQUES; MICE; NEOPLASTIC STEM CELLS; NEUROGENESIS; OCTAMER TRANSCRIPTION FACTOR-3; TRANSCRIPTION, GENETIC;

EID: 84860323566     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.03.105     Document Type: Article

References (31)

1. Nichols J., Zevnik B., Anastassiadis K., Niwa H., Klewe-Nebenius D., Chambers I., Scholer H., Smith A. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998, 95:379-391.
2. Pesce M., Scholer H.R. Oct-4: control of totipotency and germline determination. Mol. Reprod. Dev. 2000, 55:452-457.
3. Niwa H., Miyazaki J., Smith A.G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 2000, 24:372-376.
4. Lee J., Go Y., Kang I., Han Y.M., Kim J. Oct-4 controls cell-cycle progression of embryonic stem cells. Biochem. J. 2010, 426:171-181.
5. Card D.A., Hebbar P.B., Li L., Trotter K.W., Komatsu Y., Mishina Y., Archer T.K. Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol. Cell Biol. 2008, 28:6426-6438.
6. Andrews P.W., Matin M.M., Bahrami A.R., Damjanov I., Gokhale P., Draper J.S. Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of the same coin. Biochem. Soc. Trans. 2005, 33:1526-1530.
7. Greber B., Lehrach H., Adjaye J. Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells 2007, 25:455-464.
8. van der Heyden M.A., Defize L.H. Twenty one years of P19 cells: what an embryonal carcinoma cell line taught us about cardiomyocyte differentiation. Cardiovasc. Res. 2003, 58:292-302.
9. Jones-Villeneuve E.M., McBurney M.W., Rogers K.A., Kalnins V.I. Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells. J. Cell Biol. 1982, 94:253-262.
10. Pachernik J., Bryja V., Esner M., Kubala L., Dvorak P., Hampl A. Neural differentiation of pluripotent mouse embryonal carcinoma cells by retinoic acid: inhibitory effect of serum. Physiol. Res. 2005, 54:115-122.
11. Fenaux P., Wang Z.Z., Degos L. Treatment of acute promyelocytic leukemia by retinoids. Curr. Top Microbiol. Immunol. 2007, 313:101-128.
12. Xu Y.J., Zhen Y.S., Goldberg I.H. C1027 chromophore, a potent new enediyne antitumor antibiotic, induces sequence-specific double-strand DNA cleavage. Biochemistry 1994, 33:5947-5954.
13. Kennedy D.R., Beerman T.A. The radiomimetic enediyne C-1027 induces unusual DNA damage responses to double-strand breaks. Biochemistry 2006, 45:3747-3754.
14. Cai L., Chen H., Miao Q., Wu S., Shang Y., Zhen Y. Binding capability of the enediyne-associated apoprotein to human tumors and constitution of a ligand oligopeptide-integrated protein. J. Biotechnol. 2009, 144:142-150.
15. He Q.Y., Liang Y.Y., Wang D.S., Li D.D. Characteristics of mitotic cell death induced by enediyne antibiotic lidamycin in human epithelial tumor cells. Int. J. Oncol. 2002, 20:261-266.
16. Zhen Y.Z., Lin Y.J., Shang B.Y., Zhen Y.S. Enediyne lidamycin induces apoptosis in human multiple myeloma cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase. Int. J. Hematol. 2009, 90:44-51.
17. Zhen H.Y., He Q.H., Zhen Y.Z., Wang S.L., Liu Y.N., Wu W.H., Zhang X.Y., Lu A.L., Shen L. Inhibition of mouse embryonic carcinoma cell growth by lidamycin through down-regulation of embryonic stem cell-like genes Oct4, Sox2 and Myc. Invest. New Drugs 2011, 29:1188-1197.
18. Brambrink T., Foreman R., Welstead G.G., Lengner C.J., Wernig M., Suh H., Jaenisch R. Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2008, 2:151-159.
19. Zhu W.G., Hileman T., Ke Y., Wang P., Lu S., Duan W., Dai Z., Tong T., Villalona-Calero M.A., Plass C., Otterson G.A. 5-Aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation. J. Biol. Chem. 2004, 279:15161-15166.
20. Shang Y., Hu X., DiRenzo J., Lazar M.A., Brown M. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 2000, 103:843-852.
21. Pruszak J., Ludwig W., Blak A., Alavian K., Isacson O. CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells. Stem Cells 2009, 27:2928-2940.
22. Bibel M., Richter J., Schrenk K., Tucker K.L., Staiger V., Korte M., Goetz M., Barde Y.A. Differentiation of mouse embryonic stem cells into a defined neuronal lineage. Nat. Neurosci. 2004, 7:1003-1009.
23. Tewey K.M., Rowe T.C., Yang L., Halligan B.D., Liu L.F. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 1984, 226:466-468.
24. Di Cunto F., Topley G., Calautti E., Hsiao J., Ong L., Seth P.K., Dotto G.P. Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science 1998, 280:1069-1072.
25. Brugarolas J., Chandrasekaran C., Gordon J.I., Beach D., Jacks T., Hannon G.J. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 1995, 377:552-557.
26. Liu X., Bian C., Ren K., Jin H., Li B., Shao R.G. Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway. Oncol. Rep. 2007, 17:597-603.
27. Duronio R.J., O'Farrell P.H. Developmental control of a G1-S transcriptional program in Drosophila. Development 1994, 120:1503-1515.
28. Galderisi U., Jori F.P., Giordano A. Cell cycle regulation and neural differentiation. Oncogene 2003, 22:5208-5219.
29. Hung S.P., Hsu J.R., Lo C.P., Huang H.J., Wang J.P., Chen S.T. Genistein-induced neuronal differentiation is associated with activation of extracellular signal-regulated kinases and upregulation of p21 and N-cadherin. J. Cell. Biochem. 2005, 96:1061-1070.
30. Trosko J.E. Review paper: cancer stem cells and cancer nonstem cells: from adult stem cells or from reprogramming of differentiated somatic cells. Vet. Pathol. 2009, 46:176-193.
31. Ku J.L., Shin Y.K., Kim D.W., Kim K.H., Choi J.S., Hong S.H., Jeon Y.K., Kim S.H., Kim H.S., Park J.H., Kim I.J., Park J.G. Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers. Carcinogenesis 2010, 31:1003-1009.