-
1
-
-
0037129380
-
Nonalcoholic fatty liver disease
-
Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-1231.
-
(2002)
N Engl J Med
, vol.346
, pp. 1221-1231
-
-
Angulo, P.1
-
2
-
-
63649087890
-
Biological role of liver X receptors
-
Baranowski M. Biological role of liver X receptors. J Physiol Pharmacol 2008; 59: 31-55.
-
(2008)
J Physiol Pharmacol
, vol.59
, pp. 31-55
-
-
Baranowski, M.1
-
3
-
-
56149098763
-
Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways
-
Park KG, Min AK, Koh EH, Kim HS, Kim MO, Park HS, et al. Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. HEPATOLOGY 2008; 48: 1477-1486.
-
(2008)
HEPATOLOGY
, vol.48
, pp. 1477-1486
-
-
Park, K.G.1
Min, A.K.2
Koh, E.H.3
Kim, H.S.4
Kim, M.O.5
Park, H.S.6
-
4
-
-
68949091995
-
Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones
-
Hwahng SH, Ki SH, Bae EJ, Kim HE, Kim SG. Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones. HEPATOLOGY 2009; 49: 1913-1925.
-
(2009)
HEPATOLOGY
, vol.49
, pp. 1913-1925
-
-
Hwahng, S.H.1
Ki, S.H.2
Bae, E.J.3
Kim, H.E.4
Kim, S.G.5
-
5
-
-
63849206613
-
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives
-
Viollet B, Guigas B, Leclerc J, Hébrard S, Lantier L, Mounier R, et al. AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol (Oxf) 2009; 196: 81-98.
-
(2009)
Acta Physiol (Oxf)
, vol.196
, pp. 81-98
-
-
Viollet, B.1
Guigas, B.2
Leclerc, J.3
Hébrard, S.4
Lantier, L.5
Mounier, R.6
-
6
-
-
34648828532
-
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
-
Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 2007; 8: 774-785.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 774-785
-
-
Hardie, D.G.1
-
7
-
-
67749111502
-
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
-
Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 2009; 9: 563-575.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 563-575
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
8
-
-
79953755370
-
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
-
Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 2011; 13: 376-388.
-
(2011)
Cell Metab
, vol.13
, pp. 376-388
-
-
Li, Y.1
Xu, S.2
Mihaylova, M.M.3
Zheng, B.4
Hou, X.5
Jiang, B.6
-
9
-
-
62649093597
-
AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells
-
Yang J, Craddock L, Hong S, Liu ZM. AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells. J Cell Biochem 2009; 106: 414-426.
-
(2009)
J Cell Biochem
, vol.106
, pp. 414-426
-
-
Yang, J.1
Craddock, L.2
Hong, S.3
Liu, Z.M.4
-
10
-
-
0034669025
-
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
-
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 2000; 14: 2819-2830.
-
(2000)
Genes Dev
, vol.14
, pp. 2819-2830
-
-
Repa, J.J.1
Liang, G.2
Ou, J.3
Bashmakov, Y.4
Lobaccaro, J.M.5
Shimomura, I.6
-
11
-
-
0034669171
-
Role of LXRs in control of lipogenesis
-
Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, et al. Role of LXRs in control of lipogenesis. Genes Dev 2000; 14: 2831-2838.
-
(2000)
Genes Dev
, vol.14
, pp. 2831-2838
-
-
Schultz, J.R.1
Tu, H.2
Luk, A.3
Repa, J.J.4
Medina, J.C.5
Li, L.6
-
12
-
-
0035047709
-
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter
-
Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, et al. Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol Cell Biol 2001; 21: 2991-3000.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2991-3000
-
-
Yoshikawa, T.1
Shimano, H.2
Amemiya-Kudo, M.3
Yahagi, N.4
Hasty, A.H.5
Matsuzaka, T.6
-
13
-
-
0037192797
-
Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors
-
Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, et al. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J Biol Chem 2002; 277: 11019-11025.
-
(2002)
J Biol Chem
, vol.277
, pp. 11019-11025
-
-
Joseph, S.B.1
Laffitte, B.A.2
Patel, P.H.3
Watson, M.A.4
Matsukuma, K.E.5
Walczak, R.6
-
14
-
-
33845586243
-
The mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317
-
Talukdar S, Hillgartner FB. The mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317. J Lipid Res 2006; 47: 2451-2461.
