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Volumn 16, Issue 2, 2012, Pages 301-320

Hepatic Encephalopathy

Author keywords

Hepatic encephalopathy; Minimal hepatic encephalopathy; Overt hepatic encephalopathy; Treatment

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ACARBOSE; ACETYLCHOLINESTERASE; AMMONIA; AST 120; ENDOTOXIN; GLUTAMINASE; IMMUNOGLOBULIN G; INOSITOL; INTERLEUKIN 1; INTERLEUKIN 6; LACTITOL; LACTULOSE; NEOMYCIN; PENTOXIFYLLINE; POTASSIUM; PROBIOTIC AGENT; PROTHROMBIN; RIFAXIMIN; SERUM ALBUMIN; SYNBIOTIC AGENT; TESTOSTERONE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 84860280208     PISSN: 10893261     EISSN: 15578224     Source Type: Journal    
DOI: 10.1016/j.cld.2012.03.009     Document Type: Review
Times cited : (66)

References (118)
  • 1
    • 84860286810 scopus 로고    scopus 로고
    • Hepatic encephalopathy. In: Robson SC, Trey C, Kirsch RE (editors). Diagnosis and management of liver disease. Chapman & Hall, London, Chapter 13.
    • Voight M, Conn H. Hepatic encephalopathy. In: Robson SC, Trey C, Kirsch RE (editors). Diagnosis and management of liver disease. Chapman & Hall, London, p. 140-147, Chapter 13.
    • Voight, M.1    Conn, H.2
  • 2
    • 79955753653 scopus 로고    scopus 로고
    • Current concepts in the pathophysiology and management of hepatic encephalopathy
    • Frederick R.T. Current concepts in the pathophysiology and management of hepatic encephalopathy. Gastroenterol Hepatol 2011, 7(4):222-233.
    • (2011) Gastroenterol Hepatol , vol.7 , Issue.4 , pp. 222-233
    • Frederick, R.T.1
  • 3
    • 0036191173 scopus 로고    scopus 로고
    • Hepatic encephalopathy - definition, nomenclature, diagnosis and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna 1998
    • Ferenci P., Lockwood A., Mullen K., et al. Hepatic encephalopathy - definition, nomenclature, diagnosis and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna 1998. Hepatology 2002, 35:716-721.
    • (2002) Hepatology , vol.35 , pp. 716-721
    • Ferenci, P.1    Lockwood, A.2    Mullen, K.3
  • 4
    • 33846446011 scopus 로고    scopus 로고
    • Review article: the burden of hepatic encephalopathy
    • Poordad F.F. Review article: the burden of hepatic encephalopathy. Aliment Pharmacol Ther 2007, 25(Suppl 1):3-9.
    • (2007) Aliment Pharmacol Ther , vol.25 , Issue.SUPPL. 1 , pp. 3-9
    • Poordad, F.F.1
  • 5
    • 0034821089 scopus 로고    scopus 로고
    • Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy
    • Romero-Gomez M., Boza F., Garcia-Valdecasas M.S., et al. Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy. Am J Gastroenterol 2001, 96:2718-2723.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2718-2723
    • Romero-Gomez, M.1    Boza, F.2    Garcia-Valdecasas, M.S.3
  • 6
    • 12844268060 scopus 로고    scopus 로고
    • American Association for the Study of Liver Diseases. The role of transjugular intrahepatic portosystemic shunt in the management of portal hypertension
    • Boyer T.D., Haskal Z.J. American Association for the Study of Liver Diseases. The role of transjugular intrahepatic portosystemic shunt in the management of portal hypertension. Hepatology 2005, 41:386-400.
    • (2005) Hepatology , vol.41 , pp. 386-400
    • Boyer, T.D.1    Haskal, Z.J.2
  • 7
    • 79251535022 scopus 로고    scopus 로고
    • Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy
    • Bajaj J.S., Heuman D.M., Wade J.B., et al. Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy. Gastroenterology 2011, 140:478-487.
    • (2011) Gastroenterology , vol.140 , pp. 478-487
    • Bajaj, J.S.1    Heuman, D.M.2    Wade, J.B.3
  • 8
    • 77950240574 scopus 로고    scopus 로고
    • Gut flora and hepatic encephalopathy in patients with cirrhosis
    • Riordan S.M., Williams R. Gut flora and hepatic encephalopathy in patients with cirrhosis. N Engl J Med 2010, 362(12):1140-1141.
    • (2010) N Engl J Med , vol.362 , Issue.12 , pp. 1140-1141
    • Riordan, S.M.1    Williams, R.2
  • 9
    • 33847213560 scopus 로고    scopus 로고
    • Hospitalizations during the use of rifaximin versus lactulose for the treatment of hepatic encephalopathy
    • Leevy C.B., Phillips J.A. Hospitalizations during the use of rifaximin versus lactulose for the treatment of hepatic encephalopathy. Dig Dis Sci 2007, 52:737-741.
    • (2007) Dig Dis Sci , vol.52 , pp. 737-741
    • Leevy, C.B.1    Phillips, J.A.2
  • 10
    • 80052469447 scopus 로고    scopus 로고
    • The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers
    • Bajaj J.S., Wade J.B., Gibson D.P., et al. The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers. Am J Gastroenterol 2011, 106:1646-1653.
    • (2011) Am J Gastroenterol , vol.106 , pp. 1646-1653
    • Bajaj, J.S.1    Wade, J.B.2    Gibson, D.P.3
  • 11
    • 77949915191 scopus 로고    scopus 로고
    • Short-form Zarit caregiver burden interviews were valid in advanced conditions
    • Higginson I.J., Gao W., Jackson D., et al. Short-form Zarit caregiver burden interviews were valid in advanced conditions. J Clin Epidemiol 2010, 63:535-542.
    • (2010) J Clin Epidemiol , vol.63 , pp. 535-542
    • Higginson, I.J.1    Gao, W.2    Jackson, D.3
  • 12
    • 0033034892 scopus 로고    scopus 로고
    • Prognostic significance of hepatic encephalopathy in patients with cirrhosis
    • Bustamante J., Rimola A., Ventura P.J., et al. Prognostic significance of hepatic encephalopathy in patients with cirrhosis. J Hepatol 1999, 30:890-895.
    • (1999) J Hepatol , vol.30 , pp. 890-895
    • Bustamante, J.1    Rimola, A.2    Ventura, P.J.3
  • 13
    • 35449004862 scopus 로고    scopus 로고
    • Hepatic encephalopathy as a predictor of survival in patients with end-stage liver disease
    • Stewart C.A., Malinchoc M., Kim W.R., et al. Hepatic encephalopathy as a predictor of survival in patients with end-stage liver disease. Liver Transpl 2007, 13:1366-1371.
