-
2
-
-
33846217750
-
Epstein-Barr virus: Evasive maneuvers in the development of PTLD
-
Snow AL, Martinez OM,. Epstein-Barr virus: Evasive maneuvers in the development of PTLD. Am J Transplant 2007: 7: 271-277.
-
(2007)
Am J Transplant
, vol.7
, pp. 271-277
-
-
Snow, A.L.1
Martinez, O.M.2
-
3
-
-
0025632892
-
Cancers complicating organ transplantation
-
Penn I,. Cancers complicating organ transplantation. N Engl J Med 1990: 323: 1767-1769.
-
(1990)
N Engl J Med
, vol.323
, pp. 1767-1769
-
-
Penn, I.1
-
5
-
-
0028877392
-
Risk factors and pathogenesis of posttransplant lymphoproliferative disorders
-
Ho M,. Risk factors and pathogenesis of posttransplant lymphoproliferative disorders. Transplant Proc 1995: 27: 38-40.
-
(1995)
Transplant Proc
, vol.27
, pp. 38-40
-
-
Ho, M.1
-
6
-
-
17844410640
-
Epstein-Barr virus-related post-transplant lymphoproliferative disease in solid organ transplant recipients, 1988-97: A Canadian multi-centre experience
-
Allen U, Hébert D, Moore D, et al., Epstein-Barr virus-related post-transplant lymphoproliferative disease in solid organ transplant recipients, 1988-97: A Canadian multi-centre experience. Pediatr Transplant 2001: 5: 198-203.
-
(2001)
Pediatr Transplant
, vol.5
, pp. 198-203
-
-
Allen, U.1
Hébert, D.2
Moore, D.3
-
7
-
-
33749254858
-
Firstline treatment with rituximab improves survival of patients with posttransplant lymphoproliferative disease (PTLD) [abstract]
-
Gonzalez-Barca E, Domingo-Domenech E, Gomez-Codina J,. Firstline treatment with rituximab improves survival of patients with posttransplant lymphoproliferative disease (PTLD) [abstract]. Blood 2004: 104: 39a.
-
(2004)
Blood
, vol.104
-
-
Gonzalez-Barca, E.1
Domingo-Domenech, E.2
Gomez-Codina, J.3
-
8
-
-
0033610627
-
Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. ASTS/ASTP EBV-PTLD Task Force and the Mayo Clinic Organized International Consensus Development Meeting
-
Paya CV, Fung JJ, Nalesnik MA, et al., Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. ASTS/ASTP EBV-PTLD Task Force and The Mayo Clinic Organized International Consensus Development Meeting. Transplantation 1999: 68: 1517-1525.
-
(1999)
Transplantation
, vol.68
, pp. 1517-1525
-
-
Paya, C.V.1
Fung, J.J.2
Nalesnik, M.A.3
-
9
-
-
42149091128
-
Incidence of PTLD in pediatric renal transplant recipients receiving basiliximab, calcineurin inhibitor, sirolimus and steroids
-
McDonald R, Smith J, Ho M,. Incidence of PTLD in pediatric renal transplant recipients receiving basiliximab, calcineurin inhibitor, sirolimus and steroids. Am J Transplant 2008: 8: 984-989.
-
(2008)
Am J Transplant
, vol.8
, pp. 984-989
-
-
McDonald, R.1
Smith, J.2
Ho, M.3
-
10
-
-
79953254320
-
Improved survival with recent post-transplant lymphoproliferative disorder (PTLD) in children with kidney transplants
-
Dharnidharka VR, Martz KL, Stablein DM, et al., Improved survival with recent post-transplant lymphoproliferative disorder (PTLD) in children with kidney transplants. Am J Transplant 2011: 11: 751-758.
-
(2011)
Am J Transplant
, vol.11
, pp. 751-758
-
-
Dharnidharka, V.R.1
Martz, K.L.2
Stablein, D.M.3
-
11
-
-
0035025775
-
Reduction in immunosuppression as initial therapy for posttransplant lymphoproliferative disorder: Analysis of prognostic variables and long-term follow-up of 42 adult patients
-
Tsai DE, Hardy CL, Tomaszewski JE, et al., Reduction in immunosuppression as initial therapy for posttransplant lymphoproliferative disorder: Analysis of prognostic variables and long-term follow-up of 42 adult patients. Transplantation 2001: 71: 1076-1088.
-
(2001)
Transplantation
, vol.71
, pp. 1076-1088
-
-
Tsai, D.E.1
Hardy, C.L.2
Tomaszewski, J.E.3
-
12
-
-
2942718772
-
Complete immunosuppressive withdrawal as a uniform approach to post-transplant lymphoproliferative disease in pediatric liver transplantation
-
Hurwitz M, Desai DM, Cox KL, et al., Complete immunosuppressive withdrawal as a uniform approach to post-transplant lymphoproliferative disease in pediatric liver transplantation. Pediatr Transplant 2004: 8: 267-272.
-
(2004)
Pediatr Transplant
, vol.8
, pp. 267-272
-
-
Hurwitz, M.1
Desai, D.M.2
Cox, K.L.3
-
13
-
-
0042090489
-
Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas
-
Nepomuceno RR, Balatoni CE, Natkunam Y, et al., Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas. Cancer Res 2003: 63: 4472-4480.
-
(2003)
Cancer Res
, vol.63
, pp. 4472-4480
-
-
Nepomuceno, R.R.1
Balatoni, C.E.2
Natkunam, Y.3
-
14
-
-
4043142865
-
Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: Results from five multicenter studies
-
Mathew T, Kreis H, Friend P,. Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: Results from five multicenter studies. Clin Transplant 2004: 18: 446-449.
