CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain

European Journal of Pharmacology

Volumn 617, Issue 1-3, 2009, Pages 59-67

  Cortes Burgos, Luz A ^a   Zweifel, Ben S ^a   Settle, Steven L ^a   Pufahl, Robert A ^a   Anderson, Gary D ^a   Hardy, Medora M ^a   Weir, Dana E ^a   Hu, George ^a   Happa, Fernando A ^a   Stewart, Zachary ^a   Muthian, Shanmugam ^a   Graneto, Matthew J ^a   Masferrer, Jaime L ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Analgesia; Behavioral pharmacology; Inflammation

Indexed keywords

4 [3 [4 (2 METHYL 1H IMIDAZOL 1 YL)PHENYLTHIO]PHENYL]TETRAHYDRO 2H PYRAN 4 CARBOXAMIDE; ARACHIDONATE 5 LIPOXYGENASE; CARRAGEENAN; CJ 13610; FREUND ADJUVANT; IRON CHELATING AGENT; LEUKOTRIENE B4; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LIPOXYGENASE INHIBITOR; UNCLASSIFIED DRUG; ZILEUTON;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG EFFICACY; HYPERALGESIA; INFLAMMATION; MALE; NONHUMAN; OSTEOARTHRITIS; PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WEIGHT BEARING;

ADMINISTRATION, ORAL; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; BLOTTING, WESTERN; CELL LINE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FREUND'S ADJUVANT; HUMANS; HYDROXYUREA; IMIDAZOLES; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEUKOTRIENES; LIPOXYGENASE INHIBITORS; MALE; OSTEOARTHRITIS; PAIN; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY; SULFIDES;

EID: 68549092415     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.06.058     Document Type: Article

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