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Volumn 94, Issue 2, 2012, Pages 147-156

EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo

Author keywords

Antiviral; Gallocatechin; Influenza A virus; Pelargonium sidoides; Polyphenol; Prodelphinidin

Indexed keywords

ANTIVIRUS AGENT; DIMER; EPIGALLOCATECHIN; GALLOCATECHIN; MONOMER; OLIGOMER; PELARGONIUM SIDOIDES EXTRACT; UMCKALOABO; VIRUS SIALIDASE;

EID: 84860274597     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2012.03.006     Document Type: Article
Times cited : (103)

References (57)
  • 1
    • 41949088274 scopus 로고    scopus 로고
    • Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis
    • Agbabiaka T.B., Guo R., Ernst E. Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. Phytomedicine 2008, 15:378-385.
    • (2008) Phytomedicine , vol.15 , pp. 378-385
    • Agbabiaka, T.B.1    Guo, R.2    Ernst, E.3
  • 2
    • 33846818867 scopus 로고    scopus 로고
    • EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells
    • Beil W., Kilian P. EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells. Phytomedicine 2007, 14(Suppl. 6):5-8.
    • (2007) Phytomedicine , vol.14 , Issue.SUPPL. 6 , pp. 5-8
    • Beil, W.1    Kilian, P.2
  • 3
    • 53449094522 scopus 로고    scopus 로고
    • A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae)
    • Brendler T., van Wyk B.E. A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae). J. Ethnopharmacol. 2008, 119:420-433.
    • (2008) J. Ethnopharmacol. , vol.119 , pp. 420-433
    • Brendler, T.1    van Wyk, B.E.2
  • 4
    • 60549105212 scopus 로고    scopus 로고
    • Update: Influenza activity-United States, September 28, 2008-January 31, 2009
    • Centers for Disease Control and Prevention (CDC)
    • Centers for Disease Control and Prevention (CDC), 2009. Update: Influenza activity-United States, September 28, 2008-January 31, 2009. MMWR Morb. Mortal. Wkly. Rep. 58, 115-119.
    • (2009) MMWR Morb. Mortal. Wkly. Rep. , vol.58 , pp. 115-119
  • 5
    • 0036654692 scopus 로고    scopus 로고
    • Antiviral properties of prodelphinidin B-2 3'-O-gallate from green tea leaf
    • Cheng H.Y., Lin C.C., Lin T.C. Antiviral properties of prodelphinidin B-2 3'-O-gallate from green tea leaf. Antivir. Chem. Chemother. 2002, 13:223-229.
    • (2002) Antivir. Chem. Chemother. , vol.13 , pp. 223-229
    • Cheng, H.Y.1    Lin, C.C.2    Lin, T.C.3
  • 6
    • 34548437086 scopus 로고    scopus 로고
    • Pelargonium sidoides-extract (EPs 7630): registration confirms efficacy and safety
    • Conrad A., Kolodziej H., Schulz V. Pelargonium sidoides-extract (EPs 7630): registration confirms efficacy and safety. Wien. Med. Wochenschr. 2007, 157:331-336.
    • (2007) Wien. Med. Wochenschr. , vol.157 , pp. 331-336
    • Conrad, A.1    Kolodziej, H.2    Schulz, V.3
  • 8
    • 0035663005 scopus 로고    scopus 로고
    • Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells
    • Deprez S., Mila I., Huneau J.F., Tome D., Scalbert A. Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells. Antioxid. Redox Signal 2001, 3:957-967.
    • (2001) Antioxid. Redox Signal , vol.3 , pp. 957-967
    • Deprez, S.1    Mila, I.2    Huneau, J.F.3    Tome, D.4    Scalbert, A.5
  • 10
    • 34547471550 scopus 로고    scopus 로고
    • CYSTUS052, a polyphenol-rich plant extract, exerts anti-influenza virus activity in mice
    • Droebner K., Ehrhardt C., Poetter A., Ludwig S., Planz O. CYSTUS052, a polyphenol-rich plant extract, exerts anti-influenza virus activity in mice. Antiviral Res. 2007, 76:1-10.
