메뉴 건너뛰기




Volumn 87, Issue 5, 2012, Pages 562-568

Unraveling the genetic underpinnings of myeloproliferative neoplasms and understanding their effect on disease course and response to therapy: Proceedings from the 6th international post-ASH symposium

(23)  Abdel Wahab, Omar a   Pardanani, Animesh b   Bernard, Olivier A c   Finazzi, Guido d   Crispino, John D e   Gisslinger, Heinz f   Kralovics, Robert f   Odenike, Olatoyosi g   Bhalla, Kapil h   Gupta, Vikas i   Barosi, Giovanni j   Gotlib, Jason k   Guglielmelli, Paola l   Kiladjian, Jean Jacques m   Noel, Pierre n   Cazzola, Mario o   Vannucchi, Alessandro M l   Hoffman, Ronald p   Barbui, Tiziano d   Thiele, Juergen q,r   more..


Author keywords

[No Author keywords available]

Indexed keywords

CYT 387; DNA METHYLTRANSFERASE 3A; GIVINOSTAT; HEAT SHOCK PROTEIN 90 INHIBITOR; HYDROXYUREA; JANUS KINASE 2; METHOTREXATE; NUCLEIC ACID BINDING PROTEIN; PACRITINIB; PANOBINOSTAT; PEGINTERFERON ALPHA2A; POMALIDOMIDE; PROTEIN TET2; PROTEIN TYROSINE KINASE INHIBITOR; RUXOLITINIB; SAR 302503; SB 1518; STAT5 PROTEIN; TACROLIMUS; TG 101348; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

EID: 84859905706     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.23169     Document Type: Article
Times cited : (14)

References (75)
  • 1
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y, Lee BH, Mercher T, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med 2006; 3: e270.
    • (2006) PLoS Med , vol.3
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3
  • 2
    • 67650401377 scopus 로고    scopus 로고
    • Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms
    • Grand FH, Hidalgo-Curtis CE, Ernst T, et al. Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Blood 2009; 113: 6182-6192.
    • (2009) Blood , vol.113 , pp. 6182-6192
    • Grand, F.H.1    Hidalgo-Curtis, C.E.2    Ernst, T.3
  • 3
    • 77953485892 scopus 로고    scopus 로고
    • Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
    • Oh ST, Simonds EF, Jones C, et al. Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood 2010; 116: 988-992.
    • (2010) Blood , vol.116 , pp. 988-992
    • Oh, S.T.1    Simonds, E.F.2    Jones, C.3
  • 4
    • 77958021645 scopus 로고    scopus 로고
    • LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations
    • Pardanani A, Lasho T, Finke C, et al. LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations. Leukemia 2010; 24: 1713-1718.
    • (2010) Leukemia , vol.24 , pp. 1713-1718
    • Pardanani, A.1    Lasho, T.2    Finke, C.3
  • 6
    • 67349124376 scopus 로고    scopus 로고
    • TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
    • Tefferi A, Pardanani A, Lim KH, et al. TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia 2009; 23: 905-911.
    • (2009) Leukemia , vol.23 , pp. 905-911
    • Tefferi, A.1    Pardanani, A.2    Lim, K.H.3
  • 7
    • 79960248721 scopus 로고    scopus 로고
    • DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms
    • Abdel-Wahab O, Pardanani A, Rampal R, et al. DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms. Leukemia 2011; 25: 1219-1220.
    • (2011) Leukemia , vol.25 , pp. 1219-1220
    • Abdel-Wahab, O.1    Pardanani, A.2    Rampal, R.3
  • 8
    • 79960210747 scopus 로고    scopus 로고
    • DNMT3A mutations in myeloproliferative neoplasms
    • Stegelmann F, Bullinger L, Schlenk RF, et al. DNMT3A mutations in myeloproliferative neoplasms. Leukemia 2011; 25: 1217-1219.
    • (2011) Leukemia , vol.25 , pp. 1217-1219
    • Stegelmann, F.1    Bullinger, L.2    Schlenk, R.F.3
  • 9
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T, Chase AJ, Score J, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 2010; 42: 722-726.
