Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 12867-12878

  Lönn, Peter ^a   Vanlandewijck, Michael ^a   Raja, Erna ^a   Kowanetz, Marcin ^a,b   Watanabe, Yukihide ^a   Kowanetz, Katarzyna ^a,b   Vasilaki, Eleftheria ^a   Heldin, Carl Henrik ^a   Moustakas, Aristidis ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTROL MECHANISM; EPITHELIAL GROWTH; KINASE ACTIVITY; PHYSIOLOGICAL PROCESS; RECEPTOR SIGNALING; TRANSCRIPTIONAL MECHANISMS; TRANSFORMING GROWTH FACTORS; UBIQUITIN LIGASES;

AMINO ACIDS; ENZYMES; GENES; PHYSIOLOGY;

PROTEINS;

MESSENGER RNA; PROTEIN SERINE THREONINE KINASE; PROTEIN SMURF2; SALT INDUCIBLE KINASE 1; SMAD PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; ENHANCER REGION; ENZYME ACTIVITY; ENZYME INDUCTION; EPITHELIUM CELL; GENE; GENE INDUCTION; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SIK1 GENE; TRANSCRIPTION REGULATION;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TRANSFORMED; CERCOPITHECUS AETHIOPS; COS CELLS; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; KERATINOCYTES; MINK; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RESPIRATORY MUCOSA; RNA, SMALL INTERFERING; SMAD7 PROTEIN; TRANSCRIPTIONAL ACTIVATION; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN-PROTEIN LIGASES;

EID: 84859765672     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.307249     Document Type: Article

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