Pharmacology of capsaicin-, anandamide-, and N-arachidonoyl-dopamine-evoked cell death in a homogeneous transient receptor potential vanilloid subtype 1 receptor population

British Journal of Anaesthesia

Volumn 104, Issue 5, 2010, Pages 596-602

  Davies, J W ^a   Hainsworth, A H ^b,c   Guerin, C J ^d,e   Lambert, D G ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c DE MONTFORT UNIVERSITY   (United Kingdom)

^d MRC TOXICOLOGY UNIT   (United Kingdom)

^e DMBR   (Belgium)

Author keywords

Analgesics, non opioid; Apoptosis; Capsaicin; Neurotoxicity

Indexed keywords

ANANDAMIDE; CAPSAICIN; CASPASE 3; CYTOCHROME C; ICOSANOID; N ARACHIDONOYLDOPAMINE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRUCTURE; CELL VIABILITY; CHROMATIN; CYTOTOXICITY; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOCYTOCHEMISTRY; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 77951284881     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeq067     Document Type: Article

References (23)

1. Gunthorpe MJ, Chizh BA. Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway. Drug Discov Today 2009; 14: 56-67
2. Kauer JA, Gibson HE. Hot flash: TRPV channels in the brain. Trends Neurosci 2009; 32: 215-224
3. Lambert DG. Capsaicin receptor antagonists: a promising new addition to the pain clinic. Br J Anaesth 2009; 102: 153-155
4. Goswami C, Hucho T. TRPV1 expression-dependent initiation and regulation of filopodia. J Neurochem 2007; 103: 1319-1333
5. Clark N, Keeble J, Fernandes ES, et al. The transient receptor potential vanilloid 1 (TRPV1) receptor protects against the onset of sepsis after endotoxin. FASEB J 2007; 21: 3747-3755
6. Gavva NR, Bannon AW, Surapaneni S, et al. The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J Neurosci 2007; 27: 3366-3374
7. Hu DE, Easton AS, Fraser PA. TRPV1 activation results in disruption of the blood-brain barrier in the rat. Br J Pharmacol 2005; 146: 576-584
8. Gibson HE, Edwards JG, Page RS, Van Hook MJ, Kauer JA. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 2007; 57: 746-759
9. Marinelli S, Pascucci T, Bernardi G, Puglisi-Allegra S, Mercuri NB. Activation of TRPV1 in the VTA excites dopaminergic neurons and increases chemical- and noxious-induced dopamine release in the nucleus accumbens. Neuropsychopharmacology 2005; 30: 864-870
10. Marsch R, Foeller E, Rammes G, et al. Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. J Neurosci 2007; 27: 832-839
11. Goadsby PJ. Emerging therapies for migraine. Nat Clin Pract Neurol 2007; 3: 610-619
12. Cernak I, Vink R, Natale J, et al. The 'dark side' of endocannabinoids: a neurotoxic role for anandamide. J Cereb Blood Flow Metab 2004; 24: 564-578
13. Chard PS, Bleakman D, Savidge JR, Miller RJ. Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: involvement of calcium-activated proteases. Neuroscience 1995; 65: 1099-1108
14. Kim SR, Lee DY, Chung ES, Oh UT, Kim SU, Jin BK. Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro. J Neurosci 2005; 25: 662-671
15. Maccarrone M, Lorenzon T, Bari M, Melino G, Finazzi-Agro A. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. J Biol Chem 2000; 275: 31938-31945
16. Shin CY, Shin J, Kim BM, et al. Essential role of mitochondrial permeability transition in vanilloid receptor 1-dependent cell death of sensory neurons. Mol Cell Neurosci 2003; 24: 57-68
17. Shirakawa H, Yamaoka T, Sanpei K, Sasaoka H, Nakagawa T, Kaneko S. TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons. Biochem Biophys Res Commun 2008; 377: 1211-1215
18. Lam PM, Hainsworth AH, Smith GD, Owen DE, Davies J, Lambert DG. Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca(2p)](i), initiates neurotransmitter release and promotes delayed cell death. J Neurochem 2007; 102: 801-811
19. Hainsworth AH, Bhuiyan N, Green AR. The nitrone disodium 2,4-sulphophenyl-N-tert-butylnitrone (NXY-059) is without cytoprotective effect on sodium nitroprusside-induced cell death in N1E-115 neuroblastoma cells in vitro. J Cereb Blood Flow Metab 2008; 28: 24-28
20. Green DR, Kroemer G. Pharmacological manipulation of cell death: clinical applications in sight? J Clin Invest 2005; 115: 2610-2617
21. Movsesyan VA, Stoica BA, Yakovlev AG, et al. Anandamide induced cell death in primary neuronal cultures: role of calpain and caspase pathways. Cell Death Differ 2004; 11: 1121-1132
22. Macho A, Calzado MA, Muñoz-Blanco J, et al. Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium. Cell Death Differ 1999; 6: 155-165
23. Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 2008; 9: 231-241