    • (2010) Nat Genet , vol.42 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3
  • 10
    • 84857042600 scopus 로고    scopus 로고
    • Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms
    • Brecqueville M, Cervera N, Adélaïde J, et al. Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms. Blood Cancer J 2011; 1: e33.
    • (2011) Blood Cancer J , vol.1
    • Brecqueville, M.1    Cervera, N.2    Adélaïde, J.3
  • 11
    • 84856596417 scopus 로고    scopus 로고
    • Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
    • Score J, Hidalgo-Curtis C, Jones AV, et al. Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms. Blood 2011; 119: 1208-1213.
    • (2011) Blood , vol.119 , pp. 1208-1213
    • Score, J.1    Hidalgo-Curtis, C.2    Jones, A.V.3
  • 12
    • 84857051756 scopus 로고    scopus 로고
    • Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies
    • Puda A, Milosevic JD, Berg T, et al. Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies. Am J Hematol 2011; 87: 245-250.
    • (2011) Am J Hematol , vol.87 , pp. 245-250
    • Puda, A.1    Milosevic, J.D.2    Berg, T.3
  • 13
    • 84857048081 scopus 로고    scopus 로고
    • Consistent benefit of ruxolitinib over placebo in spleen volume reduction and symptom improvement across subgroups and overall survival advantage: Results from COMFORT-I (Abstract 278)
    • Verstovsek S, Mesa RA, Gotlib J, et al. Consistent benefit of ruxolitinib over placebo in spleen volume reduction and symptom improvement across subgroups and overall survival advantage: Results from COMFORT-I (Abstract 278). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Verstovsek, S.1    Mesa, R.A.2    Gotlib, J.3
  • 14
    • 84859938727 scopus 로고    scopus 로고
    • Ruxolitinib provides reductions in splenomegaly across subgroups: An analysis of spleen response in the COMFORT-II study (Abstract 279)
    • Harrison C, Kiladjian J-J, Gisslinger H, et al. Ruxolitinib provides reductions in splenomegaly across subgroups: An analysis of spleen response in the COMFORT-II study (Abstract 279). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Harrison, C.1    Kiladjian, J.-J.2    Gisslinger, H.3
  • 15
    • 84859892985 scopus 로고    scopus 로고
    • SAR302503: Interim safety, efficacy and long-term impact on JAK2 V617F allele burden in a phase I/II study in patients with myelofibrosis (Abstract 3838)
    • Pardanani A, Gotlib J, Jamieson C, et al. SAR302503: Interim safety, efficacy and long-term impact on JAK2 V617F allele burden in a phase I/II study in patients with myelofibrosis (Abstract 3838). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Pardanani, A.1    Gotlib, J.2    Jamieson, C.3
  • 16
    • 84858848011 scopus 로고    scopus 로고
    • An expanded multicenter phase I/II study of CYT387, a JAK-1/2 inhibitor for the treatment of myelofibrosis (Abstract 3849)
    • Pardanani A, Gotlib J, Gupta V, et al. An expanded multicenter phase I/II study of CYT387, a JAK-1/2 inhibitor for the treatment of myelofibrosis (Abstract 3849). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Pardanani, A.1    Gotlib, J.2    Gupta, V.3
  • 17
    • 84858848013 scopus 로고    scopus 로고
    • Results of a phase 2 study of Pacritinib (SB1518), a novel oral JAK2 inhibitor, in patients with primary, postpolycythemia vera, and postessential thrombocythemia myelofibrosis (Abstract 282)
    • Komrokji R, Wadleigh M, Seymour JF, et al. Results of a phase 2 study of Pacritinib (SB1518), a novel oral JAK2 inhibitor, in patients with primary, postpolycythemia vera, and postessential thrombocythemia myelofibrosis (Abstract 282). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Komrokji, R.1    Wadleigh, M.2    Seymour, J.F.3
  • 18
    • 84859922047 scopus 로고    scopus 로고
    • Prolonged low dose therapy with a pan-deacetylase inhibtor, panobinostat (LBH589), in patients with myelofibrosis (Abstract 794)
    • Mascarenhas J, Mercado A, Rodriguez A, et al. Prolonged low dose therapy with a pan-deacetylase inhibtor, panobinostat (LBH589), in patients with myelofibrosis (Abstract 794). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Mascarenhas, J.1    Mercado, A.2    Rodriguez, A.3
  • 19
    • 84866602529 scopus 로고    scopus 로고
    • A phase II study of the HDAC inhibitor givinostat in combination with hydroxyurea in patients with polycythemia vera resistant to hydroxyurea monotherapy (Abstract 1748)
    • Rambaldi A, Finazzi G, Vannucchi AM, et al. A phase II study of the HDAC inhibitor givinostat in combination with hydroxyurea in patients with polycythemia vera resistant to hydroxyurea monotherapy (Abstract 1748). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Rambaldi, A.1    Finazzi, G.2    Vannucchi, A.M.3
  • 20
    • 84859922046 scopus 로고    scopus 로고
    • Complete hematological, molecular and histological remissions without cytoreductive treatment lasting after pegylated-interferon α-2a (peg-IFNα-2a) therapy in polycythemia vera (PV): Long term results of a phase 2 trial (Abstract 280)
    • Turlure P, Cambier N, Roussel M, et al. Complete hematological, molecular and histological remissions without cytoreductive treatment lasting after pegylated-interferon α-2a (peg-IFNα-2a) therapy in polycythemia vera (PV): Long term results of a phase 2 trial (Abstract 280). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Turlure, P.1    Cambier, N.2    Roussel, M.3
  • 21
    • 84867507792 scopus 로고    scopus 로고
    • Pomalidomide therapy for myelofibrosis: Analysis of results from three consecutive clinical trials (Abstract 1759)
    • Begna K, Pardanani A, Mesa RA, et al. Pomalidomide therapy for myelofibrosis: Analysis of results from three consecutive clinical trials (Abstract 1759). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Begna, K.1    Pardanani, A.2    Mesa, R.A.3
  • 22
    • 84859914958 scopus 로고    scopus 로고
    • Phase II study of low-dose pomalidomide in patients with myelofibrosis and significant anemia (hemoglobin <10 g/dL) (Abstract 1757)
    • Shastri A, Kadia T, Cortes JE, et al. Phase II study of low-dose pomalidomide in patients with myelofibrosis and significant anemia (hemoglobin <10 g/dL) (Abstract 1757). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Shastri, A.1    Kadia, T.2    Cortes, J.E.3
  • 23
    • 84859922045 scopus 로고    scopus 로고
    • Results of phase II clinical trial MPD-RC 101: Allogeneic hematopoietic stem cell transplantation conditioned with fludarabine/melphalan in patients with myelofibrosis (Abstract 1750)
    • Rondelli D, Goldberg JD, Marchioli R, et al. Results of phase II clinical trial MPD-RC 101: Allogeneic hematopoietic stem cell transplantation conditioned with fludarabine/melphalan in patients with myelofibrosis (Abstract 1750). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Rondelli, D.1    Goldberg, J.D.2    Marchioli, R.3
  • 24
    • 67651065502 scopus 로고    scopus 로고
    • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    • Abdel-Wahab O, Mullally A, Hedvat C, et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood 2009; 114: 144-147.
    • (2009) Blood , vol.114 , pp. 144-147
    • Abdel-Wahab, O.1    Mullally, A.2    Hedvat, C.3
  • 25
    • 80052284526 scopus 로고    scopus 로고
    • Ten-eleven-translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
    • Ko M, Bandukwala HS, An J, et al. Ten-eleven-translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci USA 2011; 108: 14566-14571.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14566-14571
    • Ko, M.1    Bandukwala, H.S.2    An, J.3
  • 26
    • 80052285127 scopus 로고    scopus 로고
    • Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
    • Li Z, Cai X, Cai C, et al. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood 2011; 118: 4509-4518.
    • (2011) Blood , vol.118 , pp. 4509-4518
    • Li, Z.1    Cai, X.2    Cai, C.3
  • 27
    • 79960064353 scopus 로고    scopus 로고
    • Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
    • Moran-Crusio K, Reavie L, Shih A, et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell 2011; 20: 11-24.
    • (2011) Cancer Cell , vol.20 , pp. 11-24
    • Moran-Crusio, K.1    Reavie, L.2    Shih, A.3
  • 28
    • 79960062301 scopus 로고    scopus 로고
    • TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
    • Quivoron C, Couronne L, Della Valle V, et al. TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell 2011; 20: 25-38.
    • (2011) Cancer Cell , vol.20 , pp. 25-38
    • Quivoron, C.1    Couronne, L.2    Della Valle, V.3
  • 29
    • 79960768558 scopus 로고    scopus 로고
    • Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors
    • Pronier E, Almire C, Mokrani H, et al. Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors. Blood 2011; 118: 2551-2555.
    • (2011) Blood , vol.118 , pp. 2551-2555
    • Pronier, E.1    Almire, C.2    Mokrani, H.3
  • 30
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • Ko M, Huang Y, Jankowska AM, et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010; 468: 839-843.
    • (2010) Nature , vol.468 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.M.3
  • 31
    • 79956308473 scopus 로고    scopus 로고
    • Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
    • Pastor WA, Pape UJ, Huang Y, et al. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature 2011; 473: 394-397.
    • (2011) Nature , vol.473 , pp. 394-397
    • Pastor, W.A.1    Pape, U.J.2    Huang, Y.3
  • 32
    • 79954457998 scopus 로고    scopus 로고
    • Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells
    • Wu H, D'Alessio AC, Ito S, et al. Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev 2011; 25: 679-684.
    • (2011) Genes Dev , vol.25 , pp. 679-684
    • Wu, H.1    D'Alessio, A.C.2    Ito, S.3
  • 33
    • 33847055935 scopus 로고    scopus 로고
    • Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1
    • Valinluck V, Sowers LC. Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res 2007; 67: 946-950.
    • (2007) Cancer Res , vol.67 , pp. 946-950
    • Valinluck, V.1    Sowers, L.C.2
  • 34
    • 0035834708 scopus 로고    scopus 로고
    • Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1
    • Boorstein RJ, Cummings AJr, Marenstein DR, et al. Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1. J Biol Chem 2001; 276: 41991-41997.
    • (2001) J Biol Chem , vol.276 , pp. 41991-41997
    • Boorstein, R.J.1    Cummings Jr, A.2    Marenstein, D.R.3
  • 35
    • 33749171576 scopus 로고    scopus 로고
    • Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability
    • Bennett MT, Rodgers MT, Hebert AS, et al. Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability. J Am Chem Soc 2006; 128: 12510-12519.
    • (2006) J Am Chem Soc , vol.128 , pp. 12510-12519
    • Bennett, M.T.1    Rodgers, M.T.2    Hebert, A.S.3
  • 36
    • 80052495940 scopus 로고    scopus 로고
    • Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
    • He YF, Li BZ, Li Z, et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 2011; 333: 1303-1307.
    • (2011) Science , vol.333 , pp. 1303-1307
    • He, Y.F.1    Li, B.Z.2    Li, Z.3
  • 37
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010; 18: 553-567.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3
  • 38
    • 76549109434 scopus 로고    scopus 로고
    • Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
    • Abdel-Wahab O, Manshouri T, Patel J, et al. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res 2010; 70: 447-452.
    • (2010) Cancer Res , vol.70 , pp. 447-452
    • Abdel-Wahab, O.1    Manshouri, T.2    Patel, J.3
  • 39
    • 84859898270 scopus 로고    scopus 로고
    • Evaluating clonal dominance in a murine knock-in model of Jak2V617F MPN (Abstract)
    • Mullally A, Poveromo L, Brumme K, et al. Evaluating clonal dominance in a murine knock-in model of Jak2V617F MPN (Abstract). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Mullally, A.1    Poveromo, L.2    Brumme, K.3
  • 40
    • 34247337999 scopus 로고    scopus 로고
    • De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells
    • Tadokoro Y, Ema H, Okano M, et al. De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med 2007; 204: 715-722.
