MMP2-cleavage of DMP1 generates a bioactive peptide promoting differentiation of dental pulp stem/progenitor cells

European Cells and Materials

Volumn 18, Issue , 2009, Pages 84-95

  Chaussain, Catherine ^a,b,c   Eapen, Asha Sarah ^a   Huet, Eric ^d   Floris, Caroline ^b,c   Ravindran, Sriram ^a   Hao, Jianjun ^a   Menashi, Suzanne ^d   George, Anne ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b and Plateforme d'Imagerie du Vivant   (France)

^c Paris 5 Descartes University EA 2496 U F R of Odontology   (France)

^d CNRS ^*  (France)

Author keywords

Bioactivity; Cleavage product; Dentin; Differentiation; DMP1; MMP 2; Pulp stem progenitor cells

Indexed keywords

ASPARTIC ACID; DENTIN MATRIX PROTEIN 1; DNA; GELATINASE A; PEPTIDE; POLYPEPTIDE; SERINE; SIALOPROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BIOMINERALIZATION; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CONTROLLED STUDY; DENTIN; DNA BINDING; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; MESENCHYME CELL; NONHUMAN; NORMAL HUMAN; ODONTOBLAST; PHENOTYPE; PROTEIN DEGRADATION; RAT; REGULATORY MECHANISM; STEM CELL; TOOTH DEVELOPMENT; TOOTH PULP;

