The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells but not in hepatocytes

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 302, Issue 8, 2012, Pages

  Wojtalla, Alexandra ^a,b,c   Herweck, Frank ^c   Granzow, Michaela ^a   Klein, Sabine ^a   Trebicka, Jonel ^a   Huss, Sebastian ^d   Lerner, Raissa ^e   Lutz, Beat ^e   Schildberg, Frank Alexander ^b   Knolle, Percy Alexander ^b   Sauerbruch, Tilman ^a   Singer, Manfred Vincenz ^c   Zimmer, Andreas ^b   Siegmund, Sören Volker ^b,c  

^a Department of Internal Medicine I ^*  (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Hepatic fibrosis

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CASPASE 3; CHOLESTEROL; ENDOCANNABINOID; FATTY ACID AMIDASE; GLUTATHIONE; METHYL BETA CYCLODEXTRIN; N ARACHIDONOYL DOPAMINE; REACTIVE OXYGEN METABOLITE; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL MEMBRANE; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; STELLATE CELL; SYMPATHETIC NERVE CELL;

ADENOSINE TRIPHOSPHATE; ADENOVIRIDAE; ADRENERGIC FIBERS; AMIDOHYDROLASES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; ARACHIDONIC ACIDS; BLOTTING, WESTERN; CELL DEATH; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DOPAMINE; ENDOCANNABINOIDS; ENDOTHELIAL CELLS; GANGLIA, SPINAL; HEPATIC STELLATE CELLS; HEPATOCYTES; HUMANS; KUPFFER CELLS; LIVER CIRRHOSIS; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; TYROSINE 3-MONOOXYGENASE; WOUND HEALING;

EID: 84859738156     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00241.2011     Document Type: Article

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