메뉴 건너뛰기




Volumn 58, Issue 1, 2012, Pages 35-47

Pathways and gene expression profiles in hepatocellular carcinoma

Author keywords

Carcinoma, hepatocellular; Chromosome aberrations; Phenotype

Indexed keywords

AFLATOXIN; ANDROGEN RECEPTOR; BETA CATENIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; EPIDERMAL GROWTH FACTOR RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1; K RAS PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 5A; PROTEIN P53; RETINOBLASTOMA PROTEIN; SECURIN; SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; SORAFENIB; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84860283100     PISSN: 00264776     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (3)

References (88)
  • 1
    • 67650938576 scopus 로고    scopus 로고
    • Hepatocellular carcinoma - Epidemiological trends and risk factors
    • Schütte K, Bornschein J, Malfertheiner P. Hepatocellular carcinoma - epidemiological trends and risk factors. Dig Dis 2009;27:80-92.
    • (2009) Dig Dis , vol.27 , pp. 80-92
    • Schütte, K.1    Bornschein, J.2    Malfertheiner, P.3
  • 3
    • 0035732841 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: An Asian perspective
    • DOI 10.1159/000050692
    • Teo EK, Fock KM. Hepatocellular carcinoma: an Asian perspective. Dig Dis 2001;19:263-8 (Pubitemid 34297993)
    • (2001) Digestive Diseases , vol.19 , Issue.4 , pp. 263-268
    • Teo, E.K.1    Fock, K.M.2
  • 4
    • 33747517955 scopus 로고    scopus 로고
    • The epidemiology of nonalcoholic fatty liver disease in adults
    • DOI 10.1097/01.mcg.0000168638.84840.ff, PII 0000483620060300100003
    • Clark JM. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol 2006;40 Suppl 1:S5-S10. (Pubitemid 44309537)
    • (2006) Journal of Clinical Gastroenterology , vol.40 , Issue.SUPPL. 1
    • Clark, J.M.1
  • 5
    • 0035067203 scopus 로고    scopus 로고
    • 1: From mutational spectrometry to carcinogenesis
    • Smela ME, Currier SS, Bailey EA, Essigmann JM. The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis. Carcinogenesis 2001;22:535-45. (Pubitemid 32288652)
    • (2001) Carcinogenesis , vol.22 , Issue.4 , pp. 535-545
    • Smela, M.E.1    Currier, S.S.2    Bailey, E.A.3    Essigmann, J.M.4
  • 6
    • 0025828517 scopus 로고
    • Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
    • Bressac B, Kew M, Wands J, Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 1991;350:429-31. (Pubitemid 21912246)
    • (1991) Nature , vol.350 , Issue.6317 , pp. 429-431
    • Bressac, B.1    Kew, M.2    Wands, J.3    Ozturk, M.4
  • 7
    • 70350567326 scopus 로고    scopus 로고
    • Hepatic iron overload and hepatocellular carcinoma
    • Kew MC. Hepatic iron overload and hepatocellular carcinoma. Cancer Lett 2009;286:38-43.
