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ChemMedChem
Volumn 7, Issue 5, 2012, Pages 883-896
Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors
Author keywords

ADME; Antiviral agents; Lead optimization; NNRTIs; Reverse transcriptase
Indexed keywords

1 (3 BROMOPROP 1ENYL) 4 METHOXYBENZENE; 1 (4 METHOXYPHENYL) PROP 2 EN 1 OL; 1 (4 METHOXYPHENYL) PROP 2 EN 1 ONE; 1,3 DIFLUORO 2 (1 METHOXYPROP 1 EN 2 YL) BENZENE; 2 (2,6 DIFLUOROPHENYL) PROPANAL; 2 (4 METHOXYBENZYLAMINO) 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] PYRIMIADIN 4 (3H) ONE; 2 [4 (4 METHOXYPHENYL)BUT 3 EN 2 YLTHIO) 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 5 METHYLPYRIMIDIN 4 (3H) ONE; 2 [N (4 METHOXYBENZYL) N METHYLAMINO) 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] PYRIMIDIN 4 (3H) ONE; 2 AMINO 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 3 [[2 (4 METHOXYPHENYL) CYCLOPROPYL] METHYL] PYRIMIDIN 4 (3H) ONE; 3 (4 METHOXYBENZYL) 2 AMINO 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] PYRIMIDIN 4 (3H) ONE; 3 (4 METHOXYPHENYL) PROP 2 EN 1 OL; 3 (4 METHOXYPHENYL) PROP 2 YN 1 OL; 4 (4 METHOXYPHENYL) BUT 3 EN 2 OL; 6 (2,6 DIFLUOROBENZYL) 2 [3 (4 METHOXYPHENYL) 3 OXOPROPYLTHIO] 5 METHYLPYRIMIDIN 4(3H) ONE; 6 (2,6 DIFLUOROBENZYL) 2 [3 (HYDROXYIMINO) 3 (4 METHOXYPHENYL) PROPYLTHIO] 5 METHYLPYRIMIDIN 4 (3H) ONE; 6 (2,6 DIFLUOROBENZYL) 2 [3 (HYDROXYIMINO) 3 (4 METHOXYPHENYL) PROPYLTHIO] 5 METHYLPYRIMIDIN 4(3H) ONE; 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 2 [3 (4 METHOXYPHENYL) 2 METHYLENEBUT 3 ENYLTHIO] 5 METHYLPYRIMIDIN 4 (3H) ONE; 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 2 [3 (4 METHOXYPHENYL) 3 OXOPROPYLTHIO] 5 METHYLPYRIMIDIN 4 (3H) ONE; 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 2 [3 (4 METHOXYPHENYL) ALLYLTHIO] 5 METHYLPYRIMIDIN 4 (3H) ONE; 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 2 [3 (4 METHOXYPHENYL)PROP-2-YNYLTHIO)-5-METHYLPYRIMIDIN-4-YL BENZOATE (11) AND 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 2 [3 (4 METHOXYPHENYL)PROP 2 YNYLTHIO] 5 METHYLPYRIMIDIN 4 (3H) ONE; 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 2 [3 HYDROXY 3 (4 METHOXYPHENL) PENTYLTHIO] 5 METHYLPYRIMIDIN 4 (3H) ONE; 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 2 [3 HYDROXY 3 (4 METHOXYPHENL) PROPYLTHIO] 5 METHYLPYRIMIDIN 4 (3H) ONE; 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 2 [3 HYDROXY 3 (4 METHOXYPHENLY) PROPYLTHIO] 5 METHYLPYRIMIDIN 4 (3H) ONE; 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 2 [[1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL] METHYLTHIO] 5 METHYLPYRIMIDIN 4 (3H) ONE; 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 2 [[1 (4 METHOXYPHENYL) 1H 1,2,3 TRIAZOL 4 YL] METHYLTHIO] 5 METHYLPYRIMIDIN 4(3H) ONE; 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 5 METHYL 2 (PROP 2 YNYLTHIO) PYRIMIDIN 4 (3H) ONE; 6 [1 (2,6 DIFLUOROPHENYL) ETHYL] 5 METHYL 2 (PROP 2 YNYLTHIO) PYRIMIDIN 4 YL BENZOATE; METHYL 4 (2,6 DIFLUOROPHENYL) PENT 2 YNOATE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;
EID: 84860317989     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200056     Document Type: Article
Times cited : (15)
References (37)
  • 35
    • 84860332112 scopus 로고    scopus 로고
    • High-Throughput Measurements of Solubility Profiles. Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies, LogP2000, 2nd Lipophilicity Symposium, Lausanne (Switzerland), March 5-9, 2000305-325.
    • A. Avdeef, High-Throughput Measurements of Solubility Profiles. Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies, LogP2000, 2nd Lipophilicity Symposium, Lausanne (Switzerland), March 5-9, 2000, pp.305-325.
    • Avdeef, A.1

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.