메뉴 건너뛰기




Volumn 7, Issue 4, 2012, Pages

Genetic screening of new genes responsible for cellular adaptation to hypoxia using a genome-wide shRNA library

Author keywords

[No Author keywords available]

Indexed keywords

LENTIVIRUS VECTOR; SHORT HAIRPIN RNA; OXYGEN; SMALL INTERFERING RNA;

EID: 84859879204     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035590     Document Type: Article
Times cited : (14)

References (34)
  • 2
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • Gatenby RA, Gillies RJ, (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4: 891-899.
    • (2004) Nat Rev Cancer , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 3
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia, HIF1 and glucose metabolism in the solid tumour
    • Denko NC, (2008) Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 8: 705-713.
    • (2008) Nat Rev Cancer , vol.8 , pp. 705-713
    • Denko, N.C.1
  • 4
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    • Kaelin WG Jr, Ratcliffe PJ, (2008) Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30: 393-402.
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin Jr., W.G.1    Ratcliffe, P.J.2
  • 5
    • 76049100577 scopus 로고    scopus 로고
    • HIF-1: upstream and downstream of cancer metabolism
    • Semenza GL, (2009) HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20: 51-56.
    • (2009) Curr Opin Genet Dev , vol.20 , pp. 51-56
    • Semenza, G.L.1
  • 6
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O, (1956) On the origin of cancer cells. Science 123: 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 7
    • 79957567239 scopus 로고    scopus 로고
    • Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
    • Luo W, Hu H, Chang R, Zhong J, Knabel M, et al. (2011) Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 145: 732-744.
    • (2011) Cell , vol.145 , pp. 732-744
    • Luo, W.1    Hu, H.2    Chang, R.3    Zhong, J.4    Knabel, M.5
  • 8
    • 79954607456 scopus 로고    scopus 로고
    • Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase
    • Sakamoto T, Niiya D, Seiki M, (2011) Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase. J Biol Chem 286: 14691-14704.
    • (2011) J Biol Chem , vol.286 , pp. 14691-14704
    • Sakamoto, T.1    Niiya, D.2    Seiki, M.3
  • 9
    • 71049186343 scopus 로고    scopus 로고
    • Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1
    • Sakamoto T, Seiki M, (2009) Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1. J Biol Chem 284: 30350-30359.
    • (2009) J Biol Chem , vol.284 , pp. 30350-30359
    • Sakamoto, T.1    Seiki, M.2
  • 10
    • 77956910491 scopus 로고    scopus 로고
    • A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mechanism
    • Sakamoto T, Seiki M, (2010) A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mechanism. J Biol Chem 285: 29951-29964.
    • (2010) J Biol Chem , vol.285 , pp. 29951-29964
    • Sakamoto, T.1    Seiki, M.2
  • 12
    • 44449147036 scopus 로고    scopus 로고
    • Tumor cell metabolism: cancer's Achilles' heel
    • Kroemer G, Pouyssegur J, (2008) Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13: 472-482.
    • (2008) Cancer Cell , vol.13 , pp. 472-482
    • Kroemer, G.1    Pouyssegur, J.2
  • 13
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: navigating downstream
    • Manning BD, Cantley LC, (2007) AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 14
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signalling through mTOR and the unfolded protein response in cancer
    • Wouters BG, Koritzinsky M, (2008) Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer 8: 851-864.
    • (2008) Nat Rev Cancer , vol.8 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 15
    • 66249103703 scopus 로고    scopus 로고
    • RNA granules: post-transcriptional and epigenetic modulators of gene expression
    • Anderson P, Kedersha N, (2009) RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol 10: 430-436.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 430-436
    • Anderson, P.1    Kedersha, N.2
  • 16
    • 33847417585 scopus 로고    scopus 로고
    • P bodies and the control of mRNA translation and degradation
    • Parker R, Sheth U, (2007) P bodies and the control of mRNA translation and degradation. Mol Cell 25: 635-646.
    • (2007) Mol Cell , vol.25 , pp. 635-646
    • Parker, R.1    Sheth, U.2
  • 17
    • 78649375395 scopus 로고    scopus 로고
    • Translational regulation of gene expression during conditions of cell stress
    • Spriggs KA, Bushell M, Willis AE, (2010) Translational regulation of gene expression during conditions of cell stress. Mol Cell 40: 228-237.
    • (2010) Mol Cell , vol.40 , pp. 228-237
    • Spriggs, K.A.1    Bushell, M.2    Willis, A.E.3
  • 18
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC, (2003) Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 23: 9361-9374.
    • (2003) Mol Cell Biol , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3    Keith, B.4    Simon, M.C.5
  • 19
    • 0242580792 scopus 로고    scopus 로고
    • Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells
    • Kunz M, Moeller S, Koczan D, Lorenz P, Wenger RH, et al. (2003) Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells. J Biol Chem 278: 45651-45660.
    • (2003) J Biol Chem , vol.278 , pp. 45651-45660
    • Kunz, M.1    Moeller, S.2    Koczan, D.3    Lorenz, P.4    Wenger, R.H.5