-
(2004)
Clin Transplant
, vol.18
, pp. 446-449
-
-
Mathew, T.1
Kreis, H.2
Friend, P.3
-
15
-
-
0033559062
-
Treatment of Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder with foscarnet alone in an adult after simultaneous heart and renal transplantation
-
Oertel SH, Ruhnke MS, Anagnostopoulos I, et al., Treatment of Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder with foscarnet alone in an adult after simultaneous heart and renal transplantation. Transplantation 1999: 67: 765-767.
-
(1999)
Transplantation
, vol.67
, pp. 765-767
-
-
Oertel, S.H.1
Ruhnke, M.S.2
Anagnostopoulos, I.3
-
16
-
-
0035863248
-
Successful outcome with a "quintuple approach" of posttransplant lymphoproliferative disorder
-
Schaar CG, Van Der Pijl JW, Van HoekB, et al., Successful outcome with a "quintuple approach" of posttransplant lymphoproliferative disorder. Transplantation 2001: 71: 47-52.
-
(2001)
Transplantation
, vol.71
, pp. 47-52
-
-
Schaar, C.G.1
Van Der Pijl, J.W.2
Van, H.3
-
17
-
-
0034654148
-
Indications and results of chemotherapy in children with posttransplant lymphoproliferative disease after liver transplantation
-
Smets F, Vajro P, Cornu G, et al., Indications and results of chemotherapy in children with posttransplant lymphoproliferative disease after liver transplantation. Transplantation 2000: 69: 982-984.
-
(2000)
Transplantation
, vol.69
, pp. 982-984
-
-
Smets, F.1
Vajro, P.2
Cornu, G.3
-
18
-
-
27244449778
-
Low-dose chemotherapy for Epstein-Barr virus-positive post-transplantation lymphoproliferative disease in children after solid organ transplantation
-
Gross TG, Bucuvalas JC, Park JR, et al., Low-dose chemotherapy for Epstein-Barr virus-positive post-transplantation lymphoproliferative disease in children after solid organ transplantation. J Clin Oncol 2005: 23: 6481-6488.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6481-6488
-
-
Gross, T.G.1
Bucuvalas, J.C.2
Park, J.R.3
-
19
-
-
0028882437
-
Aggressive treatment for postcardiac transplant lymphoproliferation
-
Swinnen LJ, Mullen GM, Carr TJ, et al., Aggressive treatment for postcardiac transplant lymphoproliferation. Blood 1995: 86: 3333-3340.
-
(1995)
Blood
, vol.86
, pp. 3333-3340
-
-
Swinnen, L.J.1
Mullen, G.M.2
Carr, T.J.3
-
20
-
-
0141544966
-
Primary brain lymphomas after kidney transplantation: Presentation and outcome
-
Snanoudj R, Durrbach A, Leblond V, et al., Primary brain lymphomas after kidney transplantation: Presentation and outcome. Transplantation 2003: 76: 930-937.
-
(2003)
Transplantation
, vol.76
, pp. 930-937
-
-
Snanoudj, R.1
Durrbach, A.2
Leblond, V.3
-
21
-
-
84859726476
-
Treatment of recurrent post-transplant lymphoproliferative disorder (PTLD) of the central mervous system (CNS) with high-dose methotrexate (HD-MTX)
-
Twist C, Kjelson L, McKenney A, et al., Treatment of recurrent post-transplant lymphoproliferative disorder (PTLD) of the central mervous system (CNS) with high-dose methotrexate (HD-MTX). Medimond International Proceedings 2009: 111.
-
(2009)
Medimond International Proceedings
, pp. 111
-
-
Twist, C.1
Kjelson, L.2
McKenney, A.3
-
22
-
-
33645740570
-
Efficacy and safety of rituximab in B-cell post-transplantation lymphoproliferative disorders: Results of a prospective multicenter phase 2 study
-
Choquet S, Leblond V, Herbrecht R, et al., Efficacy and safety of rituximab in B-cell post-transplantation lymphoproliferative disorders: Results of a prospective multicenter phase 2 study. Blood 2006: 107: 3053-3057.
-
(2006)
Blood
, vol.107
, pp. 3053-3057
-
-
Choquet, S.1
Leblond, V.2
Herbrecht, R.3
-
23
-
-
33644891006
-
Treatment of PTLD with rituximab or chemotherapy
-
Elstrom RL, Andreadis C, Aqui NA, et al., Treatment of PTLD with rituximab or chemotherapy. Am J Transplant 2006: 6: 569-576.
-
(2006)
Am J Transplant
, vol.6
, pp. 569-576
-
-
Elstrom, R.L.1
Andreadis, C.2
Aqui, N.A.3
-
24
-
-
78349235420
-
Post-transplant lymphoproliferative disorder in children: Recent outcomes and response to dual rituximab/low-dose chemotherapy combination
-
Gupta S, Fricker FJ, González-Peralta RP, et al., Post-transplant lymphoproliferative disorder in children: Recent outcomes and response to dual rituximab/low-dose chemotherapy combination. Pediatr Transplant 2010: 14: 896-902.
-
(2010)
Pediatr Transplant
, vol.14
, pp. 896-902
-
-
Gupta, S.1
Fricker, F.J.2
González-Peralta, R.P.3
-
25
-
-
77956484551
-
Cost of paid transplantation abroad: Possible donor-origin early multiple myeloma in a renal transplant recipient treated using bortezomib
-
Solak Y, Atalay H, Anil M, et al., Cost of paid transplantation abroad: Possible donor-origin early multiple myeloma in a renal transplant recipient treated using bortezomib. Transplant Proc 2010: 42: 2813-2815.
