Induction of systemic HIV-1-specific cellular immune responses by oral exposure in the uninfected partner of discordant couples

AIDS

Volumn 24, Issue 7, 2010, Pages 969-974

  Pérez, Carina L ^a   Hasselrot, Klara ^b   Bratt, Göran ^c   Broliden, Kristina ^b   Karlsson, Annika C ^a  

^a SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cellular immunity; Cytokines; Gag; HIV; Sexual behavior; Viral load

Indexed keywords

ANTIRETROVIRUS AGENT; CYTOKINE; GAG PROTEIN; GAMMA INTERFERON; NEF PROTEIN;

ANUS INTERCOURSE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; ORAL SEXUAL CONTACT; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SELF REPORT; SEXUAL BEHAVIOR; SEXUALITY; STRUCTURED QUESTIONNAIRE; VIRUS LOAD; VIRUS TRANSMISSION;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSPOT ASSAY; FEMALE; HIV INFECTIONS; HIV SERONEGATIVITY; HIV-1; HUMANS; IMMUNITY, CELLULAR; LEUKOCYTES, MONONUCLEAR; MALE; MOUTH MUCOSA; SEXUAL BEHAVIOR; SEXUAL PARTNERS; VIRAL LOAD;

EID: 77950951770     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e328337aff8     Document Type: Article

References (25)

1. Devito C, Hinkula J, Kaul R, Lopalco L, Bwayo JJ, Plummer F, et al. Mucosal and plasma IgA from HIV-exposed seronegative individuals neutralize a primary HIV-1 isolate. AIDS 2000; 14:1917-1920.
2. Erickson AL, Willberg CB, McMahan V, Liu A, Buchbinder SP, Grohskopf LA, et al. Potentially exposed but uninfected individuals produce cytotoxic and polyfunctional human immunodeficiency virus type 1-specific CD8(R) T-cell responses which can be defined to the epitope level. Clin Vaccine Immunol 2008; 15:1745-1748.
3. Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996; 86:367-377.
4. Mazzoli S, Lopalco L, Salvi A, Trabattoni D, Lo Caputo S, Semplici F, et al. Human immunodeficiency virus (HIV)-specific IgA and HIV neutralizing activity in the serum of exposed seronegative partners of HIV-seropositive persons. J Infect Dis 1999; 180:871-875.
5. Shacklett BL, Means RE, Larsson M, Wilkens DT, Beadle TJ, Merritt MJ, et al. Dendritic cell amplification of HIV type 1-specific CD8R T cell responses in exposed, seronegative heterosexual women. AIDS Res Hum Retroviruses 2002; 18: 805-815.
6. Truong LX, Luong TT, Scott-Algara D, Versmisse P, David A, Perez-Bercoff D, et al. CD4 cell and CD8 cell-mediated resistance to HIV-1 infection in exposed uninfected intravascular drug users in Vietnam. AIDS 2003; 17:1425-1434.
7. Clerici M, Giorgi JV, Chou CC, Gudeman VK, Zack JA, Gupta P, et al. Cell-mediated immune response to human immunodeficiency virus (HIV) type 1 in seronegative homosexual men with recent sexual exposure to HIV-1. J Infect Dis 1992; 165:1012-1019.
8. Goh WC, Markee J, Akridge RE, Meldorf M, Musey L, Karchmer T, et al. Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects. J Infect Dis 1999; 179:548-557.
9. Kaul R, Plummer FA, Kimani J, Dong T, Kiama P, Rostron T, et al. HIV-1-specific mucosal CD8R lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi. J Immunol 2000; 164:1602-1611.
10. Legrand FA, Nixon DF, Loo CP, Ono E,Chapman JM, Miyamoto M, et al. Strong HIV-1-specific T cell responses in HIV-1-exposed uninfected infants and neonates revealed after regulatory T cell removal. PLoS One 2006; 1:e102.
11. Suy A, Castro P, Nomdedeu M, Garcia F, Lopez A, Fumero E, et al. Immunological profile of heterosexual highly HIV-exposed uninfected individuals: predominant role of CD4 and CD8 T-cell activation. J Infect Dis 2007; 196:1191-1201.
12. Hasselrot K, Saberg P, Hirbod T, Soderlund J, Ehnlund M, Bratt G, et al. Oral HIV-exposure elicits mucosal HIV-neutralizing antibodies in uninfected men who have sex with men. AIDS 2009; 23:329-333.
13. Perez CL, Larsen MV, Gustafsson R, Norstrom MM, Atlas A, Nixon DF, et al. Broadly immunogenic HLA class I supertype-restricted elite CTL epitopes recognized in a diverse population infected with different HIV-1 subtypes. J Immunol 2008; 180:5092-5100.
14. Karlsson AC, Martin JN, Younger SR, Bredt BM, Epling L, Ronquillo R, et al. Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells. J Immunol Methods 2003; 283:141-153.
15. Albert J, Fenyo EM. Simple, sensitive, and specific detection of human immunodeficiency virus type 1 in clinical specimens by polymerase chain reaction with nested primers. J Clin Microbiol 1990; 28:1560-1564.
16. Lyamuya E, Bredberg-Raden U, Albert J, Grankvist O, Msangi V, Kagoma C, et al. Comparison of in-house and commercial sample preparation and PCR amplification systems for detection of human immunodeficiency virus type 1 DNA in blood samples from Tanzanian adults. J Clin Microbiol 1997; 35:278-280.
17. Hasselrot K, Bratt G, Hirbod T, Saberg P, Ehnlund M, Lopalco L, et al. Orally exposed uninfected individuals have systemic anti-HIV responses associating with partners' viral load. AIDS 2010; 24:35-43.
18. Gelderblom HC, Vatakis DN, Burke SA, Lawrie SD, Bristol GC, Levy DN. Viral complementation allows HIV-1 replication without integration. Retrovirology 2008; 5:60.
19. Stevenson M, Haggerty S, Lamonica CA, Meier CM, Welch SK, Wasiak AJ. Integration is not necessary for expression of human immunodeficiency virus type 1 protein products. J Virol 1990; 64:2421-2425.
20. Cara A, Guarnaccia F, Reitz MS, Gallo RC, Lori F. Self-limiting, cell type-dependent replication of an integrase-defective human immunodeficiency virus type 1 in human primary macrophages but not T lymphocytes. Virology 1995; 208: 242-248.
21. Wu Y, Marsh JW. Gene transcription in HIV infection. Microbes Infect 2003; 5:1023-1027.
22. Melief CJ. Mini-review: regulation of cytotoxic T lymphocyte responses by dendritic cells-peaceful coexistence of cross-priming and direct priming? Eur J Immunol 2003; 33:2645-2654.
23. Zhu T, Corey L, Hwangbo Y, Lee JM, Learn GH, Mullins JI, et al. Persistence of extraordinarily low levels of genetically homogeneous human immunodeficiency virus type 1 in exposed seronegative individuals. J Virol 2003; 77:6108-6116.
24. Almeida JR, Price DA, Papagno L, Arkoub ZA, Sauce D, Bornstein E, et al. Superior control of HIV-1 replication by CD8R T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J Exp Med 2007; 204:2473-2485.
25. Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham J, et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8R T cells. Blood 2006; 107:4781-4789.