-
(2006)
J Lipid Res
, vol.47
, pp. 2451-2461
-
-
Talukdar, S.1
Hillgartner, F.B.2
-
15
-
-
0033524420
-
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta
-
Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, Corey EJ, et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A 1999; 96: 266-271.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 266-271
-
-
Janowski, B.A.1
Grogan, M.J.2
Jones, S.A.3
Wisely, G.B.4
Kliewer, S.A.5
Corey, E.J.6
-
16
-
-
13544267956
-
Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor
-
Quinet EM, Savio DA, Halpern AR, Chen L, Miller CP, Nambi P. Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor. J Lipid Res 2004; 45: 1929-1942.
-
(2004)
J Lipid Res
, vol.45
, pp. 1929-1942
-
-
Quinet, E.M.1
Savio, D.A.2
Halpern, A.R.3
Chen, L.4
Miller, C.P.5
Nambi, P.6
-
17
-
-
66849099394
-
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism
-
Jetten AM. Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal 2009; 7: e003-e034.
-
(2009)
Nucl Recept Signal
, vol.7
-
-
Jetten, A.M.1
-
18
-
-
0028920392
-
Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand
-
Wiesenberg I, Missbach M, Kahlen JP, Schräder M, Carlberg C. Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand. Nucleic Acids Res 1995; 23: 327-333.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 327-333
-
-
Wiesenberg, I.1
Missbach, M.2
Kahlen, J.P.3
Schräder, M.4
Carlberg, C.5
-
19
-
-
1842639533
-
Crystal structure of the human RORalpha ligand binding domain in complex with cholesterol sulfate at 2.2 A
-
Kallen J, Schlaeppi JM, Bitsch F, Delhon I, Fournier B. Crystal structure of the human RORalpha ligand binding domain in complex with cholesterol sulfate at 2.2 A. J Biol Chem 2004; 279: 14033-14038.
-
(2004)
J Biol Chem
, vol.279
, pp. 14033-14038
-
-
Kallen, J.1
Schlaeppi, J.M.2
Bitsch, F.3
Delhon, I.4
Fournier, B.5
-
20
-
-
53449084976
-
Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling
-
Kim EJ, Yoo YG, Yang WK, Lim YS, Na TY, Lee IK, et al. Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling. Arterioscler Thromb Vasc Biol 2008; 28: 1796-1802.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1796-1802
-
-
Kim, E.J.1
Yoo, Y.G.2
Yang, W.K.3
Lim, Y.S.4
Na, T.Y.5
Lee, I.K.6
-
21
-
-
49649099595
-
The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity
-
Lau P, Fitzsimmons RL, Raichur S, Wang SC, Lechtken A, Muscat GE. The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity. J Biol Chem 2008; 283: 18411-18421.
-
(2008)
J Biol Chem
, vol.283
, pp. 18411-18421
-
-
Lau, P.1
Fitzsimmons, R.L.2
Raichur, S.3
Wang, S.C.4
Lechtken, A.5
Muscat, G.E.6
-
22
-
-
79960416891
-
Transcriptional profiling reveals a role for RORα in regulating gene expression in obesity-associated inflammation and hepatic steatosis
-
Kang HS, Okamoto K, Takeda Y, Beak JY, Gerrish KE, Bortner CD, et al. Transcriptional profiling reveals a role for RORα in regulating gene expression in obesity-associated inflammation and hepatic steatosis. Physiol Genomics 2011; 43: 818-828.
-
(2011)
Physiol Genomics
, vol.43
, pp. 818-828
-
-
Kang, H.S.1
Okamoto, K.2
Takeda, Y.3
Beak, J.Y.4
Gerrish, K.E.5
Bortner, C.D.6
-
23
-
-
79960812575
-
Control of gene expression by the retinoic acid-related orphan receptor alpha in HepG2 human hepatoma cells
-
Chauvet C, Vanhoutteghem A, Duhem C, Saint-Auret G, Bois-Joyeux B, Djian P, et al. Control of gene expression by the retinoic acid-related orphan receptor alpha in HepG2 human hepatoma cells. PLoS One 2011; 6: e22545-e22554.