-
(2010)
Transplant Proc
, vol.42
, pp. 2813-2815
-
-
Solak, Y.1
Atalay, H.2
Anil, M.3
-
26
-
-
0032211189
-
Anti-B-cell monoclonal antibody treatment of severe posttransplant B-lymphoproliferative disorder: Prognostic factors and long-term outcome
-
Benkerrou M, Jais JP, Leblond V, et al., Anti-B-cell monoclonal antibody treatment of severe posttransplant B-lymphoproliferative disorder: Prognostic factors and long-term outcome. Blood 1998: 92: 3137-3147.
-
(1998)
Blood
, vol.92
, pp. 3137-3147
-
-
Benkerrou, M.1
Jais, J.P.2
Leblond, V.3
-
27
-
-
34247571883
-
Salvage chemotherapy for refractory and relapsed posttransplant lymphoproliferative disorders (PTLD) after treatment with single-agent rituximab
-
Trappe R, Riess H, Babel N, et al., Salvage chemotherapy for refractory and relapsed posttransplant lymphoproliferative disorders (PTLD) after treatment with single-agent rituximab. Transplantation 2007: 83: 912-918.
-
(2007)
Transplantation
, vol.83
, pp. 912-918
-
-
Trappe, R.1
Riess, H.2
Babel, N.3
-
28
-
-
0032573751
-
Interferon-alpha treatment of posttransplant lymphoproliferative disorder in recipients of solid organ transplants
-
Davis CL, Wood BL, Sabath DE, et al., Interferon-alpha treatment of posttransplant lymphoproliferative disorder in recipients of solid organ transplants. Transplantation 1998: 66: 1770-1779.
-
(1998)
Transplantation
, vol.66
, pp. 1770-1779
-
-
Davis, C.L.1
Wood, B.L.2
Sabath, D.E.3
-
29
-
-
0030944613
-
Autologous lymphokine-activated killer cell therapy of Epstein-Barr virus-positive and -negative lymphoproliferative disorders arising in organ transplant recipients
-
Nalesnik MA, Rao AS, Furukawa H, et al., Autologous lymphokine-activated killer cell therapy of Epstein-Barr virus-positive and -negative lymphoproliferative disorders arising in organ transplant recipients. Transplantation 1997: 63: 1200-1205.
-
(1997)
Transplantation
, vol.63
, pp. 1200-1205
-
-
Nalesnik, M.A.1
Rao, A.S.2
Furukawa, H.3
-
30
-
-
74049116602
-
Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease
-
Brewin J, Mancao C, Straathof K, et al., Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease. Blood 2009: 114: 4792-4803.
-
(2009)
Blood
, vol.114
, pp. 4792-4803
-
-
Brewin, J.1
Mancao, C.2
Straathof, K.3
-
31
-
-
0033569941
-
Extracorporeal photochemotherapy for Epstein-Barr virus-associated lymphoma after lung transplantation
-
Schoch OD, Boehler A, Speich R, et al., Extracorporeal photochemotherapy for Epstein-Barr virus-associated lymphoma after lung transplantation. Transplantation 1999: 68: 1056-1058.
-
(1999)
Transplantation
, vol.68
, pp. 1056-1058
-
-
Schoch, O.D.1
Boehler, A.2
Speich, R.3
-
32
-
-
0034636055
-
The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders
-
Majewski M, Korecka M, Kossev P, et al., The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders. Proc Natl Acad Sci USA 2000: 97: 4285-4290.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4285-4290
-
-
Majewski, M.1
Korecka, M.2
Kossev, P.3
-
33
-
-
0035496101
-
Epstein-Barr virus: Exploiting the immune system
-
Thorley-Lawson DA,. Epstein-Barr virus: Exploiting the immune system. Nat Rev Immunol 2001: 1: 75-82.
-
(2001)
Nat Rev Immunol
, vol.1
, pp. 75-82
-
-
Thorley-Lawson, D.A.1
-
34
-
-
0033696976
-
The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell
-
Babcock GJ, Hochberg D, Thorley-Lawson AD,. The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell. Immunity 2000: 13: 497-506.
-
(2000)
Immunity
, vol.13
, pp. 497-506
-
-
Babcock, G.J.1
Hochberg, D.2
Thorley-Lawson, A.D.3
-
35
-
-
0028970289
-
Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases
-
Miller CL, Burkhardt AL, Lee JH, et al., Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. Immunity 1995: 2: 155-166.
-
(1995)
Immunity
, vol.2
, pp. 155-166
-
-
Miller, C.L.1
Burkhardt, A.L.2
Lee, J.H.3
-
36
-
-
0032169313
-
Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals
-
Caldwell RG, Wilson JB, Anderson SJ, et al., Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals. Immunity 1998: 9: 405-411.
-
(1998)
Immunity
, vol.9
, pp. 405-411
-
-
Caldwell, R.G.1
Wilson, J.B.2
Anderson, S.J.3
-
37
-
-
0035126502
-
Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR
-
Dykstra ML, Longnecker R, Pierce SK,. Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR. Immunity 2001: 14: 57-67.
-
(2001)
Immunity
, vol.14
, pp. 57-67
-
-
Dykstra, M.L.1
Longnecker, R.2
Pierce, S.K.3
-
38
-
-
0032536860
-
Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor
-
Kilger E, Kieser A, Baumann M, et al., Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor. EMBO J 1998: 17: 1700-1709.
