Microsatellite instability in human hepatocellular carcinoma: Relationship to p53 abnormalities

Liver

Volumn 18, Issue 3, 1998, Pages 156-161

  Kazachkov, Y ^a,d   Yoffe, B ^b   Khaoustov, V I ^b   Solomon, H ^c   Klintmalm, G B G ^c   Tabor, E ^a,e  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

Hepatocellular carcinoma; Microsatellite; p53; Tumor suppressor gene

Indexed keywords

PROTEIN P53;

ADOLESCENT; ADULT; ARTICLE; BASE MISPAIRING; CLINICAL ARTICLE; CONTROLLED STUDY; DNA REPAIR; EXON; FEMALE; GENE MUTATION; GENE SEQUENCE; GENOME; HUMAN; HUMAN TISSUE; INTRON; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; MICROSATELLITE INSTABILITY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

EID: 0031845301     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0676.1998.tb00143.x     Document Type: Article

References (24)

1. TABOR E. Hepatocarcinogenesis, hepatitis viruses and altered tumor suppressor gene function. In: K Kobayashi, R H Purcell, K Shimotohno, E Tabor eds. Hepatitis C virus and its involvement in the development of hepatocellular carcinoma. Princeton. NJ: Princeton Scientific Publishing, 1995: 151-61.
2. MODRICH P. Mismatch repair, genetic stability, and cancer. Science 1994, 266: 1959-60.
3. KOLODNER R D, ALANI E. Mismatch repair and cancer susceptibility. Cur Opinion Biotechnol 1994; 5: 585-94.
4. MACDONALD G A, GREENSON J K, SAITO K. APPELMAN H D, BOLAND C R. Loss of the DNA mismatch repair genes hMSH2 and/or hMLH1 is an early event in hepatic carcinogenesis. Hepatology 1995; 22: 219A (abstr).
5. THIBODEAU S N, BREN G, SCHAID D. Microsatellite instability in cancer of the proximal colon. Science 1993; 260: 816-9.
6. RISINGER J I, UMAR A, BOYER J C, et al. Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. Cancer Res 1995; 55: 5664-9.
7. STRICKLER J G, ZHENG J, SHU Q, BURGART L J, ALBERTS S R, SHIBATA D. p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail. Cancer Res 1994; 54: 4750-5.
8. ALDAZ C M, CHEN T, SAHIN A, CUNNINGHAM J, BONDY M. Comparative allelotype of in situ and invasive human breast cancer: high frequency of microsatellite instability in lobular breast carcinomas. Cancer Res 1995; 55: 3976-81.
9. BRENTNALL T A, CHEN R, LEE J G, et al. Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis. Cancer Res 1995; 55: 4264-7.
10. MYEROFF L L, PARSONS R, KIM S-J, et al. A transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 1995; 55: 5545-7.
11. WATATANI M, YOSHIDA T, KURODA K, IEDA S, YASUTOMI M. Allelic loss of chromosome 17p, mutation of the p53 gene, and microsatellite instability in right- and left-sided colorectal cancer. Cancer 1996; 77: 1688-93.
12. UCHIDA T, WADA C, WANG C, EGAWA S, OHTANI H, KOSHIBA K. Genomic instability of microsatellite repeats and mutations of H-, K-, and N-ras, and p53 genes in renal cell carcinoma. Cancer Res 1994; 54: 3682-5.
13. KAZACHKOV Y, KHAOUSTOV V, YOFFE B, SOLOMON H, KLINTMALM G B G, TABOR E. p53 abnormalities in hepatocellular carcinoma from United States patients: analysis of all 11 exons. Carcinogenesis 1996; 17: 2207-12.
14. HSU H-C, HUANG A-M, LAI P-L, CHEN W-M, PENG S-Y, LIN S-W. Genetic alterations at the splice junction of p53 gene in human hepatocellular carcinoma. Hepatology 1994; 19: 122-8.
15. LAI M-Y, CHANG H-C, LI H-P, et al. Splicing mutations of the p53 gene in human hepatocellular carcinoma. Cancer Res 1993; 53: 1653-6.
16. SCHEINER M, HEDGES L, SCHWARTZ H S, BUTLER M G. Lack of microsatellite instability in giant cell tumor of bone. Cancer Genet Cytogenet 1996; 88: 35-8.
17. TASAKA T, LEE S, SPIRA S, et al. Infrequent microsatellite instability during the evolution of myelodysplastic syndrome to acute myelocytic leukemia. Leuk Res 1996; 20: 113-7.
18. NAKAI H, KANEKO H, HORIIKE S, et al. Multiple aberrant splicing of the p53 transcript without genomic mutations around exon-intron junctions in a case of chronic myelogenous leukaemia in blast crisis: a possible novel mechanism of p53 inactivation. Br J Haematol 1994; 87: 839-42.
19. RAIMOND J, ROULEUX F, MONSIGNY M, LEGRAND A. The second intron of the human galectin-3 gene has a strong promoter activity down-resulated by p53. FEBS Lett 1995; 363: 165-9.
20. MALKINSON A M, You M. The intronic structure of cancer-related genes regulates susceptibility to cancer. Mol Carcinog 1994; 10: 61-5.
21. NAKAI K, SAKAMOTO H. Construction of a novel database containing aberrant splicing mutations of mammalian genes. Gene 1994; 141: 171-7.
22. KAHLENBERG M S, STOLER D L, BASIK M, PETRELLY N J, RODRIGUEZ-BIGAS M, ANDERSON G R. p53 tumor suppressor gene status and the degree of genomic instability in sporadic colorectal cancers. J Natl Cancer Inst 1996; 88: 1665-70.
23. KONISHI M, KIKUCHI-YANOSHITA R, et al. Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis and sporadic colon cancer. Gastroenterology 1996; 111: 307-17.
24. SALVUCCI M, LEMOINE A, AZOULAY D, et al. Frequent microsatellite instability in post hepatitis B viral cirrhosis. Oncogene 13: 2681-5.