Performance of the hepatic encephalopathy scoring algorithm in a clinical trial of patients with cirrhosis and severe hepatic encephalopathy

American Journal of Gastroenterology

Volumn 104, Issue 6, 2009, Pages 1392-1400

  Hassanein, Tarek ^a   Blei, Andres T ^b   Perry, William ^c   Hilsabeck, Robin ^c,d,e   Stange, Jan ^f   Larsen, Fin S ^g   Brown Jr , Robert S ^h   Caldwell, Stephen ⁱ   McGuire, Brendan ^j   Nevens, Frederik ^k   Fontana, Robert ^l  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^e UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^f UNIVERSITY OF ROSTOCK   (Germany)

^g International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^h Howard Hughes Medical Institute   (United States)

ⁱ UNIVERSITY OF VIRGINIA   (United States)

^j and Clinical Center   (United States)

^k UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^l UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN;

ADULT; AGED; ALBUMIN DIALYSIS; ARTICLE; CLINICAL FEATURE; CLINICAL RESEARCH; COGNITION; CONTROLLED STUDY; DISEASE SEVERITY; DISORIENTATION; FEMALE; HEPATIC ENCEPHALOPATHY; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MOTOR PERFORMANCE; PERFORMANCE MEASUREMENT SYSTEM; PRIORITY JOURNAL; SCORING SYSTEM; SOMNOLENCE; VERBAL BEHAVIOR;

ADULT; AGED; ALBUMINS; COGNITION; EUROPE; FEMALE; FOLLOW-UP STUDIES; GLASGOW COMA SCALE; HEPATIC ENCEPHALOPATHY; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; MOTOR ACTIVITY; NEUROPSYCHOLOGICAL TESTS; PROGNOSIS; RENAL DIALYSIS; SEVERITY OF ILLNESS INDEX; UNITED STATES; YOUNG ADULT;

EID: 67349128647     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2009.160     Document Type: Article

References (29)

1. Sanaka MR, Ong JP, Mullen KD. Challenges of designing hepatic encephalopathy treatment trials. Hepatology 200338:527-8.
2. Als-Nielsen B, Gluud LL, Gluud C. Non-absorbable disaccharides for the treatment of hepatic encephalopathy: systematic review of randomised clinical trials. BMJ 2004;328:1046.
3. Conn HO, Leevy CM, Vlahcevic ZR et al. Comparison of lactulose and neomycin in the treatment of chronic portal-systemic encephalopathy. A double blind controlled trial. Gastroenterology 1977;72:573-83.
4. Ferenci P, Lockwood A, Mullen K et al. Hepatic encephalopathy - definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 2002;35:716-21.
5. Jennett B, Teasdale G, Braakman R et al. Predicting outcome in individual patients after severe head injury. Lancet 1976;15:1031-4.
6. Vilstrup H, Gluud C, Hardt F et al. Branched chain enriched amino acid vs. glucose treatment of hepatic encephalopathy. A double-blind study of 65 patients with cirrhosis. J Hepatol 1990;10:291-6.
7. Laccetti M, Manes G, Uomo G et al. Flumazenil in the treatment of acute hepatic encephalopathy in cirrhotic patients: a double blind randomized placebo controlled study. Dig Liver Dis 2000;32:335-8.
8. Pomier-Layrargues G, Giguere JF, Lavoie J et al. Flumazenil in cirrhotic patients in hepatic coma: a randomized double-blind placebo-controlled crossover trial. Hepatology 1994;19:32-7.
9. Barbar G, DiLorenzo G, Soldini M et al. Flumazenil for hepatic encephalopathy grade III and IVa in patients with cirrhosis: an Italian multicenter double-blind, placebo-controlled, cross-over study. Hepatology 9098;28:374-8.
10. Atterbury CE, Maddrey WC, Conn HO. Neomycin-sorbitol and lactulose in the treatment of acute portal-systemic encephalopathy. A controlled, double-blind clinical trial. Am J Dig Dis 1978;23:398-406.
11. Hassanein T, Flemming T, Brown RS et al. A prospective, controlled study of the clinical efficacy of extracorporeal albumin dialysis using the molecular adsorbent recirculating system (MARS) for the treatment of patients with hepatic encephalopathy. Hepatology 2007;46:1853-62.
12. Sen S, Williams R, Jalan R. Emerging indications for albumin dialysis. Am J Gastroenterol 2005;100:468-75.
13. Hassanein TI, Hilsabeck RC, Perry W. Introduction to the Hepatic Encephalopathy Scoring Algorithm (HESA). Dig Dis Sci 2007;53:529-38.
14. Wechsler D. Wechsler Memory Scale - Revised: Manual. The Psychological Corporation: San Antonio, TX , 1987.
15. Brandt J. The Hopkins Verbal Learning Test: development of a new memory test with six equivalent forms. Clin Neuropsychol 1991;5:125-42.
16. Benedict RHB. Brief Visuospatial Memory Test - Revised: Manual. The Psychological Corporation: San Antonio, TX , 1997.
17. Randolph C. Repeatable Battery for the Assessment of Neuropsychological Status: Manual. The Psychological Corporation: San Antonio, TX, 1998.
18. Wechsler D. Wechsler Adult Intelligence Scale - 3rd Edition: Manual. The Psychological Corporation: San Antonio, TX , 1997.
19. Wilkinson GS. Wide Range Achievement Test - 3rd Revision: Manual. The Psychological Corporation: San Antonio, TX , 1993.
20. Jensen MP, Turner JA, Romano JM et al. Comparative reliability and validity of chronic pain intensity measures. Pain 1999;83:157-62.
21. Sen S, Williams R, Jalan R. The pathophysiological basis of acute-on-chronic liver failure. Liver 2002;22:5-13.
22. Kircheis G, Wettstein M, Timmermann L et al. Critical ficker-frequency for quantification of low-grade hepatic encephalopathy. Hepatology 2002;35:357-66.
23. Kaplan PW The EEG in metabolic encephalopathy and coma. J Clin Neurophysiol 2004;21:307-18.
24. Kramer L, Gendo A, Madl C et al. A controlled study of sorbent suspension dialysis in chronic liver disease and hepatic encephalopathy. Int J Artif Organs 2001;24:434-42.
25. Cadranel JF, el Younsi M, Pidoux B et al. Flumazenil therapy for hepatic encephalopathy in cirrhotic patients: a double-blind pragmatic randomized, placebo study. Eur J Gastroenterol Hepatol 1995;7:325-9.
26. Gyr K, Meier R, Huassler J et al. Evaluation of the effcacy and safety of flumazenil in the treatment of portal systemic encephalopathy: a double blind, randomized, placebo controlled multicenter study. Gut 1996;39:319-24.
27. Dawson AM, Sherlock S, Summerskill WM. The treatment and prognosis of hepatic coma. Lancet 1956;27:689-94.
28. Haussinger D, Cordoba J, Kircheis G et al. Defnition and assessment of low-grade hepatic encephalopathy. In: Haussinger D, Kircheis G, Schliess F (eds). Hepatic Encephalopathy and Nitrogen Metabolism. Springer , The Netherlands , 2006, pp. 423-32.
29. Dahaba AA, Worm HC, Zhu SM et al. Sensitivity and specifcity of bispec-tral index for classification of overt hepatic encephalopathy. A multicenter, observer-blinded, validation study. Gut 2008;57:77-83.