-
(1998)
EMBO J
, vol.17
, pp. 1700-1709
-
-
Kilger, E.1
Kieser, A.2
Baumann, M.3
-
39
-
-
0034710968
-
Tonsillar memory B cells, latently infected with Epstein-Barr virus, express the restricted pattern of latent genes previously found only in Epstein-Barr virus-associated tumors
-
Babcock GJ, Thorley-Lawson DA,. Tonsillar memory B cells, latently infected with Epstein-Barr virus, express the restricted pattern of latent genes previously found only in Epstein-Barr virus-associated tumors. Proc Natl Acad Sci USA 2000: 97: 12250-12255.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 12250-12255
-
-
Babcock, G.J.1
Thorley-Lawson, D.A.2
-
40
-
-
0022309824
-
An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells
-
Wang D, Liebowitz D, Kieff E,. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 1985: 43: 831-840.
-
(1985)
Cell
, vol.43
, pp. 831-840
-
-
Wang, D.1
Liebowitz, D.2
Kieff, E.3
-
41
-
-
0027449255
-
Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation
-
Kaye KM, Izumi KM, Kieff E,. Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proc Natl Acad Sci USA 1993: 90: 9150-9154.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 9150-9154
-
-
Kaye, K.M.1
Izumi, K.M.2
Kieff, E.3
-
42
-
-
0028878977
-
The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
-
Mosialos G, Birkenbach M, Yalamanchili R, et al., The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 1995: 80: 389-399.
-
(1995)
Cell
, vol.80
, pp. 389-399
-
-
Mosialos, G.1
Birkenbach, M.2
Yalamanchili, R.3
-
43
-
-
0030716307
-
Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule
-
Gires O, Zimber-Strobl U, Gonnella R, et al., Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule. EMBO J 1997: 16: 6131-6140.
-
(1997)
EMBO J
, vol.16
, pp. 6131-6140
-
-
Gires, O.1
Zimber-Strobl, U.2
Gonnella, R.3
-
44
-
-
0033536591
-
Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses
-
Uchida J, Yasui T, Takaoka-Shichijo Y, et al., Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses. Science 1999: 286: 300-303.
-
(1999)
Science
, vol.286
, pp. 300-303
-
-
Uchida, J.1
Yasui, T.2
Takaoka-Shichijo, Y.3
-
45
-
-
0025772343
-
Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death
-
Henderson S, Rowe M, Gregory C, et al., Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell 1991: 65: 1107-1115.
-
(1991)
Cell
, vol.65
, pp. 1107-1115
-
-
Henderson, S.1
Rowe, M.2
Gregory, C.3
-
46
-
-
0026465540
-
The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B
-
Laherty CD, Hu HM, Opipari AW, et al., The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B. J Biol Chem 1992: 267: 24157-24160.
-
(1992)
J Biol Chem
, vol.267
, pp. 24157-24160
-
-
Laherty, C.D.1
Hu, H.M.2
Opipari, A.W.3
-
47
-
-
33747803613
-
EBV can protect latently infected B cell lymphomas from death receptor-induced apoptosis
-
Snow AL, Lambert SL, Natkunam Y, et al., EBV can protect latently infected B cell lymphomas from death receptor-induced apoptosis. J Immunol 2006: 177: 3283-3293.
-
(2006)
J Immunol
, vol.177
, pp. 3283-3293
-
-
Snow, A.L.1
Lambert, S.L.2
Natkunam, Y.3
-
48
-
-
40049106893
-
Latent membrane protein 1 of EBV activates phosphatidylinositol 3-kinase to induce production of IL-10
-
Lambert SL, Martinez OM,. Latent membrane protein 1 of EBV activates phosphatidylinositol 3-kinase to induce production of IL-10. J Immunol 2007: 179: 8225-8234.
-
(2007)
J Immunol
, vol.179
, pp. 8225-8234
-
-
Lambert, S.L.1
Martinez, O.M.2
-
49
-
-
0029956392
-
Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: Role in NF-kappaB activation
-
Devergne O, Hatzivassiliou E, Izumi KM, et al., Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: Role in NF-kappaB activation. Mol Cell Biol 1996: 16: 7098-7108.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 7098-7108
-
-
Devergne, O.1
Hatzivassiliou, E.2
Izumi, K.M.3
-
50
-
-
0032901776
-
Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2
-
Eliopoulos AG, Blake SM, Floettmann JE, et al., Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2. J Virol 1999: 73: 1023-1035.
-
(1999)
J Virol
, vol.73
, pp. 1023-1035
-
-
Eliopoulos, A.G.1
Blake, S.M.2
Floettmann, J.E.3
-
51
-
-
0033153426
-
Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins
-
Gires O, Kohlhuber F, Kilger E, et al., Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins. EMBO J 1999: 18: 3064-3073.
-
(1999)
EMBO J
, vol.18
, pp. 3064-3073
-
-
Gires, O.1
Kohlhuber, F.2
Kilger, E.3
-
52
-
-
0028987479
-
Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus
-
Mitchell T, Sugden B,. Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus. J Virol 1995: 69: 2968-2976.
-
(1995)
J Virol
, vol.69
, pp. 2968-2976
-
-
Mitchell, T.1
Sugden, B.2
-
53
-
-
0037423201
-
Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling
-
Dawson CW, Tramountanis G, Eliopoulos AG, et al., Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling. J Biol Chem 2003: 278: 3694-3704.
-
(2003)
J Biol Chem
, vol.278
, pp. 3694-3704
-
-
Dawson, C.W.1
Tramountanis, G.2
Eliopoulos, A.G.3
-
54
-
-
27144542052
-
Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K
-
Mainou BA, Everly DNJ, Raab-Traub N,. Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K. Oncogene 2005: 24: 6917-6924.
-
(2005)
Oncogene
, vol.24
, pp. 6917-6924
-
-
Mainou, B.A.1
Everly, D.N.J.2
Raab-Traub, N.3
-
55
-
-
0033981052
-
Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EmuLMP2A transgenic mice
-
Caldwell RG, Brown RC, Longnecker R,. Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EmuLMP2A transgenic mice. J Virol 2000: 74: 1101-1113.