EID: 73449107721     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Almushayt A, Narayanan K, Zaki AE, George A (2006) Dentin matrix protein 1 induces cytodifferentiation of dental pulp stem cells into odontoblasts. Gene Ther 13: 611-620.
2. Boukpessi T, Menashi S, Camoin L, Tencate JM, Goldberg M, Chaussain-Miller C (2008) The effect of stromelysin-1 (MMP-3) on non-collagenous extracellular matrix proteins of demineralized dentin and the adhesive properties of restorative resins. Biomaterials 29: 4367-4373.
3. Bourd-Boittin K, Fridman R, Fanchon S, Septier D, Goldberg M, Menashi S (2005) Matrix metalloproteinase inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development. Exp Cell Res 304: 493-505.
4. Chaussain-Miller C, Fioretti F, Goldberg M, Menashi S (2006) The role of matrix metalloproteinases (MMPs) in human caries. J Dent Res 85: 22-32.
5. d'Aquino R, Graziano A, Sampaolesi M, Laino G, Pirozzi G, De Rosa A, Papaccio G (2007) Human postnatal dental pulp cells co-differentiate into osteoblasts and endotheliocytes: a pivotal synergy leading to adult bone tissue formation. Cell Death Differ 14: 1162-1171.
6. Dean RA, Overall CM (2007) Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome. Mol Cell Proteomics 6: 611-623.
7. Dean RA, Butler GS, Hamma-Kourbali Y, Delbe J, Brigstock DR, Courty J, Overall CM (2007) Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis. Mol Cell Biol 27: 8454-8465.
8. Gajjeraman S, Narayanan K, Hao J, Qin C, George A (2007) Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite. J Biol Chem 282: 1193-1204.
9. Godovikova V, Ritchie HH (2007) Dynamic processing of recombinant dentin sialoprotein-phosphophoryn protein. J Biol Chem 282: 31341-31348.
10. Goldberg M, Septier D, Bourd K, Hall R, George A, Goldberg H, Menashi S (2003) Immunohistochemical localization of MMP-2, MMP-9, TIMP-1, and TIMP-2 in the forming rat incisor. Connect Tissue Res 44: 143-153.
11. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, DenBesten P, Robey PG, Shi S (2002) Stem cell properties of human dental pulp stem cells. J Dent Res 81: 531-535.
12. Hao J, Ramachandran A, George A (2009) Temporal and spatial localization of the dentin matrix proteins during dentin biomineralization. J Histochem Cytochem 57: 227-237.
13. Hao J, Zou B, Narayanan K, George A (2004) Differential expression patterns of the dentin matrix proteins during mineralized tissue formation. Bone 34: 921-932.
14. He G, George A (2004) Dentin matrix protein 1 immobilized on type I collagen fibrils facilitates apatite deposition in vitro. J Biol Chem 279: 11649-11656.
15. He G, Dahl T, Veis A, George A (2003) Dentin matrix protein 1 initiates hydroxyapatite formation in vitro. Connect Tissue Res 44: 240-245.
16. Huang GT, Shagramanova K, Chan SW (2006) Formation of odontoblast-like cells from cultured human dental pulp cells on dentin in vitro. J Endod 32: 1066-1073.
17. Huang B, Maciejewska I, Sun Y, Peng T, Qin D, Lu Y, Bonewald L, Butler WT, Feng J, Qin C (2008) Identification of full-length dentin matrix protein 1 in dentin and bone. Calcif Tissue Int 82: 401-410.
18. Huang GT, Gronthos S, Shi S (2009) Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res 88:792-806
19. Laino G, d'Aquino R, Graziano A, Lanza V, Carinci F, Naro F, Pirozzi G, Papaccio G (2005) A new population of human adult dental pulp stem cells: a useful source of living autologous fibrous bone tissue (LAB). J Bone Miner Res 20: 1394-1402.
20. Lu Y, Qin C, Xie Y, Bonewald LF, Feng JQ (2009) Studies of the DMP1 57-kDa functional domain both in vivo and in vitro. Cells Tissues Organs 189: 175-185.
21. Maciejewska I, Cowan C, Svoboda K, Butler WT, D'Souza R, Qin C (2009) The NH2-terminal and COOH-terminal fragments of dentin matrix protein 1 (DMP1) localize differently in the compartments of dentin and growth plate of bone. J Histochem Cytochem 57: 155-166.
22. Mannello F, Tonti GA, Bagnara GP, Papa S (2006) Role and function of matrix metalloproteinases in the differentiation and biological characterization of mesenchymal stem cells. Stem Cells 24: 475-481.
23. Martin-De Las Heras S, Valenzuela A, Overall CM (2000) The matrix metalloproteinase gelatinase A in human dentine. Arch Oral Biol 45: 757-765.
24. Mazzoni A, Mannello F, Tay FR, Tonti GA, Papa S, Mazzotti G, Di Lenarda R, Pashley DH, Breschi L (2007) Zymographic analysis and characterization of MMP-2 and -9 forms in human sound dentin. J Dent Res 86: 436-440.
25. Narayanan K, Ramachandran A, Hao J, He G, Park KW, Cho M, George A (2003) Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. J Biol Chem 278: 17500-17508.
26. Narayanan K, Gajjeraman S, Ramachandran A, Hao J, George A (2006) Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation. J Biol Chem 281: 19064-19071.
27. Page-McCaw A, Ewald AJ, Werb Z (2007) Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol 8: 221-233.
28. Palosaari H, Pennington CJ, Larmas M, Edwards DR, Tjaderhane L, Salo T (2003) Expression profile of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue. Eur J Oral Sci 111: 117-127.
29. Paula-Silva FW, Ghosh A, Silva LA, Kapila YL (2009) TNF-alpha promotes an odontoblastic phenotype in dental pulp cells. J Dent Res 88: 339-344.
30. Qin C, Brunn JC, Cook RG, Orkiszewski RS, Malone JP, Veis A, Butler WT (2003) Evidence for the proteolytic processing of dentin matrix protein 1. Identification and characterization of processed fragments and cleavage sites. J Biol Chem 278: 34700-34708.
31. Ravindran S, Narayanan K, Eapen AS, Hao J, Ramachandran A, Blond S, George A (2008) Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin matrix protein 1. J Biol Chem 283: 29658-29670.
32. Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (2000) MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. Genomics 67: 54-68.
33. Shi S, Gronthos S (2003) Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J Bone Miner Res 18: 696-704.
34. Six N, Septier D, Chaussain-Miller C, Blacher R, DenBesten P, Goldberg M (2007) Dentonin, a MEPE fragment, initiates pulp-healing response to injury. J Dent Res 86: 780-785.
35. Srinivasan R, Chen B, Gorski JP, George A (1999) Recombinant expression and characterization of dentin matrix protein 1. Connect Tissue Res 40: 251-258.
36. Steiglitz BM, Ayala M, Narayanan K, George A, Greenspan DS (2004) Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1. J Biol Chem 279: 980-986.
37. Tjaderhane L, Larjava H, Sorsa T, Uitto VJ, Larmas M, Salo T (1998). The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions. J Dent Res 77: 1622-1629.
38. Turk BE, Huang LL, Piro ET, Cantley LC (2001). Determination of protease cleavage site motifs using mixture-based oriented peptide libraries. Nat Biotechnol 19: 661-667.
39. van Strijp AJ, Jansen DC, DeGroot J, ten Cate JM, Everts V (2003) Host-derived proteinases and degradation of dentine collagen in situ. Caries Res 37: 58-65.
40. Visse R, Nagase H (2003) Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 92: 827-839.
41. Yamakoshi Y, Hu JC, Iwata T, Kobayashi K, Fukae M, Simmer JP (2006) Dentin sialophosphoprotein is processed by MMP-2 and MMP-20 in vitro and in vivo. J Biol Chem 281: 38235-38243.
42. Zhang W, Walboomers XF, Shi S, Fan M, Jansen JA (2006) Multilineage differentiation potential of stem cells derived from human dental pulp after cryopreservation. Tissue Eng 12: 2813-2823.