Oct-4 controls cell-cycle progression of embryonic stem cells

Biochemical Journal

Volumn 426, Issue 2, 2010, Pages 171-181

  Lee, Jungwoon ^a   Go, Yeorim ^a   Kang, Inyoung ^a   Han, Yong Mahn ^b   Kim, Jungho ^a  

^a Sogang University   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Cell cycle control; Differentiation; Enbryonic stem cell; G1 cell cycle arrest; Oct 4; P21; Self renewal

Indexed keywords

CELL CYCLE; CELL-CYCLE ARREST; CELL-CYCLE CONTROL; CELL-CYCLE PROGRESSION; DELETION ANALYSIS; DOWN-REGULATION; EMBRYONIC STEM CELLS; EMBRYONIC STEMS; ENBRYONIC STEM CELLS; ES CELLS; FUNCTIONAL DOMAINS; PLURIPOTENCY; PLURIPOTENT; PLURIPOTENT STEM CELLS; PROTEIN LEVEL; S-PHASE;

CELL PROLIFERATION; GENE EXPRESSION;

STEM CELLS;

OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN P21;

ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYONIC STEM CELL; GENE DELETION; GENE REPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; EMBRYONIC STEM CELLS; HUMANS; MICE; OCTAMER TRANSCRIPTION FACTOR-3;

EID: 76549101973     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091439     Document Type: Article

References (49)