    • (2007) Liver Transpl , vol.13 , pp. 1366-1371
    • Stewart, C.A.1    Malinchoc, M.2    Kim, W.R.3
  • 14
    • 84856622127 scopus 로고    scopus 로고
    • Severity of chronic cognitive impairment in cirrhosis increases with number of episodes of overt hepatic encephalopathy
    • Bajaj J.S., Schubert C.M., Sanyal A.J., et al. Severity of chronic cognitive impairment in cirrhosis increases with number of episodes of overt hepatic encephalopathy. J Hepatol 2010, 52(Suppl 1):S66.
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Bajaj, J.S.1    Schubert, C.M.2    Sanyal, A.J.3
  • 15
    • 77952744973 scopus 로고    scopus 로고
    • Persistence of cognitive impairment after resolution of overt hepatic encephalopathy
    • Bajaj J.S., Schubert C.M., Heuman D.M., et al. Persistence of cognitive impairment after resolution of overt hepatic encephalopathy. Gastroenterology 2010, 138(7):2332-2340.
    • (2010) Gastroenterology , vol.138 , Issue.7 , pp. 2332-2340
    • Bajaj, J.S.1    Schubert, C.M.2    Heuman, D.M.3
  • 16
    • 67949085071 scopus 로고    scopus 로고
    • Prognosis and 1-year mortality of intensive care unit patients with severe hepatic encephalopathy
    • Fichet J., Mercier E., Genee O., et al. Prognosis and 1-year mortality of intensive care unit patients with severe hepatic encephalopathy. J Crit Care 2009, 24:364-370.
    • (2009) J Crit Care , vol.24 , pp. 364-370
    • Fichet, J.1    Mercier, E.2    Genee, O.3
  • 17
    • 0000803632 scopus 로고
    • Summer skill WH. Blood-ammonium levels in liver disease and hepatic coma
    • Phear E.A., Sherlock S. Summer skill WH. Blood-ammonium levels in liver disease and hepatic coma. Lancet 1955, 268:836-840.
    • (1955) Lancet , vol.268 , pp. 836-840
    • Phear, E.A.1    Sherlock, S.2
  • 19
    • 0036829480 scopus 로고    scopus 로고
    • Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS
    • Olde Damink S.W., Jalan R., Redhead D.N., et al. Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS. Hepatology 2002, 36:1163-1171.
    • (2002) Hepatology , vol.36 , pp. 1163-1171
    • Olde Damink, S.W.1    Jalan, R.2    Redhead, D.N.3
  • 20
    • 3442900767 scopus 로고    scopus 로고
    • Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy
    • Romero-Gomez M., Ramos-Guerrero R., Grande L., et al. Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy. J Hepatol 2004, 41:49-54.
    • (2004) J Hepatol , vol.41 , pp. 49-54
    • Romero-Gomez, M.1    Ramos-Guerrero, R.2    Grande, L.3
  • 21
    • 0021972022 scopus 로고
    • Functional hepatocyte heterogeneity in ammonia metabolism. The intercellular glutamine cycle
    • Haussinger D., Sies H., Gerok W. Functional hepatocyte heterogeneity in ammonia metabolism. The intercellular glutamine cycle. J Hepatol 1985, 1:3-14.
    • (1985) J Hepatol , vol.1 , pp. 3-14
    • Haussinger, D.1    Sies, H.2    Gerok, W.3
  • 22
    • 0022587806 scopus 로고
    • Regulation of glutamine metabolism in dog kidney in vivo
    • Vinay P., Kemieux G., Gougoux A., et al. Regulation of glutamine metabolism in dog kidney in vivo. Kidney Int 1986, 29:68-79.
    • (1986) Kidney Int , vol.29 , pp. 68-79
    • Vinay, P.1    Kemieux, G.2    Gougoux, A.3
  • 23
    • 0020057890 scopus 로고
    • Renal ammoniagenesis in an early stage of metabolic acidosis in man
    • Tizianello A., Deferrari G., Garibotto G., et al. Renal ammoniagenesis in an early stage of metabolic acidosis in man. J Clin Invest 1982, 69:240-250.
    • (1982) J Clin Invest , vol.69 , pp. 240-250
    • Tizianello, A.1    Deferrari, G.2    Garibotto, G.3
  • 24
    • 0024228587 scopus 로고
    • Renal ammoniagenesis during the adaptation to metabolic acidosis in man
    • Tizianello A., Deferrari G., Garibotto G., et al. Renal ammoniagenesis during the adaptation to metabolic acidosis in man. Contrib Nephrol 1988, 63:105-113.
    • (1988) Contrib Nephrol , vol.63 , pp. 105-113
    • Tizianello, A.1    Deferrari, G.2    Garibotto, G.3
  • 25
    • 0037904292 scopus 로고    scopus 로고
    • The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis
    • Olde Damink S.W., Jalan R., Deutz N.E., et al. The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis. Hepatology 2003, 37:1277-1285.
    • (2003) Hepatology , vol.37 , pp. 1277-1285
    • Olde Damink, S.W.1    Jalan, R.2    Deutz, N.E.3
  • 26
    • 0032492478 scopus 로고    scopus 로고
    • Cerebral edema and increased intracranial pressure in chronic liver disease
    • Donovan J.P., Schafer D.F., Shaw B.W., et al. Cerebral edema and increased intracranial pressure in chronic liver disease. Lancet 1998, 351:719-721.
    • (1998) Lancet , vol.351 , pp. 719-721
    • Donovan, J.P.1    Schafer, D.F.2    Shaw, B.W.3
  • 27
    • 50649113720 scopus 로고    scopus 로고
    • Cerebral edema and hyperammonemia after transjugular intrahepatic portosystemic shunt placement in a cirrhotic patient
    • Kavitt R.T., Yang V.L., Jensen D.M. Cerebral edema and hyperammonemia after transjugular intrahepatic portosystemic shunt placement in a cirrhotic patient. Clin Gastroenterol Hepatol 2008, 6:1054-1056.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1054-1056
    • Kavitt, R.T.1    Yang, V.L.2    Jensen, D.M.3
  • 28
    • 0030833288 scopus 로고    scopus 로고
    • The peripheral benzodiazepine receptor and neurosteroids in hepatic encephalopathy
    • Norenberg M.D., Itzhak Y., Bender A.S. The peripheral benzodiazepine receptor and neurosteroids in hepatic encephalopathy. Adv Exp Med Biol 1997, 420:95-111.
    • (1997) Adv Exp Med Biol , vol.420 , pp. 95-111
    • Norenberg, M.D.1    Itzhak, Y.2    Bender, A.S.3
  • 29
    • 0025292201 scopus 로고
    • " Endogenous" benzodiazepine activity in body fluids of patients with hepatic encephalopathy
    • Mullen K.D., Szauter K.M., Kaminsky-Russ K. " Endogenous" benzodiazepine activity in body fluids of patients with hepatic encephalopathy. Lancet 1990, 336:81-83.
    • (1990) Lancet , vol.336 , pp. 81-83
    • Mullen, K.D.1    Szauter, K.M.2    Kaminsky-Russ, K.3
  • 30
    • 55749088032 scopus 로고    scopus 로고
    • Brain cholinergic impairment in liver failure
    • Garcia-Ayllon M.S., Cauli O., Silveyra M.X., et al. Brain cholinergic impairment in liver failure. Brain 2008, 131:2946-2956.
