Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells

Journal of Immunology

Volumn 184, Issue 8, 2010, Pages 4107-4114

  Schurich, Anna ^a   Berg, Martina ^a   Stabenow, Dirk ^a   Böttcher, Jan ^a   Kern, Michaela ^a   Schild, Hans Jörg ^b   Kurts, Christian ^a   Schuette, Verena ^a   Burgdorf, Sven ^a   Diehl, Linda ^a   Limmer, Andreas ^a   Knolle, Percy A ^a  

^a UNIVERSITY OF BONN   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROGRAMMED DEATH 1 LIGAND 1; T LYMPHOCYTE RECEPTOR; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS PRESENTATION; EFFECTOR CELL; ENDOTHELIUM CELL; FLOW CYTOMETRY; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LIVER SINUSOID; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS HEPATITIS; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL CYCLE G0 PHASE; COCULTURE; COMPARATIVE STUDY; CYTOLOGY; CYTOTOXICITY TEST; IMMUNOLOGY; LIVER; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE MUTANT; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN PRESENTATION; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; CROSS-PRIMING; CYTOTOXICITY TESTS, IMMUNOLOGIC; ENDOTHELIAL CELLS; G0 PHASE; IMMUNE TOLERANCE; LIVER; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OVALBUMIN;

EID: 77951573803     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902580     Document Type: Article

References (34)

