Intestinal translocation capabilities of wheat allergens using the Caco-2 cell line

Journal of Agricultural and Food Chemistry

Volumn 55, Issue 11, 2007, Pages 4576-4583

  Bodinier, Marie ^a   Legoux, Marie Anne ^a   Pineau, Florence ^a   Triballeau, Sylvie ^a   Segain, Jean Pierre ^a   Brossard, Chantal ^a   Denery Papini, Sandra ^a  

^a Universite de Nantes   (France)

Author keywords

5 gliadins; Allergy; Caco 2; Crossing; Intestinal barrier; LTP; Wheat proteins

Indexed keywords

GLIADIN; GLUTEN; GLUTENIN; PLANT ANTIGEN;

ARTICLE; CELL STRAIN CACO 2; HUMAN; IMPEDANCE; METABOLISM; SMALL INTESTINE; WHEAT ALLERGY;

ANTIGENS, PLANT; CACO-2 CELLS; ELECTRIC IMPEDANCE; GLIADIN; GLUTEN; HUMANS; INTESTINE, SMALL; WHEAT HYPERSENSITIVITY;

TRITICUM AESTIVUM;

EID: 34250661329     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf070187e     Document Type: Article

References (33)

1. Moneret-Vautrin, D. A.; Kanny, G. Update on threshold doses of food allergens: implications for patients and the food industry. Curr. Opin. Allergy Clin. Immunol. 2004, 4, 215-219.
2. Hischenhuber, C.; Crevel, R.; Jarry, B.; Maki, M.; Moneret-Vautrin, D. A.; Romano, A.; Troncone, R.; Ward, R. Review article: safe amounts of gluten for patients with wheat allergy or coeliac disease. Aliment. Pharmacol. Ther. 2006, 23, 559-575.
3. Palosuo, K. Update on wheat hypersensitivity. Curr. Opin. Allergy Clin. Immunol. 2003, 3, 205-209.
4. Battais, C. P.; Popineau, Y.; Kanny, G.; Moneret-Vautrin, D. A. D.-P. S. Food allergy to wheat: differences in immunoglobulin E-binding proteins as a function of age or symptoms. J. Cereal Sci. 2005, 42, 109-117.
5. Matsuo, H.; Morimoto, K.; Akaki, T.; Kaneko, S.; Kusatake, K.; Kuroda, T.; Niihara, H.; Hide, M.; Morita, E. Exercise and aspirin increase levels of circulating gliadin peptides in patients with wheat-dependent exercise-induced anaphylaxis. Clin. Exp. Allergy 2005, 35, 461-466.
6. Balimane, P. V.; Chong, S. Cell culture-based models for intestinal permeability: a critique. Drug Discovery Today 2005, 10, 335-343.
7. Heyman, M. Symposium on 'dietary influences on mucosal immunity'. How dietary antigens access the mucosal immune system. Proc. Nutr. Soc. 2001, 60, 419-426.
8. Heyman, M.; Grasset, E.; Ducroc, R.; Desjeux, J. F. Antigen absorption by the jejunal epithelium of children with cow's milk allergy. Pediatr. Res. 1988, 24, 197-202.
9. Moreno, F. J.; Rubio, L. A.; Olano, A.; Clemente, A. Uptake of 2S albumin allergens, Ber e 1 and Ses i 1, across human intestinal epithelial Caco-2 cell monolayers. J. Agric. Food Chem. 2006, 54, 8631-8639.
10. Rytkonen, J.; Valkonen, K. H.; Virtanen, V.; Foxwell, R. A.; Kyd, J. M.; Cripps, A. W.; Karttunen, T. J. Enterocyte and M-cell transport of native and heat-denatured bovine β-lactoglobulin: significance of heat denaturation. J. Agric. Food Chem. 2006, 54, 1500-1507.
11. Yu, L. C.; Yang, P. C.; Berin, M. C.; Di Leo, V.; Conrad, D. H.; McKay, D. M.; Satoskar, A. R.; Perdue, M. H. Enhanced transepithelial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by interleukin-4. Gastroenterology 2001, 121, 370-381.
12. Fogh, J.; Fogh, J. M.; Orfeo, T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J. Natl. Cancer Inst. 1977, 59, 221-226.
13. Ranaldi, G.; Consalvo, R.; Sambuy, Y.; Scarino, M. L. Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in serum-supplemented and serum-free media. Toxicol. in Vitro 2003, 17, 761-767.
14. Sambruy, Y.; Ferruzza, S.; Ranaldi, G.; De Angelis, I. Intestinal cell culture models: applications in toxicology and pharmacology. Cell Biol. Toxicol. 2001, 17, 301-317.
15. Sander, G. R.; Cummins, A. G.; Henshall, T.; Powell, B. C. Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins. FEBS Lett. 2005, 579, 4851-4855.
16. Untersmayr, E.; Jensen-Jarolim, E. The effect of gastric digestion on food allergy. Curr. Opin. Allergy Clin. Immunol. 2006, 6, 214-219.
17. Battais, F.; Pineau, F.; Popineau, Y.; Aparicio, C.; Kanny, G.; Guerin, L.; Moneret-Vautrin, D. A.; Denery-Papini, S. Food allergy to wheat: identification of immunogloglin E and immunoglobulin G-binding proteins with sequential extracts and purified proteins from wheat flour. Clin. Exp. Allergy 2003, 33, 962-970.
18. Douliez, J. P.; Jegou, S.; Pato, C.; Larre, C.; Molle, D.; Marion, D. Identification of a new form of lipid transfer protein (LTP1) in wheat seeds. J. Agric. Food Chem. 2001, 49, 1805-1808.
19. Frister, H.; Meisel, H.; Schlimme, E. OPA method modified by use of N,N-dimethyl-2-mercaptoethyl ammonium chloride as thiol component. Fresenius' Z. Anal. Chem. 1988, 330, 631-633.
20. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55-63.
21. Douady, D.; Guerbette, F.; Grosbois, M.; Kader, J.-C. Purification of phospholipid transfer protein from maize seeds using a two-step chromatographic procedure. Physiol. Veg. 1985, 23, 373-380.
22. Astwood, J. D.; Leach, J. N.; Fuchs, R. L. Stability of food allergens to digestion in vitro. Nat. Biotechnol. 1996, 14, 1269-1273.
23. Asero, R.; Mistrello, G.; Roncarolo, D.; de Vries, S. C.; Gautier, M. F.; Ciurana, C. L.; Verbeek, E.; Mohammadi, T.; Knul-Brettlova, V.; Akkerdaas, J. H.; Bulder, I.; Aalberse, R. C.; van Ree, R. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int. Arch. Allergy Immunol. 2000, 122, 20-32.
24. Masson, P.; Popineau, Y.; Pineau, F. Limited hydrolysis of γ-gliadin by pepsin: fractionation and partial characterisation of large polypeptides. Lebensm.- Wiss. - Technol. 1989, 22, 157-163.
25. Marsh, M. N. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 1992, 102, 330-354.
26. De Ritis, G.; Occorsio, P.; Auricchio, S.; Gramenzi, F.; Morisi, G.; Silano, V. Toxicity of wheat flour proteins and protein-derived peptides for in vitro developing intestine from rat fetus. Pediatr. Res. 1979, 13, 1255-1261.
27. Giovannini, C.; Matarrese, P.; Scazzocchio, B.; Vari, R.; D'Archivio, M.; Straface, E.; Masella, R.; Malorni, W.; De Vincenzi, M. Wheat gliadin induces apoptosis of intestinal cells via an autocrine mechanism involving Fas-Fas ligand pathway. FEBS Lett. 2003, 540, 117-124.
28. Heyman, M. Gut barrier dysfunction in food allergy. Eur. J. Gastroenterol. Hepatol. 2005, 17, 1279-1285.
29. Caillard, I.; Tome, D. Transport of β-lactoglobulin and α-lactalbumin in enterocyte-like Caco-2 cells. Reprod. Nutr. Dev. 1995, 35, 179-188.
30. Matsuo, H.; Morita, E.; Tatham, A. S.; Morimoto, K.; Horikawa, T.; Osuna, H.; Ikezawa, Z.; Kaneko, S.; Kohno, K.; Dekio, S. Identification of the IgE-binding epitope in ω-5 gliadin, a major allergen in wheat-dependent exercise-induced anaphylaxis. J. Biol. Chem. 2004, 279, 12135-12140.
31. Battais, F.; Mothes, T.; Moneret-Vautrin, D. A.; Pineau, F.; Kanny, G.; Popineau, Y.; Bodinier, M.; Denery-Papini, S. Identification of IgE-binding epitopes on gliadins for patients with food allergy to wheat. Allergy 2005, 60, 815-821.
32. Berin, M. C.; Kiliaan, A. J.; Yang, P. C.; Groot, J. A.; Taminiau, J. A.; Perdue, M. H. Rapid transepithelial antigen transport in rat jejunum: impact of sensitization and the hypersensitivity reaction. Gastroenterology 1997, 113, 856-864.
33. Bevilacqua, C.; Montagnac, G.; Benmerah, A.; Candalh, C.; Brousse, N.; Cerf-Bensussan, N.; Perdue, M. H.; Heyman, M. Food allergens are protected from degradation during CD23-mediated transepithelial transport. Int. Arch. Allergy Immunol. 2004, 135, 108-116.