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Volumn 9, Issue , 2012, Pages

Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: Involvement of PPAR-α

Author keywords

Inflammation; PPAR ; SCI; Simvastatin

Indexed keywords

3 NITROTYROSINE; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN BAX; PROTEIN BCL 2; SIMVASTATIN;

EID: 84860209867     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-81     Document Type: Article
Times cited : (55)

References (77)
  • 1
    • 0028795058 scopus 로고
    • Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat
    • 10.1016/0006-8993(94)01410-J, 7749740
    • Bartholdi D, Schwab ME. Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat. Brain Res 1995, 672:177-186. 10.1016/0006-8993(94)01410-J, 7749740.
    • (1995) Brain Res , vol.672 , pp. 177-186
    • Bartholdi, D.1    Schwab, M.E.2
  • 2
    • 0027521580 scopus 로고
    • Potential involvement of the transcription factor NF-kappa B in neurological disorders
    • 10.1016/0098-2997(93)90004-W, 8264332
    • Kaltschmidt B, Baeuerle PA, Kaltschmidt C. Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med 1993, 14:171-190. 10.1016/0098-2997(93)90004-W, 8264332.
    • (1993) Mol Aspects Med , vol.14 , pp. 171-190
    • Kaltschmidt, B.1    Baeuerle, P.A.2    Kaltschmidt, C.3
  • 3
    • 0026575478 scopus 로고
    • Macrophages and inflammatory damage in spinal cord injury
    • Blight AR. Macrophages and inflammatory damage in spinal cord injury. J Neurotrauma 1992, 9(Suppl 1):S83-91.
    • (1992) J Neurotrauma , vol.9 , Issue.SUPPL. 1
    • Blight, A.R.1
  • 4
    • 34249290749 scopus 로고    scopus 로고
    • An overview of tissue engineering approaches for management of spinal cord injuries
    • Samadikuchaksaraei A. An overview of tissue engineering approaches for management of spinal cord injuries. J Neuroengineering Rehabil 2007, 4:15.
    • (2007) J Neuroengineering Rehabil , vol.4 , pp. 15
    • Samadikuchaksaraei, A.1
  • 6
    • 49749146408 scopus 로고    scopus 로고
    • Effects of HMG-CoA reductase inhibition by simvastatin on vascular dysfunction induced by lipopolysaccharide in rats
    • 10.1159/000135629, 18509252
    • Alvarez de Sotomayor M, Vega S, Mingorance C, Marhuenda E, Herrera MD. Effects of HMG-CoA reductase inhibition by simvastatin on vascular dysfunction induced by lipopolysaccharide in rats. Pharmacology 2008, 82:89-96. 10.1159/000135629, 18509252.
    • (2008) Pharmacology , vol.82 , pp. 89-96
    • Alvarez de Sotomayor, M.1    Vega, S.2    Mingorance, C.3    Marhuenda, E.4    Herrera, M.D.5
  • 7
    • 67749135385 scopus 로고    scopus 로고
    • Simvastatin reduces endotoxin-induced nuclear factor kappaB activation and mortality in guinea pigs despite lowering circulating low-density lipoprotein cholesterol
    • 10.1097/SHK.0b013e318193c514, 19008785
    • Fraunberger P, Grone E, Grone HJ, Walli AK. Simvastatin reduces endotoxin-induced nuclear factor kappaB activation and mortality in guinea pigs despite lowering circulating low-density lipoprotein cholesterol. Shock 2009, 32:159-163. 10.1097/SHK.0b013e318193c514, 19008785.
    • (2009) Shock , vol.32 , pp. 159-163
    • Fraunberger, P.1    Grone, E.2    Grone, H.J.3    Walli, A.K.4
  • 8
    • 38049175023 scopus 로고    scopus 로고
    • Statins: a new insight into their mechanisms of action and consequent pleiotropic effects
    • Jasinska M, Owczarek J, Orszulak-Michalak D. Statins: a new insight into their mechanisms of action and consequent pleiotropic effects. Pharmacol Rep 2007, 59:483-499.
