Evaluation of an aqueous-ethanolic extract from Pelargonium sidoides (EPs® 7630) for its activity against group A-streptococci adhesion to human HEp-2 epithelial cells

Journal of Ethnopharmacology

Volumn 133, Issue 1, 2011, Pages 147-152

  Janecki, Aneta ^a   Conrad, Andreas ^b   Engels, Inge ^b   Frank, Uwe ^b   Kolodziej, Herbert ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Anti adhesion; Group A streptococci; Pelargonium sidoides; Proanthocyanidins

Indexed keywords

FLAVAN DERIVATIVE; PELARGONIUM SIDOIDES EXTRACT; PROANTHOCYANIDIN DERIVATIVE; PYROGALLOL;

ARTICLE; BACTERIAL INFECTION; BACTERIUM ADHERENCE; BINDING SITE; DRUG POTENCY; DRUG SCREENING; FLOW CYTOMETRY; GERANIACEAE; HUMAN; HUMAN CELL; NONHUMAN; PLANT ROOT; POWDER; STREPTOCOCCUS GROUP A; STREPTOCOCCUS PYOGENES;

ANTI-BACTERIAL AGENTS; BACTERIAL ADHESION; CELL LINE, TUMOR; EPITHELIAL CELLS; ETHANOL; HUMANS; PELARGONIUM; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; STREPTOCOCCUS PYOGENES;

BACTERIA (MICROORGANISMS); GERANIACEAE; PELARGONIUM SIDOIDES; STREPTOCOCCUS PYOGENES; STREPTOCOCCUS SP. 'GROUP A';

EID: 78650680252     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.09.018     Document Type: Article

References (46)