    • (2009) Cancer Lett , vol.286 , pp. 38-43
    • Kew, M.C.1
  • 9
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • DOI 10.1038/ng0802-339
    • Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002;31:339-46. (Pubitemid 35154440)
    • (2002) Nature Genetics , vol.31 , Issue.4 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 11
    • 0027367008 scopus 로고
    • Proposal for standardized criteria for the diagnosis of benign, borderline, and malignant hepatocellular lesions arising in chronic advanced liver disease
    • DOI 10.1097/00000478-199311000-00004
    • Ferrell LD, Crawford JM, Dhillon AP, Scheuer PJ, Nakanuma Y. Proposal for standardized criteria for the diagnosis of benign, borderline, and malignant hepatocellular lesions arising in chronic advanced liver disease. Am J Surg Pathol 1993;17:1113-23. (Pubitemid 23313785)
    • (1993) American Journal of Surgical Pathology , vol.17 , Issue.11 , pp. 1113-1123
    • Ferrell, L.D.1    Crawford, J.M.2    Dhillon, A.P.3    Scheuer, P.J.4    Nakanuma, Y.5
  • 12
    • 1242329815 scopus 로고    scopus 로고
    • Hepatocellular nodules in cirrhosis: Focus on diagnostic criteria on liver biopsy. A western experience
    • Roncalli M. Hepatocellular nodules in cirrhosis: focus on diagnostic criteria on liver biopsy. A Western experience. Liver Transpl 2004;10:S9-S15. (Pubitemid 38240093)
    • (2004) Liver Transplantation , vol.10 , Issue.2 SUPPL. 1
    • Roncalli, M.1
  • 13
    • 0033867475 scopus 로고    scopus 로고
    • Genetics of hepatocellular carcinoma
    • DOI 10.1006/scbi.2000.0319
    • Buendia MA. Genetics of hepatocellular carcinoma. Semin Cancer Biol 2000;10:185-200. (Pubitemid 30614220)
    • (2000) Seminars in Cancer Biology , vol.10 , Issue.3 , pp. 185-200
    • Annick, B.M.1
  • 14
    • 20344399151 scopus 로고    scopus 로고
    • Early hepatocellular carcinoma and dysplastic nodules
    • DOI 10.1055/s-2005-871193
    • Kojiro M, Roskams T. Early hepatocellular carcinoma and dysplastic nodules. Semin Liver Dis 2005;25:133-42. (Pubitemid 40781066)
    • (2005) Seminars in Liver Disease , vol.25 , Issue.2 , pp. 133-142
    • Kojiro, M.1    Roskams, T.2
  • 19
    • 33745532794 scopus 로고    scopus 로고
    • Genetics of hepatocellular tumors
    • DOI 10.1038/sj.onc.1209547, PII 1209547
    • Laurent-Puig P, Zucman-Rossi J. Genetics of hepatocellular tumors. Oncogene 2006;25:3778-86. (Pubitemid 43980473)
    • (2006) Oncogene , vol.25 , Issue.27 , pp. 3778-3786
    • Laurent-Puig, P.1    Zucman-Rossi, J.2
  • 21
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995;81:323-30.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 22
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman JG, Merlo A, Mao L, Lapidus RG, Issa JP, Davidson NE et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 1995;55:4525-30.
    • (1995) Cancer Res , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.P.5    Davidson, N.E.6
  • 24
    • 0021748312 scopus 로고
    • Hypomethylation of DNA in human cancer cells:A site-specific change in the c-myc oncogene
    • Cheah MS, Wallace CD, Hoffman RM. Hypomethylation of DNA in human cancer cells:a site-specific change in the c-myc oncogene. J Natl Cancer Inst 1984;73.1057-65.
    • (1984) J Natl Cancer Inst , vol.73 , pp. 1057-1065
    • Cheah, M.S.1    Wallace, C.D.2    Hoffman, R.M.3
  • 26
    • 0031442751 scopus 로고    scopus 로고
    • Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis
    • Sun L, Hui AM, Kanai Y, Sakamoto M, Hirohashi S. Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis. Jpn J Cancer Res 1998;88:1165-70.
    • (1998) Jpn J Cancer Res , vol.88 , pp. 1165-1170
    • Sun, L.1    Hui, A.M.2    Kanai, Y.3    Sakamoto, M.4    Hirohashi, S.5
  • 27
    • 0033052844 scopus 로고    scopus 로고
    • DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis
    • Kanai Y, Hui AM, Sun L, Ushijima S, Sakamoto M, Tsuda H et al. DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis. Hepatology 1999;29:703-9. (Pubitemid 29109583)