    • (2007) Pharmacol Rep , vol.59 , pp. 483-499
    • Jasinska, M.1    Owczarek, J.2    Orszulak-Michalak, D.3
  • 9
    • 4744363569 scopus 로고    scopus 로고
    • Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats
    • 10.1097/10.shk.0000115756.74059.ce, 14770041
    • Giusti-Paiva A, Martinez MR, Felix JV, da Rocha MJ, Carnio EC, Elias LL, Antunes-Rodrigues J. Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats. Shock 2004, 21:271-275. 10.1097/10.shk.0000115756.74059.ce, 14770041.
    • (2004) Shock , vol.21 , pp. 271-275
    • Giusti-Paiva, A.1    Martinez, M.R.2    Felix, J.V.3    da Rocha, M.J.4    Carnio, E.C.5    Elias, L.L.6    Antunes-Rodrigues, J.7
  • 10
    • 0038458980 scopus 로고    scopus 로고
    • Statins as potential therapeutic agents in neuroinflammatory disorders
    • 10.1097/00019052-200306000-00021, 12858078
    • Stuve O, Youssef S, Steinman L, Zamvil SS. Statins as potential therapeutic agents in neuroinflammatory disorders. Curr Opin Neurol 2003, 16:393-401. 10.1097/00019052-200306000-00021, 12858078.
    • (2003) Curr Opin Neurol , vol.16 , pp. 393-401
    • Stuve, O.1    Youssef, S.2    Steinman, L.3    Zamvil, S.S.4
  • 12
    • 0037322961 scopus 로고    scopus 로고
    • Modulation of the inflammatory process by statins
    • Crisby M. Modulation of the inflammatory process by statins. Drugs Today (Barc) 2003, 39:137-143.
    • (2003) Drugs Today (Barc) , vol.39 , pp. 137-143
    • Crisby, M.1
  • 13
    • 0023756692 scopus 로고
    • Retinoic acid and thyroid hormone induce gene expression through a common responsive element
    • 10.1038/336262a0, 2848197
    • Umesono K, Giguere V, Glass CK, Rosenfeld MG, Evans RM. Retinoic acid and thyroid hormone induce gene expression through a common responsive element. Nature 1988, 336:262-265. 10.1038/336262a0, 2848197.
    • (1988) Nature , vol.336 , pp. 262-265
    • Umesono, K.1    Giguere, V.2    Glass, C.K.3    Rosenfeld, M.G.4    Evans, R.M.5
  • 14
    • 0034406481 scopus 로고    scopus 로고
    • PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer
    • 10.1016/S0165-6147(00)01559-5, 11121836
    • Murphy GJ, Holder JC. PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer. Trends Pharmacol Sci 2000, 21:469-474. 10.1016/S0165-6147(00)01559-5, 11121836.
    • (2000) Trends Pharmacol Sci , vol.21 , pp. 469-474
    • Murphy, G.J.1    Holder, J.C.2
  • 15
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: nuclear control of metabolism
    • 10.1210/er.20.5.649, 10529898
    • Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 1999, 20:649-688. 10.1210/er.20.5.649, 10529898.
    • (1999) Endocr Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 16
    • 11144310564 scopus 로고    scopus 로고
    • An overview on biological mechanisms of PPARs
    • 10.1016/j.phrs.2004.07.012, 15629253
    • Kota BP, Huang TH, Roufogalis BD. An overview on biological mechanisms of PPARs. Pharmacol Res 2005, 51:85-94. 10.1016/j.phrs.2004.07.012, 15629253.
    • (2005) Pharmacol Res , vol.51 , pp. 85-94
    • Kota, B.P.1    Huang, T.H.2    Roufogalis, B.D.3
  • 17
    • 0035955411 scopus 로고    scopus 로고
    • 5-aminoisoquinolinone, a potent inhibitor of poly (adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size
    • 10.1016/S0014-2999(01)01359-0, 11698068
    • Wayman N, McDonald MC, Thompson AS, Threadgill MD, Thiemermann C. 5-aminoisoquinolinone, a potent inhibitor of poly (adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size. Eur J Pharmacol 2001, 430:93-100. 10.1016/S0014-2999(01)01359-0, 11698068.