1. ® 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells Phytomedicine 14 2007 5 8
2. T. Brendler, and E. van Wyk A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae) Journal of Ethnopharmacology 119 2008 420 433
3. Burger, O., Weiss, E., Sharon, N., Tabak, M., Neeman, I., Ofek, I., 2002. Inhibition of Helicobacter pylori adhesion to human gastric mucus by a high-molecular weight constituent of cranberry juice. Critical Reviews in Food Science and Nutrition 42, 279-284.
4. H.J. Busscher, W. Norde, and H.C. vander Wei Specific molecular recognition and nonspecific contributions to bacterial interaction forces Applied Environmental Microbiology 74 2008 2559 2564
5. ® 7630): a randomized, double-blind, placebo-controlled trial Explore 1 2005 437 445
6. ® 7630) inhibits the interactions of group A streptococci and host epithelia in-vitro Phytomedicine 14 2007 52 59
7. O. Dangles, and C. Dufour Flavonoid-protein interactions M. Andersen, K.R. Markham, Flavonoids: Chemistry, Biochemistry and Application 2006 Taylor and Francis Boca Raton 443 469
8. N.F. Dmitrieva, E.S. Vylegzhanina, K.B. Grabovskaya, S.V. Bitko, and I.B. Naumova Some chemical and biological properties of lipoteichoic acid of group A Streptococcus Vestnik Akademii Meditsinskikh Nauk 7 1986 30 34
9. L.Y. Foo, Y. Lu, A.B. Howell, and N. Vorsa A-type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic p-fimbriated E. coli Journal of Natural Products 63 2000 1225 1228
10. L.Y. Foo, Y. Lu, A.B. Howell, and N. Vorsa The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro Phytochemistry 54 2000 173 181
11. A.E. Hagerman, and L.G. Butler The specificity of proanthocyanidin- protein interactions Journal of Biological Chemistry 256 1981 4494 4497
12. ® 7630-solution in acute bronchitis in childhood: report of a multicentre observational study Phytomedicine 14 2007 60 64
13. E. Haslam Plant Polyphenols-Vegetable Tannins Revisited 1989 Cambridge University Press Cambridge, Great Britain
14. A.B. Howell, N. Vora, A. Der Marderosian, and L.Y. Foo Inhibition of the adherence of p-fimbriated Escherichia coli to uroepithelial cell surfaces by proanthocyanidin extracts from cranberries New England Journal of Medicine 339 1998 1085 1086
15. J.R. Johnson, N. Kaster, M.A. Kuskowski, and G.V. Ling Identification of urovirulence traits in Escherichia coli by comparison of urinary and rectal E. coli isolates from dogs with urinary tract infection Journal of Clinical Microbiology 41 2003 337 345
16. O. Kayser, and H. Kolodziej Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme Planta Medica 63 1997 508 510
17. ® 7630 Phytomedicine 14 2007 18 26
18. H. Kolodziej Occurrence of procyanidins in Nelia meyeri Phytochemistry 23 1984 1745 1752
19. H. Kolodziej Procyanidins from medicinal birch: bonding patterns and sequence of units in triflavanoids of mixed stereochemistry Phytochemistry 28 1989 3487 3492
20. H. Kolodziej Oligomeric flavan-3-ols from medicinal willow bark Phytochemistry 29 1990 955 960
21. H. Kolodziej, O. Kayser, K.P. Latt, and D. Ferreira Evaluation of the antimicrobial potency of tannins and related compounds using the microdilution broth method Planta Medica 65 1999 444 446
22. H. Kolodziej Pelargonium reniforme and Pelargonium sidoides: their botany, chemistry and medicinal use M. Lis-Balchin, Geranium and Pelargonium 2002 Taylor and Francis London 262 290
23. ® Phytomedicine 14 2007 9 17
24. H. Kolodziej Aqueous ethanolic extract of the roots of Pelargonium sidoides - new scientific evidence for an old anti-infective phytopharmaceutical Planta Medica 74 2008 661 666
25. D. LaPenta, C. Rubens, E. Chi, and P. Clearly Group A streptococci efficiently invade human respiratory epithelial cells Proceedings of the National Academy of Science USA 1994 12115 12119 Vol. 91
26. C. Lengsfeld, A. Deters, G. Faller, and A. Hensel High molecular weight polysaccharides from black currant seeds inhibit adhesion of Helicobacter pylori to human gastric mucosa Planta Medica 70 2004 620 626
27. ® 7630-solution - an effective therapeutic option in acute and exacerbating bronchitis Phytomedicine 14 2007 65 68
28. ® 7630) in the treatment of acute bronchitis in adults and children Phytomedicine 14 2007 69 73
29. T.A. Ngueyemem, G. Brusotti, G. Marubini, P. Grisoli, C. Dacarro, G. Vidari, P. Vita Finzi, and G. Caccialanza Validation of use of a traditional remedy from Bridelia grandis (Pierre ex Hutch) stem bark against oral Streptococci Journal of Ethnopharmacology 120 2008 13 16
30. R. Nowack, and W. Schmitt Cranberry juice for prophylaxis of urinary tract infections - Conclusions from clinical experience and research Phytomedicine 15 2008 653 667
31. Ph. Eur. 6.0, 2008. Wiss. Verlagsgesellschaft mbH, Stuttgart, Germany, p. 328.
32. A. Podbielski, and B. Kreikemeyer The background of tissue specificity of Streptococcus pyogenes Bioforum 29 2006 32 34
33. A. Salminen, V. Loimaranta, J.A.F. Joosten, A. Salam Khan, J. Hacker, R.J. Pieters, and J. Finne Inhibition of P-fimbriated Escherichia coli adhesion by multivalent galabiose derivatives studied by a live-bacteria application of surface plasmon resonance Journal of Applied Chemistry 60 2007 495 501
34. B.M. Schmidt, A.B. Howell, B. McEniry, C.T. Knight, D. Seigler, J.W. Erdman, and M.A. Lila Effective separation of potent antiproliferation and antiadhesion components from wild blueberry (Vaccinium angustifolium Ait.) fruits Journal of Agriculture and Food Chemistry 52 2004 6433 6442
35. D.R. Schmidt, and A.E. Sobota An examination of the anti-adherence activity of cranberry juice on urinary and non-urinary bacterial isolates Microbios 55 1988 173 181
36. ® 7630 Planta Medica 74 2008 667 674
37. ® 7630) and pharmacological screening in CNS models Phytomedicine 14 2007 32 39
38. C.R. Sethman, R.J. Doyle, and M.M. Cowan Flow cytometric evaluation of adhesion of Streptococcus pyogenes to epithelial cells Journal of Microbiological Methods 51 2002 35 42
39. N. Sharon Carbohydrates as future anti-adhesion drugs for infection diseases Biochimica et Biophysica Acta 1760 2006 527 537
40. J.J.A. Van der Walt, and P.J. Vorster Phytogeograpgy of Pelargonium Bothalia 14 1983 517 523
41. J.J.A. Van der Walt, and P.J. Vorster Pelargoniums of Southern Africa vol. 3 1988 National Botanic Gardens Kirstenbosch
42. C. Watt, and M.G. Breyer-Brandwyk Medicinal and Poisonous Plants of Southern and Eastern Africa 1962 Livingstone Edinburgh, London pp. 449-455
43. E.I. Weiss, R. Lev-Dor, N. Sharon, and I. Ofek Inhibitory effect of a high molecular weight constituent of cranberry on adhesion of oral bacteria Critical Reviews in Food Science and Nutrition 42 2002 285 292
44. ® 7630) inhibits in situ adhesion of Helicobacter pylori to human stomach Phytomedicine 14 2007 285 288
45. N. Wittschier, C. Lengsfeld, S. Vorthems, U. Stratmann, J.F. Ernst, E.J. Verspohl, and A. Hensel Large molecules as anti-adhesive compounds against pathogens Journal of Pharmacy and Pharmacology 59 2007 777 786
46. N. Wittschier, G. Faller, and A. Hensel Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa Journal of Ethnopharmacology 125 2009 218 223