    • (2008) Brain , vol.131 , pp. 2946-2956
    • Garcia-Ayllon, M.S.1    Cauli, O.2    Silveyra, M.X.3
  • 31
    • 79952008643 scopus 로고    scopus 로고
    • Acetylcholinesterase activity in an experimental rat model of type C hepatic encephalopathy
    • Mendez M., Mendez-Lopez M., Lopez L., et al. Acetylcholinesterase activity in an experimental rat model of type C hepatic encephalopathy. Acta Histochem 2011, 113:358-362.
    • (2011) Acta Histochem , vol.113 , pp. 358-362
    • Mendez, M.1    Mendez-Lopez, M.2    Lopez, L.3
  • 32
    • 79955784094 scopus 로고    scopus 로고
    • Transdermal rivastigmine for treatment of encephalopathy in liver cirrhosis - a randomized placebo controlled trial (TREC TRIAL)
    • Basu P., Shah N.J., Krishnaswamy N., et al. Transdermal rivastigmine for treatment of encephalopathy in liver cirrhosis - a randomized placebo controlled trial (TREC TRIAL). J Hepatol 2010, 52(Suppl 1):S67-S68.
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Basu, P.1    Shah, N.J.2    Krishnaswamy, N.3
  • 33
    • 67349206170 scopus 로고    scopus 로고
    • Hyponatremia is a risk factor of hepatic encephalopathy in patients with cirrhosis: a prospective study with time-dependent analysis
    • Guevara M., Baccaro M.E., Torre A., et al. Hyponatremia is a risk factor of hepatic encephalopathy in patients with cirrhosis: a prospective study with time-dependent analysis. Am J Gastroenterol 2009, 104:1382-1389.
    • (2009) Am J Gastroenterol , vol.104 , pp. 1382-1389
    • Guevara, M.1    Baccaro, M.E.2    Torre, A.3
  • 34
    • 33845637697 scopus 로고    scopus 로고
    • CAPPS investigators. Hyponatremia in cirrhosis: results of a patient population survey
    • Angeli P., Wong F., Watson H., et al. CAPPS investigators. Hyponatremia in cirrhosis: results of a patient population survey. Hepatology 2006, 44:1535-1542.
    • (2006) Hepatology , vol.44 , pp. 1535-1542
    • Angeli, P.1    Wong, F.2    Watson, H.3
  • 35
    • 2542525380 scopus 로고    scopus 로고
    • Brain edema in acute liver failure. A window to the pathogenesis of hepatic encephalopathy
    • Vaquero J., Chung C., Blei A.T. Brain edema in acute liver failure. A window to the pathogenesis of hepatic encephalopathy. Ann Hepatol 2003, 2:12-22.
    • (2003) Ann Hepatol , vol.2 , pp. 12-22
    • Vaquero, J.1    Chung, C.2    Blei, A.T.3
  • 36
    • 1642532385 scopus 로고    scopus 로고
    • Infection, inflammation, and hepatic encephalopathy, synergism redefined
    • Blei A.T. Infection, inflammation, and hepatic encephalopathy, synergism redefined. J Hepatol 2004, 40:327-330.
    • (2004) J Hepatol , vol.40 , pp. 327-330
    • Blei, A.T.1
  • 37
    • 34347399958 scopus 로고    scopus 로고
    • Hyperammonemia acts synergistically with lipopolysaccharide in inducing changes in cerebral hemodynamics in rats anaesthetized with pentobarbital
    • Pedersen H.R., Ring-Larsen H., Olsen N.V., et al. Hyperammonemia acts synergistically with lipopolysaccharide in inducing changes in cerebral hemodynamics in rats anaesthetized with pentobarbital. J Hepatol 2007, 47:245-252.
    • (2007) J Hepatol , vol.47 , pp. 245-252
    • Pedersen, H.R.1    Ring-Larsen, H.2    Olsen, N.V.3
  • 38
    • 0343314896 scopus 로고    scopus 로고
    • Enhanced monocyte activation and hepatotoxicity in response to endotoxin in portal hypertension
    • Perez del Pulgar S., Pizcueta P., Engel P., et al. Enhanced monocyte activation and hepatotoxicity in response to endotoxin in portal hypertension. J Hepatol 2000, 32:25-31.
    • (2000) J Hepatol , vol.32 , pp. 25-31
    • Perez del Pulgar, S.1    Pizcueta, P.2    Engel, P.3
  • 39
    • 0023901892 scopus 로고
    • Endotoxin levels measured by a chromogenic assay in portal, hepatic, and peripheral blood in patients with cirrhosis
    • Lumsden A.B., Henderson J.M., Kutner M.H. Endotoxin levels measured by a chromogenic assay in portal, hepatic, and peripheral blood in patients with cirrhosis. Hepatology 1988, 8:232-236.
    • (1988) Hepatology , vol.8 , pp. 232-236
    • Lumsden, A.B.1    Henderson, J.M.2    Kutner, M.H.3
  • 40
    • 84856407574 scopus 로고    scopus 로고
    • Rifaximin reduces endotoxemia and improves liver function and disease severity in patients with decompensated cirrhosis
    • Kalambokis G.N., Tsianos E.V. Rifaximin reduces endotoxemia and improves liver function and disease severity in patients with decompensated cirrhosis. Hepatology 2012, 55:655-656.
    • (2012) Hepatology , vol.55 , pp. 655-656
    • Kalambokis, G.N.1    Tsianos, E.V.2
  • 41
    • 0026691627 scopus 로고
    • Serum levels of cytokines in chronic liver diseases
    • Tilg H., Wilmer A., Vogel W., et al. Serum levels of cytokines in chronic liver diseases. Gastroenterology 1992, 103:264-274.
    • (1992) Gastroenterology , vol.103 , pp. 264-274
    • Tilg, H.1    Wilmer, A.2    Vogel, W.3
  • 42
    • 1842453220 scopus 로고    scopus 로고
    • Gut microflora in the pathogenesis of the complications of cirrhosis
    • Garcia-Tsao G. Gut microflora in the pathogenesis of the complications of cirrhosis. Best Pract Res Clin Gastroenterol 2004, 18:353-372.
    • (2004) Best Pract Res Clin Gastroenterol , vol.18 , pp. 353-372
    • Garcia-Tsao, G.1
  • 43
    • 78650175565 scopus 로고    scopus 로고
    • Endotoxaemia in the pathogenesis of cytopenias in liver cirrhosis. Could simple antibiotics raise blood counts?
    • Kalambokis G., Tsianos E.V. Endotoxaemia in the pathogenesis of cytopenias in liver cirrhosis. Could simple antibiotics raise blood counts?. Med Hypotheses 2011, 76:105-109.
