Differential oxidation of two thiophene-containing regioisomers to reactive metabolites by cytochrome P450 2C9

Chemical Research in Toxicology

Volumn 25, Issue 4, 2012, Pages 895-903

  Rademacher, Peter M ^a   Woods, Caleb M ^a   Huang, Qingbiao ^b   Szklarz, Grazyna D ^b   Nelson, Sidney D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,5 OXYGEN; 2 ACETYLTHIOPHENE OXIDE; CARBON; CYTOCHROME P450 2C9; HYDROXYTHIOPHENE; OXYGEN DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOLACTONE; THIOPHENE; TIENILIC ACID; TIENILIC ACID ISOMER; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; ISOMER; LIVER INJURY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; OXIDATION KINETICS; REACTION ANALYSIS; STRUCTURE ANALYSIS; TAUTOMER;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; DIURETICS; HUMANS; NADP; OXIDATION-REDUCTION; RATS; STEREOISOMERISM; TICRYNAFEN;

RATTUS;

EID: 84859860273     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200519d     Document Type: Article

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