    • (2007) J Exp Med , vol.204 , pp. 715-722
    • Tadokoro, Y.1    Ema, H.2    Okano, M.3
  • 41
    • 84555207349 scopus 로고    scopus 로고
    • Dnmt3a is essential for hematopoietic stem cell differentiation
    • Challen GA, Sun D, Jeong M, et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet 2011; 44: 23-31.
    • (2011) Nat Genet , vol.44 , pp. 23-31
    • Challen, G.A.1    Sun, D.2    Jeong, M.3
  • 42
    • 79960227474 scopus 로고    scopus 로고
    • Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
    • Abdel-Wahab O, Pardanani A, Patel J, et al. Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms. Leukemia 2011; 25: 1200-1202.
    • (2011) Leukemia , vol.25 , pp. 1200-1202
    • Abdel-Wahab, O.1    Pardanani, A.2    Patel, J.3
  • 43
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T, Chase AJ, Score J, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 2010; 42: 722-726.
    • (2010) Nat Genet , vol.42 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3
  • 44
    • 81055126771 scopus 로고    scopus 로고
    • EZH2 mutational status predicts poor survival in myelofibrosis
    • Guglielmelli P, Biamonte F, Score J, et al. EZH2 mutational status predicts poor survival in myelofibrosis. Blood 2011; 118: 5227-5234.
    • (2011) Blood , vol.118 , pp. 5227-5234
    • Guglielmelli, P.1    Biamonte, F.2    Score, J.3
  • 45
    • 0037320925 scopus 로고    scopus 로고
    • Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
    • Su IH, Basavaraj A, Krutchinsky AN, et al. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol 2003; 4: 124-131.
    • (2003) Nat Immunol , vol.4 , pp. 124-131
    • Su, I.H.1    Basavaraj, A.2    Krutchinsky, A.N.3
  • 46
    • 84856746717 scopus 로고    scopus 로고
    • Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease
    • Herrera-Merchan A, Arranz L, Ligos JM, et al. Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease. Nat Commun 2012; 3: 623.
    • (2012) Nat Commun , vol.3 , pp. 623
    • Herrera-Merchan, A.1    Arranz, L.2    Ligos, J.M.3
  • 47
    • 79958061888 scopus 로고    scopus 로고
    • Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors
    • Hornakova T, Springuel L, Devreux J, et al. Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors. Hematologica 2011; 96: 845-853.
    • (2011) Hematologica , vol.96 , pp. 845-853
    • Hornakova, T.1    Springuel, L.2    Devreux, J.3
  • 48
    • 0034660853 scopus 로고    scopus 로고
    • STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells
    • Demoulin JB, Uyttenhove C, Lejeune D, et al. STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells. Cancer Res 2000; 60: 3971-3977.
    • (2000) Cancer Res , vol.60 , pp. 3971-3977
    • Demoulin, J.B.1    Uyttenhove, C.2    Lejeune, D.3
  • 49
    • 84858273599 scopus 로고    scopus 로고
    • Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms
    • [e-pub ahead of print]
    • Deshpande A, Reddy MM, Schade GO, et al. Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms. Leukemia 2011 [e-pub ahead of print].
    • (2011) Leukemia
    • Deshpande, A.1    Reddy, M.M.2    Schade, G.O.3
  • 50
    • 82555173115 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells
    • Fiskus W, Verstovsek S, Manshouri T, et al. Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells. Clin Cancer Res 2011; 17: 7347-7358.
    • (2011) Clin Cancer Res , vol.17 , pp. 7347-7358
    • Fiskus, W.1    Verstovsek, S.2    Manshouri, T.3
  • 51
    • 0035760303 scopus 로고    scopus 로고
    • Diagnostic and clinical relevance of the number of circulating CD34(+) cells in myelofibrosis with myeloid metaplasia
    • Barosi G, Viarengo G, Pecci A, et al. Diagnostic and clinical relevance of the number of circulating CD34(+) cells in myelofibrosis with myeloid metaplasia. Blood 2001; 98: 3249-3255.