    • (1999) Hepatology , vol.29 , Issue.3 , pp. 703-709
    • Kanai, Y.1    Hui, A.-M.2    Sun, L.3    Ushijima, S.4    Sakamoto, M.5    Tsuda, H.6    Hirohashi, S.7
  • 28
    • 0028964323 scopus 로고
    • Expression of antisense to DNA methyltransferase mRNA induces DNA methylation and inhibits tumorigenesis
    • MacLeod AR, Szyf M. Expression of antisense to DNA methyltransferase mRNA induces DNA methylation and inhibits tumorigenesis. J Biol Chem 1995;270:8037-43
    • (1995) J Biol Chem , vol.270 , pp. 8037-8043
    • MacLeod, A.R.1    Szyf, M.2
  • 31
    • 0031845301 scopus 로고    scopus 로고
    • Microsatellite instability in human hepatocellular carcinoma: Relationship to p53 abnormalities
    • Kazachkov Y, Yoffe B, Khaoustov VI, Salomon H, Klintmalm GB, Tabor E. Microsatellite instability in human hepatocellular carcinoma: relationship to p53 abnormalities. Liver 1998;18:156-61. (Pubitemid 28368064)
    • (1998) Liver , vol.18 , Issue.3 , pp. 156-161
    • Kazachkov, Y.1    Yoffe, B.2    Khaoustov, V.I.3    Solomon, H.4    Klintmalm, G.B.G.5    Tabor, E.6
  • 32
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • DOI 10.1126/science.1064921
    • Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschi T. Identification of novel genes encoding for small expressed RNAs. Science 2001;294:853-8. (Pubitemid 33032103)
    • (2001) Science , vol.294 , Issue.5543 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 33
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • DOI 10.1126/science.1065062
    • Lau NC, Lim LP, Weinstein EG, Bartel DP. An abundant class of tiny RNAs with probably regulatory roles in Caenorhabditis elegans. Science 2001;294:858-62. (Pubitemid 33032104)
    • (2001) Science , vol.294 , Issue.5543 , pp. 858-862
    • Lau, N.C.1    Lim, L.P.2    Weinstein, E.G.3    Bartel, D.P.4
  • 34
    • 0038343499 scopus 로고    scopus 로고
    • MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing
    • DOI 10.1016/S0092-8674(03)00428-8
    • Ambros V. MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 2003;113:673-6. (Pubitemid 36724931)
    • (2003) Cell , vol.113 , Issue.6 , pp. 673-676
    • Ambros, V.1
  • 35
    • 18144365478 scopus 로고    scopus 로고
    • MicroRNA biogenesis and cancer
    • DOI 10.1158/0008-5472.CAN-05-0298
    • Gregory RJ, Shiekhattar R. MicroRNA biogenesis and cancer. Cancer Res 2005;65:3509-12. (Pubitemid 40616320)
    • (2005) Cancer Research , vol.65 , Issue.9 , pp. 3509-3512
    • Gregory, R.I.1    Shiekhattar, R.2
  • 37
    • 70349871321 scopus 로고    scopus 로고
    • MicroRNA expression, survival, and response to interferon in liver cancer
    • Ji J, Shi J, Budhu A, Yu Z, Forques M, Roessler S et al. MicroRNA expression, survival, and response to interferon in liver cancer. N Engl J Med 2009;361:1437-47.
    • (2009) N Engl J Med , vol.361 , pp. 1437-1447
    • Ji, J.1    Shi, J.2    Budhu, A.3    Yu, Z.4    Forques, M.5    Roessler, S.6
  • 40
    • 33747819801 scopus 로고    scopus 로고
    • mTOR and cancer: Insights into a complex relationship
    • DOI 10.1038/nrc1974, PII NRC1974
    • Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 2006;6:729-34. (Pubitemid 44286004)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 729-734
    • Sabatini, D.M.1
  • 44
    • 33745577640 scopus 로고    scopus 로고
    • Comparative and integrative functional genomics of HCC
    • DOI 10.1038/sj.onc.1209561, PII 1209561
    • Lee JS, Thorgeirsson SS. Comparative and integrative functional genomics of HCC. Oncogene 2006;25:3801-9. (Pubitemid 43980475)
    • (2006) Oncogene , vol.25 , Issue.27 , pp. 3801-3809
    • Lee, J.-S.1    Thorgeirsson, S.S.2
  • 45
    • 33645453248 scopus 로고    scopus 로고
    • Epigenetic instability and chromosomal instability in hepatocellular carcinoma
    • Katoh H, Shibata T, Kokubu A, Ojima H, Fukuyama M, Kanai Y et al. Epigenetic instability and chromosomal instability in hepatocellular carcinoma. Am J Pathol 2006;168:1375-84.