    • (2011) Med Hypotheses , vol.76 , pp. 105-109
    • Kalambokis, G.1    Tsianos, E.V.2
  • 44
    • 84856683368 scopus 로고    scopus 로고
    • Rifaximin improves thrombocytopenia in patients with alcoholic cirrhosis in association with reduction of endotoxaemia
    • Kalambokis G.N., Mouzaki A., Rodi M., et al. Rifaximin improves thrombocytopenia in patients with alcoholic cirrhosis in association with reduction of endotoxaemia. Liver Int 2012, 32:467-475.
    • (2012) Liver Int , vol.32 , pp. 467-475
    • Kalambokis, G.N.1    Mouzaki, A.2    Rodi, M.3
  • 45
    • 0018772982 scopus 로고
    • Correlation between serum IgG, platelet membrane IgG, and platelet function in hypergammaglobulinemic states
    • McGrath K.M., Stuart J.J., Richards F. Correlation between serum IgG, platelet membrane IgG, and platelet function in hypergammaglobulinemic states. Br J Haematol 1979, 42:585-591.
    • (1979) Br J Haematol , vol.42 , pp. 585-591
    • McGrath, K.M.1    Stuart, J.J.2    Richards, F.3
  • 46
    • 0038241772 scopus 로고    scopus 로고
    • A role of autoantibody-mediated platelet destruction in thrombocytopenia in patients with cirrhosis
    • Kajihara M., Jato S., Okazaki Y., et al. A role of autoantibody-mediated platelet destruction in thrombocytopenia in patients with cirrhosis. Hepatology 2003, 37:1267-1276.
    • (2003) Hepatology , vol.37 , pp. 1267-1276
    • Kajihara, M.1    Jato, S.2    Okazaki, Y.3
  • 47
    • 0029155948 scopus 로고
    • Association between low-grade disseminated intravascular coagulation and endotoxemia in patients with liver cirrhosis
    • Violi F., Ferri D., Basili S., et al. Association between low-grade disseminated intravascular coagulation and endotoxemia in patients with liver cirrhosis. Gastroenterology 1995, 109:531-539.
    • (1995) Gastroenterology , vol.109 , pp. 531-539
    • Violi, F.1    Ferri, D.2    Basili, S.3
  • 48
    • 0027957298 scopus 로고
    • Effect of human recombinant cytokines on the induction of macrophages procoagulant activity
    • Schwager I., Jungi T.W. Effect of human recombinant cytokines on the induction of macrophages procoagulant activity. Blood 1994, 83:152-160.
    • (1994) Blood , vol.83 , pp. 152-160
    • Schwager, I.1    Jungi, T.W.2
  • 49
    • 44949145653 scopus 로고    scopus 로고
    • Hepatic encephalopathy
    • Lippincott Williams & Wilkins, Philadelphia
    • Cordoba J., Blei A.T. Hepatic encephalopathy. Schiff's diseases of the liver 2007, vol. 1:569-599. Lippincott Williams & Wilkins, Philadelphia. 10th edition.
    • (2007) Schiff's diseases of the liver , vol.1 , pp. 569-599
    • Cordoba, J.1    Blei, A.T.2
  • 50
    • 67349128647 scopus 로고    scopus 로고
    • Performance of the hepatic encephalopathy scoring algorithm in a clinical trial of patients with cirrhosis and severe hepatic encephalopathy
    • Hassanein T., Blei A.T., Perry W., et al. Performance of the hepatic encephalopathy scoring algorithm in a clinical trial of patients with cirrhosis and severe hepatic encephalopathy. Am J Gastroenterol 2009, 104:1392-1400.
    • (2009) Am J Gastroenterol , vol.104 , pp. 1392-1400
    • Hassanein, T.1    Blei, A.T.2    Perry, W.3
  • 51
    • 0034030150 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of rifaximin in the treatment of hepatic encephalopathy: a double-blind, randomized, dose-finding multi-centre study
    • Williams R., James O.F., Morgan M.Y. Evaluation of the efficacy and safety of rifaximin in the treatment of hepatic encephalopathy: a double-blind, randomized, dose-finding multi-centre study. Eur J Gastroenterol Hepatol 2000, 12:203-208.
    • (2000) Eur J Gastroenterol Hepatol , vol.12 , pp. 203-208
    • Williams, R.1    James, O.F.2    Morgan, M.Y.3
  • 52
    • 0017744177 scopus 로고
    • Comparison of lactulose and neomycin in the treatment of chronic portal-systemic-encephalopathy: a double blind controlled trial
    • Conn H.O., Leevy C.M., Vlahcevic Z.R., et al. Comparison of lactulose and neomycin in the treatment of chronic portal-systemic-encephalopathy: a double blind controlled trial. Gastroenterology 1977, 72:573-583.
    • (1977) Gastroenterology , vol.72 , pp. 573-583
    • Conn, H.O.1    Leevy, C.M.2    Vlahcevic, Z.R.3
  • 53
    • 0035018910 scopus 로고    scopus 로고
    • Neuropsychological characterization of hepatic encephalopathy
    • Weissenborn K., Ennen J.C., Schomerus H., et al. Neuropsychological characterization of hepatic encephalopathy. J Hepatol 2001, 34:768-773.
    • (2001) J Hepatol , vol.34 , pp. 768-773
    • Weissenborn, K.1    Ennen, J.C.2    Schomerus, H.3
  • 54
    • 0035164417 scopus 로고    scopus 로고
    • Quality of life in cirrhotics with minimal hepatic encephalopathy
    • Schomerus H., Hamster W. Quality of life in cirrhotics with minimal hepatic encephalopathy. Metab Brain Dis 2001, 16:37-41.
    • (2001) Metab Brain Dis , vol.16 , pp. 37-41
    • Schomerus, H.1    Hamster, W.2
  • 56
    • 0029818592 scopus 로고    scopus 로고
    • Neuropsychological characterization and detection of subclinical hepatic encephalopathy
    • McCrea M., Cordoba J., Vessey M., et al. Neuropsychological characterization and detection of subclinical hepatic encephalopathy. Arch Neurol 1996, 53(8):758-763.
    • (1996) Arch Neurol , vol.53 , Issue.8 , pp. 758-763
    • McCrea, M.1    Cordoba, J.2    Vessey, M.3
  • 57
    • 0035018910 scopus 로고    scopus 로고
    • Neurophysiological characterization of hepatic encephalopathy
    • Weissenborn K., Scholz M., Hinrichs H., et al. Neurophysiological characterization of hepatic encephalopathy. J Hepatol 2001, 34:768-773.
    • (2001) J Hepatol , vol.34 , pp. 768-773
    • Weissenborn, K.1    Scholz, M.2    Hinrichs, H.3
  • 58
    • 0030451813 scopus 로고    scopus 로고
    • Subclinical hepatic encephalopathy
    • Quero J.C., Schalm S.W. Subclinical hepatic encephalopathy. Semin Liver Dis 1996, 16:321-328.
    • (1996) Semin Liver Dis , vol.16 , pp. 321-328
    • Quero, J.C.1    Schalm, S.W.2
  • 59
    • 47149100487 scopus 로고    scopus 로고
    • The need for better clinical trials
    • Kamath P.S. The need for better clinical trials. Hepatology 2008, 48:1-3.
