Enediyne lidamycin induces apoptosis in human multiple myeloma cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase

International Journal of Hematology

Volumn 90, Issue 1, 2009, Pages 44-51

  Zhen, Yong Zhan ^a,b   Lin, Ya Jun ^a   Shang, Bo Yang ^a   Zhen, Yong Su ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b NORTH CHINA COAL MEDICAL COLLEGE   (China)

Author keywords

Apoptosis; Lidamycin; MAPKs; Multiple myeloma

Indexed keywords

ANTIBIOTIC AGENT; CASPASE 3; CASPASE 7; DEXAMETHASONE; DOXORUBICIN; LIDAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; VINCRISTINE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; MULTIPLE MYELOMA; PROTEIN EXPRESSION;

AMINOGLYCOSIDES; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENEDIYNES; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MULTIPLE MYELOMA; NEOPLASM PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLY(ADP-RIBOSE) POLYMERASES;

EID: 70350568219     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-009-0340-3     Document Type: Article

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