    • (2006) Am J Pathol , vol.168 , pp. 1375-1384
    • Katoh, H.1    Shibata, T.2    Kokubu, A.3    Ojima, H.4    Fukuyama, M.5    Kanai, Y.6
  • 48
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • DOI 10.1016/j.ccr.2006.06.016, PII S1535610806002145
    • Budhu A, Forgues M, Ye Q-H, Jia HL, He P, Zanetti KA et al. Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 2006;10:99-111. (Pubitemid 44202603)
    • (2006) Cancer Cell , vol.10 , Issue.2 , pp. 99-111
    • Budhu, A.1    Forgues, M.2    Ye, Q.-H.3    Jia, H.-L.4    He, P.5    Zanetti, K.A.6    Kammula, U.S.7    Chen, Y.8    Qin, L.-X.9    Tang, Z.-Y.10    Wang, X.W.11
  • 49
    • 33646562819 scopus 로고    scopus 로고
    • Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma
    • DOI 10.1002/hep.21196
    • Branda M, Wands JR. Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma. Hepatology 2006;43:891-902. (Pubitemid 43724611)
    • (2006) Hepatology , vol.43 , Issue.5 , pp. 891-902
    • Branda, M.1    Wands, J.R.2
  • 50
    • 33645742425 scopus 로고    scopus 로고
    • A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    • Lee JS, Heo J, Libbrecht L, Chu IS, Kaposi-Novak P, Calvisi DF et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med 2006;12:410-6.
    • (2006) Nat Med , vol.12 , pp. 410-416
    • Lee, J.S.1    Heo, J.2    Libbrecht, L.3    Chu, I.S.4    Kaposi-Novak, P.5    Calvisi, D.F.6
  • 51
    • 53049086329 scopus 로고    scopus 로고
    • Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
    • Chiang DY, Villanueva A, Hoshida Y, Peix J, Newell P, Minquez B et al. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res 2008;68:6779-88.
    • (2008) Cancer Res , vol.68 , pp. 6779-6788
    • Chiang, D.Y.1    Villanueva, A.2    Hoshida, Y.3    Peix, J.4    Newell, P.5    Minquez, B.6
  • 52
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • DOI 10.1126/science.275.5307.1787
    • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997;275:1787-90. (Pubitemid 27136715)
    • (1997) Science , vol.275 , Issue.5307 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 54
    • 0034495080 scopus 로고    scopus 로고
    • Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis
    • Hsu HC, Jeng YM, Mao TL, Chu JS, Lai PL, Peng SY. Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 2000;157:763-70.
    • (2000) Am J Pathol , vol.157 , pp. 763-770
    • Hsu, H.C.1    Jeng, Y.M.2    Mao, T.L.3    Chu, J.S.4    Lai, P.L.5    Peng, S.Y.6
  • 55
    • 0032761853 scopus 로고    scopus 로고
    • Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C infection
    • Huang H, Fujii H, Sankila A, Mahler-Araujo BM, Matsuda M, Cathomas G et al. Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C infection. Am J Pathol 1999;155:1795-801.
    • (1999) Am J Pathol , vol.155 , pp. 1795-1801
    • Huang, H.1    Fujii, H.2    Sankila, A.3    Mahler-Araujo, B.M.4    Matsuda, M.5    Cathomas, G.6
  • 56
    • 20344366296 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Molecular pathways and new therapeutic targets
    • DOI 10.1055/s-2005-871200
    • Roberts LR, Gores GJ. Hepatocellular carcinoma: molecular pathways and new therapeutic targets. Semin Liver Dis 2005;25:212-25 (Pubitemid 40781073)
    • (2005) Seminars in Liver Disease , vol.25 , Issue.2 , pp. 212-225
    • Roberts, L.R.1    Gores, G.J.2
  • 57
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • DOI 10.1038/sj.onc.1210421, PII 1210421
    • Dhillon AS, Hagan S, Rath O, Kolch W. MAP kinase signaling pathways in cancer. Oncogene 2007;26:3279-90. (Pubitemid 46763021)
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 58
    • 69949129964 scopus 로고    scopus 로고
    • Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo
    • Newell P, Toffanin S, Villanueva A, Chiang DY, Minquez B, Cabellos L et al. Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. J Hepatol 2009;51:725-33.
    • (2009) J Hepatol , vol.51 , pp. 725-733
    • Newell, P.1    Toffanin, S.2    Villanueva, A.3    Chiang, D.Y.4    Minquez, B.5    Cabellos, L.6
  • 60
    • 40849124295 scopus 로고    scopus 로고
    • Novel advancements in the management of hepatocellular carcinoma in 2008
    • Llovet JM, Bruix J. Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol 2008;48:S20-37.
