-
2
-
-
77951776829
-
Alzheimer's disease: Strategies for disease modification
-
Citron M., Alzheimer's disease: strategies for disease modification Nature Reviews Drug Discovery 2010 9 5 387 398
-
(2010)
Nature Reviews Drug Discovery
, vol.9
, Issue.5
, pp. 387-398
-
-
Citron, M.1
-
3
-
-
70350153272
-
The chemistry of Alzheimer's disease
-
Rauk A., The chemistry of Alzheimer's disease Chemical Society Reviews 2009 38 9 2698 2715
-
(2009)
Chemical Society Reviews
, vol.38
, Issue.9
, pp. 2698-2715
-
-
Rauk, A.1
-
4
-
-
70350686620
-
Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease
-
Scott L. E., Orvig C., Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease Chemical Reviews 2009 109 10 4885 4910
-
(2009)
Chemical Reviews
, vol.109
, Issue.10
, pp. 4885-4910
-
-
Scott, L.E.1
Orvig, C.2
-
5
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy J. A., Higgins G. A., Alzheimer's disease: the amyloid cascade hypothesis Science 1992 256 5054 184 185
-
(1992)
Science
, vol.256
, Issue.5054
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
6
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J., Selkoe D. J., The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 2002 297 5580 353 356
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
7
-
-
4043088415
-
The role of beta amyloid in Alzheimer's disease: Still a cause of everything or the only one who got caught?
-
Verdile G., Fuller S., Atwood C. S., Laws S. M., Gandy S. E., Martins R. N., The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught? Pharmacological Research 2004 50 4 397 409
-
(2004)
Pharmacological Research
, vol.50
, Issue.4
, pp. 397-409
-
-
Verdile, G.1
Fuller, S.2
Atwood, C.S.3
Laws, S.M.4
Gandy, S.E.5
Martins, R.N.6
-
8
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid -peptide
-
Haass C., Selkoe D. J., Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid -peptide Nature Reviews Molecular Cell Biology 2007 8 2 101 112
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.2
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
9
-
-
49149124343
-
Amyloid- protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar G. M., Li S., Mehta T. H., Garcia-Munoz A., Shepardson N. E., Smith I., Brett F. M., Farrell M. A., Rowan M. J., Lemere C. A., Regan C. M., Walsh D. M., Sabatini B. L., Selkoe D. J., Amyloid- protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory Nature Medicine 2008 14 8 837 842
-
(2008)
Nature Medicine
, vol.14
, Issue.8
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
Brett, F.M.7
Farrell, M.A.8
Rowan, M.J.9
Lemere, C.A.10
Regan, C.M.11
Walsh, D.M.12
Sabatini, B.L.13
Selkoe, D.J.14
-
10
-
-
3242737470
-
Challenging the amyloid cascade hypothesis: Senile plaques and amyloid- as protective adaptations to Alzheimer disease
-
Lee H.-G., Casadesus G., Zhu X., Takeda A., Perry G., Smith M. A., Challenging the amyloid cascade hypothesis: senile plaques and amyloid- as protective adaptations to Alzheimer disease Annals of the New York Academy of Sciences 2004 1019 1 4
-
(2004)
Annals of the New York Academy of Sciences
, vol.1019
, pp. 1-4
-
-
Lee, H.-G.1
Casadesus, G.2
Zhu, X.3
Takeda, A.4
Perry, G.5
Smith, M.A.6
-
11
-
-
77949830350
-
The Alzheimer's disease-associated amyloid -protein is an antimicrobial peptide
-
ARTICLE NO. E9505
-
Soscia S. J., Kirby J. E., Washicosky K. J., Tucker S. M., Ingelsson M., Hyman B., Burton M. A., Goldstein L. E., Duong S., Tanzi R. E., Moir R. D., The Alzheimer's disease-associated amyloid -protein is an antimicrobial peptide PLoS ONE 2010 5 3, article no. e9505
-
(2010)
PLoS ONE
, vol.5
, Issue.3
-
-
Soscia, S.J.1
Kirby, J.E.2
Washicosky, K.J.3
Tucker, S.M.4
Ingelsson, M.5
Hyman, B.6
Burton, M.A.7
Goldstein, L.E.8
Duong, S.9
Tanzi, R.E.10
Moir, R.D.11
-
12
-
-
77954132249
-
Amyloid- -induced neuronal dysfunction in Alzheimer's disease: From synapses toward neural networks
-
Palop J. J., Mucke L., Amyloid- -induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks Nature Neuroscience 2010 13 7 812 818
-
(2010)
Nature Neuroscience
, vol.13
, Issue.7
, pp. 812-818
-
-
Palop, J.J.1
Mucke, L.2
-
13
-
-
20444440369
-
Metals and amyloid- in Alzheimer's disease
-
Maynard C. J., Bush A. I., Masters C. L., Cappai R., Li Q.-X., Metals and amyloid- in Alzheimer's disease International Journal of Experimental Pathology 2005 86 3 147 159
-
(2005)
International Journal of Experimental Pathology
, vol.86
, Issue.3
, pp. 147-159
-
-
Maynard, C.J.1
Bush, A.I.2
Masters, C.L.3
Cappai, R.4
Li, Q.-X.5
-
15
-
-
46749100924
-