    • (2001) Blood , vol.98 , pp. 3249-3255
    • Barosi, G.1    Viarengo, G.2    Pecci, A.3
  • 52
    • 24944563475 scopus 로고    scopus 로고
    • Circulating CD34+, CD133+, and vascular endothelial growth factor receptor 2-positive endothelial progenitor cells in myelofibrosis with myeloid metaplasia
    • Massa M, Rosti V, Ramajoli I, et al. Circulating CD34+, CD133+, and vascular endothelial growth factor receptor 2-positive endothelial progenitor cells in myelofibrosis with myeloid metaplasia. J Clin Oncol 2005; 23: 5688-5695.
    • (2005) J Clin Oncol , vol.23 , pp. 5688-5695
    • Massa, M.1    Rosti, V.2    Ramajoli, I.3
  • 53
    • 84859914956 scopus 로고    scopus 로고
    • Characterization of Splenic CD34+ cells from patients with primary myelofibrosis (Abstract 2810)
    • Wang X, Prakash S, Lu M, et al. Characterization of Splenic CD34+ cells from patients with primary myelofibrosis (Abstract 2810). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Wang, X.1    Prakash, S.2    Lu, M.3
  • 54
    • 77956696835 scopus 로고    scopus 로고
    • Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
    • Verstovsek S, Kantarjian H, Mesa RA, et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med 2010; 363: 1117-1127.
    • (2010) N Engl J Med , vol.363 , pp. 1117-1127
    • Verstovsek, S.1    Kantarjian, H.2    Mesa, R.A.3
  • 55
    • 77951031498 scopus 로고    scopus 로고
    • Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis
    • Koppikar P, Abdel-Wahab O, Hedvat C, et al. Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis. Blood 2010; 115: 2919-2927.
    • (2010) Blood , vol.115 , pp. 2919-2927
    • Koppikar, P.1    Abdel-Wahab, O.2    Hedvat, C.3
  • 56
    • 79954433836 scopus 로고    scopus 로고
    • Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: A comprehensive cytokine profiling study
    • Tefferi A, Vaidya R, Caramazza D, et al. Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: A comprehensive cytokine profiling study. J Clin Oncol 2011; 29: 1356-1363.
    • (2011) J Clin Oncol , vol.29 , pp. 1356-1363
    • Tefferi, A.1    Vaidya, R.2    Caramazza, D.3
  • 57
    • 79953045011 scopus 로고    scopus 로고
    • Circulating levels of MCP-1, sIL-2R, IL-15, and IL-8 predict anemia response to pomalidomide therapy in myelofibrosis
    • Pardanani A, Begna K, Finke C, et al. Circulating levels of MCP-1, sIL-2R, IL-15, and IL-8 predict anemia response to pomalidomide therapy in myelofibrosis. Am J Hematol 2011; 86: 343-345.
    • (2011) Am J Hematol , vol.86 , pp. 343-345
    • Pardanani, A.1    Begna, K.2    Finke, C.3
  • 58
    • 77953274727 scopus 로고    scopus 로고
    • Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
    • Mullally A, Lane SW, Ball B, et al. Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell 2010; 17: 584-596.
    • (2010) Cancer Cell , vol.17 , pp. 584-596
    • Mullally, A.1    Lane, S.W.2    Ball, B.3
  • 59
    • 79751532774 scopus 로고    scopus 로고
    • JAK inhibitor therapy for myelofibrosis: Critical assessment of value and limitations
    • Pardanani A, Vannucchi AM, Passamonti F, et al. JAK inhibitor therapy for myelofibrosis: Critical assessment of value and limitations. Leukemia 2011; 25: 218-225.
    • (2011) Leukemia , vol.25 , pp. 218-225
    • Pardanani, A.1    Vannucchi, A.M.2    Passamonti, F.3
  • 60
    • 84859914957 scopus 로고    scopus 로고
    • Critical requirement for Stat5 in a mouse model of polycythemia vera
    • e-pub ahead of print].