    • (2001) Eur J Pharmacol , vol.430 , pp. 93-100
    • Wayman, N.1    McDonald, M.C.2    Thompson, A.S.3    Threadgill, M.D.4    Thiemermann, C.5
  • 18
    • 0345118108 scopus 로고    scopus 로고
    • Immunolocalization of peroxisome proliferator-activated receptors and retinoid × receptors in the adult rat CNS
    • 10.1016/j.neuroscience.2003.08.064, 14667448
    • Moreno S, Farioli-Vecchioli S, Ceru MP. Immunolocalization of peroxisome proliferator-activated receptors and retinoid × receptors in the adult rat CNS. Neuroscience 2004, 123:131-145. 10.1016/j.neuroscience.2003.08.064, 14667448.
    • (2004) Neuroscience , vol.123 , pp. 131-145
    • Moreno, S.1    Farioli-Vecchioli, S.2    Ceru, M.P.3
  • 19
    • 0027191040 scopus 로고
    • CDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor
    • 10.1021/bi00072a015, 7684926
    • Sher T, Yi HF, McBride OW, Gonzalez FJ. cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 1993, 32:5598-5604. 10.1021/bi00072a015, 7684926.
    • (1993) Biochemistry , vol.32 , pp. 5598-5604
    • Sher, T.1    Yi, H.F.2    McBride, O.W.3    Gonzalez, F.J.4
  • 21
    • 33646524699 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and inflammation
    • 10.1016/j.pharmthera.2005.08.007, 16168490
    • Moraes LA, Piqueras L, Bishop-Bailey D. Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther 2006, 110:371-385. 10.1016/j.pharmthera.2005.08.007, 16168490.
    • (2006) Pharmacol Ther , vol.110 , pp. 371-385
    • Moraes, L.A.1    Piqueras, L.2    Bishop-Bailey, D.3
  • 22
    • 0037094349 scopus 로고    scopus 로고
    • Involvement of the peroxisome proliferator-activated receptor alpha in the immunomodulation caused by peroxisome proliferators in mice
    • 10.1016/S0006-2952(02)00923-1, 12034374
    • Yang Q, Xie Y, Alexson SE, Nelson BD, DePierre JW. Involvement of the peroxisome proliferator-activated receptor alpha in the immunomodulation caused by peroxisome proliferators in mice. Biochem Pharmacol 2002, 63:1893-1900. 10.1016/S0006-2952(02)00923-1, 12034374.
    • (2002) Biochem Pharmacol , vol.63 , pp. 1893-1900
    • Yang, Q.1    Xie, Y.2    Alexson, S.E.3    Nelson, B.D.4    DePierre, J.W.5
  • 23
    • 10044243883 scopus 로고    scopus 로고
    • Role of endogenous and exogenous ligands for the peroxisome proliferators activated receptors alpha (PPAR-alpha) in the development of inflammatory bowel disease in mice
    • 10.1038/labinvest.3700185, 15492755
    • Cuzzocrea S, Di Paola R, Mazzon E, Genovese T, Muia C, Centorrino T, Caputi AP. Role of endogenous and exogenous ligands for the peroxisome proliferators activated receptors alpha (PPAR-alpha) in the development of inflammatory bowel disease in mice. Lab Invest 2004, 84:1643-1654. 10.1038/labinvest.3700185, 15492755.
    • (2004) Lab Invest , vol.84 , pp. 1643-1654
    • Cuzzocrea, S.1    Di Paola, R.2    Mazzon, E.3    Genovese, T.4    Muia, C.5    Centorrino, T.6    Caputi, A.P.7
  • 24
    • 52149113573 scopus 로고    scopus 로고
    • Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury
    • Genovese T, Esposito E, Mazzon E, Di Paola R, Muia C, Meli R, Bramanti P, Cuzzocrea S. Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury. Shock 2008, 30:142-152.