    • (2008) J Hepatol , vol.48
    • Llovet, J.M.1    Bruix, J.2
  • 61
    • 20344366296 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Molecular pathways and new therapeutic targets
    • DOI 10.1055/s-2005-871200
    • Roberts LR, Gores GJ. Hepatocellular carcinoma: molecular pathways and new therapeutic targets. Semin Liver Dis 2005;25:212-25. (Pubitemid 40781073)
    • (2005) Seminars in Liver Disease , vol.25 , Issue.2 , pp. 212-225
    • Roberts, L.R.1    Gores, G.J.2
  • 64
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinomas weighty connection
    • Starley BQ, Calcagno CJ, Harrison SA. Nonalcoholic fatty liver disease and hepatocellular carcinomas weighty connection. Hepatology 2010;51:1820-32.
    • (2010) Hepatology , vol.51 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 65
    • 77949875878 scopus 로고    scopus 로고
    • IGF activation in a molecular subclass hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage
    • Tovar V, Alsinet C, Villanueva A, Hoshida Y, Chiang DY, Solè M et al. IGF activation in a molecular subclass hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage. J Hepatol 2010;52:550-9.
    • (2010) J Hepatol , vol.52 , pp. 550-559
    • Tovar, V.1    Alsinet, C.2    Villanueva, A.3    Hoshida, Y.4    Chiang, D.Y.5    Solè, M.6
  • 66
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
    • DOI 10.1053/j.gastro.2007.04.061, PII S0016508507007998
    • El Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132:2557-76. (Pubitemid 46890874)
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 67
    • 40449113855 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression and gene copy number in conventional hepatocellular carcinoma
    • DOI 10.1309/WF10QAAED3PP93BH
    • Buckley AF, Burgart LJ, Sahai V, Kakar S. Epidermal growth factor receptor expression and gene copy number in conventional hepatocellular carcinoma. Am J Clin Pathol 2008;129:245-51. (Pubitemid 352029315)
    • (2008) American Journal of Clinical Pathology , vol.129 , Issue.2 , pp. 245-251
    • Buckley, A.F.1    Burgart, L.J.2    Sahai, V.3    Kakar, S.4
  • 69
    • 0036432994 scopus 로고    scopus 로고
    • Hypoxia-induced angiogenesis in human hepatocellular carcinoma
    • Kim KR, Moon HE, Kim KW Hypoxia-induced angiogenesis in human hepatocellular carcinoma. J Mol Med 2002;80:703-14
    • (2002) J Mol Med , vol.80 , pp. 703-714
    • Kim, K.R.1    Moon, H.E.2    Kim, K.W.3
  • 71
    • 0031807538 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in human hepatocellular carcinoma
    • DOI 10.1002/hep.510280111
    • Yamaguchi R, Yano H, Iemura A, Ogasawara S, Haramaki M, Kojiro M. Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology 1998;28:68-77. (Pubitemid 28299987)
    • (1998) Hepatology , vol.28 , Issue.1 , pp. 68-77
    • Yamaguchi, R.1    Yano, H.2    Iemura, A.3    Ogasawara, S.4    Haramaki, M.5    Kojiro, M.6
  • 73
    • 46249085489 scopus 로고    scopus 로고
    • Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer
    • DOI 10.1002/hep.22283
    • Coulouarn C, Factor VM, Thorgeirsson SS. Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer. Hepatology 2008;47:2059-67. (Pubitemid 351945572)
    • (2008) Hepatology , vol.47 , Issue.6 , pp. 2059-2067
    • Coulouarn, C.1    Factor, V.M.2    Thorgeirsson, S.S.3
  • 74
    • 66149163340 scopus 로고    scopus 로고
    • Hepatitis B and hepatocellular carcinoma
    • Di Bisceglie AM. Hepatitis B and hepatocellular carcinoma. Hepatology 2009;49(Suppl 5):S56-60.
