Infants with late breast milk acquisition of HIV-1 generate interferon-gamma responses more rapidly than infants with early peripartum acquisition

Clinical and Experimental Immunology

Volumn 156, Issue 3, 2009, Pages 511-517

  Lohman Payne, B ^a,b,c   Slyker, J A ^c,e   Richardson, B A ^c,d   Farquhar, C ^c   Majiwa, M ^b   Maleche Obimbo, E ^b   Mbori Ngacha, D ^b   Overbaugh, J ^d   Rowland Jones, S ^e   John Stewart, G ^c  

^a IARTP   (United States)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

CD8 + T cell; ELISPOT; Kenya; Mother to child HIV 1 transmission; Neonatal

Indexed keywords

EPITOPE; GAG PROTEIN; GAMMA INTERFERON; VIRUS DNA; VIRUS RNA;

ARTICLE; BREAST MILK; CD8+ T LYMPHOCYTE; CORRELATION ANALYSIS; DISEASE COURSE; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INFANT; KAPLAN MEIER METHOD; KENYA; LOG RANK TEST; MAJOR CLINICAL STUDY; PERINATAL PERIOD; PRIORITY JOURNAL; VIRUS LOAD; VIRUS REPLICATION;

AGE FACTORS; CD8-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INFANT; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; INTERFERON-GAMMA; MILK, HUMAN; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PRENATAL EXPOSURE DELAYED EFFECTS; VIRAL LOAD;

EID: 66149153530     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2009.03937.x     Document Type: Article

References (30)