    • (2008) Shock , vol.30 , pp. 142-152
    • Genovese, T.1    Esposito, E.2    Mazzon, E.3    Di Paola, R.4    Muia, C.5    Meli, R.6    Bramanti, P.7    Cuzzocrea, S.8
  • 25
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1
    • 10.1074/jbc.274.45.32048, 10542237
    • Delerive P, De Bosscher K, Besnard S, Vanden Berghe W, Peters JM, Gonzalez FJ, Fruchart JC, Tedgui A, Haegeman G, Staels B. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. J Biol Chem 1999, 274:32048-32054. 10.1074/jbc.274.45.32048, 10542237.
    • (1999) J Biol Chem , vol.274 , pp. 32048-32054
    • Delerive, P.1    De Bosscher, K.2    Besnard, S.3    Vanden Berghe, W.4    Peters, J.M.5    Gonzalez, F.J.6    Fruchart, J.C.7    Tedgui, A.8    Haegeman, G.9    Staels, B.10
  • 26
    • 0034711185 scopus 로고    scopus 로고
    • Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators
    • 10.1074/jbc.M004045200, 10980195
    • Delerive P, Gervois P, Fruchart JC, Staels B. Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators. J Biol Chem 2000, 275:36703-36707. 10.1074/jbc.M004045200, 10980195.
    • (2000) J Biol Chem , vol.275 , pp. 36703-36707
    • Delerive, P.1    Gervois, P.2    Fruchart, J.C.3    Staels, B.4
  • 27
    • 20444440328 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis
    • Okamoto H, Iwamoto T, Kotake S, Momohara S, Yamanaka H, Kamatani N. Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis. Clin Exp Rheumatol 2005, 23:323-330.
    • (2005) Clin Exp Rheumatol , vol.23 , pp. 323-330
    • Okamoto, H.1    Iwamoto, T.2    Kotake, S.3    Momohara, S.4    Yamanaka, H.5    Kamatani, N.6
  • 28
    • 33646817773 scopus 로고    scopus 로고
    • Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-alpha via inhibition of the protein kinase C signaling pathway
    • 10.1161/01.RES.0000202706.70992.95, 16397146
    • Paumelle R, Blanquart C, Briand O, Barbier O, Duhem C, Woerly G, Percevault F, Fruchart JC, Dombrowicz D, Glineur C, Staels B. Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-alpha via inhibition of the protein kinase C signaling pathway. Circ Res 2006, 98:361-369. 10.1161/01.RES.0000202706.70992.95, 16397146.
    • (2006) Circ Res , vol.98 , pp. 361-369
    • Paumelle, R.1    Blanquart, C.2    Briand, O.3    Barbier, O.4    Duhem, C.5    Woerly, G.6    Percevault, F.7    Fruchart, J.C.8    Dombrowicz, D.9    Glineur, C.10    Staels, B.11
  • 30
    • 79955796563 scopus 로고    scopus 로고
    • Simvastatin antagonizes CD40L secretion, CXC chemokine formation, and pulmonary infiltration of neutrophils in abdominal sepsis
    • Zhang S, Rahman M, Zhang S, Qi Z, Thorlacius H. Simvastatin antagonizes CD40L secretion, CXC chemokine formation, and pulmonary infiltration of neutrophils in abdominal sepsis. J Leukoc Biol 89:735-742.
    • J Leukoc Biol , vol.89 , pp. 735-742
    • Zhang, S.1    Rahman, M.2    Zhang, S.3    Qi, Z.4    Thorlacius, H.5
  • 31
    • 0021998590 scopus 로고
    • Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium
    • 10.1016/0160-5402(85)90029-4, 2997548
    • Mullane KM, Kraemer R, Smith B. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 1985, 14:157-167. 10.1016/0160-5402(85)90029-4, 2997548.
    • (1985) J Pharmacol Methods , vol.14 , pp. 157-167
    • Mullane, K.M.1    Kraemer, R.2    Smith, B.3
  • 32
    • 33645983692 scopus 로고    scopus 로고
    • Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    • 10.1089/neu.2006.23.635, 16689667
    • Basso DM, Fisher LC, Anderson AJ, Jakeman LB, McTigue DM, Popovich PG. Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J Neurotrauma 2006, 23:635-659. 10.1089/neu.2006.23.635, 16689667.