    • (2008) Hepatology , vol.48 , pp. 1-3
    • Kamath, P.S.1
  • 60
    • 33947362948 scopus 로고    scopus 로고
    • Testing for minimal hepatic encephalopathy in the United States: an AASLD survey
    • Bajaj J.S., Etemadian A., Hafeezullah M., et al. Testing for minimal hepatic encephalopathy in the United States: an AASLD survey. Hepatology 2007, 45:833-834.
    • (2007) Hepatology , vol.45 , pp. 833-834
    • Bajaj, J.S.1    Etemadian, A.2    Hafeezullah, M.3
  • 61
    • 0034944406 scopus 로고    scopus 로고
    • Hepatic encephalopathy
    • Practice Parameters Committee of the American College of Gastroenterology
    • Blei A.T., Cordoba J., Practice Parameters Committee of the American College of Gastroenterology Hepatic encephalopathy. Am J Gastroenterol 2001, 96:1968-1976.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1968-1976
    • Blei, A.T.1    Cordoba, J.2
  • 62
    • 0030879021 scopus 로고    scopus 로고
    • Treatment of hepatic encephalopathy
    • Riordan S.M., Williams R. Treatment of hepatic encephalopathy. N Engl J Med 1997, 337(7):473-479.
    • (1997) N Engl J Med , vol.337 , Issue.7 , pp. 473-479
    • Riordan, S.M.1    Williams, R.2
  • 63
    • 44949122693 scopus 로고    scopus 로고
    • Hepatic encephalopathy
    • Munoz S.J. Hepatic encephalopathy. Med Clin North Am 2008, 92:795-812.
    • (2008) Med Clin North Am , vol.92 , pp. 795-812
    • Munoz, S.J.1
  • 64
    • 80053905011 scopus 로고    scopus 로고
    • 4 levels and protein restriction obsolete?
    • 4 levels and protein restriction obsolete?. Pract Gastroenterol 2011, 95:6-18.
    • (2011) Pract Gastroenterol , vol.95 , pp. 6-18
    • Caruana, P.1    Shah, N.2
  • 65
    • 35449004138 scopus 로고    scopus 로고
    • The treatment of hepatic encephalopathy
    • Morgan M.Y., Blei A., Grungreiff K., et al. The treatment of hepatic encephalopathy. Metab Brain Dis 2007, 22:389-405.
    • (2007) Metab Brain Dis , vol.22 , pp. 389-405
    • Morgan, M.Y.1    Blei, A.2    Grungreiff, K.3
  • 66
    • 2342487336 scopus 로고    scopus 로고
    • Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomized trials
    • Als-Nielsen B., Gluud L.L., Gluud C. Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomized trials. BMJ 2004, 328:1046.
    • (2004) BMJ , vol.328 , pp. 1046
    • Als-Nielsen, B.1    Gluud, L.L.2    Gluud, C.3
  • 67
    • 67649200866 scopus 로고    scopus 로고
    • Impact of preoperative overt hepatic encephalopathy on neurocognitive function after liver transplantation
    • Sotil E.U., Gottstein J., Ayala E., et al. Impact of preoperative overt hepatic encephalopathy on neurocognitive function after liver transplantation. Liver Transpl 2009, 15:184-192.
    • (2009) Liver Transpl , vol.15 , pp. 184-192
    • Sotil, E.U.1    Gottstein, J.2    Ayala, E.3
  • 68
    • 33846419087 scopus 로고    scopus 로고
    • Review article the current pharmacological therapies for hepatic encephalopathy
    • Bass N.M. Review article the current pharmacological therapies for hepatic encephalopathy. Aliment Pharmacol Ther 2007, 25(Suppl 1):23-31.
    • (2007) Aliment Pharmacol Ther , vol.25 , Issue.SUPPL. 1 , pp. 23-31
    • Bass, N.M.1
  • 69
    • 0030701641 scopus 로고    scopus 로고
    • Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy
    • Watanabe A., Sakai T., Sato S. Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy. Hepatology 1997, 26:1410-1414.
    • (1997) Hepatology , vol.26 , pp. 1410-1414
    • Watanabe, A.1    Sakai, T.2    Sato, S.3
  • 70
    • 79751499077 scopus 로고    scopus 로고
    • Rifaximin improves psychometric performance and health-related quality of life in patients with minimal hepatic encephalopathy (The RIME Trial)
    • Sidhu S.S., Goyal O., Mishra B.P., et al. Rifaximin improves psychometric performance and health-related quality of life in patients with minimal hepatic encephalopathy (The RIME Trial). Am J Gastroenterol 2011, 106(2):307-316.
    • (2011) Am J Gastroenterol , vol.106 , Issue.2 , pp. 307-316
    • Sidhu, S.S.1    Goyal, O.2    Mishra, B.P.3
  • 71
    • 84860300698 scopus 로고    scopus 로고
    • Functional core modulation following treatment of minimal hepatic encephalopathy with l-ornithine l-aspartate: a potential novel mechanism of action
    • Mcphail M.J., Leech R., Grover V.P., et al. Functional core modulation following treatment of minimal hepatic encephalopathy with l-ornithine l-aspartate: a potential novel mechanism of action. 46th annual meeting of the european-association-for-the-study-of-the-liver (EASL) 2011, 54:S74-S75.
    • (2011) 46th annual meeting of the european-association-for-the-study-of-the-liver (EASL) , vol.54
    • Mcphail, M.J.1    Leech, R.2    Grover, V.P.3
  • 72
    • 70349292158 scopus 로고    scopus 로고
    • Precipitating factors of hepatic encephalopathy at a tertiary care hospital Jamshoro, Hyderabad
    • Devrajani B.R., Shah S.Z., Devrajani T., et al. Precipitating factors of hepatic encephalopathy at a tertiary care hospital Jamshoro, Hyderabad. J Pak Med Assoc 2009, 59:683-686.
    • (2009) J Pak Med Assoc , vol.59 , pp. 683-686
    • Devrajani, B.R.1    Shah, S.Z.2    Devrajani, T.3
  • 73
    • 0742299585 scopus 로고    scopus 로고
    • Bacterial infections associated with hepatic encephalopathy: prevalence and outcome
    • Strauss E., Gomes de Sa Ribeiro Mde F. Bacterial infections associated with hepatic encephalopathy: prevalence and outcome. Ann Hepatol 2003, 2:41-45.
    • (2003) Ann Hepatol , vol.2 , pp. 41-45
    • Strauss, E.1    Gomes de Sa Ribeiro Mde, F.2
  • 74
    • 14644389447 scopus 로고    scopus 로고
    • Endoscopic coagulation therapy is successful for improving encephalopathy in cirrhotic patients with gastric antral vascular ectasia
    • Zushi S., Imai Y., Fukuda K., et al. Endoscopic coagulation therapy is successful for improving encephalopathy in cirrhotic patients with gastric antral vascular ectasia. Dig Endosc 2005, 17:32-35.