Therapeutics for Alzheimer's disease based on the metal hypothesis
-
Bush A. I., Tanzi R. E., Therapeutics for Alzheimer's disease based on the metal hypothesis Neurotherapeutics 2008 5 3 421 432
-
(2008)
Neurotherapeutics
, vol.5
, Issue.3
, pp. 421-432
-
-
Bush, A.I.1
Tanzi, R.E.2
-
16
-
-
77953940704
-
Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics
-
Duce J. A., Bush A. I., Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics Progress in Neurobiology 2010 92 1 1 18
-
(2010)
Progress in Neurobiology
, vol.92
, Issue.1
, pp. 1-18
-
-
Duce, J.A.1
Bush, A.I.2
-
17
-
-
34248683911
-
Metals ions and neurodegeneration
-
Molina-Holgado F., Hider R. C., Gaeta A., Williams R., Francis P., Metals ions and neurodegeneration Biometals 2007 20 3-4 639 654
-
(2007)
Biometals
, vol.20
, Issue.34
, pp. 639-654
-
-
Molina-Holgado, F.1
Hider, R.C.2
Gaeta, A.3
Williams, R.4
Francis, P.5
-
18
-
-
33745726690
-
Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis)
-
Gaggelli E., Kozlowski H., Valensin D., Valensin G., Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis) Chemical Reviews 2006 106 6 1995 2044
-
(2006)
Chemical Reviews
, vol.106
, Issue.6
, pp. 1995-2044
-
-
Gaggelli, E.1
Kozlowski, H.2
Valensin, D.3
Valensin, G.4
-
19
-
-
67649392464
-
Alzheimer's disease, metal ions and metal homeostatic therapy
-
Zatta P., Drago D., Bolognin S., Sensi S. L., Alzheimer's disease, metal ions and metal homeostatic therapy Trends in Pharmacological Sciences 2009 30 7 346 355
-
(2009)
Trends in Pharmacological Sciences
, vol.30
, Issue.7
, pp. 346-355
-
-
Zatta, P.1
Drago, D.2
Bolognin, S.3
Sensi, S.L.4
-
20
-
-
34548356689
-
Causes of oxidative stress in Alzheimer disease
-
Zhu X., Su B., Wang X., Smith M. A., Perry G., Causes of oxidative stress in Alzheimer disease Cellular and Molecular Life Sciences 2007 64 17 2202 2210
-
(2007)
Cellular and Molecular Life Sciences
, vol.64
, Issue.17
, pp. 2202-2210
-
-
Zhu, X.1
Su, B.2
Wang, X.3
Smith, M.A.4
Perry, G.5
-
21
-
-
72949094439
-
Copper and zinc binding to amyloid- : Coordination, dynamics, aggregation, reactivity and metal-ion transfer
-
Faller P., Copper and zinc binding to amyloid- : coordination, dynamics, aggregation, reactivity and metal-ion transfer ChemBioChem 2009 10 18 2837 2845
-
(2009)
ChemBioChem
, vol.10
, Issue.18
, pp. 2837-2845
-
-
Faller, P.1
-
22
-
-
59449097016
-
Bioinorganic chemistry of copper and zinc ions coordinated to amyloid- peptide
-
Faller P., Hureau C., Bioinorganic chemistry of copper and zinc ions coordinated to amyloid- peptide Dalton Transactions 2009 7 1080 1094
-
(2009)
Dalton Transactions
, Issue.7
, pp. 1080-1094
-
-
Faller, P.1
Hureau, C.2
-
23
-
-
69749106568
-
A -mediated ROS production by Cu ions: Structural insights, mechanisms and relevance to Alzheimer's disease
-
Hureau C., Faller P., A -mediated ROS production by Cu ions: structural insights, mechanisms and relevance to Alzheimer's disease Biochimie 2009 91 10 1212 1217
-
(2009)
Biochimie
, vol.91
, Issue.10
, pp. 1212-1217
-
-
Hureau, C.1
Faller, P.2
-
24
-
-
0032507975
-
Copper, iron and zinc in Alzheimer's disease senile plaques
-
Lovell M. A., Robertson J. D., Teesdale W. J., Campbell J. L., Markesbery W. R., Copper, iron and zinc in Alzheimer's disease senile plaques Journal of the Neurological Sciences 1998 158 1 47 52
-
(1998)
Journal of the Neurological Sciences
, vol.158
, Issue.1
, pp. 47-52
-
-
Lovell, M.A.1
Robertson, J.D.2
Teesdale, W.J.3
Campbell, J.L.4
Markesbery, W.R.5
-
25
-
-
33745004381
-
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with -amyloid deposits in Alzheimer's disease
-
Miller L. M., Wang Q., Telivala T. P., Smith R. J., Lanzirotti A., Miklossy J., Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with -amyloid deposits in Alzheimer's disease Journal of Structural Biology 2006 155 1 30 37
-
(2006)
Journal of Structural Biology
, vol.155
, Issue.1
, pp. 30-37
-
-
Miller, L.M.1
Wang, Q.2
Telivala, T.P.3
Smith, R.J.4
Lanzirotti, A.5
Miklossy, J.6
-
26
-
-
23844434035
-
Aluminum-triggered structural modifications and aggregation of -amyloids
-
Ricchelli F., Drago D., Filippi B., Tognon G., Zatta P., Aluminum-triggered structural modifications and aggregation of -amyloids Cellular and Molecular Life Sciences 2005 62 15 1724 1733
-
(2005)
Cellular and Molecular Life Sciences
, vol.62
, Issue.15
, pp. 1724-1733
-
-
Ricchelli, F.1
Drago, D.2
Filippi, B.3
Tognon, G.4
Zatta, P.5
-
27
-
-
0034527983
-
Metal chelation as a potential therapy for Alzheimer's disease
-
Cuajungco M. P., Fagt K. Y., