A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase

Journal of Biological Chemistry

Volumn 283, Issue 8, 2008, Pages 4690-4698

  Chopra, Shaileja ^a   Dooling, Russell M ^a   Horner, Caroline Glyn ^a   Howell, Elizabeth E ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; ESCHERICHIA COLI; VOLUMETRIC ANALYSIS;

ACTIVE SITES; ANTIBACTERIAL DRUGS; BALANCING ACTS; BINDING SURFACES; CATALYTIC EFFICIENCIES; COFACTOR; DIHYDROFOLATE; HOMOTETRAMER; IN-VIVO; ISOTHERMAL TITRATION CALORIMETRIES; MUTANT CLONES; OSMOLYTES; R67 DIHYDROFOLATE REDUCTASES; ROLE OF WATERS; STEADY STATES; TETRAHYDROFOLATE; TRIMETHOPRIM; WATER ACTIVITIES; WATER MOLECULES; WILD TYPES;

WATER CONTENT;

DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SORBITOL; TRIMETHOPRIM; WATER; DRUG DERIVATIVE; ESCHERICHIA COLI PROTEIN; FOLIC ACID; FOLIC ACID ANTAGONIST; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SWEETENING AGENT;

ARTICLE; CATALYSIS; COMPLEX FORMATION; ENZYME KINETICS; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR CLONING; OSMOLALITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; SENSITIVITY ANALYSIS; STEADY STATE; WATER TRANSPORT; ANTIBIOTIC RESISTANCE; BINDING SITE; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; ESCHERICHIA COLI; GROWTH, DEVELOPMENT AND AGING; METABOLISM; OSMOSIS; OXIDATION REDUCTION REACTION; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE;

ESCHERICHIA COLI;

BINDING SITES; CATALYSIS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FOLIC ACID; FOLIC ACID ANTAGONISTS; NADP; OSMOSIS; OXIDATION-REDUCTION; PROTEIN STRUCTURE, QUATERNARY; SORBITOL; SWEETENING AGENTS; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM; WATER;

EID: 41949105752     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709443200     Document Type: Article

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