The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis

Hepatology

Volumn 37, Issue 6, 2003, Pages 1277-1285

  Olde Damink, Steven W M ^a,b   Jalan, Rajiv ^b,c   Deutz, Nicolaas E P ^a   Redhead, Doris N ^b   Dejong, Cornelis H C ^a,b   Hynd, Paula ^b   Jalan, Rosy A ^b   Hayes, Peter C ^b   Soeters, Peter B ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID;

ADULT; AMMONIA BLOOD LEVEL; AMMONIA FORMATION; ARTERY BLOOD FLOW; ARTICLE; BLOOD FLOW VELOCITY; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DETOXIFICATION; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEPATIC VEIN; HUMAN; HYPERAMMONEMIA; KIDNEY FUNCTION; KIDNEY VEIN; LIVER CIRRHOSIS; LIVER METABOLISM; MALE; METABOLIC RATE; MUSCLE LEVEL; PORTAL VEIN; PRIORITY JOURNAL; VEIN BLOOD FLOW;

EID: 0037904292     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2003.50221     Document Type: Article

References (43)

1. Butterworth RF. The neurobiology of hepatic encephalopathy. Semin Liver Dis 1996;16:235-244.
2. Basile AS, Jones EA. Ammonia and GABA-ergic neurotransmission: interrelated factors in the pathogenesis of hepatic encephalopathy. HEPATOLOGY 1997;25:1303-1305.
3. Bessman AN, Hawkins R. The relative effects of enterically administered plasma and packed cells on circulating blood ammonia. Gastroenterology 1963;45:368-373.
4. Nencki M, Pawlow JP, Zaleski J. Ueber den Ammoniakgehalt des Blutes und der Organe und die Harnstoffbildung bei den Saugethieren. Arch exp Pathol Pharmakol 1896;37:26-51.
5. Weber FL Jr, Veach GL. The importance of the small intestine in gut ammonium production in the fasting dog. Gastroenterology 1979;77:235-240.
6. Meijer AJ, Lamers WH, Chamuleau RA. Nitrogen metabolism and ornithine cycle function. Physiol Rev 1990;70:701-748.
7. Atkinson DE. Functional roles of urea synthesis in vertebrates. Physiol Zool 1992;65:243-267.
8. Lockwood AH, McDonald JM, Reiman RE, Gelbard AS, Laughlin JS, Duffy TE, Plum F. The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia. J Clin Invest 1979;63:449-460.
9. Olde Damink SWM, Jalan R, Redhead DN, Hayes PC, Deutz NEP, Soeters PB. Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS. HEPATOLOGY 2002;36:1163-1171.
10. Hill RJ, Koningsberg W. The structure of human hemoglobin. J Biol Chem 1962;237:3151-3156.
11. Owen OE, Reichle FA, Mozzoli MA, Kreulen T, Patel MS, Elfenbein IB, Golsorkhi M, et al. Hepatic, gut, and renal substrate flux rates in patients with hepatic cirrhosis. J Clin Invest 1981;68:240-252.
12. Uusaro A, Ruokonen E, Takala J. Estimation of splanchnic blood flow by the Fick principle in man and problems in the use of indocyanine green. Cardiovasc Res 1995;30:106-112.
13. Selkurt EE. Measurement of renal blood flow. Meth Med Res 1948;1:191-199.
14. Granger DN, Bulkley GB. Measurement of blood flow. Applications to the splanchnic circulation. Baltimore/London: Williams & Wilkins, 1981:1-507.
15. Dejong CHC, Kampman MT, Deutz NEP, Soeters PB. Altered glutamine metabolism in rat portal drained viscera and hindquarter during hyperammonemia. Gastroenterology 1992;102:936-948.
16. van Eijk HM, Rooyakkers DR, Soeters PB, Deutz NEP. Determination of amino acid isotope enrichment using liquid chromatography-mass spectrometry. Anal Biochem 1999;271:8-17.
17. Owen EE, Tyor MP, Flanagan JF, Berry JN. The kidney as a source of blood ammonia in patients with liver disease: the effect of acetazolamide. J Clin Invest 1960;39:288-294.
18. Ten Have GAM, Bost MCF, Suyk-Wierts JCAW, van den Bogaard AEJM, Deutz NEP. Simultaneous measurement of metabolic flux in portally-drained viscera, liver, spleen, kidney and hindquarter in the conscious pig. Lab Anim 1996;30:347-358.
19. Walser EM, Harris VM, Harman JT, Park HM, Siddiqui AR. Quantification of inrrahepatic portosystemic shunting after placement of a transjugular intrahepatic portosystemic shunt. J Vasc Interv Radiol 1996;7:263-267.
