Bone morphogenetic protein-2-induced Wnt/β-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes

Arthritis Research and Therapy

Volumn 14, Issue 2, 2012, Pages

  Papathanasiou, Ioanna ^a,b   Malizos, Konstantinos N ^a,b   Tsezou, Aspasia ^a,b  

^a UNIVERSITY OF THESSALY   (Greece)

^b Institute for Biomedical Research and Technology   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; AGGRECANASE 1; AGGRECANASE 2; BETA CATENIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; BONE MORPHOGENETIC PROTEIN RECEPTOR 1B; COLLAGEN TYPE 10; COLLAGEN TYPE 2; COLLAGENASE 3; GELATINASE B; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LYMPHOID ENHANCER FACTOR 1; MATRILYSIN; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; OSTEOGENIC PROTEIN 1; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 4; UNCLASSIFIED DRUG; WNT PROTEIN; BMP2 PROTEIN, HUMAN; CTNNB1 PROTEIN, HUMAN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN L5, HUMAN; LOW-DENSITY LIPOPROTEIN L5, HUMAN;

ADULT; ARTICLE; CARTILAGE CELL; CATABOLISM; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTROPHY; MALE; OSTEOARTHRITIS; PROTEIN BINDING; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WNT SIGNALING PATHWAY; AGED; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADULT; AGED; BETA CATENIN; BONE MORPHOGENETIC PROTEIN 2; CELLS, CULTURED; CHONDROCYTES; FEMALE; HUMANS; HYPERTROPHY; LIPOPROTEINS, LDL; MALE; METABOLISM; MIDDLE AGED; OSTEOARTHRITIS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 84859804984     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3805     Document Type: Article

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