    • (2005) Dig Endosc , vol.17 , pp. 32-35
    • Zushi, S.1    Imai, Y.2    Fukuda, K.3
  • 75
    • 0037784079 scopus 로고    scopus 로고
    • Enhanced renal ammonia excretion following volume expansion in patients with well compensated cirrhosis of the liver
    • Jalan R., Kapoor D. Enhanced renal ammonia excretion following volume expansion in patients with well compensated cirrhosis of the liver. Gut 2003, 52:1041-1045.
    • (2003) Gut , vol.52 , pp. 1041-1045
    • Jalan, R.1    Kapoor, D.2
  • 76
    • 73149123930 scopus 로고    scopus 로고
    • Phase 2, multicenter, randomized study of AST-120 (spherical carbon adsorbent) vs. lactulose in the treatment of low-grade hepatic encephalopathy
    • Pockros P., Hassanein T., Vierling J., et al. Phase 2, multicenter, randomized study of AST-120 (spherical carbon adsorbent) vs. lactulose in the treatment of low-grade hepatic encephalopathy. J Hepatol 2009, 50(Supp 1):S43-S44.
    • (2009) J Hepatol , vol.50 , Issue.SUPPL. 1
    • Pockros, P.1    Hassanein, T.2    Vierling, J.3
  • 77
    • 0033976958 scopus 로고    scopus 로고
    • Partial pressure of ammonia versus ammonia in hepatic encephalopathy
    • Kramer L., Tribl B., Gendo A., et al. Partial pressure of ammonia versus ammonia in hepatic encephalopathy. Hepatology 2000, 31:30-34.
    • (2000) Hepatology , vol.31 , pp. 30-34
    • Kramer, L.1    Tribl, B.2    Gendo, A.3
  • 78
    • 0037440759 scopus 로고    scopus 로고
    • Correlation between ammonia levels and the severity of hepatic encephalopathy
    • Ong J.P., Aggarwal A., Krieger D., et al. Correlation between ammonia levels and the severity of hepatic encephalopathy. Am J Med 2003, 114:188-193.
    • (2003) Am J Med , vol.114 , pp. 188-193
    • Ong, J.P.1    Aggarwal, A.2    Krieger, D.3
  • 79
    • 0034071025 scopus 로고    scopus 로고
    • Post-feeding hyperammonaemia in patients with transjugular intrahepatic portosystemic shunt and liver cirrhosis: role of small intestinal ammonia release and route of nutrient administration
    • Plauth M., Roske A.E., Romaniuk P., et al. Post-feeding hyperammonaemia in patients with transjugular intrahepatic portosystemic shunt and liver cirrhosis: role of small intestinal ammonia release and route of nutrient administration. Gut 2000, 46:849-855.
    • (2000) Gut , vol.46 , pp. 849-855
    • Plauth, M.1    Roske, A.E.2    Romaniuk, P.3
  • 80
    • 0037309495 scopus 로고    scopus 로고
    • Liver transplantation improves hepatic myelopathy: evidence by three cases
    • Weissenborn K., Tietge U.J., Bokemeyer M., et al. Liver transplantation improves hepatic myelopathy: evidence by three cases. Gastroenterology 2003, 124:346-351.
    • (2003) Gastroenterology , vol.124 , pp. 346-351
    • Weissenborn, K.1    Tietge, U.J.2    Bokemeyer, M.3
  • 82
    • 69249166158 scopus 로고    scopus 로고
    • Secondary prophylaxis of hepatic encephalopathy: an open label randomized controlled trial of lactulose versus placebo
    • Sharma B.C., Sharma P., Agrawal A., et al. Secondary prophylaxis of hepatic encephalopathy: an open label randomized controlled trial of lactulose versus placebo. Gastroenterology 2009, 137:885-891.
    • (2009) Gastroenterology , vol.137 , pp. 885-891
    • Sharma, B.C.1    Sharma, P.2    Agrawal, A.3
  • 83
    • 80052456333 scopus 로고    scopus 로고
    • Lactulose: how many ways can one drug be prescribed?
    • Lukers B., Nierman D.M., Schiano T.D. Lactulose: how many ways can one drug be prescribed?. Am J Gastroenterol 2011, 106(9):1726-1727.
    • (2011) Am J Gastroenterol , vol.106 , Issue.9 , pp. 1726-1727
    • Lukers, B.1    Nierman, D.M.2    Schiano, T.D.3
  • 84
    • 79960398790 scopus 로고    scopus 로고
    • Treatment of patients with hepatic encephalopathy: review of the latest data from EASL 2011
    • Bass N. Treatment of patients with hepatic encephalopathy: review of the latest data from EASL 2011. Gastroenterol Hepatol 2011, 7(Suppl 9):1-15.
    • (2011) Gastroenterol Hepatol , vol.7 , Issue.SUPPL. 9 , pp. 1-15
    • Bass, N.1
  • 85
    • 75749125436 scopus 로고    scopus 로고
    • Bifidobacterium combined with fructo-oligosaccharide versus lactulose in the treatment of patients with hepatic encephalopathy
    • Malaguarnera M., Gargante M.P., Malaguarnera G., et al. Bifidobacterium combined with fructo-oligosaccharide versus lactulose in the treatment of patients with hepatic encephalopathy. Eur J Gastroenterol Hepatol 2010, 22:199-206.
    • (2010) Eur J Gastroenterol Hepatol , vol.22 , pp. 199-206
    • Malaguarnera, M.1    Gargante, M.P.2    Malaguarnera, G.3
  • 86
    • 19944429052 scopus 로고    scopus 로고
    • Dietary fiber decreases ammonia levels in patients with cirrhosis
    • [author reply: 219]
    • Iwasa M., Nakao M., Kato Y., et al. Dietary fiber decreases ammonia levels in patients with cirrhosis. Hepatology 2005, 41:217-218. [author reply: 219].
    • (2005) Hepatology , vol.41 , pp. 217-218
    • Iwasa, M.1    Nakao, M.2    Kato, Y.3
  • 87
    • 2342580955 scopus 로고    scopus 로고
    • Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis
    • Liu Q., Duan Z.P., Ha D.K., et al. Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology 2004, 39:1441-1449.
    • (2004) Hepatology , vol.39 , pp. 1441-1449
    • Liu, Q.1    Duan, Z.P.2    Ha, D.K.3
  • 88
    • 77954836890 scopus 로고    scopus 로고
    • Changing face of hepatic encephalopathy: role of inflammation and oxidative stress
    • Seyan A.S., Hughes R.D., Shawcross D.L. Changing face of hepatic encephalopathy: role of inflammation and oxidative stress. World J Gastroenterol 2010, 16:3347-3357.
    • (2010) World J Gastroenterol , vol.16 , pp. 3347-3357
    • Seyan, A.S.1    Hughes, R.D.2    Shawcross, D.L.3
  • 89
    • 13544253737 scopus 로고    scopus 로고
    • A randomized controlled trial of acarbose in hepatic encephalopathy
    • Gentile S., Guarino G., Romano M., et al. A randomized controlled trial of acarbose in hepatic encephalopathy. Clin Gastroenterol Hepatol 2005, 3:184-191.