  • 20
    • 3042616216 scopus 로고    scopus 로고
    • Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis
    • Zhang L, Hill RP, (2004) Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis. Cancer Res 64: 4180-4189.
    • (2004) Cancer Res , vol.64 , pp. 4180-4189
    • Zhang, L.1    Hill, R.P.2
  • 21
    • 0029874184 scopus 로고    scopus 로고
    • Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL
    • Shimizu S, Eguchi Y, Kamiike W, Itoh Y, Hasegawa J, et al. (1996) Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL. Cancer Res 56: 2161-2166.
    • (1996) Cancer Res , vol.56 , pp. 2161-2166
    • Shimizu, S.1    Eguchi, Y.2    Kamiike, W.3    Itoh, Y.4    Hasegawa, J.5
  • 22
    • 0028950645 scopus 로고
    • Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL
    • Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, et al. (1995) Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature 374: 811-813.
    • (1995) Nature , vol.374 , pp. 811-813
    • Shimizu, S.1    Eguchi, Y.2    Kosaka, H.3    Kamiike, W.4    Matsuda, H.5
  • 23
    • 0037131159 scopus 로고    scopus 로고
    • Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3
    • Huang J, Zhao Q, Mooney SM, Lee FS, (2002) Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. J Biol Chem 277: 39792-39800.
    • (2002) J Biol Chem , vol.277 , pp. 39792-39800
    • Huang, J.1    Zhao, Q.2    Mooney, S.M.3    Lee, F.S.4
  • 24
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV, (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3: 177-185.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 25
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC, (2006) HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 3: 187-197.
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 26
    • 43449100393 scopus 로고    scopus 로고
    • Extracellular acidification elicits spatially and temporally distinct Ca2+ signals
    • Huang WC, Swietach P, Vaughan-Jones RD, Ansorge O, Glitsch MD, (2008) Extracellular acidification elicits spatially and temporally distinct Ca2+ signals. Curr Biol 18: 781-785.
    • (2008) Curr Biol , vol.18 , pp. 781-785
    • Huang, W.C.1    Swietach, P.2    Vaughan-Jones, R.D.3    Ansorge, O.4    Glitsch, M.D.5
  • 28
    • 67651095905 scopus 로고    scopus 로고
    • Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity
    • Arif A, Jia J, Mukhopadhyay R, Willard B, Kinter M, et al. (2009) Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity. Mol Cell 35: 164-180.
    • (2009) Mol Cell , vol.35 , pp. 164-180
    • Arif, A.1    Jia, J.2    Mukhopadhyay, R.3    Willard, B.4    Kinter, M.5
  • 29
    • 11144353595 scopus 로고    scopus 로고
    • RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies
    • Kashuba VI, Li J, Wang F, Senchenko VN, Protopopov A, et al. (2004) RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies. Proc Natl Acad Sci U S A 101: 4906-4911.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4906-4911
    • Kashuba, V.I.1    Li, J.2    Wang, F.3    Senchenko, V.N.4    Protopopov, A.5
  • 30
    • 0034660855 scopus 로고    scopus 로고
    • Identification on a human sarcoma of two new genes with tumor-specific expression
    • Martelange V, De Smet C, De Plaen E, Lurquin C, Boon T, (2000) Identification on a human sarcoma of two new genes with tumor-specific expression. Cancer Res 60: 3848-3855.
    • (2000) Cancer Res , vol.60 , pp. 3848-3855
    • Martelange, V.1    De Smet, C.2    De Plaen, E.3    Lurquin, C.4    Boon, T.5
  • 31
    • 34250888278 scopus 로고    scopus 로고
    • Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways
    • van Dijk EL, Schilders G, Pruijn GJ, (2007) Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. Rna 13: 1027-1035.
    • (2007) Rna , vol.13 , pp. 1027-1035
    • van Dijk, E.L.1    Schilders, G.2    Pruijn, G.J.3
  • 32
    • 77954145997 scopus 로고    scopus 로고
    • Frequent alterations of the candidate genes hMLH1, ITGA9 and RBSP3 in early dysplastic lesions of head and neck: clinical and prognostic significance
    • Ghosh A, Ghosh S, Maiti GP, Sabbir MG, Zabarovsky ER, et al. (2010) Frequent alterations of the candidate genes hMLH1, ITGA9 and RBSP3 in early dysplastic lesions of head and neck: clinical and prognostic significance. Cancer Sci 101: 1511-1520.
    • (2010) Cancer Sci , vol.101 , pp. 1511-1520
    • Ghosh, A.1    Ghosh, S.2    Maiti, G.P.3    Sabbir, M.G.4    Zabarovsky, E.R.5
  • 33
    • 77950454438 scopus 로고    scopus 로고
    • Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer
    • Senchenko VN, Anedchenko EA, Kondratieva TT, Krasnov GS, Dmitriev AA, et al. (2010) Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer. BMC Cancer 10: 75.
    • (2010) BMC Cancer , vol.10 , pp. 75
    • Senchenko, V.N.1    Anedchenko, E.A.2    Kondratieva, T.T.3    Krasnov, G.S.4    Dmitriev, A.A.5
  • 34
    • 0025494911 scopus 로고
    • Purification and some properties of proliferation suppressing factor from human lung adenocarcinoma PC-8
    • Shinmoto H, Dosako S, Yamada K, Shirahata S, Murakami H, (1990) Purification and some properties of proliferation suppressing factor from human lung adenocarcinoma PC-8. Cytotechnology 4: 121-126.
    • (1990) Cytotechnology , vol.4 , pp. 121-126
    • Shinmoto, H.1    Dosako, S.2    Yamada, K.3    Shirahata, S.4    Murakami, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.