    • (2007) Antiviral Res. , vol.76 , pp. 1-10
    • Droebner, K.1    Ehrhardt, C.2    Poetter, A.3    Ludwig, S.4    Planz, O.5
  • 11
    • 34547489997 scopus 로고    scopus 로고
    • A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance
    • Ehrhardt C., Hrincius E.R., Korte V., Mazur I., Droebner K., Poetter A., Dreschers S., Schmolke M., Planz O., Ludwig S. A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance. Antiviral Res. 2007, 76:38-47.
    • (2007) Antiviral Res. , vol.76 , pp. 38-47
    • Ehrhardt, C.1    Hrincius, E.R.2    Korte, V.3    Mazur, I.4    Droebner, K.5    Poetter, A.6    Dreschers, S.7    Schmolke, M.8    Planz, O.9    Ludwig, S.10
  • 14
    • 79952217106 scopus 로고    scopus 로고
    • Antiviral agents for the treatment and chemoprophylaxis of influenza - recommendations of the Advisory Committee on Immunization Practices (ACIP)
    • Fiore A.E., Fry A., Shay D., Gubareva L., Bresee J.S., Uyeki T.M. Antiviral agents for the treatment and chemoprophylaxis of influenza - recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep. 2011, 60:1-24.
    • (2011) MMWR Recomm. Rep. , vol.60 , pp. 1-24
    • Fiore, A.E.1    Fry, A.2    Shay, D.3    Gubareva, L.4    Bresee, J.S.5    Uyeki, T.M.6
  • 15
    • 78650875211 scopus 로고    scopus 로고
    • Oligomeric proanthocyanidins from Rumex acetosa L. inhibit the attachment of herpes simplex virus type-1
    • Gescher K., Hensel A., Hafezi W., Derksen A., Kühn J. Oligomeric proanthocyanidins from Rumex acetosa L. inhibit the attachment of herpes simplex virus type-1. Antiviral Res. 2011, 89:9-18.
    • (2011) Antiviral Res. , vol.89 , pp. 9-18
    • Gescher, K.1    Hensel, A.2    Hafezi, W.3    Derksen, A.4    Kühn, J.5
  • 16
    • 79952703921 scopus 로고    scopus 로고
    • Proanthocyanidin-enriched extract from Myrothamnus flabellifolia Welw. exerts antiviral activity against herpes simplex virus type 1 by inhibition of viral adsorption and penetration
    • Gescher K., Kühn J., Lorentzen E., Hafezi W., Derksen A., Deters A., Hensel A. Proanthocyanidin-enriched extract from Myrothamnus flabellifolia Welw. exerts antiviral activity against herpes simplex virus type 1 by inhibition of viral adsorption and penetration. J. Ethnopharmacol. 2011, 134:468-474.
    • (2011) J. Ethnopharmacol. , vol.134 , pp. 468-474
    • Gescher, K.1    Kühn, J.2    Lorentzen, E.3    Hafezi, W.4    Derksen, A.5    Deters, A.6    Hensel, A.7
  • 17
    • 0019876875 scopus 로고
    • The specificity of proanthocyanidin-protein interactions
    • Hagerman A.E., Butler L.G. The specificity of proanthocyanidin-protein interactions. J. Biol. Chem. 1981, 256:4494-4497.
    • (1981) J. Biol. Chem. , vol.256 , pp. 4494-4497
    • Hagerman, A.E.1    Butler, L.G.2
  • 18
    • 70350605265 scopus 로고    scopus 로고
    • Pomegranate (Punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir
    • Haidari M., Ali M., Ward Casscells S., Madjid M. Pomegranate (Punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir. Phytomedicine 2009, 16:1127-1136.
    • (2009) Phytomedicine , vol.16 , pp. 1127-1136
    • Haidari, M.1    Ali, M.2    Ward Casscells, S.3    Madjid, M.4
  • 19
    • 54449099369 scopus 로고    scopus 로고
    • The multifunctional NS1 protein of influenza A viruses
    • Hale B.G., Randall R.E., Ortin J., Jackson D. The multifunctional NS1 protein of influenza A viruses. J. Gen. Virol. 2008, 89:2359-2376.
    • (2008) J. Gen. Virol. , vol.89 , pp. 2359-2376
    • Hale, B.G.1    Randall, R.E.2    Ortin, J.3    Jackson, D.4
  • 20
    • 79851496686 scopus 로고    scopus 로고
    • Emerging influenza antiviral resistance threats
    • Hayden F.G., de Jong M.D. Emerging influenza antiviral resistance threats. J. Infect. Dis. 2011, 203:6-10.