1. Obimbo E, Mbori-Ngacha D, Otieno PA et al. Correlates of viral load in Kenyan HIV-1 infected children. 2nd International AIDS Society conference on HIV-1 pathogenesis and treatment, Paris, France, 2003.
2. Obimbo E, Mbori-Ngacha DA, Ochieng JO et al. Predictors of early mortality in a cohort of human immunodeficiency virus type 1-infected African children. Pediatr Infect Dis J 2004 23 : 536 43. (Pubitemid 38802299)
3. Richardson B A, Mbori-Ngacha D, Lavreys L et al. Comparison of human immunodeficiency virus type 1 viral load in Kenyan men, women, and infants during primary and early infection. J Virol 2003 77 : 7120 3. (Pubitemid 36666906)
4. Becquart P, Petitjean G, Al Tabaa Y et al. Detection of a large T-cell reservoir able to replicate HIV-1 actively in breast milk. AIDS 2006 20 : 1453 62. (Pubitemid 43948254)
5. DeVange Panteleeff D, Emery S, Richardson BA et al. Validation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay with genital swabs and breast milk samples. J Clin Microbiol 2002 40 : 3929 37. (Pubitemid 35285770)
6. Koulinska IN, Villamor E, Msamanga G et al. Risk of HIV-1 transmission by breastfeeding among mothers infected with recombinant and non-recombinant HIV-1 genotypes. Virus Res 2006 120 : 191 8. (Pubitemid 43964968)
7. Shapiro R, Ndung'u T, Lockman S et al. Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk. J Infect Dis 2005 192 : 713 9. (Pubitemid 41193068)
8. Kuijpers TW, Vossen MT, Gent MR et al. Frequencies of circulating cytolytic, CD45RA+ CD27-, CD8+ T lymphocytes depend on infection with CMV. J Immunol 2003 170 : 4342 8.
9. Adkins B, Leclerc C, Marshall-Clarke S. Neonatal adaptive immunity comes of age. Nat Rev 2004 4 : 553 64. (Pubitemid 38931770)
10. Lohman BL, Slyker JA, Richardson BA et al. Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants. J Virol 2005 79 : 8121 30. (Pubitemid 40853515)
11. Farquhar C, VanCott TC, Mbori-Ngacha DA et al. Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk. J Infect Dis 2002 186 : 1173 6. (Pubitemid 35177123)
12. Bunce M, O'Neill CM, Barnardo MC et al. Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5, and DQB1 by PCR with 144 primer mixes utilitizing sequence specific primers (PCR-SSP). Tissue Antigens 1995 46 : 355 67. (Pubitemid 26001354)
13. DeVange Panteleeff D, John GC, Nduati R et al. Rapid method for screening dried blood samples on filter paper for human immunodeficiency virus type 1 DNA. J Clin Microbiol 1999 37 : 350 3. (Pubitemid 29056402)
14. Emery S, Bodrug S, Richardson BA et al. Evaluation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay using primary subtype A, C, and D isolates from Kenya. J Clin Microbiol 2000 38 : 2688 95. (Pubitemid 30485151)
15. Beattie T, Kaul R, Rostron T et al. Screening for HIV-specific T-cell responses using overlapping 15-mer peptide pools or optimized epitopes. AIDS 2004 18 : 1 12. (Pubitemid 39037485)
16. Thobakgale CF, Ramduth D, Reddy S et al. Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants. J Virol 2007 81 : 12775 84. (Pubitemid 350156915)
17. Koup RA, Safrit JT, Cao Y et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 1994 68 : 4650 5. (Pubitemid 24183063)
18. Maleche Obimbo E, Walmalwa D, Richardson B et al. Viral load pattern in Kenyan HIV infected infants. J AIDS 2009 50 (in press).
19. Legrand FA, Nixon DF, Loo CP et al. Strong HIV-1-specific T cell responses in HIV-1-exposed uninfected infants and neonates revealed after regulatory T cell removal. PLoS One 2006 1 : e102.
20. Vekemans J, Ota MO, Wang EC et al. T cell responses to vaccines in infants: defective interferon-gamma production after oral polio vaccination. Clin Exp Immunol 2002 127 : 495 8. (Pubitemid 34437821)
21. Velilla PA, Rugeles MT, Chougnet CA. Defective antigen-resenting cell function in human neonates. Clin Immunol 2006 121 : 251 9.
22. Mbori-Ngacha D, Nduati R, John G et al. Morbidity and mortality in breastfed and formula fed infants of HIV-1 infected women: results of a randomized clinical trial. JAMA 2001 286 : 2413 20. (Pubitemid 33098159)
23. Betts MR, Amborzak DR, Douek D et al. Analysis of total human immunodeficiency virus (HIV)-specific CD4+ and CD8+ T-cell responses: relationship to viral load in untreated HIV infection. J Virol 2001 75 : 11983 91. (Pubitemid 33115870)
24. Buseyne F, Le Chenadec J, Corre B et al. Inverse correlation between memory gag-specific cytotoxic T lymphocytes and viral replication in human immunodeficiency virus-infected children. J Infect Dis 2002 186 : 1589 96. (Pubitemid 35379635)
25. Connick E, Schlichtemeier RL, Purner MB et al. Relationship between human immunodeficiency virus type 1 (HIV-1)-specific memory cytotoxic T lymphocytes and virus load after recent seroconversion. J Infect Dis 2001 184 : 1465 70. (Pubitemid 33108863)
26. Patke DS, Langan SJ, Carruth LM et al. Association of gag-specific T lymphocyte responses during the early phase of human immunodeficiency virus type 1 infection and lower virus set point. J Infect Dis 2002 186 : 1177 80. (Pubitemid 35177124)
27. Leligdowicz A, Yindom LM, Onyango C et al. Robust gag-specific T cell responses characterize viremia control in HIV-2 infection. J Clin Invest 2007 117 : 3067 74. (Pubitemid 47529636)
28. Buseyne F, Burgard M, Teglas JP et al. Early HIV-specific cytotoxic T lymphocytes and disease progression in children born to HIV-infected mothers. AIDS Res Hum Retrovir 1998 14 : 1435 44. (Pubitemid 28507335)
29. Buseyne F, Le Chenadec J, Burgard M et al. In HIV Type 1-infected children cytotoxic T lymphocyte responses are associated with greater reduction of viremia under antiretroviral therapy. AIDS Res Hum Retrovir 2005 21 : 719 27. (Pubitemid 41254238)
30. Pillay T, Zhang HT, Drijfhout JW et al. Unique acquisition of cytotoxic T lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection. J Virol 2005 79 : 12100 5. (Pubitemid 41279328)