Structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor

Journal of Biological Chemistry

Volumn 287, Issue 17, 2012, Pages 14012-14022

  Lema Tome, Carla M ^a   Palma, Enzo ^a,b   Ferluga, Sara ^a   Lowther, W Todd ^a   Hantgan, Roy ^a   Wykosky, Jill ^a,c   Debinski, Waldemar ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b GENENTECH INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT ACTIVATION; ALANINE SUBSTITUTION; ANTI-CANCER THERAPIES; ANTITUMOR EFFECT; CELL TRANSFORMATION; CELLULAR RESPONSE; CONDITIONED MEDIAS; CONSERVED REGIONS; DELETERIOUS EFFECTS; DOWN-REGULATION; EXTRACELLULAR ENVIRONMENTS; FUNCTIONAL ACTIVITIES; FUNCTIONAL CHARACTERIZATION; GLIOBLASTOMA MULTIFORME; STRUCTURE-FUNCTION RELATIONSHIP;

ACTIVATION ANALYSIS; LIGANDS; PHOSPHORYLATION; TISSUE CULTURE;

AMINO ACIDS;

EPHRIN A1; EPHRIN RECEPTOR A2; MITOGEN ACTIVATED PROTEIN KINASE; MONOMER; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN VARIANT; RAS PROTEIN; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; GLIOBLASTOMA; GLIOMA CELL; LIGAND BINDING; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALANINE; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL MEMBRANE; EPHRIN-A1; GENE EXPRESSION REGULATION; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, EPHA2; SEQUENCE HOMOLOGY, AMINO ACID; SURFACE PLASMON RESONANCE;

EID: 84859999967     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.311670     Document Type: Article

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