    • (2006) J Neurotrauma , vol.23 , pp. 635-659
    • Basso, D.M.1    Fisher, L.C.2    Anderson, A.J.3    Jakeman, L.B.4    McTigue, D.M.5    Popovich, P.G.6
  • 34
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • 10.1016/0003-2697(76)90527-3, 942051
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254. 10.1016/0003-2697(76)90527-3, 942051.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 35
    • 19344375176 scopus 로고    scopus 로고
    • Role of endogenous ligands for the peroxisome proliferators activated receptors alpha in the secondary damage in experimental spinal cord trauma
    • 10.1016/j.expneurol.2005.03.003, 15899263
    • Genovese T, Mazzon E, Di Paola R, Cannavo G, Muia C, Bramanti P, Cuzzocrea S. Role of endogenous ligands for the peroxisome proliferators activated receptors alpha in the secondary damage in experimental spinal cord trauma. Exp Neurol 2005, 194:267-278. 10.1016/j.expneurol.2005.03.003, 15899263.
    • (2005) Exp Neurol , vol.194 , pp. 267-278
    • Genovese, T.1    Mazzon, E.2    Di Paola, R.3    Cannavo, G.4    Muia, C.5    Bramanti, P.6    Cuzzocrea, S.7
  • 37
    • 58149188481 scopus 로고    scopus 로고
    • Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells
    • Kimura T, Mogi C, Tomura H, Kuwabara A, Im DS, Sato K, Kurose H, Murakami M, Okajima F. Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. J Immunol 2008, 181:7332-7340.
    • (2008) J Immunol , vol.181 , pp. 7332-7340
    • Kimura, T.1    Mogi, C.2    Tomura, H.3    Kuwabara, A.4    Im, D.S.5    Sato, K.6    Kurose, H.7    Murakami, M.8    Okajima, F.9
  • 38
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and I kappa B proteins: new discoveries and insights
    • 10.1146/annurev.immunol.14.1.649, 8717528
    • Baldwin AS. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996, 14:649-683. 10.1146/annurev.immunol.14.1.649, 8717528.
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin, A.S.1
  • 39
    • 0027207242 scopus 로고
    • Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation
    • 359784, 8497253
    • Beg AA, Finco TS, Nantermet PV, Baldwin AS. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation. Mol Cell Biol 1993, 13:3301-3310. 359784, 8497253.
    • (1993) Mol Cell Biol , vol.13 , pp. 3301-3310
    • Beg, A.A.1    Finco, T.S.2    Nantermet, P.V.3    Baldwin, A.S.4
  • 41
    • 11844269840 scopus 로고    scopus 로고
    • Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation
    • 10.1016/j.tibs.2004.11.009, 15653325
    • Viatour P, Merville MP, Bours V, Chariot A. Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem Sci 2005, 30:43-52. 10.1016/j.tibs.2004.11.009, 15653325.
    • (2005) Trends Biochem Sci , vol.30 , pp. 43-52
    • Viatour, P.1    Merville, M.P.2    Bours, V.3    Chariot, A.4
  • 42
    • 3342967871 scopus 로고    scopus 로고
    • Pathophysiology and pharmacologic treatment of acute spinal cord injury
    • 10.1016/j.spinee.2003.07.007, 15246307
    • Kwon BK, Tetzlaff W, Grauer JN, Beiner J, Vaccaro AR. Pathophysiology and pharmacologic treatment of acute spinal cord injury. Spine J 2004, 4:451-464. 10.1016/j.spinee.2003.07.007, 15246307.
    • (2004) Spine J , vol.4 , pp. 451-464
    • Kwon, B.K.1    Tetzlaff, W.2    Grauer, J.N.3    Beiner, J.4    Vaccaro, A.R.5
  • 43
    • 0032079920 scopus 로고    scopus 로고
    • Acute inflammatory response in spinal cord following impact injury
    • 10.1006/exnr.1998.6785, 9582256
    • Carlson SL, Parrish ME, Springer JE, Doty K, Dossett L. Acute inflammatory response in spinal cord following impact injury. Exp Neurol 1998, 151:77-88. 10.1006/exnr.1998.6785, 9582256.
