Use of isotopes and LC-MS-ESI-TOF for mechanistic studies of tienilic acid metabolic activation

Advances in Experimental Medicine and Biology

Volumn 500, Issue , 2001, Pages 139-144

  Belghazi, Maya ^b   Jean, Pascale ^a   Poli, Sonia ^a   Schmitter, Jean Marie ^b   Mansuy, Daniel ^a   Dansette, Patrick M ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ISOTOPE; TIENILIC ACID;

ANIMAL CELL; CHEMICAL ANALYSIS; CHEMICAL REACTION; CONFERENCE PAPER; DRUG ACTIVATION; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOFIBRATE; CYTOCHROME P-450 ENZYME SYSTEM; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; ISOTOPE LABELING; MICROSOMES, LIVER; NADP; OXIDATION-REDUCTION; OXYGEN; RATS; SOLVENTS; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; TICRYNAFEN; URICOSURIC AGENTS; WATER; YEASTS;

ANIMALIA;

EID: 0035702199     PISSN: 00652598     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-1-4615-0667-6_17     Document Type: Article

References (5)

1. Opposite behaviors of reactive metabolites of tienilic acid and its isomer toward liver proteins: Use of specific anti-tienilic acid-protein adduct antibodies and the possible relationship with different hepatotoxic effects of the two compounds
2. Electrospray ionization mass spectrometric analysis of intact cytochrome P450: Identification of tienilic acid adducts to P450 2C9
3. Thiophene derivatives as new mechanism-based inhibitors of cytochrome-P450 - Inactivation of yeast-expressed human liver cytochrome-P-450-2C9 by tienilic acid
4. Thiophene sulfoxides as reactive metabolites: Formation upon microsomal oxidation of a 3-aroylthiophene and fate in the presence of nucleophiles in vitro and in vivo