-
(2000)
J Virol
, vol.74
, pp. 1101-1113
-
-
Caldwell, R.G.1
Brown, R.C.2
Longnecker, R.3
-
56
-
-
0033756107
-
Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt
-
Scholle F, Bendt KM, Raab-Traub N,. Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt. J Virol 2000: 74: 10681-10689.
-
(2000)
J Virol
, vol.74
, pp. 10681-10689
-
-
Scholle, F.1
Bendt, K.M.2
Raab-Traub, N.3
-
57
-
-
34948821852
-
Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival
-
Mancao C, Hammerschmidt W,. Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival. Blood 2007: 110: 3715-3721.
-
(2007)
Blood
, vol.110
, pp. 3715-3721
-
-
Mancao, C.1
Hammerschmidt, W.2
-
58
-
-
13444254201
-
Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling
-
Morrison JA, Raab-Traub N,. Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling. J Virol 2005: 79: 2375-2382.
-
(2005)
J Virol
, vol.79
, pp. 2375-2382
-
-
Morrison, J.A.1
Raab-Traub, N.2
-
59
-
-
0030754766
-
The immunoreceptor tyrosine-based activation motif of Epstein-Barr virus LMP2A is essential for blocking BCR-mediated signal transduction
-
Fruehling S, Longnecker R,. The immunoreceptor tyrosine-based activation motif of Epstein-Barr virus LMP2A is essential for blocking BCR-mediated signal transduction. Virology 1997: 235: 241-251.
-
(1997)
Virology
, vol.235
, pp. 241-251
-
-
Fruehling, S.1
Longnecker, R.2
-
60
-
-
0034761377
-
C-terminal domain of the Epstein-Barr virus LMP2A membrane protein contains a clustering signal
-
Matskova L, Ernberg I, Pawson T, et al., C-terminal domain of the Epstein-Barr virus LMP2A membrane protein contains a clustering signal. J Virol 2001: 75: 10941-10949.
-
(2001)
J Virol
, vol.75
, pp. 10941-10949
-
-
Matskova, L.1
Ernberg, I.2
Pawson, T.3
-
61
-
-
0030025859
-
Regulation of Epstein-Barr virus latency by latent membrane protein 2
-
Longnecker R, Miller CL,. Regulation of Epstein-Barr virus latency by latent membrane protein 2. Trends Microbiol 1996: 4: 38-42.
-
(1996)
Trends Microbiol
, vol.4
, pp. 38-42
-
-
Longnecker, R.1
Miller, C.L.2
-
62
-
-
0028088994
-
An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking
-
Miller CL, Lee JH, Kieff E, et al., An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking. Proc Natl Acad Sci USA 1994: 91: 772-776.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 772-776
-
-
Miller, C.L.1
Lee, J.H.2
Kieff, E.3
-
63
-
-
9644279753
-
Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway
-
Portis T, Longnecker R,. Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway. Oncogene 2004: 23: 8619-8628.
-
(2004)
Oncogene
, vol.23
, pp. 8619-8628
-
-
Portis, T.1
Longnecker, R.2
-
64
-
-
0033808329
-
The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo
-
Merchant M, Caldwell RG, Longnecker R,. The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo. J Virol 2000: 74: 9115-9124.
-
(2000)
J Virol
, vol.74
, pp. 9115-9124
-
-
Merchant, M.1
Caldwell, R.G.2
Longnecker, R.3
-
65
-
-
52949107952
-
Adoptive cell therapy against EBV-related malignancies: A survey of clinical results
-
Merlo A, Turrini R, Dolcetti R, et al., Adoptive cell therapy against EBV-related malignancies: A survey of clinical results. Expert Opin Biol Ther 2008: 8: 1265-1294.
-
(2008)
Expert Opin Biol Ther
, vol.8
, pp. 1265-1294
-
-
Merlo, A.1
Turrini, R.2
Dolcetti, R.3
-
66
-
-
33645310982
-
ITAM-mediated tonic signalling through pre-BCR and BCR complexes
-
Monroe JG,. ITAM-mediated tonic signalling through pre-BCR and BCR complexes. Nat Rev Immunol 2006: 6: 283-294.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 283-294
-
-
Monroe, J.G.1
-
67
-
-
0342711256
-
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
-
Lam KP, Kuhn R, Rajewsky K,. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 1997: 90: 1073-1083.
-
(1997)
Cell
, vol.90
, pp. 1073-1083
-
-
Lam, K.P.1
Kuhn, R.2
Rajewsky, K.3
-
68
-
-
2942582913
-
Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer
-
Kraus M, Alimzhanov MB, Rajewsky N, et al., Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell 2004: 117: 787-800.
-
(2004)
Cell
, vol.117
, pp. 787-800
-
-
Kraus, M.1
Alimzhanov, M.B.2
Rajewsky, N.3
-
69
-
-
0037143733
-
Deletion of immunoglobulin beta in developing B cells leads to cell death
-
Meffre E, Nussenzweig MC,. Deletion of immunoglobulin beta in developing B cells leads to cell death. Proc Natl Acad Sci USA 2002: 99: 11334-11339.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11334-11339
-
-
Meffre, E.1
Nussenzweig, M.C.2
-
70
-
-
16844381831
-
Mechanisms of B-cell lymphoma pathogenesis
-
Kuppers R,. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005: 5: 251-262.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 251-262
-
-
Kuppers, R.1
-
71
-
-
33646492861
-
Cutting edge: Constitutive B cell receptor signaling is critical for basal growth of B lymphoma
-
Gururajan M, Jennings CD, Bondada S,. Cutting edge: Constitutive B cell receptor signaling is critical for basal growth of B lymphoma. J Immunol 2006: 176: 5715-5719.
