The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

Biochemical Journal

Volumn 394, Issue 3, 2006, Pages 545-555

  Jaleel, Mahaboobi ^a   Villa, Fabrizio ^a   Deak, Maria ^a   Toth, Rachel ^a   Prescott, Alan R ^a   Van Aalten, Daan M F ^a   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

AMP activated protein kinase (AMPK); LKB1 tumour suppressor protein kinase; Peutz Jeghers syndrome (PJS); Small angle X ray scattering analysis (SAXS analysis); Ubiquitination

Indexed keywords

CONFORMATIONS; GENES; SCATTERING; X RAYS;

AMP-ACTIVATED PROTEIN KINASE (AMPK); LKB1 TUMOUR SUPPRESSOR PROTEIN KINASE; PEUTZ-JEGHERS SYNDROME (PJS); SMALL-ANGLE X-RAY SCATTERING ANALYSIS (SAXS ANALYSIS); UBIQUITINATION;

ENZYMES;

ADAPTOR PROTEIN; BRSK ENZYME; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ISOENZYME; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; POLYUBIQUITIN; PROTEIN KINASE LKB1; PROTEIN MARK2; PROTEIN MO25; PROTEIN SIK; PROTEIN STRAD; SIK ENZYME; TRYPSIN; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CELL LINE; ENZYME ACTIVATION; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; UBIQUITIN;

EID: 33644994653     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051844     Document Type: Article

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