    • (1998) Exp Neurol , vol.151 , pp. 77-88
    • Carlson, S.L.1    Parrish, M.E.2    Springer, J.E.3    Doty, K.4    Dossett, L.5
  • 45
    • 2442711384 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells
    • 10.1161/01.RES.0000127122.22685.0A, 15142970
    • Marx N, Duez H, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells. Circ Res 2004, 94:1168-1178. 10.1161/01.RES.0000127122.22685.0A, 15142970.
    • (2004) Circ Res , vol.94 , pp. 1168-1178
    • Marx, N.1    Duez, H.2    Fruchart, J.C.3    Staels, B.4
  • 46
    • 0034965596 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in inflammation control
    • 10.1677/joe.0.1690453, 11375115
    • Delerive P, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors in inflammation control. J Endocrinol 2001, 169:453-459. 10.1677/joe.0.1690453, 11375115.
    • (2001) J Endocrinol , vol.169 , pp. 453-459
    • Delerive, P.1    Fruchart, J.C.2    Staels, B.3
  • 48
    • 12244312473 scopus 로고    scopus 로고
    • Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin
    • 10.1002/jnr.10481, 12503084
    • Bao F, DeWitt DS, Prough DS, Liu D. Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin. J Neurosci Res 2003, 71:220-227. 10.1002/jnr.10481, 12503084.
    • (2003) J Neurosci Res , vol.71 , pp. 220-227
    • Bao, F.1    DeWitt, D.S.2    Prough, D.S.3    Liu, D.4
  • 49
    • 0037439232 scopus 로고    scopus 로고
    • Peroxynitrite generated in the rat spinal cord induces apoptotic cell death and activates caspase-3
    • 10.1016/S0306-4522(02)00571-7, 12535938
    • Bao F, Liu D. Peroxynitrite generated in the rat spinal cord induces apoptotic cell death and activates caspase-3. Neuroscience 2003, 116:59-70. 10.1016/S0306-4522(02)00571-7, 12535938.
    • (2003) Neuroscience , vol.116 , pp. 59-70
    • Bao, F.1    Liu, D.2
  • 50
    • 27444435011 scopus 로고    scopus 로고
    • Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin
    • 10.1089/neu.2005.22.1123, 16238488
    • Liu D, Bao F, Prough DS, Dewitt DS. Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin. J Neurotrauma 2005, 22:1123-1133. 10.1089/neu.2005.22.1123, 16238488.
    • (2005) J Neurotrauma , vol.22 , pp. 1123-1133
    • Liu, D.1    Bao, F.2    Prough, D.S.3    Dewitt, D.S.4
  • 51
    • 4644312193 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro
    • Scott GS, Szabo C, Hooper DC. Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro. J Neurotrauma 2004, 21:1255-1263.
    • (2004) J Neurotrauma , vol.21 , pp. 1255-1263
    • Scott, G.S.1    Szabo, C.2    Hooper, D.C.3
  • 52
    • 33846196606 scopus 로고    scopus 로고
    • Role of peroxynitrite in secondary oxidative damage after spinal cord injury
    • 10.1111/j.1471-4159.2006.04312.x, 17181549
    • Xiong Y, Rabchevsky AG, Hall ED. Role of peroxynitrite in secondary oxidative damage after spinal cord injury. J Neurochem 2007, 100:639-649. 10.1111/j.1471-4159.2006.04312.x, 17181549.
    • (2007) J Neurochem , vol.100 , pp. 639-649
    • Xiong, Y.1    Rabchevsky, A.G.2    Hall, E.D.3
  • 54
    • 0028952832 scopus 로고
    • Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture
    • Bolanos JP, Heales SJ, Land JM, Clark JB. Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture. J Neurochem 1995, 64:1965-1972.
    • (1995) J Neurochem , vol.64 , pp. 1965-1972
    • Bolanos, J.P.1    Heales, S.J.2    Land, J.M.3    Clark, J.B.4
  • 55
    • 0346100520 scopus 로고    scopus 로고
    • Peroxynitrite reactivity with amino acids and proteins
    • 10.1007/s00726-003-0018-8, 14661092
    • Alvarez B, Radi R. Peroxynitrite reactivity with amino acids and proteins. Amino Acids 2003, 25:295-311. 10.1007/s00726-003-0018-8, 14661092.