    • Yan D, Hutchison RE, Mohi G. Critical requirement for Stat5 in a mouse model of polycythemia vera. Blood 2011 [e-pub ahead of print].
    • (2011) Blood
    • Yan, D.1    Hutchison, R.E.2    Mohi, G.3
  • 61
    • 84859865097 scopus 로고    scopus 로고
    • Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and Jak2V617F in mice
    • e-pub ahead of print].
    • Walz C, Ahmed W, Lazarides K, et al. Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and Jak2V617F in mice. Blood 2012 [e-pub ahead of print].
    • (2012) Blood
    • Walz, C.1    Ahmed, W.2    Lazarides, K.3
  • 62
    • 43249084493 scopus 로고    scopus 로고
    • Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice
    • Tiedt R, Hao-Shen H, Sobas MA, et al. Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood 2008; 111: 3931-3940.
    • (2008) Blood , vol.111 , pp. 3931-3940
    • Tiedt, R.1    Hao-Shen, H.2    Sobas, M.A.3
  • 63
    • 78249256979 scopus 로고    scopus 로고
    • Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling
    • Chen E, Beer PA, Godfrey AL, et al. Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling. Cancer Cell 2010; 18: 524-535.
    • (2010) Cancer Cell , vol.18 , pp. 524-535
    • Chen, E.1    Beer, P.A.2    Godfrey, A.L.3
  • 64
    • 77950352432 scopus 로고    scopus 로고
    • A dynamic prognostic model to predict survival in primary myelofibrosis: A study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)
    • Passamonti F, Cervantes F, Vannucchi AM, et al. A dynamic prognostic model to predict survival in primary myelofibrosis: A study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood 2010; 115: 1703-1708.
    • (2010) Blood , vol.115 , pp. 1703-1708
    • Passamonti, F.1    Cervantes, F.2    Vannucchi, A.M.3
  • 65
    • 79952087335 scopus 로고    scopus 로고
    • DIPSS plus: A refined dynamic international prognostic scoring system for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status
    • Gangat N, Caramazza D, Vaidya R, et al. DIPSS plus: A refined dynamic international prognostic scoring system for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status. J Clin Oncol 2011; 29: 392-397.
    • (2011) J Clin Oncol , vol.29 , pp. 392-397
    • Gangat, N.1    Caramazza, D.2    Vaidya, R.3
  • 66
    • 80055075486 scopus 로고    scopus 로고
    • Predictors of greater than 80% 2-year mortality in primary myelofibrosis: A Mayo Clinic study of 884 karyotypically annotated patients
    • Tefferi A, Jimma T, Gangat N, et al. Predictors of greater than 80% 2-year mortality in primary myelofibrosis: A Mayo Clinic study of 884 karyotypically annotated patients. Blood 2011; 118: 4595-4598.
    • (2011) Blood , vol.118 , pp. 4595-4598
    • Tefferi, A.1    Jimma, T.2    Gangat, N.3
  • 67
    • 84859926479 scopus 로고    scopus 로고
    • Survival and prognosis among 1,263 patients with polycythemia vera: An international study (Abstract 277)
    • Tefferi A, Rumi E, Finazzi G, et al. Survival and prognosis among 1, 263 patients with polycythemia vera: An international study (Abstract 277). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Tefferi, A.1    Rumi, E.2    Finazzi, G.3
  • 68
    • 79952333359 scopus 로고    scopus 로고
    • Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis
    • Pardanani A, Gotlib JR, Jamieson C, et al. Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis. J Clin Oncol 2011; 29: 789-796.
    • (2011) J Clin Oncol , vol.29 , pp. 789-796
    • Pardanani, A.1    Gotlib, J.R.2    Jamieson, C.3
  • 69
    • 80054028202 scopus 로고    scopus 로고
    • Long-term outcome of treatment with ruxolitinib in myelofibrosis
    • Tefferi A, Litzow MR, Pardanani A. Long-term outcome of treatment with ruxolitinib in myelofibrosis. N Engl J Med 2011; 365: 1455-1457.