    • (2011) J. Infect. Dis. , vol.203 , pp. 6-10
    • Hayden, F.G.1    de Jong, M.D.2
  • 22
    • 0032497537 scopus 로고    scopus 로고
    • Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries
    • Howell A.B., Vorsa N., Der Marderosian A., Foo L.Y. Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries. N. Engl. J. Med. 1998, 339:1085-1086.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1085-1086
    • Howell, A.B.1    Vorsa, N.2    Der Marderosian, A.3    Foo, L.Y.4
  • 25
    • 78149461967 scopus 로고    scopus 로고
    • Anti-adhesive activities of flavan-3-ols and proanthocyanidins in the interaction of group A-streptococci and human epithelial cells
    • Janecki A., Kolodziej H. Anti-adhesive activities of flavan-3-ols and proanthocyanidins in the interaction of group A-streptococci and human epithelial cells. Molecules 2010, 15:7139-7152.
    • (2010) Molecules , vol.15 , pp. 7139-7152
    • Janecki, A.1    Kolodziej, H.2
  • 26
    • 78650680252 scopus 로고    scopus 로고
    • Evaluation of an aqueous-ethanolic extract from Pelargonium sidoides (EPs® 7630) for its activity against group A-streptococci adhesion to human HEp-2 epithelial cells
    • Janecki A., Conrad A., Engels I., Frank U., Kolodziej H. Evaluation of an aqueous-ethanolic extract from Pelargonium sidoides (EPs® 7630) for its activity against group A-streptococci adhesion to human HEp-2 epithelial cells. J. Ethnopharmacol. 2010, 133:147-152.
    • (2010) J. Ethnopharmacol. , vol.133 , pp. 147-152
    • Janecki, A.1    Conrad, A.2    Engels, I.3    Frank, U.4    Kolodziej, H.5
  • 27
    • 70349992632 scopus 로고    scopus 로고
    • Possible harms of oseltamivir - a call for urgent action
    • Jefferson T., Jones M., Doshi P., Del Mar C. Possible harms of oseltamivir - a call for urgent action. Lancet 2009, 374:1312-1313.
    • (2009) Lancet , vol.374 , pp. 1312-1313
    • Jefferson, T.1    Jones, M.2    Doshi, P.3    Del Mar, C.4
  • 28
    • 77949454253 scopus 로고    scopus 로고
    • Efficacy and tolerability of EPs 7630 in children and adolescents with acute bronchitis - a randomized, double-blind, placebo-controlled multicenter trial with a herbal drug preparation from Pelargonium sidoides roots
    • Kamin W., Maydannik V., Malek F.A., Kieser M. Efficacy and tolerability of EPs 7630 in children and adolescents with acute bronchitis - a randomized, double-blind, placebo-controlled multicenter trial with a herbal drug preparation from Pelargonium sidoides roots. Int. J. Clin. Pharmacol. Ther. 2010, 48:184-191.
    • (2010) Int. J. Clin. Pharmacol. Ther. , vol.48 , pp. 184-191
    • Kamin, W.1    Maydannik, V.2    Malek, F.A.3    Kieser, M.4
  • 30
    • 33846833861 scopus 로고    scopus 로고
    • In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparation EPs 7630
    • Kolodziej H., Kiderlen A.F. In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparation EPs 7630. Phytomedicine 2007, 14(Suppl. 6):18-26.
    • (2007) Phytomedicine , vol.14 , Issue.SUPPL. 6 , pp. 18-26
    • Kolodziej, H.1    Kiderlen, A.F.2
  • 31
    • 0037573531 scopus 로고    scopus 로고
    • Pharmacological profile of extracts of Pelargonium sidoides and their constituents
    • Kolodziej H., Kayser O., Radtke O.A., Kiderlen A.F., Koch E. Pharmacological profile of extracts of Pelargonium sidoides and their constituents. Phytomedicine 2003, 10(Suppl. 4):18-24.