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 184-191
    • Gentile, S.1    Guarino, G.2    Romano, M.3
  • 90
    • 17844402953 scopus 로고    scopus 로고
    • Rifaximin: a nonabsorbable rifamycin antibiotic for use in nonsystemic gastrointestinal infections
    • Gerard L., Garey K.W., DuPont H.L. Rifaximin: a nonabsorbable rifamycin antibiotic for use in nonsystemic gastrointestinal infections. Expert Rev Anti Infect Ther 2005, 3:201-211.
    • (2005) Expert Rev Anti Infect Ther , vol.3 , pp. 201-211
    • Gerard, L.1    Garey, K.W.2    DuPont, H.L.3
  • 91
    • 18644365788 scopus 로고    scopus 로고
    • Rifaximin: in vitro and in vivo antibacterial activity - a review
    • Jiang Z.D., DuPont H.L. Rifaximin: in vitro and in vivo antibacterial activity - a review. Chemotherapy 2005, 51(Suppl 1):67-72.
    • (2005) Chemotherapy , vol.51 , Issue.SUPPL. 1 , pp. 67-72
    • Jiang, Z.D.1    DuPont, H.L.2
  • 92
    • 44849089446 scopus 로고    scopus 로고
    • Effects of rifaximin on bacterial virulence mechanisms at supra-and sub-inhibitory concentrations
    • Debbia E.A., Maioli E., Roveta S., et al. Effects of rifaximin on bacterial virulence mechanisms at supra-and sub-inhibitory concentrations. J Chemother 2008, 20:186-194.
    • (2008) J Chemother , vol.20 , pp. 186-194
    • Debbia, E.A.1    Maioli, E.2    Roveta, S.3
  • 93
    • 80053214571 scopus 로고    scopus 로고
    • Randomised clinical trial: rifaximin improves health-related quality of life in cirrhotic patients with hepatic encephalopathy - a double-blind placebo-controlled study
    • Sanyal A., Younossi Z.M., Bass N.M., et al. Randomised clinical trial: rifaximin improves health-related quality of life in cirrhotic patients with hepatic encephalopathy - a double-blind placebo-controlled study. Aliment Pharmacol Ther 2011, 34:853-861.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 853-861
    • Sanyal, A.1    Younossi, Z.M.2    Bass, N.M.3
  • 94
    • 79953176189 scopus 로고    scopus 로고
    • Rifaximin treatment improved quality of life in patients with hepatic encephalopathy: results of a large, randomized, placebo-controlled trial
    • Sanyal A., Bass N., Mullen K., et al. Rifaximin treatment improved quality of life in patients with hepatic encephalopathy: results of a large, randomized, placebo-controlled trial. J Hepatol 2010, 52(Suppl 1):S7.
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Sanyal, A.1    Bass, N.2    Mullen, K.3
  • 95
    • 77950246404 scopus 로고    scopus 로고
    • Rifaximin treatment in hepatic encephalopathy
    • Bass N.M., Mullen K.D., Sanyal A., et al. Rifaximin treatment in hepatic encephalopathy. N Engl J Med 2010, 362:1071-1081.
    • (2010) N Engl J Med , vol.362 , pp. 1071-1081
    • Bass, N.M.1    Mullen, K.D.2    Sanyal, A.3
  • 96
    • 84856600336 scopus 로고    scopus 로고
    • Long term efficacy and survival in patients treated with the gut-selective antibiotic rifaximin (550 mg BID) for the maintenance of remission from overt hepatic encephalopathy
    • Mullen K.D., Poordad F., Rossaro L., et al. Long term efficacy and survival in patients treated with the gut-selective antibiotic rifaximin (550 mg BID) for the maintenance of remission from overt hepatic encephalopathy. Gastroenterol Hepatol 2011, 7(6 Suppl 9):1-15.
    • (2011) Gastroenterol Hepatol , vol.7 , Issue.6 SUPPL. 9 , pp. 1-15
    • Mullen, K.D.1    Poordad, F.2    Rossaro, L.3
  • 97
    • 80053183783 scopus 로고    scopus 로고
    • Long-term administration of rifaximin improves the prognosis of patients with alcohol-related decompensated cirrhosis: a case-control study
    • Vlachogiannakos K., Viazis N., Vasianopoulou P., et al. Long-term administration of rifaximin improves the prognosis of patients with alcohol-related decompensated cirrhosis: a case-control study. Hepatology 2010, 52:328A.
    • (2010) Hepatology , vol.52
    • Vlachogiannakos, K.1    Viazis, N.2    Vasianopoulou, P.3
  • 98
    • 84856622028 scopus 로고    scopus 로고
    • Impact of rifaximin treatment on survival in patients with end-stage liver disease
    • Leise M.D., Pedersen R., Kamath P.S., et al. Impact of rifaximin treatment on survival in patients with end-stage liver disease. Hepatology 2010, 52:331A.
    • (2010) Hepatology , vol.52
    • Leise, M.D.1    Pedersen, R.2    Kamath, P.S.3
  • 99
    • 77952188537 scopus 로고    scopus 로고
    • Naloxone in the management of hepatic encephalopathy
    • Jiang Q., Jiang G., Welty T.E., et al. Naloxone in the management of hepatic encephalopathy. J Clin Pharm Ther 2010, 35:333-341.
    • (2010) J Clin Pharm Ther , vol.35 , pp. 333-341
    • Jiang, Q.1    Jiang, G.2    Welty, T.E.3
  • 100
    • 3843109209 scopus 로고    scopus 로고
    • Benzodiazepine receptor antagonists for hepatic encephalopathy
    • CD002798
    • Als-Nielsen B., Gluud L.L., Gluud C. Benzodiazepine receptor antagonists for hepatic encephalopathy. Cochrane Database Syst Rev 2004, 2. CD002798.
    • (2004) Cochrane Database Syst Rev , vol.2
    • Als-Nielsen, B.1    Gluud, L.L.2    Gluud, C.3
  • 101
    • 3442901065 scopus 로고    scopus 로고
    • Normal protein diet for episodic hepatic encephalopathy: results of a randomized study
    • Cordoba J., Lopez-Hellin J., Planas M., et al. Normal protein diet for episodic hepatic encephalopathy: results of a randomized study. J Hepatol 2004, 41:38-43.
    • (2004) J Hepatol , vol.41 , pp. 38-43
    • Cordoba, J.1    Lopez-Hellin, J.2    Planas, M.3
  • 102
    • 75749105423 scopus 로고    scopus 로고
    • Review article: the modern management of hepatic encephalopathy
    • Bajaj J.S. Review article: the modern management of hepatic encephalopathy. Aliment Pharmacol Ther 2010, 31(5):537-547.