-
(2006)
J Immunol
, vol.176
, pp. 5715-5719
-
-
Gururajan, M.1
Jennings, C.D.2
Bondada, S.3
-
72
-
-
80054805087
-
Syk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of Epstein-Barr virus+ (EBV+) B cell lymphomas
-
Hatton O, Phillips LK, Vaysberg M, et al., Syk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of Epstein-Barr virus+ (EBV+) B cell lymphomas. J Biol Chem 2011: 286: 37368-37378.
-
(2011)
J Biol Chem
, vol.286
, pp. 37368-37378
-
-
Hatton, O.1
Phillips, L.K.2
Vaysberg, M.3
-
73
-
-
41349110211
-
SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma
-
Chen L, Monti S, Juszczynski P, et al., SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood 2008: 111: 2230-2237.
-
(2008)
Blood
, vol.111
, pp. 2230-2237
-
-
Chen, L.1
Monti, S.2
Juszczynski, P.3
-
74
-
-
67650458526
-
Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia
-
Buchner M, Fuchs S, Prinz G, et al., Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia. Cancer Res 2009: 69: 5424-5432.
-
(2009)
Cancer Res
, vol.69
, pp. 5424-5432
-
-
Buchner, M.1
Fuchs, S.2
Prinz, G.3
-
75
-
-
77952886100
-
Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia
-
Buchner M, Baer C, Prinz G, et al., Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia. Blood 2010: 115: 4497-4506.
-
(2010)
Blood
, vol.115
, pp. 4497-4506
-
-
Buchner, M.1
Baer, C.2
Prinz, G.3
-
76
-
-
70349237504
-
B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406
-
Quiroga MP, Balakrishnan K, Kurtova AV, et al., B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood 2009: 114: 1029-1037.
-
(2009)
Blood
, vol.114
, pp. 1029-1037
-
-
Quiroga, M.P.1
Balakrishnan, K.2
Kurtova, A.V.3
-
77
-
-
63849309885
-
Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target
-
Young RM, Hardy IR, Clarke RL, et al., Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target. Blood 2009: 113: 2508-2516.
-
(2009)
Blood
, vol.113
, pp. 2508-2516
-
-
Young, R.M.1
Hardy, I.R.2
Clarke, R.L.3
-
78
-
-
78649759107
-
The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the EÎ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling
-
Suljagic M, Longo PG, Bennardo S, et al., The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the EÎ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling. Blood 2010: 116: 4894-4905.
-
(2010)
Blood
, vol.116
, pp. 4894-4905
-
-
Suljagic, M.1
Longo, P.G.2
Bennardo, S.3
-
79
-
-
77951002653
-
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
-
Friedberg JW, Sharman J, Sweetenham J, et al., Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood 2010: 115: 2578-2585.
-
(2010)
Blood
, vol.115
, pp. 2578-2585
-
-
Friedberg, J.W.1
Sharman, J.2
Sweetenham, J.3
-
80
-
-
0034680108
-
The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells
-
Coopman PJ, Do MT, Barth M, et al., The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature 2000: 406: 742-747.
-
(2000)
Nature
, vol.406
, pp. 742-747
-
-
Coopman, P.J.1
Do, M.T.2
Barth, M.3
-
81
-
-
33746671852
-
The Syk tyrosine kinase: A new negative regulator in tumor growth and progression
-
Coopman PJ, Mueller SC,. The Syk tyrosine kinase: A new negative regulator in tumor growth and progression. Cancer Lett 2006: 241: 159-173.
-
(2006)
Cancer Lett
, vol.241
, pp. 159-173
-
-
Coopman, P.J.1
Mueller, S.C.2
-
82
-
-
38849136014
-
Sixteen-kinase gene expression identifies luminal breast cancers with poor prognosis
-
Finetti P, Cervera N, Charafe-Jauffret E, et al., Sixteen-kinase gene expression identifies luminal breast cancers with poor prognosis. Cancer Res 2008: 68: 767-776.
-
(2008)
Cancer Res
, vol.68
, pp. 767-776
-
-
Finetti, P.1
Cervera, N.2
Charafe-Jauffret, E.3
-
83
-
-
33746910265
-
Concordance among gene-expression-based predictors for breast cancer
-
Fan C, Oh DS, Wessels L, et al., Concordance among gene-expression-based predictors for breast cancer. N Engl J Med 2006: 355: 560-569.
-
(2006)
N Engl J Med
, vol.355
, pp. 560-569
-
-
Fan, C.1
Oh, D.S.2
Wessels, L.3
-
84
-
-
18244409687
-
Gene expression profiling predicts clinical outcome of breast cancer
-
Veer LV, Dai H, Van De Vijver M, et al., Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002: 415: 530-536.
-
(2002)
Nature
, vol.415
, pp. 530-536
-
-
Veer, L.V.1
Dai, H.2
Van De Vijver, M.3
-
85
-
-
0031661310
-
Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein-Barr virus latency
-
Fruehling S, Swart R, Dolwick KM, et al., Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein-Barr virus latency. J Virol 1998: 72: 7796-7806.
-
(1998)
J Virol
, vol.72
, pp. 7796-7806
-
-
Fruehling, S.1
Swart, R.2
Dolwick, K.M.3
-
86
-
-
19944428353
-
Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
-
Lombardo LJ, Lee FY, Chen P, et al., Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 2004: 47: 6658-6661.
-
(2004)
J Med Chem
, vol.47
, pp. 6658-6661
-
-
Lombardo, L.J.1
Lee, F.Y.2
Chen, P.3
-
87
-
-
53049104807
-
Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer
-
Chang Q, Jorgensen C, Pawson T, et al., Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer. Br J Cancer 2008: 99: 1074-1082.