20. Carter P, Welbourne TC. Glutamate transport asymmetry in renal glutamine metabolism. Am J Physiol 1998;274:E877-E884.
21. Gelfand RA, Glickman MG, Castellino P, Louard RJ, DeFronzo RA. Measurement of L-[1-14C] leucine kinetics in splanchnic and leg tissues in humans. Effect of amino acid infusion. Diabetes 1988;37:1365-1372.
22. Gaiani S, Bolondi L, Li Bassi S, Santi V, Zironi G, Barbara L. Effect of meal on portal hemodynamics in healthy humans and in patients with chronic liver disease. HEPATOLOGY 1989;9:815-819.
23. de Vries PJ, de Hooge P, Hoekstra JB, van Hattum J. Blunted postprandial reaction of portal venous flow in chronic liver disease, assessed with duplex Doppler: significance for prognosis. J Hepatol 1994;21:966-973.
24. Ludwig D, Schwarting K, Korbel CM, Bruning A, Schiefer B, Stange EF. The postprandial portal flow is related to the severity of portal hypertension and liver cirrhosis. J Hepatol 1998;28:631-638.
25. Miyake M, Harada M, Taoka Y, Nishitani H. Evaluation by MR imaging of the velocity and volume of pre- and postprandial portal blood flow in the presence or absence of liver cirrhosis. Nippon Igaku Hoshasen Gakkai Zasshi 1997;57:244-248.
26. Clemmesen JO, Tygstrup N, Ott P. Hepatic plasma flow estimated according to Fick's principle in patients with hepatic encephalopathy: evaluation of indocyanine green and D-sorbitol as test substances. HEPATOLOGY 1998;27:666-673.
27. Cooper AJ, Plum F. Biochemistry and physiology of brain ammonia. Physiol Rev 1987;67:440-519.
28. Dejong CHC, Deutz NEP, Soeters PB. Intestinal glutamine and ammonia metabolism during chronic hyperammonaemia induced by liver insufficiency. Gut 1993;34:1112-1119.
29. Windmueller HG, Spaeth AE. Uptake and metabolism of plasma glutamine by the small intestine. J Biol Chem 1974;249:5070-5079.
30. Deutz NEP, Reijven PL, Athanasas G, Soeters PB. Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs. Clin Sci 1992;83:607-614.
31. Debarin JF, Zahner B, Meyenberger C, Romanowski B, Schopke W, Marincek B, Fuchs WA. Azygos blood flow: phase contrast quantitation in volunteers and patients with portal hypertension pre- and postintrahepatic shunt placement. HEPATOLOGY 1996;24:1109-1115.
32. Dejong CHC, Deutz NEP, Soeters PB. Renal ammonia and glutamine metabolism during liver insufficiency-induced hyperammonemia in the rat. J Clin Invest 1993;92:2834-2840.
33. Owen EE, Johnson JH, Tyor MP. The effect of induced hyperammonemia on renal ammonia metabolism. J Clin Invest 1961;40:215-221.
34. Nathans D, Fahey JL, Ship AG. Sites of origin and removal of blood ammonia formed during glycine infusion; Effect of L-arginine. J Lab Clin Med 1958;51:123-128.
35. Pitts RF, DeHaas J, Klein J. Relation of renal amino and amide nitrogen extraction to ammonia production. Am J Physiol 1963;204:187-191.
36. Owen EE, Robinson RR. Amino acid extraction and ammonia metabolism by the human kidney during prolonged administration of ammonium chloride. J Clin Invest 1963;42:263-276.
37. Tannen RL. Ammonia metabolism. Am J Physiol 1978;235:F265-F277.
38. Good DW, Burg MB. Ammonia production by individual segments of the rat nephron. J Clin Invest 1984;73:602-610.
39. Halperin ML, Kamel KS, Ethier JH, Stinebaugh BJ, Jungas RL. Biochemistry and physiology of ammonium excretion. In: Seldin DW, Giebisch G, eds. The Kidney: Physiology and Pathophysiology. New York: Raven Press, Ltd, 1992.
40. Welters CF, Deutz NEP, Dejong CHC, Soeters PB. Enhanced renal vein ammonia efflux after a protein meal in the pig. J Hepatol 1999;31:489-496.
41. Newsholme EA, Leech AR. Biochemistry for the Medical Sciences. 1st ed. New York: John Wiley & Sons, 1983.
42. Pitts RF, Stone WJ. Renal metabolism of alanine. J Clin Invest 1967;46:530-538.
43. Fabbri A, Marchesini G, Bianchi G, Bugianesi E, Bortoluzzi L, Zoli M, Pisi E. Unresponsiveness of hepatic nitrogen metabolism to glucagon infusion in patients with cirrhosis: dependence on liver cell failure. HEPATOLOGY 1993;18:28-35.