Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease

Journal of Infectious Diseases

Volumn 187, Issue 5, 2003, Pages 741-747

  Rousseau, Christine M ^a   Nduati, Ruth W ^c   Richardson, Barbra A ^a,b   Steele, Matthew S ^b   John Stewart, Grace C ^b   Mbori Ngacha, Dorothy A ^c   Kreiss, Joan K ^b   Overbaugh, Julie ^a,d  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF NAIROBI   (Kenya)

^d C3 168 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

ARTICLE; BREAST FEEDING; BREAST MILK; COLOSTRUM; CONTROLLED STUDY; DELIVERY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; LACTATION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MATERNAL DISEASE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RISK FACTOR; SAMPLING; VIRUS LOAD; VIRUS SHEDDING; VIRUS TRANSMISSION;

BREAST FEEDING; CHILD, PRESCHOOL; DISEASE TRANSMISSION, VERTICAL; DNA, VIRAL; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INFANT; INFANT FOOD; INFANT, NEWBORN; LONGITUDINAL STUDIES; MILK, HUMAN; PREGNANCY; RNA, VIRAL; VIRAL LOAD; VIRUS SHEDDING;

EID: 0037333250     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/374273     Document Type: Article

References (34)

1. UNAIDS. AIDS epidemic update, 2001. Available at: http://www.unaids.org/epidemic_update/.
2. Nduati R, John G, Mbori-Ngacha D, et al. Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial. JAMA 2000; 283:1167-74.
3. Dunn DT, Newell ML, Ades AE, Peckham CS. Risk of human immunodeficiency virus type 1 transmission through breastfeeding. Lancet 1992; 340:585-8.
4. Leroy V, Newell ML, Dabis F, et al. International multicenter pooled analysis of late postnatal mother-to-child transmission of HIV-1 infection. Ghent International Working Group on Mother-to-Child Transmission of HIV. Lancet 1998; 352:597-600.
5. John GC, Richardson BA, Nduati RW, Mbori-Ngacha D, Kreiss JK. Timing of breast milk HIV-1 transmission: a meta-analysis. East Afr Med J 2001; 78:75-9.
6. Shaffer N, Chuachoowong R, Mock PA, et al. Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: a randomised controlled trial. Bangkok Collaborative Perinatal HIV Transmission Study Group. Lancet 1999; 353:773-80.
7. Wiktor SZ, Ekpini E, Karon JM, et al. Short-course oral zidovudine for prevention of mother-to-child transmission of HIV-1 in Abidjan, Cote d'Ivoire: a randomised trial. Lancet 1999; 353:781-5.
8. Dabis F, Elenga N, Meda N, et al. 18-Month mortality and perinatal exposure to zidovudine in West Africa. AIDS 2001; 15:771-9.
9. Connor EM, Sperling RS, Gelber R, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med 1994; 331:1173-80.
10. Mofenson LM, McIntyre JA. Advances and research directions in the prevention of mother-to-child HIV-1 transmission. Lancet 2000; 355:2237-44.
11. Efficacy of three short-course regimens of zidovudine and lamivudine in preventing early and late transmission of HIV-1 from mother to child in Tanzania, South Africa, and Uganda (Petra study): a randomised, double-blind, placebo-controlled trial. Lancet 2002; 359:1178-86.
12. Guay LA, Musoke P, Fleming T, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet 1999; 354:795-802.
13. Van de Perre P, Simonon A, Hitimana DG, et al. Infective and anti-infective properties of breastmilk from HIV-1-infected women. Lancet 1993; 341:914-8.
14. Semba RD, Kumwenda N, Hoover DR, et al. Human immunodeficiency virus load in breast milk, mastitis, and mother-to-child transmission of human immunodeficiency virus type 1. J Infect Dis 1999; 180:93-8.
15. Pillay K, Coutsoudis A, York D, Kuhn L, Coovadia HM. Cell-free virus in breast milk of HIV-1-seropositive women. J Acquit Immune Defic Syndr 2000; 24:330-6.
16. Lewis P, Nduati R, Kreiss JK, et al. Cell-free HIV-1 in breast milk. J Infect Dis 1998; 177:34-9.
17. John GC, Nduati RW, Mbori-Ngacha DA, et al. Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections. J Infect Dis 2001; 183:206-12.
18. Van de Perre P, Lepage P, Homsy J, Dabis F. Mother-to-infant transmission of human immunodeficiency virus by breast milk: presumed innocent or presumed guilty? Clin Infect Dis 1992; 15:502-7.
19. Garcia PM, Kalish LA, Pitt J, et al. Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group. N Engl J Med 1999; 341:394-402.
20. St Louis ME, Kamenga M, Brown C, et al. Risk for perinatal HIV-1 transmission according to maternal immunologic, virologic, and placental factors. JAMA 1993; 269:2853-9.
21. Nduati RW, John GC, Richardson BA, et al. Human immunodeficiency virus type 1-infected cells in breast milk: association with immunosuppression and vitamin A deficiency. J Infect Dis 1995; 172:1461-8.
22. John GC, Nduati RW, Mbori-Ngacha D, et al. Genital shedding of human immunodeficiency virus type 1 DNA during pregnancy: association with immunosuppression, abnormal cervical or vaginal discharge, and severe vitamin A deficiency. J Infect Dis 1997; 175:57-62.
23. Neilson J, John G, Carr JK, et al. Subtypes of HIV-1 and disease stage among women in Nairobi, Kenya. J Virol 1999; 73:4393-403.
24. Emery S, Bodrug S, Richardson BA, et al. Evaluation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay using primary subtype A, C, and D isolates from Kenya. J Clin Microbiol 2000; 38:2688-95.
25. Panteleeff DD, Emery S, Richardson B, et al. Validation of the performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay for genital swabs and breastmilk samples. J Clin Microbiol 2002; 40:3929-37.
26. Lawrence RA, Lawrence RM. Breastfeeding: a guide for the medical profession. 5th ed. St. Louis: Mosby, 1994.
27. Hanson DL, Chu SY, Farizo KM, Ward JW. Distribution of CD4+ T lymphocytes at diagnosis of acquired immunodeficiency syndrome-defining and other human immunodeficiency virus-related illnesses. The Adult and Adolescent Spectrum of HIV Disease Project Group. Arch Intern Med 1995; 155:1537-42.
28. Riordan J, Auerbach KG. Breastfeeding and human lactation. 2nd ed. Sudbury, MA: Jones & Bartlett, 1999.
29. Quinn TC, Wawer MJ, Sewankambo N, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med 2000; 342:921-9.
30. Miotti PG, Taha TE, Kumwenda NI, et al. HIV transmission through breastfeeding: a study in Malawi. JAMA 1999; 282:744-9.
31. Poss M, Martin HL, Kreiss JK, et al. Diversity in virus populations from genital secretions and peripheral blood from women recently infected with human immunodeficiency virus type 1. J Virol 1995; 69:8118-22.
32. Delwart E, Mullins J, Gupta P, et al. Human immunodeficiency virus type 1 populations in blood and semen. J Virol 1998; 72:617-23.
33. Zhu T, Wang N, Carr A, et al. Genetic characterization of human immunodeficiency virus type 1 in blood and genital secretions: evidence for viral compartmentalization and selection during sexual transmission. J Virol 1996; 70:3098-107.
34. Korber BT, Kunstman KJ, Patterson BK, et al. Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences. J Virol 1994; 68:7467-81.