-
(2011)
PLoS One
, vol.6
-
-
Chauvet, C.1
Vanhoutteghem, A.2
Duhem, C.3
Saint-Auret, G.4
Bois-Joyeux, B.5
Djian, P.6
-
24
-
-
54549090146
-
The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno- and endobiotic gene regulation
-
Wada T, Kang HS, Jetten AM, Xie W. The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno- and endobiotic gene regulation. Exp Biol Med 2008; 233: 1191-1201.
-
(2008)
Exp Biol Med
, vol.233
, pp. 1191-1201
-
-
Wada, T.1
Kang, H.S.2
Jetten, A.M.3
Xie, W.4
-
25
-
-
40849086444
-
Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)
-
Wada T, Kang HS, Angers M, Gong H, Bhatia S, Khadem S, et al. Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol 2008; 73: 891-899.
-
(2008)
Mol Pharmacol
, vol.73
, pp. 891-899
-
-
Wada, T.1
Kang, H.S.2
Angers, M.3
Gong, H.4
Bhatia, S.5
Khadem, S.6
-
26
-
-
77955258637
-
Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle
-
Raichur S, Fitzsimmons RL, Myers SA, Pearen MA, Lau P, Eriksson N, et al. Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle. Nucleic Acids Res 2010; 38: 4296-4312.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 4296-4312
-
-
Raichur, S.1
Fitzsimmons, R.L.2
Myers, S.A.3
Pearen, M.A.4
Lau, P.5
Eriksson, N.6
-
27
-
-
3543029821
-
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
-
Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 2004; 279: 32345-32353.
-
(2004)
J Biol Chem
, vol.279
, pp. 32345-32353
-
-
Samuel, V.T.1
Liu, Z.X.2
Qu, X.3
Elder, B.D.4
Bilz, S.5
Befroy, D.6
-
28
-
-
77953243855
-
A second class of nuclear receptors for oxysterols: regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)
-
Wang Y, Kumar N, Crumbley C, Griffin PR, Burris TP. A second class of nuclear receptors for oxysterols: regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). Biochim Biophys Acta 2010; 1801: 917-923.
-
(2010)
Biochim Biophys Acta
, vol.1801
, pp. 917-923
-
-
Wang, Y.1
Kumar, N.2
Crumbley, C.3
Griffin, P.R.4
Burris, T.P.5
-
29
-
-
74549224652
-
The benzenesulfoamide T0901317[N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(tri fluoromethyl) ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist
-
Kumar N, Solt LA, Conkright JJ, Wang Y, Istrate MA, Busby SA, et al. The benzenesulfoamide T0901317[N-(2, 2, 2-trifluoroethyl)-N-[4-[2, 2, 2-trifluoro-1-hydroxy-1-(trifluoromethyl) ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist. Mol Pharmacol 2010; 77: 228-236.
-
(2010)
Mol Pharmacol
, vol.77
, pp. 228-236
-
-
Kumar, N.1
Solt, L.A.2
Conkright, J.J.3
Wang, Y.4
Istrate, M.A.5
Busby, S.A.6
-
30
-
-
77957871769
-
Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha
-
Goldwasser J, Cohen PY, Yang E, Balaguer P, Yarmush ML, Nahmias Y. Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha. PLoS One 2010; 5: e12399-e12407.
-
(2010)
PLoS One
, vol.5
-
-
Goldwasser, J.1
Cohen, P.Y.2
Yang, E.3
Balaguer, P.4
Yarmush, M.L.5
Nahmias, Y.6
-
31
-
-
0031907862
-
Orphan nuclear receptor ROR alpha-deficient mice display the cerebellar defects of staggerer
-
Dussault I, Fawcett D, Matthyssen A, Bader JA, Giguère V. Orphan nuclear receptor ROR alpha-deficient mice display the cerebellar defects of staggerer. Mech Dev 1998; 70: 147-153.
-
(1998)
Mech Dev
, vol.70
, pp. 147-153
-
-
Dussault, I.1
Fawcett, D.2
Matthyssen, A.3
Bader, J.A.4
Giguère, V.5
|