Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cells

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Liu, Lingling ^a   Wang, Yong Dong ^a   Wu, Jing ^a   Cui, Jimmy ^a   Chen, Taosheng ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PAX3;

ARTICLE; BINDING SITE; CARNITINE PALMITOYLTRANSFERASE A1 GENE; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; DOWN REGULATION; FUSION GENE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; METASTASIS; MICROARRAY ANALYSIS; MUTATIONAL ANALYSIS; PAX3 FKHR GENE; PROMOTER REGION; RHABDOMYOSARCOMA; TRANSACTIVATION; TRANSCRIPTION REGULATION;

BINDING SITES; CARNITINE O-PALMITOYLTRANSFERASE; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ONCOGENE PROTEINS, FUSION; PAIRED BOX TRANSCRIPTION FACTORS; RESPONSE ELEMENTS; RHABDOMYOSARCOMA, ALVEOLAR; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84860210772     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-154     Document Type: Article

References (30)

1. Linardic CM. PAX3-FOXO1 fusion gene in rhabdomyosarcoma. Cancer Lett 2008, 270(1):10-18. 10.1016/j.canlet.2008.03.035, 2575376, 18457914.
2. Kikuchi K, Tsuchiya K, Otabe O, Gotoh T, Tamura S, Katsumi Y, Yagyu S, Tsubai-Shimizu S, Miyachi M, Iehara T, et al. Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma. Biochem Biophys Res Commun 2008, 365(3):568-574. 10.1016/j.bbrc.2007.11.017, 18022385.
3. Nishijo K, Chen QR, Zhang L, McCleish AT, Rodriguez A, Cho MJ, Prajapati SI, Gelfond JA, Chisholm GB, Michalek JE, et al. Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma. Cancer Res 2009, 69(7):2902-2911. 10.1158/0008-5472.CAN-08-3723, 2789740, 19339268.
4. Libura J, Drukala J, Majka M, Tomescu O, Navenot JM, Kucia M, Marquez L, Peiper SC, Barr FG, Janowska-Wieczorek A, et al. CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion. Blood 2002, 100(7):2597-2606. 10.1182/blood-2002-01-0031, 12239174.
5. Zhang Y, Wang C. Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells. Oncogene 2011, 30(32):3549-3462. 10.1038/onc.2011.69, 3205923, 21423212.
6. Ji S, You Y, Kerner J, Hoppel CL, Schoeb TR, Chick WS, Hamm DA, Sharer JD, Wood PA. Homozygous carnitine palmitoyltransferase 1b (muscle isoform) deficiency is lethal in the mouse. Mol Genet Metab 2008, 93(3):314-322. 10.1016/j.ymgme.2007.10.006, 2270477, 18023382.
7. Nyman LR, Cox KB, Hoppel CL, Kerner J, Barnoski BL, Hamm DA, Tian L, Schoeb TR, Wood PA. Homozygous carnitine palmitoyltransferase 1a (liver isoform) deficiency is lethal in the mouse. Mol Genet Metab 2005, 86(1-2):179-187.
8. Wolfgang MJ, Cha SH, Millington DS, Cline G, Shulman GI, Suwa A, Asaumi M, Kurama T, Shimokawa T, Lane MD. Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. J Neurochem 2008, 105(4):1550-1559. 10.1111/j.1471-4159.2008.05255.x, 18248603.
9. Wolfgang MJ, Kurama T, Dai Y, Suwa A, Asaumi M, Matsumoto S, Cha SH, Shimokawa T, Lane MD. The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc Natl Acad Sci U S A 2006, 103(19):7282-7287. 10.1073/pnas.0602205103, 1564279, 16651524.
10. Zaugg K, Yao Y, Reilly PT, Kannan K, Kiarash R, Mason J, Huang P, Sawyer SK, Fuerth B, Faubert B, et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev 2011, 25(10):1041-1051. 10.1101/gad.1987211, 3093120, 21576264.
11. Zeng FY, Cui J, Liu L, Chen T. PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis. Cancer Lett 2009, 284(2):157-164. 10.1016/j.canlet.2009.04.016, 2739888, 19442434.
12. Zeng FY, Dong H, Cui J, Liu L, Chen T. Glycogen synthase kinase 3 regulates PAX3-FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells. Biochem Biophys Res Commun 2010, 391(1):1049-1055. 10.1016/j.bbrc.2009.12.017, 2812657, 19995556.
13. Pondugula SR, Tong AA, Wu J, Cui J, Chen T. Protein phosphatase 2Cbetal regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. Drug Metab Dispos 2010, 38(9):1411-1416. 10.1124/dmd.110.032128, 2939471, 20538721.