    • (2003) Amino Acids , vol.25 , pp. 295-311
    • Alvarez, B.1    Radi, R.2
  • 56
    • 34047136750 scopus 로고    scopus 로고
    • FeTPPS protects against global cerebral ischemic-reperfusion injury in gerbils
    • 10.1016/j.phrs.2007.01.002, 17292620
    • Sharma SS, Dhar A, Kaundal RK. FeTPPS protects against global cerebral ischemic-reperfusion injury in gerbils. Pharmacol Res 2007, 55:335-342. 10.1016/j.phrs.2007.01.002, 17292620.
    • (2007) Pharmacol Res , vol.55 , pp. 335-342
    • Sharma, S.S.1    Dhar, A.2    Kaundal, R.K.3
  • 57
    • 33747658370 scopus 로고    scopus 로고
    • Neuroprotective effects of FeTMPyP: a peroxynitrite decomposition catalyst in global cerebral ischemia model in gerbils
    • 10.1016/j.phrs.2006.06.009, 16877004
    • Dhar A, Kaundal RK, Sharma SS. Neuroprotective effects of FeTMPyP: a peroxynitrite decomposition catalyst in global cerebral ischemia model in gerbils. Pharmacol Res 2006, 54:311-316. 10.1016/j.phrs.2006.06.009, 16877004.
    • (2006) Pharmacol Res , vol.54 , pp. 311-316
    • Dhar, A.1    Kaundal, R.K.2    Sharma, S.S.3
  • 58
    • 0037432615 scopus 로고    scopus 로고
    • Multiple pathways of peroxynitrite cytotoxicity
    • Szabo C. Multiple pathways of peroxynitrite cytotoxicity. Toxicol Lett 2003, 140-141:105-112.
    • (2003) Toxicol Lett , vol.140-141 , pp. 105-112
    • Szabo, C.1
  • 59
    • 0036829062 scopus 로고    scopus 로고
    • Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors
    • 10.1016/S0898-6568(02)00053-0, 12220615
    • Haddad JJ. Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors. Cell Signal 2002, 14:879-897. 10.1016/S0898-6568(02)00053-0, 12220615.
    • (2002) Cell Signal , vol.14 , pp. 879-897
    • Haddad, J.J.1
  • 60
    • 67749145552 scopus 로고    scopus 로고
    • The role endogenous and exogenous ligands for the peroxisome proliferator-activated receptor alpha (PPAR-alpha) in the regulation of inflammation in macrophages
    • Crisafulli C, Cuzzocrea S. The role endogenous and exogenous ligands for the peroxisome proliferator-activated receptor alpha (PPAR-alpha) in the regulation of inflammation in macrophages. Shock 2008, 32(1):62-73.
    • (2008) Shock , vol.32 , Issue.1 , pp. 62-73
    • Crisafulli, C.1    Cuzzocrea, S.2
  • 62
    • 0035572718 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors
    • 10.1161/hq1101.098486, 11701455
    • Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol 2001, 21:1712-1719. 10.1161/hq1101.098486, 11701455.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1712-1719
    • Takemoto, M.1    Liao, J.K.2
  • 63
    • 0037255574 scopus 로고    scopus 로고
    • Evidence for the presence of both peroxisome proliferator-activated receptors alpha and beta in the rat spinal cord
    • 10.1016/S0891-0618(02)00093-5, 12573457
    • Benani A, Kremarik-Bouillaud P, Bianchi A, Netter P, Minn A, Dauca M. Evidence for the presence of both peroxisome proliferator-activated receptors alpha and beta in the rat spinal cord. J Chem Neuroanat 2003, 25:29-38. 10.1016/S0891-0618(02)00093-5, 12573457.