    • (2010) Aliment Pharmacol Ther , vol.31 , Issue.5 , pp. 537-547
    • Bajaj, J.S.1
  • 103
    • 84856618164 scopus 로고    scopus 로고
    • Chronic hepatic encephalopathy (HE) in patients with severe liver cirrhosis: efficacy of the wheat and milk protein free diet in the reduction of clinical episodes
    • Balzola F., Sanna C., Ottobrelli A., et al. Chronic hepatic encephalopathy (HE) in patients with severe liver cirrhosis: efficacy of the wheat and milk protein free diet in the reduction of clinical episodes. Gastroenterol Hepatol 2011, 7(6 Suppl 9):1-15.
    • (2011) Gastroenterol Hepatol , vol.7 , Issue.6 SUPPL. 9 , pp. 1-15
    • Balzola, F.1    Sanna, C.2    Ottobrelli, A.3
  • 104
    • 78449271709 scopus 로고    scopus 로고
    • Clinical trial: oral zinc in hepatic encephalopathy
    • Takuma Y., Nouso K., Makino Y., et al. Clinical trial: oral zinc in hepatic encephalopathy. Aliment Pharmacol Ther 2010, 32:1080-1090.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 1080-1090
    • Takuma, Y.1    Nouso, K.2    Makino, Y.3
  • 105
    • 58549112777 scopus 로고    scopus 로고
    • L-ornithine-l-aspartate in the management of hepatic encephalopathy: a meta-analysis
    • Jiang Q., Jiang X.H., Zheng M.H., et al. L-ornithine-l-aspartate in the management of hepatic encephalopathy: a meta-analysis. J Gastroenterol Hepatol 2009, 24:9-14.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 9-14
    • Jiang, Q.1    Jiang, X.H.2    Zheng, M.H.3
  • 108
    • 83655192001 scopus 로고    scopus 로고
    • Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial
    • Malaguarnera M., Vacante M., Motta M., et al. Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial. Metab Brain Dis 2011, 26:281-289.
    • (2011) Metab Brain Dis , vol.26 , pp. 281-289
    • Malaguarnera, M.1    Vacante, M.2    Motta, M.3
  • 109
    • 37749045276 scopus 로고    scopus 로고
    • Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis
    • Hassanein T.I., Tofteng F., Brown R.S., et al. Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis. Hepatology 2007, 46:1853-1862.
    • (2007) Hepatology , vol.46 , pp. 1853-1862
    • Hassanein, T.I.1    Tofteng, F.2    Brown, R.S.3
  • 110
    • 17044379742 scopus 로고    scopus 로고
    • Pharmacological prophylaxis of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: a randomized controlled study
    • Riggio O., Masini A., Efrati C., et al. Pharmacological prophylaxis of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: a randomized controlled study. J Hepatol 2005, 42(5):674-679.
    • (2005) J Hepatol , vol.42 , Issue.5 , pp. 674-679
    • Riggio, O.1    Masini, A.2    Efrati, C.3
  • 111
    • 0023722349 scopus 로고
    • Lack of preventive effect of branched-chain amino acid solution on postoperative hepatic encephalopathy in patients with cirrhosis: a randomized, prospective trial
    • Kanematsu T., Koyanagi N., Matsumata T., et al. Lack of preventive effect of branched-chain amino acid solution on postoperative hepatic encephalopathy in patients with cirrhosis: a randomized, prospective trial. Surgery 1988, 104(3):482-488.
    • (1988) Surgery , vol.104 , Issue.3 , pp. 482-488
    • Kanematsu, T.1    Koyanagi, N.2    Matsumata, T.3
  • 112
    • 0028561961 scopus 로고
    • Is the intestinal lavage with a solution of mannitol effective in the prevention of post-hemorrhagic hepatic encephalopathy in patients with liver cirrhosis? Results of a randomized prospective study
    • Rolachon A., Zarski J.P., Lutz J.M., et al. Is the intestinal lavage with a solution of mannitol effective in the prevention of post-hemorrhagic hepatic encephalopathy in patients with liver cirrhosis? Results of a randomized prospective study. Gastroenterol Clin Biol 1994, 18(12):1057-1062.
    • (1994) Gastroenterol Clin Biol , vol.18 , Issue.12 , pp. 1057-1062
    • Rolachon, A.1    Zarski, J.P.2    Lutz, J.M.3
  • 113
    • 0023184945 scopus 로고
    • Acidifying enemas (lactitol and lactose) vs. nonacidifying enemas (tap water) to treat acute portal-systemic encephalopathy: a double-blind, randomized clinical trial
    • Uribe M., Campollo O., Vargas F., et al. Acidifying enemas (lactitol and lactose) vs. nonacidifying enemas (tap water) to treat acute portal-systemic encephalopathy: a double-blind, randomized clinical trial. Hepatology 1987, 7(4):639-643.
    • (1987) Hepatology , vol.7 , Issue.4 , pp. 639-643
    • Uribe, M.1    Campollo, O.2    Vargas, F.3
  • 114
    • 0031003989 scopus 로고    scopus 로고
    • Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study
    • Kircheis G., Nilius R., Held C., et al. Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study. Hepatology 1997, 25(6):1351-1360.
    • (1997) Hepatology , vol.25 , Issue.6 , pp. 1351-1360
    • Kircheis, G.1    Nilius, R.2    Held, C.3
  • 115
    • 0032079801 scopus 로고    scopus 로고
    • Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study
    • Stauch S., Kircheis G., Adler G., et al. Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study. J Hepatol 1998, 28(5):856-864.
    • (1998) J Hepatol , vol.28 , Issue.5 , pp. 856-864
    • Stauch, S.1    Kircheis, G.2    Adler, G.3
  • 116
    • 0026661330 scopus 로고
    • Sodium benzoate in the treatment of acute hepatic encephalopathy: a double-blind randomized trial
    • Sushma S., Dasarathy S., Tandon R.K., et al. Sodium benzoate in the treatment of acute hepatic encephalopathy: a double-blind randomized trial. Hepatology 1992, 16(1):138-144.
    • (1992) Hepatology , vol.16 , Issue.1 , pp. 138-144
    • Sushma, S.1    Dasarathy, S.2    Tandon, R.K.3
  • 117
    • 0021176374 scopus 로고
    • Oral zinc supplementation improves hepatic encephalopathy. Results of a randomized controlled trial
    • Reding P., Duchateau J., Bataille C. Oral zinc supplementation improves hepatic encephalopathy. Results of a randomized controlled trial. Lancet 1984, 2(8401):493-495.
    • (1984) Lancet , vol.2 , Issue.8401 , pp. 493-495
    • Reding, P.1    Duchateau, J.2    Bataille, C.3
  • 118
    • 0025768460 scopus 로고
    • Short-term oral zinc supplementation does not improve chronic hepatic encephalopathy. Results of a double-blind crossover trial
    • Riggio O., Ariosto F., Merli M., et al. Short-term oral zinc supplementation does not improve chronic hepatic encephalopathy. Results of a double-blind crossover trial. Dig Dis Sci 1991, 36(9):1204-1208.
    • (1991) Dig Dis Sci , vol.36 , Issue.9 , pp. 1204-1208
    • Riggio, O.1    Ariosto, F.2    Merli, M.3


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