14. Lee K, Kerner J, Hoppel CL. Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex. J Biol Chem 2011, 286(29):25655-25662. 10.1074/jbc.M111.228692, 3138250, 21622568.
15. Lim SK, Orhant-Prioux M, Toy W, Tan KY, Lim YP. Tyrosine phosphorylation of transcriptional coactivator WW-domain binding protein 2 regulates estrogen receptor alpha function in breast cancer via the Wnt pathway. FASEB J 2011, 25(9):3004-3018. 10.1096/fj.10-169136, 21642474.
16. Oudin MJ, Gajendra S, Williams G, Hobbs C, Lalli G, Doherty P. Endocannabinoids regulate the migration of subventricular zone-derived neuroblasts in the postnatal brain. J Neurosci 2011, 31(11):4000-4011. 10.1523/JNEUROSCI.5483-10.2011, 21411643.
17. Yang D, Kedei N, Li L, Tao J, Velasquez JF, Michalowski AM, Toth BI, Marincsak R, Varga A, Biro T, et al. RasGRP3 contributes to formation and maintenance of the prostate cancer phenotype. Cancer Res 2010, 70(20):7905-7917. 10.1158/0008-5472.CAN-09-4729, 2955810, 20876802.
18. Yang D, Tao J, Li L, Kedei N, Toth ZE, Czap A, Velasquez JF, Mihova D, Michalowski AM, Yuspa SH, et al. RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma. Oncogene 2011, 30(45):4590-4600. 10.1038/onc.2011.166, 21602881.
19. Ebauer M, Wachtel M, Niggli FK, Schafer BW. Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR. Oncogene 2007, 26(51):7267-7281. 10.1038/sj.onc.1210525, 17525748.
20. Xia SJ, Holder DD, Pawel BR, Zhang C, Barr FG. High expression of the PAX3-FKHR oncoprotein is required to promote tumorigenesis of human myoblasts. Am J Pathol 2009, 175(6):2600-2608. 10.2353/ajpath.2009.090192, 2789624, 19893043.
21. Cao L, Yu Y, Bilke S, Walker RL, Mayeenuddin LH, Azorsa DO, Yang F, Pineda M, Helman LJ, Meltzer PS. Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer. Cancer Res 2010, 70(16):6497-6508. 10.1158/0008-5472.CAN-10-0582, 2922412, 20663909.
22. Xia SJ, Barr FG. Analysis of the transforming and growth suppressive activities of the PAX3-FKHR oncoprotein. Oncogene 2004, 23(41):6864-6871. 10.1038/sj.onc.1207850, 15286710.
23. Zhang L, Wang C. Identification of a new class of PAX3-FKHR target promoters: a role of the Pax3 paired box DNA binding domain. Oncogene 2007, 26(11):1595-1605. 10.1038/sj.onc.1209958, 2238811, 16964289.
24. Hernlund E, Ihrlund LS, Khan O, Ates YO, Linder S, Panaretakis T, Shoshan MC. Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. Int J Cancer 2008, 123(2):476-483. 10.1002/ijc.23525, 18452174.
25. Mercado GE, Barr FG. Fusions involving PAX and FOX genes in the molecular pathogenesis of alveolar rhabdomyosarcoma: recent advances. Curr Mol Med 2007, 7(1):47-61. 10.2174/156652407779940440, 17311532.
26. Schreurs M, Kuipers F, van der Leij FR. Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome. Obes Rev 2010, 11(5):380-388. 10.1111/j.1467-789X.2009.00642.x, 19694967.
27. Henique C, Mansouri A, Fumey G, Lenoir V, Girard J, Bouillaud F, Prip-Buus C, Cohen I. Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis. J Biol Chem 2010, 285(47):36818-36827. 10.1074/jbc.M110.170431, 2978610, 20837491.
28. Wan J, Jiang L, Lu Q, Ke L, Li X, Tong N. Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells. Biochem Biophys Res Commun 2010, 391(3):1567-1572. 10.1016/j.bbrc.2009.12.127, 20040361.
29. Mazzarelli P, Pucci S, Bonanno E, Sesti F, Calvani M, Spagnoli LG. Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation?. Cancer Biol Ther 2007, 6(10):1606-1613. 10.4161/cbt.6.10.4742, 18253084.
30. Lin H, Lu JP, Laflamme P, Qiao S, Shayegan B, Bryskin I, Monardo L, Wilson BC, Singh G, Pinthus JH. Inter-related in vitro effects of androgens, fatty acids and oxidative stress in prostate cancer: a mechanistic model supporting prevention strategies. Int J Oncol 2010, 37(4):761-766.