    • (2003) Phytomedicine , vol.10 , Issue.SUPPL. 4 , pp. 18-24
    • Kolodziej, H.1    Kayser, O.2    Radtke, O.A.3    Kiderlen, A.F.4    Koch, E.5
  • 32
  • 34
    • 33847404107 scopus 로고    scopus 로고
    • Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs 7630): a randomised, double-blind, placebo-controlled, multicentre study
    • Matthys H., Heger M. Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs 7630): a randomised, double-blind, placebo-controlled, multicentre study. Curr. Med. Res. Opin. 2007, 23:323-331.
    • (2007) Curr. Med. Res. Opin. , vol.23 , pp. 323-331
    • Matthys, H.1    Heger, M.2
  • 35
    • 0038587633 scopus 로고    scopus 로고
    • Efficacy and safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A randomised, double-blind, placebo-controlled trial
    • Matthys H., Eisebitt R., Seith B., Heger M. Efficacy and safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A randomised, double-blind, placebo-controlled trial. Phytomedicine 2003, 10(Suppl. 4):7-17.
    • (2003) Phytomedicine , vol.10 , Issue.SUPPL. 4 , pp. 7-17
    • Matthys, H.1    Eisebitt, R.2    Seith, B.3    Heger, M.4
  • 36
    • 79952736046 scopus 로고    scopus 로고
    • Investigation of the influence of EPs® 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses
    • Michaelis M., Doerr H.W., Cinatl J. Investigation of the influence of EPs® 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses. Phytomedicine 2010, 18:384-386.
    • (2010) Phytomedicine , vol.18 , pp. 384-386
    • Michaelis, M.1    Doerr, H.W.2    Cinatl, J.3
  • 37
    • 77749326569 scopus 로고    scopus 로고
    • Possible neuropsychiatric reaction to high-dose oseltamivir during acute 2009 H1N1 influenza A infection
    • Nakamura K., Schwartz B.S., Lindegardh N., Keh C., Guglielmo B.J. Possible neuropsychiatric reaction to high-dose oseltamivir during acute 2009 H1N1 influenza A infection. Clin. Infect. Dis. 2010, 50:e47-49.
    • (2010) Clin. Infect. Dis. , vol.50
    • Nakamura, K.1    Schwartz, B.S.2    Lindegardh, N.3    Keh, C.4    Guglielmo, B.J.5
  • 38
    • 35348894897 scopus 로고    scopus 로고
    • Predicted tracheobronchial and pulmonary deposition in a murine asthma model
    • Oldham M.J., Robinson R.J. Predicted tracheobronchial and pulmonary deposition in a murine asthma model. Anat. Rec. (Hoboken) 2007, 290:1309-1314.
    • (2007) Anat. Rec. (Hoboken) , vol.290 , pp. 1309-1314
    • Oldham, M.J.1    Robinson, R.J.2
  • 40
    • 72449195360 scopus 로고    scopus 로고
    • Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)
    • Pleschka S., Stein M., Schoop R., Hudson J.B. Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV). Virol. J. 2009, 6:197.
    • (2009) Virol. J. , vol.6 , pp. 197
    • Pleschka, S.1    Stein, M.2    Schoop, R.3    Hudson, J.B.4
  • 41
    • 0002099464 scopus 로고
    • Regional deposition of inhaled monodisperse coarse and fine aerosol particles in small laboratory animals
    • Pergamon Press, Oxford
    • Raabe O.G., Al-Bayati M.A., Teague S.V., Rasolt A. Regional deposition of inhaled monodisperse coarse and fine aerosol particles in small laboratory animals. Inhaled Particles VI 1988, 53-63. Pergamon Press, Oxford.
    • (1988) Inhaled Particles VI , pp. 53-63
    • Raabe, O.G.1    Al-Bayati, M.A.2    Teague, S.V.3    Rasolt, A.4
  • 42
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw S., Nihal M., Ahmad N. Dose translation from animal to human studies revisited. FASEB J. 2008, 22:659-661.
    • (2008) FASEB J. , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 45
  • 46
    • 33846807698 scopus 로고    scopus 로고
    • Mass spectroscopic characterisation of oligomeric proanthocyanidins derived from an extract of Pelargonium sidoides roots (EPs 7630) and pharmacological screening in CNS models
    • Schötz K., Nöldner M. Mass spectroscopic characterisation of oligomeric proanthocyanidins derived from an extract of Pelargonium sidoides roots (EPs 7630) and pharmacological screening in CNS models. Phytomedicine 2007, 14(Suppl. 6):32-39.