    • (2003) J Chem Neuroanat , vol.25 , pp. 29-38
    • Benani, A.1    Kremarik-Bouillaud, P.2    Bianchi, A.3    Netter, P.4    Minn, A.5    Dauca, M.6
  • 64
    • 0029661982 scopus 로고    scopus 로고
    • The PPARalpha-leukotriene B4 pathway to inflammation control
    • 10.1038/384039a0, 8900274
    • Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, Wahli W. The PPARalpha-leukotriene B4 pathway to inflammation control. Nature 1996, 384:39-43. 10.1038/384039a0, 8900274.
    • (1996) Nature , vol.384 , pp. 39-43
    • Devchand, P.R.1    Keller, H.2    Peters, J.M.3    Vazquez, M.4    Gonzalez, F.J.5    Wahli, W.6
  • 65
    • 0030841938 scopus 로고    scopus 로고
    • Recent update on the PPAR alpha-null mouse
    • 10.1016/S0300-9084(97)81506-4, 9209711
    • Gonzalez FJ. Recent update on the PPAR alpha-null mouse. Biochimie 1997, 79:139-144. 10.1016/S0300-9084(97)81506-4, 9209711.
    • (1997) Biochimie , vol.79 , pp. 139-144
    • Gonzalez, F.J.1
  • 67
    • 23044458952 scopus 로고    scopus 로고
    • The central role of Fas-ligand cell signaling in inflammatory lung diseases
    • 10.1111/j.1582-4934.2004.tb00318.x, 15491504
    • Dosreis GA, Borges VM, Zin WA. The central role of Fas-ligand cell signaling in inflammatory lung diseases. J Cell Mol Med 2004, 8:285-293. 10.1111/j.1582-4934.2004.tb00318.x, 15491504.
    • (2004) J Cell Mol Med , vol.8 , pp. 285-293
    • Dosreis, G.A.1    Borges, V.M.2    Zin, W.A.3
  • 69
    • 0032478820 scopus 로고    scopus 로고
    • Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression
    • 10.1074/jbc.273.14.8048, 9525905
    • Bauer MK, Vogt M, Los M, Siegel J, Wesselborg S, Schulze-Osthoff K. Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression. J Biol Chem 1998, 273:8048-8055. 10.1074/jbc.273.14.8048, 9525905.
    • (1998) J Biol Chem , vol.273 , pp. 8048-8055
    • Bauer, M.K.1    Vogt, M.2    Los, M.3    Siegel, J.4    Wesselborg, S.5    Schulze-Osthoff, K.6
  • 71
    • 17444427385 scopus 로고    scopus 로고
    • Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury
    • 10.1038/sj.sc.3101674, 15520836
    • Xu W, Chi L, Xu R, Ke Y, Luo C, Cai J, Qiu M, Gozal D, Liu R. Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury. Spinal Cord 2005, 43:204-213. 10.1038/sj.sc.3101674, 15520836.
    • (2005) Spinal Cord , vol.43 , pp. 204-213
    • Xu, W.1    Chi, L.2    Xu, R.3    Ke, Y.4    Luo, C.5    Cai, J.6    Qiu, M.7    Gozal, D.8    Liu, R.9
  • 74
    • 0031819433 scopus 로고    scopus 로고
    • Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha)
    • 10.1093/carcin/19.1.43, 9472691
    • Roberts RA, James NH, Woodyatt NJ, Macdonald N, Tugwood JD. Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha). Carcinogenesis 1998, 19:43-48. 10.1093/carcin/19.1.43, 9472691.
    • (1998) Carcinogenesis , vol.19 , pp. 43-48
    • Roberts, R.A.1    James, N.H.2    Woodyatt, N.J.3    Macdonald, N.4    Tugwood, J.D.5
  • 75
    • 59049103155 scopus 로고    scopus 로고
    • Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation
    • 10.1161/CIRCULATIONAHA.108.813311, 2745913, 19075102
    • Liu PY, Liu YW, Lin LJ, Chen JH, Liao JK. Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation. Circulation 2009, 119:131-138. 10.1161/CIRCULATIONAHA.108.813311, 2745913, 19075102.
    • (2009) Circulation , vol.119 , pp. 131-138
    • Liu, P.Y.1    Liu, Y.W.2    Lin, L.J.3    Chen, J.H.4    Liao, J.K.5


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