Immune approaches for the prevention of breast milk transmission of HIV-1

Advances in Experimental Medicine and Biology

Volumn 743, Issue , 2012, Pages 185-195

  Lohman Payne, Barbara ^a,b   Slyker, Jennifer ^b   Rowland Jones, Sarah L ^c  

^a UNIVERSITY OF NAIROBI   (Kenya)

^b UNIVERSITY OF WASHINGTON   (United States)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; MODIFIED VACCINIA VIRUS ANKARA 5T4 VACCINE; NEVIRAPINE;

ACTIVE IMMUNIZATION; ARTICLE; BREAST MILK; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOREACTIVITY; INFECTION PREVENTION; INFECTION RISK; MIXED INFECTION; MUCOSAL IMMUNITY; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; RISK ASSESSMENT; SIMIAN IMMUNODEFICIENCY VIRUS; SINGLE DRUG DOSE; TREATMENT PLANNING; VACCINE PRODUCTION; VIRUS TRANSMISSION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84859882011     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-2251-8_13     Document Type: Article

References (80)

1. Datta P, Embree JE, Kreiss J, Ndinya-Achola JO, Braddick M, Temmerman M et al (1994) Mother-to-child transmission of HIV-1: report from the Nairobi study. J Infect Dis 170:1134-1140
2. Coutsoudis A, Dabis F, Fawzi W, Gaillard P, Haverkamp G, Harris DR et al (2004) Late postnatal transmission of HIV-1 in breast-fed children: an individual patient data meta-analysis. J Infect Dis 189(12):2154-2166
3. Rousseau CM, Nduati RW, Richardson BA, John-Stewart GC, Mbori-Ngacha DA, Kreiss JK et al (2004) Association of levels of HIV-1-infected breast milk cells and risk of mother-to-child transmission. J Infect Dis 190(10): 1880-1888
4. Rousseau CM, Nduati RW, Richardson BA, Steele MS, John-Stewart GC, Mbori-Ngacha DA et al (2003) Longitudinal analysis of human immunodefi ciency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease. J Infect Dis 187(5):741-747
5. Obimbo EM, Mbori-Ngacha DA, Ochieng JO, Richardson BA, Otieno PA, Bosire R et al (2004) Predictors of early mortality in a cohort of human immunodefi ciency virus type 1-infected African children. Pediatr Infect Dis J 23(6):536-543
6. Newell ML, Coovadia H, Cortina-Borja M, Rollins N, Gaillard P, Dabis F (2004) Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis. Lancet 364(9441):1236-1243
7. Richardson BA, Mbori-Ngacha D, Lavreys L, John-Stewart GC, Nduati R, Panteleeff DD et al (2003) Comparison of human immunodefi ciency virus type 1 viral loads in Kenyan women, men, and infants during primary and early infection. J Virol 77(12):7120-7123
8. Mphatswe W, Blanckenberg N, Tudor-Williams G, Prendergast A, Thobakgale C, Mkhwanazi N et al (2007) High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis. AIDS 21(10):1253-1261
9. Rouet F, Sakarovitch C, Msellati P, Elenga N, Montcho C, Viho I et al (2003) Pediatric viral human immunodefi - ciency virus type 1 RNA levels, timing of infection, and disease progression in African HIV-1-infected children. Pediatrics 112(4):e289
10. Shearer WT, Quinn TC, LaRussa P, Lew JF, Mofenson L, Almy S et al (1997) Viral load and disease progression in infants infected with human immunodefi ciency virus type 1. Women and Infants Transmission Study Group. N Engl J Med 336(19):1337-1342
11. Lepage P, Spira R, Kalibala S, Pillay K, Giaquinto C, Castetbon K et al (1998) Care of human immunodefi ciency virus-infected children in developing countries. International Working Group on Mother-to-Child Transmission of HIV. Pediatr Infect Dis J 17(7):581-586
12. Zijenah LS, Moulton LH, Iliff P, Nathoo K, Munjoma MW, Mutasa K et al (2004) Timing of mother-to-child transmission of HIV-1 and infant mortality in the fi rst 6 months of life in Harare, Zimbabwe. AIDS 18(2):273-280
13. Marinda E, Humphrey JH, Iliff PJ, Mutasa K, Nathoo KJ, Piwoz EG et al (2007) Child mortality according to maternal and infant HIV status in Zimbabwe. Pediatr Infect Dis J 26(6):519-526
14. Michaelsson J, Mold JE, McCune JM, Nixon DF (2006) Regulation of T cell responses in the developing human fetus. J Immunol 176(10):5741-5748
15. Mold JE, Michaelsson J, Burt TD, Muench MO, Beckerman KP, Busch MP et al (2008) Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 322(5907):1562-1565