-
(2008)
Br J Cancer
, vol.99
, pp. 1074-1082
-
-
Chang, Q.1
Jorgensen, C.2
Pawson, T.3
-
88
-
-
67449156112
-
Antitumor effects and biomarkers of activity of AZD0530, a Src inhibitor, in pancreatic cancer
-
Rajeshkumar NV, Tan AC, De Oliveira E, et al., Antitumor effects and biomarkers of activity of AZD0530, a Src inhibitor, in pancreatic cancer. Clin Cancer Res 2009: 15: 4138-4146.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4138-4146
-
-
Rajeshkumar, N.V.1
Tan, A.C.2
De Oliveira, E.3
-
89
-
-
58249103866
-
Aberrant activation of androgen receptor in a new neuropeptide-autocrine model of androgen-insensitive prostate cancer
-
Yang JC, Ok J-H, Busby JE, et al., Aberrant activation of androgen receptor in a new neuropeptide-autocrine model of androgen-insensitive prostate cancer. Cancer Res 2009: 69: 151-160.
-
(2009)
Cancer Res
, vol.69
, pp. 151-160
-
-
Yang, J.C.1
Ok, J.-H.2
Busby, J.E.3
-
90
-
-
20444500171
-
SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models
-
Golas JM, Lucas J, Etienne C, et al., SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res 2005: 65: 5358-5364.
-
(2005)
Cancer Res
, vol.65
, pp. 5358-5364
-
-
Golas, J.M.1
Lucas, J.2
Etienne, C.3
-
91
-
-
67649366381
-
Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts
-
Messersmith WA, Rajeshkumar NV, Tan AC, et al., Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts. Mol Cancer Ther 2009: 8: 1484-1493.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1484-1493
-
-
Messersmith, W.A.1
Rajeshkumar, N.V.2
Tan, A.C.3
-
92
-
-
77956042544
-
SRC: A century of science brought to the clinic
-
Aleshin A, Finn RS,. SRC: A century of science brought to the clinic. Neoplasia 2010: 12: 599-607.
-
(2010)
Neoplasia
, vol.12
, pp. 599-607
-
-
Aleshin, A.1
Finn, R.S.2
-
93
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman JA, Luo J, Cantley LC,. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006: 7: 606-619.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
94
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, et al., High frequency of mutations of the PIK3CA gene in human cancers. Science 2004: 304: 554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
95
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning BD, Cantley LC,. AKT/PKB signaling: Navigating downstream. Cell 2007: 129: 1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
97
-
-
79957983577
-
Targeting the PI3K/Akt/mTOR pathway - Beyond rapalogs
-
Markman B, Dienstmann R, Tabernero J,. Targeting the PI3K/Akt/mTOR pathway-beyond rapalogs. Oncotarget 2010: 1: 530-543.
-
(2010)
Oncotarget
, vol.1
, pp. 530-543
-
-
Markman, B.1
Dienstmann, R.2
Tabernero, J.3
-
98
-
-
58249120506
-
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance
-
Ihle NT, Lemos R, Wipf P, et al., Mutations in the phosphatidylinositol- 3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Res 2009: 69: 143-150.
-
(2009)
Cancer Res
, vol.69
, pp. 143-150
-
-
Ihle, N.T.1
Lemos, R.2
Wipf, P.3
-
99
-
-
79952686437
-
Final results from a phase I, dose-escalation study of PX-866, an irreversible, pan-isoform inhibitor of PI3 kinase
-
3089
-
Jimeno A, Herbst RS, Falchook GS, et al., Final results from a phase I, dose-escalation study of PX-866, an irreversible, pan-isoform inhibitor of PI3 kinase. J Clin Oncol 2010: 28 (15 Suppl): Abstract 3089.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Jimeno, A.1
Herbst, R.S.2
Falchook, G.S.3
-
100
-
-
76749171098
-
Phase i dose-escalation study of XL147, a PI3K inhibitor administered orally to patients with solid tumors
-
Abstract 3500
-
Shapiro G, Kwak E, Baselga J, et al., Phase I dose-escalation study of XL147, a PI3K inhibitor administered orally to patients with solid tumors. J Clin Oncol 2009: 27 (146 Suppl): Abstract 3500.
-
(2009)
J Clin Oncol
, vol.27
, Issue.146 SUPPL.
-
-
Shapiro, G.1
Kwak, E.2
Baselga, J.3
-
101
-
-
84859733069
-
NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials, shows significant antitumor activity in xenograft and primary tumor models
-
2010 Apr 17-21; Washington, DC; Philadelphia, PA: AACR, Abstract 4497
-
Maira M, Menezes D, Pecchi S, et al., NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials, shows significant antitumor activity in xenograft and primary tumor models. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC; Philadelphia, PA: AACR, 2010. Abstract 4497.
-
(2010)
Proceedings of the 101st Annual Meeting of the American Association for Cancer Research
-
-
Maira, M.1
Menezes, D.2
Pecchi, S.3
-
102
-
-
84859733072
-
Biological characterization of NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials
-
2010 Apr 17-21; Washington, DC; Philadelphia, PA: AACR, Abstract 4498
-
Voliva CF, Pecchi S, Burger M, et al., Biological characterization of NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC; Philadelphia, PA: AACR, 2010. Abstract 4498.