1. Niwa, H. (2001) Molecular mechanism to maintain stem cell renewal of ES cells. Cell Struct. Funct. 26, 137-148
2. Okamoto, K., Okazawa, H., Okuda, A., Sakai, M., Muramatsu, M. and Hamada, H. (1990) A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60, 461-472
3. Scholer, H. R., Dressler, G. R., Balling, R., Rohdewohld, H. and Gruss, P. (1990) Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J. 9, 2185-2195
4. Rosner, M. H., Vigano, M. A., Ozato, K., Timmons, P. M., Poirier, F., Rigby, P. W. and Staudt, L. M. (1990) A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345, 686-692
5. Goto, T., Adjaye, J., Rodeck, C. H. and Monk, M. (1999) Identification of genes expressed in human primordial germ cells at the time of entry of the female germ line into meiosis. Mol. Hum. Reprod. 5, 851-860
6. Hansis, C., Grifo, J. A. and Krey, L. C. (2000) Oct-4 expression in inner cell mass and trophectoderm of human blastocysts. Mol. Hum. Reprod. 6, 999-1004
7. Burdon, T., Smith, A. and Savatier, P. (2002) Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol. 12, 432-438
8. Scholer, H. R., Ruppert, S., Suzuki, N., Chowdhury, K. and Gruss, P. (1990) New type of POU domain in germ line-specific protein Oct-4. Nature 344, 435-439
9. Yeom, Y. I., Ha, H. S., Balling, R., Scholer, H. R. and Artzt, K. (1991) Structure, expression and chromosomal location of the Oct-4 gene. Mech. Dev. 35, 171-179
10. Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Scholer, H. and Smith, A. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95, 379-391
11. Pesce, M., Wang, X., Wolgemuth, D. J. and Scholer, H. (1998) Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech. Dev. 71, 89-98
12. Niwa, H., Miyazaki, J. and Smith, A. G. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24, 372-376
13. Abdel-Rahman, B., Fiddler, M., Rappolee, D. and Pergament, E. (1995) Expression of transcription regulating genes in human preimplantation embryos. Hum. Reprod. 10, 2787-2792
14. Scholer, H. R., Balling, R., Hatzopoulos, A. K., Suzuki, N. and Gruss, P. (1989) Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO J. 8, 2551-2557
15. Scholer, H. R. (1991) Octamania: the POU factors in murine development. Trends Genet. 7, 323-329
16. Brehm, A., Ohbo, K. and Scholer, H. (1997) The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain. Mol. Cell. Biol. 17, 154-162
17. Lee, J., Rhee, B. K., Bae, G. Y., Han, Y. M. and Kim, J. (2005) Stimulation of Oct-4 activity by Ewing's sarcoma protein. Stem Cells 23, 738-751
18. Chew, J. L., Loh, Y. H., Zhang, W., Chen, X., Tam, W. L., Yeap, L. S., Li, P., Ang, Y. S., Lim, B., Robson, P. and Ng, H. H. (2005) Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol. Cell. Biol. 25, 6031-6046
19. Butteroni, C., De Felici, M., Scholer, H. R. and Pesce, M. (2000) Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins. J. Mol. Biol. 304, 529-540
20. Brehm, A., Ohbo, K., Zwerschke, W., Botquin, V., Jansen-Durr, P. and Scholer, H. R. (1999) Synergism with germ line transcription factor Oct-4: viral oncoproteins share the ability to mimic a stem cell-specific activity. Mol. Cell. Biol. 19, 2635-2643
21. Scholer, H. R., Ciesiolka, T. and Gruss, P. (1991) A nexus between Oct-4 and E1A: implications for gene regulation in embryonic stem cells. Cell 66, 291-304
22. Lee, J., Kim, H. K., Han, Y. M. and Kim, J. (2008) Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int. J. Biochem. Cell Biol. 40, 1043-1054
23. Sambrook, J. and Russell, D. W. (2001) Molecular Cloning: a Laboratory Manual, Cold Spring Harbor Laboratory Press, New York
24. Lee, J., Kim, H. K., Rho, J. Y., Han, Y. M. and Kim, J. (2006) The human OCT-4 isoforms differ in their ability to confer self-renewal. J. Biol. Chem. 281, 33554-33565
25. Niwa, H., Masui, S., Chambers, I., Smith, A. G. and Miyazaki, J. (2002) Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells. Mol. Cell. Biol. 22, 1526-1536
26. Lee, J., Kim, J. Y., Kang, I. Y., Kim, H. K., Han, Y. M. and Kim, J. (2007) The EWS-Oct-4 fusion gene encodes a transforming gene. Biochem. J. 406, 519-526
27. Odorico, J. S., Kaufman, D. S. and Thomson, J. A. (2001) Multilineage differentiation from human embryonic stem cell lines. Stem Cells 19, 193-204
28. Pesce, M. and Scholer, H. R. (2001) Oct-4: gatekeeper in the beginnings of mammalian development. Stem Cells 19, 271-278
29. Evans, M. J. and Kaufman, M. H. (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154-156
30. Koestenbauer, S., Zech, N. H., Juch, H., Vanderzwalmen, P., Schoonjans, L. and Dohr, G. (2006) Embryonic stem cells: similarities and differences between human and murine embryonic stem cells. Am. J. Reprod. Immunol. 55, 169-180
31. Rodda, D. J., Chew, J. L., Lim, L. H., Loh, Y. H., Wang, B., Ng, H. H. and Robson, P. (2005) Transcriptional regulation of nanog by OCT4 and SOX2. J. Biol. Chem. 280, 24731-24737
32. Kuroda, T., Tada, M., Kubota, H., Kimura, H., Hatano, S. Y., Suemori, H., Nakatsuji, N. and Tada, T. (2005) Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol. Cell. Biol. 25, 2475-2485
33. Tomioka, M., Nishimoto, M., Miyagi, S., Katayanagi, T., Fukui, N., Niwa, H., Muramatsu, M. and Okuda, A. (2002) Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex. Nucleic Acids Res. 30, 3202-3213
34. Ambrosetti, D. C., Basilico, C. and Dailey, L. (1997) Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites. Mol. Cell. Biol. 17, 6321-6329
35. Ben-Shushan, E., Thompson, J. R., Gudas, L. J. and Bergman, Y. (1998) Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site. Mol. Cell. Biol. 18, 1866-1878
36. Beck, F., Erler, T., Russell, A. and James, R. (1995) Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes. Dev. Dyn. 204, 219-227
37. Cserjesi, P., Brown, D., Lyons, G. E. and Olson, E. N. (1995) Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev. Biol. 170, 664-678
38. Sherr, C. J. (2000) The Pezcoller lecture: cancer cell cycles revisited. Cancer Res. 60, 3689-3695
39. Sherr, C. J. and Roberts, J. M. (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512
40. Gartel, A. L. and Tyner, A. L. (2002) The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol. Cancer Ther. 1, 639-649
41. Neganova, I. and Lako, M. (2008) G1 to S phase cell cycle transition in somatic and embryonic stem cells. J. Anat. 213, 30-44
42. Becker, K. A., Ghule, P. N., Therrien, J. A., Lian, J. B., Stein, J. L., van Wijnen, A. J. and Stein, G. S. (2006) Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase. J. Cell. Physiol. 209, 883-893
43. Fluckiger, A. C., Marcy, G., Marchand, M., Negre, D., Cosset, F. L., Mitalipov, S., Wolf, D., Savatier, P. and Dehay, C. (2006) Cell cycle features of primate embryonic stem cells. Stem Cells 24, 547-556
44. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. and Elledge, S. J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816
45. Xiong, Y., Hannon, G. J., Zhang, H., Casso, D., Kobayashi, R. and Beach, D. (1993) p21 is a universal inhibitor of cyclin kinases. Nature 366, 701-704
46. Gartel, A. L. and Tyner, A. L. (1999) Transcriptional regulation of the p21(WAF1/CIP1) gene. Exp. Cell Res. 246, 280-289
47. Maki, C. G. and Howley, P. M. (1997) Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol. Cell. Biol. 17, 355-363
48. Sheaff, R. J., Singer, J. D., Swanger, J., Smitherman, M., Roberts, J. M. and Clurman, B. E. (2000) Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination. Mol. Cell. 5, 403-410
49. Touitou, R., Richardson, J., Bose, S., Nakanishi, M., Rivett, J. and Allday, M. J. (2001) A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 α-subunit of the 20S proteasome. EMBO J. 20, 2367-2375