    • (2011) N Engl J Med , vol.365 , pp. 1455-1457
    • Tefferi, A.1    Litzow, M.R.2    Pardanani, A.3
  • 70
    • 84859914033 scopus 로고    scopus 로고
    • Comparison of outcomes of advanced myelofibrosis patients treated with Ruxolitinib (INCB018424) to those of a historical control group: Survival advantage of Ruxolitinib therapy (Abstract 793)
    • Verstovsek S, Kantarjian HM, Estrov Z, et al. Comparison of outcomes of advanced myelofibrosis patients treated with Ruxolitinib (INCB018424) to those of a historical control group: Survival advantage of Ruxolitinib therapy (Abstract 793). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Verstovsek, S.1    Kantarjian, H.M.2    Estrov, Z.3
  • 71
    • 84859902129 scopus 로고    scopus 로고
    • The MD Anderson cancer center (MDACC) experience with Ruxolitinib, an oral JAK1 and JAK2 inhibitor, in myelofibrosis: Long-term Follow-up outcomes of 107 patients from a phase I/II study (Abstract 3851)
    • Verstovsek S, Estrov A, Cortes JE, et al. The MD Anderson cancer center (MDACC) experience with Ruxolitinib, an oral JAK1 and JAK2 inhibitor, in myelofibrosis: Long-term Follow-up outcomes of 107 patients from a phase I/II study (Abstract 3851). Blood 2011; 118.
    • (2011) Blood , pp. 118
    • Verstovsek, S.1    Estrov, A.2    Cortes, J.E.3
  • 72
    • 77955716180 scopus 로고    scopus 로고
    • Clonal analysis of erythroid progenitors suggests that pegylated interferon alpha-2a treatment targets JAK2V617F clones without affecting TET2 mutant cells
    • Kiladjian JJ, Masse A, Cassinat B, et al. Clonal analysis of erythroid progenitors suggests that pegylated interferon alpha-2a treatment targets JAK2V617F clones without affecting TET2 mutant cells. Leukemia 2010; 24: 1519-1523.
    • (2010) Leukemia , vol.24 , pp. 1519-1523
    • Kiladjian, J.J.1    Masse, A.2    Cassinat, B.3
  • 73
    • 84859898269 scopus 로고    scopus 로고
    • Dynamics of mutant alleles in patients with advanced essential thrombocythemia (ET) or polycythemia (PV) during pegylated interferon-Alfa-2A (PEG-IFN-α-2A; Pegasys) therapy (Abstract 281)
    • Quintas-Cardama A, Abdel-Wahab O, Levine RL, et al. Dynamics of mutant alleles in patients with advanced essential thrombocythemia (ET) or polycythemia (PV) during pegylated interferon-Alfa-2A (PEG-IFN-α-2A; Pegasys) therapy (Abstract 281). Blood 2011; 118.
    • (2011) Blood , vol.118
    • Quintas-Cardama, A.1    Abdel-Wahab, O.2    Levine, R.L.3
  • 74
    • 84155169034 scopus 로고    scopus 로고
    • Long-term outcome of pomalidomide therapy in myelofibrosis
    • Begna KH, Pardanani A, Mesa R, et al. Long-term outcome of pomalidomide therapy in myelofibrosis. Am J Hematol 2012; 87: 66-68.
    • (2012) Am J Hematol , vol.87 , pp. 66-68
    • Begna, K.H.1    Pardanani, A.2    Mesa, R.3
  • 75
    • 79958761494 scopus 로고    scopus 로고
    • A phase II trial of panobinostat, an orally available deacetylase inhibitor (DACi), in patients with primary myelofibrosis (PMF), postessential thrombocythemia (ET), and postpolycythemia vera (PV) myelofibrosis (Abstract 630)
    • DeAngelo DJTA, Fiskus W, Mesa RA, et al. A phase II trial of panobinostat, an orally available deacetylase inhibitor (DACi), in patients with primary myelofibrosis (PMF), postessential thrombocythemia (ET), and postpolycythemia vera (PV) myelofibrosis (Abstract 630). Blood 2010; 116.
    • (2010) Blood , vol.116
    • DeAngelo, D.J.T.A.1    Fiskus, W.2    Mesa, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.