    • (2009) Hepatology , vol.49 , Issue.SUPPL. 5
    • Di Bisceglie, A.M.1
  • 76
    • 0028567172 scopus 로고
    • Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma
    • Hagen TM, Huang S, Curnutte J, Fowler P, Martinez V, Wehr CM et al. Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc Natl Acad Sci U S A 1994;91:12808-12.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 12808-12812
    • Hagen, T.M.1    Huang, S.2    Curnutte, J.3    Fowler, P.4    Martinez, V.5    Wehr, C.M.6
  • 78
    • 77951622187 scopus 로고    scopus 로고
    • Viral hepatocarcinogenesis
    • Tsai WL, Chung RT. Viral hepatocarcinogenesis. Oncogene 2010;29:2309-24.
    • (2010) Oncogene , vol.29 , pp. 2309-2324
    • Tsai, W.L.1    Chung, R.T.2
  • 80
    • 34249303417 scopus 로고    scopus 로고
    • Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis
    • DOI 10.1016/j.canlet.2006.11.010, PII S0304383506006392
    • Feitelson MA, Lee J. Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett 2007;252:157-70. (Pubitemid 46809787)
    • (2007) Cancer Letters , vol.252 , Issue.2 , pp. 157-170
    • Feitelson, M.A.1    Lee, J.2
  • 82
    • 77955429498 scopus 로고    scopus 로고
    • Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC):Molecular mechanisms and novel paradigms
    • Paris
    • Brechot C, Kremsdorf D, Soussan P, Pineau P, Dejean A, Paterlini-Brechot P et al. Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC):Molecular mechanisms and novel paradigms. Pathol Biol (Paris) 2010;58:278-87.
    • (2010) Pathol Biol , vol.58 , pp. 278-287
    • Brechot, C.1    Kremsdorf, D.2    Soussan, P.3    Pineau, P.4    Dejean, A.5    Paterlini-Brechot, P.6
  • 83
    • 3543150890 scopus 로고    scopus 로고
    • Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway
    • Yun C, Cho H, Kim SJ, Lee JH, Park SY, Chan GK et al. Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogenactivated protein pathway. Mol Cancer Res 2004;2:159-69. (Pubitemid 39030306)
    • (2004) Molecular Cancer Research , vol.2 , Issue.3 , pp. 159-169
    • Yun, C.1    Cho, H.2    Kim, S.-J.3    Lee, J.-H.4    Park, S.Y.5    Chan, G.K.6    Cho, H.7
  • 85
    • 77950609088 scopus 로고    scopus 로고
    • Expression of pituitary tumortransforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: Evidence for an HBV X protein-mediated inhibition of PTTG1 ubiquitination and degradation
    • Molina-Jimenez F, Benedicto I, Murata M, Martìn-Vilchez S, Seki T, Antonio Pintotr-Toro J et al. Expression of pituitary tumortransforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: evidence for an HBV X protein-mediated inhibition of PTTG1 ubiquitination and degradation. Hepatology 2010;51:777-87.
    • (2010) Hepatology , vol.51 , pp. 777-787
    • Molina-Jimenez, F.1    Benedicto, I.2    Murata, M.3    Martìn-Vilchez, S.4    Seki, T.5    Antonio Pintotr-Toro, J.6
  • 86
    • 0031954421 scopus 로고    scopus 로고
    • The mouse equivalent of the human p53ser249 mutation p53ser246 enhances aflatoxin hepatocarcinogenesis in hepatitis B surface antigen transgenic and p53 heterozygous null mice
    • DOI 10.1002/hep.510270411
    • Ghebranious N, Sell S. The mouse equivalent of the human p53ser249 mutation p53ser246 enhances aflatoxin hepatocarcinogenesis in hepatitis B surface antigen transgenic and p53 heterozygous null mice. Hepatology 1998;27:967-73. (Pubitemid 28160481)
    • (1998) Hepatology , vol.27 , Issue.4 , pp. 967-973
    • Ghebranious, N.1    Sell, S.2
  • 88
    • 0029114785 scopus 로고
    • Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein
    • Ray RB, Lagging LM, Meyer K, Steele R, Ray R. Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein. Virus Res 1995;37:209-20.
    • (1995) Virus Res , vol.37 , pp. 209-220
    • Ray, R.B.1    Lagging, L.M.2    Meyer, K.3    Steele, R.4    Ray, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.