-
(2010)
Proceedings of the 101st Annual Meeting of the American Association for Cancer Research
-
-
Voliva, C.F.1
Pecchi, S.2
Burger, M.3
-
103
-
-
77956573681
-
A first-in-human phase i study of BKM120, an oral pan-class i PI3K inhibitor, in patients (pts) with advanced solid tumors
-
Abstract 3003
-
Baselga J, De Jonge MJ, Rodon J, et al., A first-in-human phase I study of BKM120, an oral pan-class I PI3K inhibitor, in patients (pts) with advanced solid tumors. J Clin Oncol 2010: 28 (15 Suppl): Abstract 3003.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Baselga, J.1
De Jonge, M.J.2
Rodon, J.3
-
104
-
-
77956572401
-
A first-in-human phase i study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumors
-
Abstract 2541
-
Von Hoff DD, Lorusso P, Tibes R, et al., A first-in-human phase I study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumors. J Clin Oncol 2010: 28 (15 Suppl): Abstract 2541.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Von Hoff, D.D.1
Lorusso, P.2
Tibes, R.3
-
105
-
-
77957201023
-
Phosphatidylinositol 3-kinase-Î inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
-
Herman SEM, Gordon AL, Wagner AJ, et al., Phosphatidylinositol 3-kinase-Î inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood 2010: 116: 2078-2088.
-
(2010)
Blood
, vol.116
, pp. 2078-2088
-
-
Herman, S.E.M.1
Gordon, A.L.2
Wagner, A.J.3
-
106
-
-
78751553221
-
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
-
Lannutti BJ, Meadows SA, Herman SEM, et al., CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood 2011: 117: 591-594.
-
(2011)
Blood
, vol.117
, pp. 591-594
-
-
Lannutti, B.J.1
Meadows, S.A.2
Herman, S.E.M.3
-
107
-
-
77957203544
-
Interim results from a phase i study of CAL-101, a selective oral inhibitor of phosphatidylinositol 3-kinase p110d isoform, in patients with relapsed or refractory hematologic malignancies
-
Abstract 3032
-
Furman RR, Byrd JC, Flinn IW, et al., Interim results from a phase I study of CAL-101, a selective oral inhibitor of phosphatidylinositol 3-kinase p110d isoform, in patients with relapsed or refractory hematologic malignancies. J Clin Oncol 2010: 28 (15 Suppl): Abstract 3032.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Furman, R.R.1
Byrd, J.C.2
Flinn, I.W.3
-
108
-
-
77954615408
-
MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo
-
Hirai H, Sootome H, Nakatsuru Y, et al., MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Ther 2010: 9: 1956-1967.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1956-1967
-
-
Hirai, H.1
Sootome, H.2
Nakatsuru, Y.3
-
109
-
-
77956587792
-
First-in-class phase i trial of a selective Akt inhibitor, MK2206 (MK), evaluating alternate day (QOD) and once weekly (QW) doses in advanced cancer patients (pts) with evidence of target modulation and antitumor activity
-
Abstract 3009
-
Yap TA, Patnaik A, Fearen I, et al., First-in-class phase I trial of a selective Akt inhibitor, MK2206 (MK), evaluating alternate day (QOD) and once weekly (QW) doses in advanced cancer patients (pts) with evidence of target modulation and antitumor activity. J Clin Oncol 2010: 28 (15 Suppl): Abstract 3009.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Yap, T.A.1
Patnaik, A.2
Fearen, I.3
-
110
-
-
39149123820
-
A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity
-
Garlich JR, De P, Dey N, et al., A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res 2008: 68: 206-215.
-
(2008)
Cancer Res
, vol.68
, pp. 206-215
-
-
Garlich, J.R.1
De, P.2
Dey, N.3
-
111
-
-
80054751392
-
Phase i study of the multikinase prodrug SF1126 in solid tumors and B-cell malignancies
-
Abstract 3015
-
Mahadevan D, Chiorean EG, Harris W, et al., Phase I study of the multikinase prodrug SF1126 in solid tumors and B-cell malignancies. J Clin Oncol 2011: 29: Abstract 3015.
-
(2011)
J Clin Oncol
, vol.29
-
-
Mahadevan, D.1
Chiorean, E.G.2
Harris, W.3
-
112
-
-
51049109033
-
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
-
Maira S-M, Stauffer F, Brueggen J, et al., Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 2008: 7: 1851-1863.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1851-1863
-
-
Maira, S.-M.1
Stauffer, F.2
Brueggen, J.3
-
113
-
-
51849111524
-
NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
-
Serra V, Markman B, Scaltriti M, et al., NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 2008: 68: 8022-8030.
-
(2008)
Cancer Res
, vol.68
, pp. 8022-8030
-
-
Serra, V.1
Markman, B.2
Scaltriti, M.3
-
114
-
-
77956602070
-
First-in-human phase i study of the oral PI3K inhibitor BEZ235 in patients (pts) with advanced solid tumors
-
Abstract 3005
-
Burris H, Rodon J, Sharma S, et al., First-in-human phase I study of the oral PI3K inhibitor BEZ235 in patients (pts) with advanced solid tumors. J Clin Oncol 2010: 28 (15 Suppl): Abstract 3005.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Burris, H.1
Rodon, J.2
Sharma, S.3
-
115
-
-
79953052206
-
Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide
-
Prasad G, Sottero T, Yang X, et al., Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide. Neuro Oncol 2011: 13: 384-392.
-
(2011)
Neuro Oncol
, vol.13
, pp. 384-392
-
-
Prasad, G.1
Sottero, T.2
Yang, X.3
-
116
-
-
77957104533
-
A phase i dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765 (SAR245409), a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced malignancies
-
Abstract 3030
-
Brana I, Lorusso P, Baselga J, et al., A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765 (SAR245409), a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced malignancies. J Clin Oncol 2010: 28 (15 Suppl): Abstract 3030.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Brana, I.1
Lorusso, P.2
Baselga, J.3
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