1. Knolle, P. A., and G. Gerken. 2000. Local control of the immune response in the liver. Immunol. Rev. 174: 21-34.
2. Crispe, I. N. 2009. The liver as a lymphoid organ. Annu. Rev. Immunol. 27: 147-163.
3. Limmer, A., J. Ohl, C. Kurts, H. G. Ljunggren, Y. Reiss, M. Groettrup, F. Momburg, B. Arnold, and P. A. Knolle. 2000. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigenspecific T-cell tolerance. Nat. Med. 6: 1348-1354.
4. Smedsrød, B. 2004. Clearance function of scavenger endothelial cells. Comp. Hepatol. 3(Suppl 1): S22.
5. von Oppen, N., A. Schurich, S. Hegenbarth, D. Stabenow, R. Tolba, R. Weiskirchen, A. Geerts, W. Kolanus, P. Knolle, and L. Diehl. 2009. Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization. Hepatology . 49: 1664-1672.
6. Diehl, L., A. Schurich, R. Grochtmann, S. Hegenbarth, L. Chen, and P. A. Knolle. 2008. Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance. Hepatology. 47: 296-305. (Pubitemid 351171067)
7. Schwartz, R. H. 2003. T cell anergy. Annu. Rev. Immunol. 21: 305-334.
8. Lanzavecchia, A., G. Lezzi, and A. Viola. 1999. From TCR engagement to T cell activation: a kinetic view of T cell behavior. Cell 96: 1-4. (Pubitemid 29044146)
9. Rachmilewitz, J., and A. Lanzavecchia. 2002. A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding. Trends Immunol. 23: 592-595. (Pubitemid 35449098)
10. Rechtsteiner, G., T. Warger, M. Hofmann, H. G. Rammensee, H. Schild, and M. P. Radsak. 2006. Precursor frequency can compensate for lower TCR expression in T cell competition during priming in vivo. Eur. J. Immunol. 36: 2613-2623.
11. Lohse, A. W., P. A. Knolle, K. Bilo, A. Uhrig, C. Waldmann, M. Ibe, E. Schmitt, G. Gerken, and K. H. Meyer Zum Büschenfelde. 1996. Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells. Gastroenterology 110: 1175-1181.
12. Benseler, V., G. W. McCaughan, H. J. Schlitt, G. A. Bishop, D. G. Bowen, and P. Bertolino. 2007. The liver: a special case in transplantation tolerance. Semin. Liver Dis. 27: 194-213.
13. Steinman, R. M., D. Hawiger, and M. C. Nussenzweig. 2003. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21: 685-711.
14. Kawai, T., and S. Akira. 2006. Innate immune recognition of viral infection. Nat. Immunol. 7: 131-137.
15. Sumpter, T. L., M. Abe, D. Tokita, and A. W. Thomson. 2007. Dendritic cells, the liver, and transplantation. Hepatology. 46: 2021-2031.
16. Prlic, M., and M. J. Bevan. 2008. Exploring regulatory mechanisms of CD8+ T cell contraction. Proc. Natl. Acad. Sci. USA 105: 16689-16694.
17. Prlic, M., G. Hernandez-Hoyos, and M. J. Bevan. 2006. Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response. J. Exp. Med. 203: 2135-2143.
18. Kurts, C., R. M. Sutherland, G. Davey, M. Li, A. M. Lew, E. Blanas, F. R. Carbone, J. F. Miller, and W. R. Heath. 1999. CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose. Proc. Natl. Acad. Sci. USA 96: 12703-12707.
19. Schurich, A., J. P. Bottcher, S. Burgdorf, P. Penzler, S. Hegenbarth, M. Kern, A. Dolf, E. Endl, J. Schultze, E. Wiertz, et al. 2009. Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells. Hepatology . 50: 909-919.
20. Weiner, H. L., A. Friedman, A. Miller, S. J. Khoury, A. al-Sabbagh, L. Santos, M. Sayegh, R. B. Nussenblatt, D. E. Trentham, and D. A. Hafler. 1994. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12: 809-837.
21. Zajac, A. J., J. N. Blattman, K. Murali-Krishna, D. J. Sourdive, M. Suresh, J. D. Altman, and R. Ahmed. 1998. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188: 2205-2213.
22. Redmond, W. L., and L. A. Sherman. 2005. Peripheral tolerance of CD8 T lymphocytes. Immunity 22: 275-284.
23. Barber, D. L., E. J. Wherry, D. Masopust, B. Zhu, J. P. Allison, A. H. Sharpe, G. J. Freeman, and R. Ahmed. 2006. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439: 682-687.
24. Penna, A., M. Pilli, A. Zerbini, A. Orlandini, S. Mezzadri, L. Sacchelli, G. Missale, and C. Ferrari. 2007. Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection. Hepatology. 5: 588-601. (Pubitemid 46450610)
25. Kuipers, H., F. Muskens, M. Willart, D. Hijdra, F. B. van Assema, A. J. Coyle, H. C. Hoogsteden, and B. N. Lambrecht. 2006. Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4+ T cell activation. Eur. J. Immunol. 36: 2472-2482.
26. Sheppard, K. A., L. J. Fitz, J. M. Lee, C. Benander, J. A. George, J. Wooters, Y. Qiu, J. M. Jussif, L. L. Carter, C. R. Wood, and D. Chaudhary. 2004. PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS Lett. 574: 37-41.
27. van Stipdonk, M. J., G. Hardenberg, M. S. Bijker, E. E. Lemmens, N. M. Droin, D. R. Green, and S. P. Schoenberger. 2003. Dynamic programming of CD8+ T lymphocyte responses. Nat. Immunol. 4: 361-365.
28. Schluns, K. S., and L. Lefrançois. 2003. Cytokine control of memory T-cell development and survival. Nat. Rev. Immunol. 3: 269-279.
29. Knolle, P. A., E. Schmitt, S. Jin, T. Germann, R. Duchmann, S. Hegenbarth, G. Gerken, and A. W. Lohse. 1999. Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells. Gastroenterology 116: 1428-1440.
30. Klugewitz, K., F. Blumenthal-Barby, A. Schrage, P. A. Knolle, A. Hamann, and I. N. Crispe. 2002. Immunomodulatory effects of the liver: deletion of activated CD4+ effector cells and suppression of IFN-gamma-producing cells after intravenous protein immunization. J. Immunol. 169: 2407-2413. (Pubitemid 34920983)
31. Klugewitz, K., S. A. Topp, U. Dahmen, T. Kaiser, S. Sommer, E. Kury, and A. Hamann. 2002. Differentiation-dependent and subset-specific recruitment of T-helper cells into murine liver. Hepatology . 35: 568-578. (Pubitemid 34183960)
32. Janssen, E. M., E. E. Lemmens, T. Wolfe, U. Christen, M. G. von Herrath, and S. P. Schoenberger. 2003. CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature 421: 852-856.
33. Shedlock, D. J., and H. Shen. 2003. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300: 337-339. (Pubitemid 36433726)
34. Bennett, S. R., F. R. Carbone, F. Karamalis, R. A. Flavell, J. F. Miller, and W. R. Heath. 1998. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393: 478-480. (Pubitemid 28292195)