    • (2007) Phytomedicine , vol.14 , Issue.SUPPL. 6 , pp. 32-39
    • Schötz, K.1    Nöldner, M.2
  • 49
    • 27644518720 scopus 로고    scopus 로고
    • Antiviral effect of catechins in green tea on influenza virus
    • Song J.M., Lee K.H., Seong B.L. Antiviral effect of catechins in green tea on influenza virus. Antiviral Res. 2005, 68:66-74.
    • (2005) Antiviral Res. , vol.68 , pp. 66-74
    • Song, J.M.1    Lee, K.H.2    Seong, B.L.3
  • 51
    • 77956896558 scopus 로고    scopus 로고
    • Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins
    • Sundararajan A., Ganapathy R., Huan L., Dunlap J.R., Webby R.J., Kotwal G.J., Sangster M.Y. Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins. Antiviral Res. 2010, 88:1-9.
    • (2010) Antiviral Res. , vol.88 , pp. 1-9
    • Sundararajan, A.1    Ganapathy, R.2    Huan, L.3    Dunlap, J.R.4    Webby, R.J.5    Kotwal, G.J.6    Sangster, M.Y.7
  • 53
    • 79955875648 scopus 로고    scopus 로고
    • Anti-infective activities of Pelargonium sidoides (EPS(R) 7630): effects of induced NO production on Leishmania major in infected macrophages and antiviral effects as assessed in a fibroblast-virus protection assay
    • Thäle C., Kiderlen A.F., Kolodziej H. Anti-infective activities of Pelargonium sidoides (EPS(R) 7630): effects of induced NO production on Leishmania major in infected macrophages and antiviral effects as assessed in a fibroblast-virus protection assay. Planta Med. 2011, 77:718-725.
    • (2011) Planta Med. , vol.77 , pp. 718-725
    • Thäle, C.1    Kiderlen, A.F.2    Kolodziej, H.3
  • 54
    • 0026558848 scopus 로고
    • Hamamelis virginiana: identification and assay of proanthocyanidins, phenolic acids and flavonoids in leaf extracts
    • Vennat B., Gross D., Pourrat H. Hamamelis virginiana: identification and assay of proanthocyanidins, phenolic acids and flavonoids in leaf extracts. Pharm. Acta Helv. 1992, 67:11-14.
    • (1992) Pharm. Acta Helv. , vol.67 , pp. 11-14
    • Vennat, B.1    Gross, D.2    Pourrat, H.3
  • 55
    • 33847740239 scopus 로고    scopus 로고
    • An extract of Pelargonium sidoides (EPs 7630) inhibits in situ adhesion of Helicobacter pylori to human stomach
    • Wittschier N., Faller G., Hensel A. An extract of Pelargonium sidoides (EPs 7630) inhibits in situ adhesion of Helicobacter pylori to human stomach. Phytomedicine 2007, 14:285-288.
    • (2007) Phytomedicine , vol.14 , pp. 285-288
    • Wittschier, N.1    Faller, G.2    Hensel, A.3
  • 56
    • 0032997780 scopus 로고    scopus 로고
    • Human salivary tea catechin levels and catechin esterase activities: implication in human cancer prevention studies
    • Yang C.S., Lee M.J., Chen L. Human salivary tea catechin levels and catechin esterase activities: implication in human cancer prevention studies. Cancer Epidemiol. Biomarkers Prev. 1999, 8:83-89.
    • (1999) Cancer Epidemiol. Biomarkers Prev. , vol.8 , pp. 83-89
    • Yang, C.S.1    Lee, M.J.2    Chen, L.3
  • 57
    • 0031081319 scopus 로고    scopus 로고
    • Plant polyphenols: biologically active compounds or non-selective binders to protein?
    • Zhu M., Phillipson J.D., Greengrass P.M., Bowery N.E., Cai Y. Plant polyphenols: biologically active compounds or non-selective binders to protein?. Phytochemistry 1997, 44:441-447.
    • (1997) Phytochemistry , vol.44 , pp. 441-447
    • Zhu, M.1    Phillipson, J.D.2    Greengrass, P.M.3    Bowery, N.E.4    Cai, Y.5


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