16. Chheda S, Palkowetz KH, Garofalo R, Rassin DK, Goldman AS (1996) Decreased interleukin-10 production by neonatal monocytes and T cells: relationship to decreased production and expression of tumor necrosis factor - [alpha] and its receptors. Pediatr Res 40:475-483
17. Lilic D, Cant AJ, Abinun M, Calvert JE, Spickett GP (1997) Cytokine production differs in children and adults. Pediatr Res 42:237-240
18. Prescott SL, Macaubas C, Holt BJ, Smallacombe TB, Loh R, Sly PD et al (1998) Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profi le. J Immunol 160(10):4730-4737
19. Holt PG, Jones CA (2000) The development of the immune system during pregnancy and early life. Allergy 55(8):688-697
20. Miles DJ, van der Sande M, Jeffries D, Kaye S, Ismaili J, Ojuola O et al (2007) Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation. J Virol 81(11):5766-5776
21. Slyker JA, Lohman-Payne BL, John-Stewart GC, Maleche-Obimbo E, Emery S, Richardson B et al (2009) Acute cytomegalovirus infection in Kenyan HIV-infected infants. AIDS 23(16):2173-2181
22. John-Stewart G, Mbori-Ngacha D, Ekpini R, Janoff EN, Nkengasong J, Read JS et al (2004) Breast-feeding and Transmission of HIV-1. J Acquir Immune Defi c Syndr 35(2):196-202
23. Aldrovandi GM, Kuhn L (2010) What infants and breasts can teach us about natural protection from HIV infection. J Infect Dis 202(Suppl 3):S366-S370
24. John-Stewart GC, Mbori-Ngacha D, Payne BL, Farquhar C, Richardson BA, Emery S et al (2009) HIV-1-specifi c cytotoxic T lymphocytes and breast milk HIV-1 transmission. J Infect Dis 199:889-898
25. Hasselrot K, Bratt G, Hirbod T, Saberg P, Ehnlund M, Lopalco L et al (2010) Orally exposed uninfected individuals have systemic anti-HIV responses associating with partners viral load. AIDS 24(1):35-43
26. Perez CL, Hasselrot K, Bratt G, Broliden K, Karlsson AC (2010) Induction of systemic HIV-1-specifi c cellular immune responses by oral exposure in the uninfected partner of discordant couples. AIDS 24(7):969-974
27. Cheynier R, Langlade-Demoyen P, Marescot M-R, Blanche S, Blondin G, Wain-Hobson S et al (1992) Cytotoxic T lymphocyte responses in the peripheral blood of children born to HIV-1-infected mothers. Eur J Immunol 22: 2211-2217
28. Rowland-Jones SL, Nixon DF, Aldhous MC, Gotch F, Ariyoshi K, Hallam N et al (1993) HIV-specifi c CTL activity in an HIV-exposed but uninfected infant. Lancet 341:860-861
29. Aldhous MC, Watret KC, Mok JY, Bird AG, Froebel KS (1994) Cytotoxic T lymphocyte activity and CD8 subpopulations in children at risk of HIV infection. Clin Exp Immunol 97(1):61-67
30. Kuhn L, Coutsoudis A, Moodley D, Trabattoni D, Mngqundaniso N, Shearer GM et al (2001) T-helper cell responses to HIV envelope peptides in cord blood: protection against intrapartum and breast-feeding transmission. AIDS 15(1):1-9
31. Adkins B, Leclerc C, Marshall-Clarke S (2004) Neonatal adaptive immunity comes of age. Nat Rev 4:553-564
32. Levy O (2007) Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol 7:379-389
33. Velilla PA, Rugeles MT, Chougnet CA (2006) Defective antigen-presenting cell function in human neonates. Clin Immunol 121:251-259
34. Marchant A, Appay V, van der Sande M, Dulphy N, Liesnard C, Kidd M et al (2003) Mature CD8+ T lymphocyte response to viral infection during foetal life. J Clin Invest 111:1747-1755
35. Marchant A, Goetghebuer T, Ota MO, Wolfe I, Ceesay SJ, De Groote D et al (1999) Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guerin vaccination. J Immunol 163(4):2249-2255
36. Ota MO, Vekemans J, Schlegel-Haueter SE, Fielding K, Sanneh M, Kidd M et al (2002) Infl uence of Mycobacterium bovis bacillus Calmette-Guerin on antibody and cytokine responses to human neonatal vaccination. J Immunol 168(2):919-925
37. Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL et al (2005) Cord blood CD4+CD25+-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood 105:750-758
38. Legrand FA, Nixon DF, Loo CP, Ono E, Chapman JM, Miyamoto M et al (2006) Strong HIV-1-specifi c T cell responses in HIV-1-exposed uninfected infants and neonates revealed after regulatory T cell removal. PLoS One 1:e102
39. Hartigan-OConnor DJ, Abel K, McCune JM (2007) Suppression of SIV-specifi c CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J Exp Med 204:2679-2692
40. Flanagan KL, Halliday A, Burl S, Landgraf K, Jagne YJ, Noho-Konteh F et al (2010) The effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth. Eur J Immunol 40(4):1062-1072
41. Gans H, Yasukawa L, Rinki M, DeHovitz R, Forghani B, Beeler J et al (2001) Immune responses to measles and mumps vaccination of infants at 6, 9, and 12 months. J Infect Dis 184:817-826
42. Lohman-Payne B, Slyker JA, Richardson BA, Farquhar C, Majiwa M, Maleche-Obimbo E et al (2009) Infants with late breast milk acquisition of HIV-1 generate interferon-gamma responses more rapidly than infants with early peripartum acquisition. Clin Exp Immunol 156(3):511-517
43. Abrams EJ, Weedon J, Steketee RW, Lambert G, Bamji M, Brown T et al (1998) Association of human immunodefi ciency virus (HIV) load early in life with disease progression among HIV-infected infants. New York City Perinatal HIV Transmission Collaborative Study Group. J Infect Dis 178(1):101-108
44. Biggar RJ, Janes M, Pilon R, Miotti P, Taha TE, Broadhead R et al (1999) Virus levels in untreated African infants infected with human immunodefi ciency virus type 1. J Infect Dis 180(6):1838-1843
45. Newell M-L, Peckham C, Dunn D, Ades T, Giaquinto C, The European Collaborative Study (1994) Natural history of vertically acquired human immunodefi ciency virus-1 infection. Pediatrics 94(6 Pt 1):815-819
46. Doyle M, Atkins JT, Rivera-Matos IR (1996) Congenital cytomegalovirus infection in infants infected with human immunodefi ciency virus type 1. Pediatr Infect Dis J 15(12):1102-1106
47. Kovacs A, Schluchter M, Easley K, Demmler G, Shearer W, La Russa P et al (1999) Cytomegalovirus infection and HIV-1 disease progression in infants born to HIV-1-infected women. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group. N Engl J Med 341(2):77-84
48. Nigro G, Krzysztofi ak A, Gattinara GC, Mango T, Mazzocco M, Porcaro MA et al (1996) Rapid progression of HIV disease in children with cytomegalovirus DNAemia. AIDS 10(10):1127-1133
49. Mole L, Ripich S, Margolis D, Holodniy M (1997) The impact of active herpes simplex virus infection on human immunodefi ciency virus load. J Infect Dis 176(3):766-770
50. Schacker T, Zeh J, Hu H, Shaughnessy M, Corey L (2002) Changes in plasma human immunodefi ciency virus type 1 RNA associated with herpes simplex virus reactivation and suppression. J Infect Dis 186(12):1718-1725
51. Kublin JG, Patnaik P, Jere CS, Miller WC, Hoffman IF, Chimbiya N et al (2005) Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study. Lancet 365(9455):233-240
52. Hoffman IF, Jere CS, Taylor TE, Munthali P, Dyer JR, Wirima JJ et al (1999) The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration. AIDS 13(4):487-494
53. Slyker JA, Lohman-Payne BL, Rowland-Jones SL, Otieno P, Maleche-Obimbo E, Richardson B et al (2009) The detection of cytomegalovirus DNA in maternal plasma is associated with mortality in HIV-1-infected women and their infants. AIDS 23(1):117-124
54. Gantt S, Carlsson J, Shetty AK, Seidel KD, Qin X, Mutsvangwa J et al (2008) Cytomegalovirus and Epstein-Barr virus in breast milk are associated with HIV-1 shedding but not with mastitis. AIDS 22(12):1453-1460
55. Griffi ths PD (2006) CMV as a cofactor enhancing progression of AIDS. J Clin Virol 35(4):489-492
56. Pitisuttithum P, Gilbert P, Gurwith M, Heyward W, Martin M, van Griensven F et al (2006) Randomized, doubleblind, placebo-controlled effi cacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J Infect Dis 194(12):1661-1671
57. Buchbinder SP, Mehrotra DV, Duerr A, Fitzgerald DW, Mogg R, Li D et al (2008) Effi cacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-ofconcept trial. Lancet 372(9653):1881-1893
58. McElrath MJ, De Rosa SC, Moodie Z, Dubey S, Kierstead L, Janes H et al (2008) HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. Lancet 372(9653):1894-1905
59. Liu J, OBrien KL, Lynch DM, Simmons NL, La Porte A, Riggs AM et al (2009) Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys. Nature 457(7225):87-91
60. Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, Drummond DD et al (2009) Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodefi ciency virus challenge. Nat Med 15(3):293-299
61. Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, Chiu J, Paris R et al (2009) Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 361(23):2209-2220
62. Abel K, Pahar B, Van Rompay KKA, Fritts L, Sin C, Schmidt K et al (2006) Rapid virus dissemination in infant macaques after oral simian immunodefi ciency virus exposure in the presence of local innate immune responses. J Virol 80:6357-6367
63. Kumar RB, Maher DM, Herzberg MC, Southern PJ (2006) Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection. Virol J 3:25-38
64. Azizi A, Ghunaim H, Diaz-Mitoma F, Mestecky J (2010) Mucosal HIV vaccines: a holy grail or a dud? Vaccine 28:4015-4026
65. Wright PF, Mestecky J, McElrath MJ, Keefer MC, Gorse GJ, Goepfert PA et al (2004) Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G protein. J Infect Dis 189:1221-1231
66. Kotton CN, Lankowski AJ, Scott N, Sisul D, Chen LM, Raschke K et al (2006) Safety and immunogenicity of attenuated Salmonella enterica serovar Typhimurium delivering an HIV-1 gag antigen via the Salmonella type III secretion system. Vaccine 24:6216-6224
67. Van Rompay KKA, Otsyula MG, Tarara RP, Canfield DR, Berardi CJ, McChesney MB et al (1996) Vaccination of pregnant macaques protects newborns against mucosal simain immunodefi ciency virus infection. J Infect Dis 173:1327-1335
68. Van Rompay KKA, Berardi CJ, Dillard-Telm S, Tarara RP, Canfield DR, Valverde CR et al (1998) Passive immunization of newborn rhesus macaques prevents oral simian immunodefi ciency virus infection. J Infect Dis 177:1247-1259
69. Hofmann-Lehmann R, Vlasak J, Rasmussen RA, Smith BA, Baba TW, Liska V et al (2001) Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simianhuman immunodefi ciency virus challenge. J Virol 75:7470-7480
70. Ferrantelli F, Rasmussen RA, Buckley KA, Li PL, Wang T, Montefi ori DC et al (2004) Complete protection of neonatal rhesus macaques against oral exposure to pathogenic simian-human immunodefi ciency virus by human anti-HIV monoclonal antibodies. J Infect Dis 189:2149-2153
71. Ferrantelli F, Buckley KA, Rasmussen RA, Chalmers A, Wang T, Li PL et al (2007) Time dependence of protective post-exposure prophylaxis with human monoclonal antibodies against pathogenic SHIV challenge in newborn macaques. Virology 358:69-78
72. Van Rompay KKA, Greenier JL, Cole KS, Earl P, Moss B, Steckbeck JD et al (2003) Immunization of newborn rhesus macaques with simian immunodefi ciency virus (SIV) vaccines prolongs survival after oral challenge with virulent SIVmac251. J Virol 77:179-190
73. Van Rompay KKA, Abel K, Lawson JR, Singh RP, Schmidt KA, Evans T et al (2005) Attenuated poxvirus-based simian immunodefi ciency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV. J Acquir Immune Defi c Syndr 38:124-134
74. Cristillo AD, Lisziewicz J, He L, Lori F, Galmin L, Trocio JN et al (2007) HIV-1 prophylactic vaccine comprised of topical DermaVir prime and protein boost elicits cellular immune responses and controls pathogenic R5 SHIV162P3. Virology 366:197-211
75. McFarland EJ, Johnson DC, Muresan P, Fenton T, Tomaras GD, McNamara J et al (2006) HIV-1 vaccine induced immune responses in newborns of HIV-1 infected mothers. AIDS 20(11):1481-1489
76. Selin LK, Lin M-L, Kraemer KA, Pardoll DM, Schneck JP, Varga SM et al (1999) Attrition of T cell memory: selective loss of LCMV epitope-specifi c memory CD8 T cells following infections with heterologous viruses. Immunity 11:733-742
77. Ota MO, Vekemans J, Schlegel-Haueter SE, Fielding K, Sanneh M, Kidd M et al (2002) Infl uence of Mycobacterium bovis bacillus Calmette-Guerin on antibody and cytokine responses to human neonatal vaccine. J Immunol 168:919-925
78. Vidor E (2007) The nature and consequences of intra- and inter-vaccine interference. J Comp Pathol 137(Suppl 1): S62-S66
79. Shinefield HR (2010) Overview of the development and current use of CRM197 conjugate vaccines for pediatric use. Vaccine 28:4335-4339
80. Baba TW, Liska V, Khimani AH, Ray NB, Dailey PJ, Penninck D et al (1999) Live attenuated, multiply deleted simian immunodefi ciency virus causes AIDS in infant and adult macaques. Nat Med 5:194-203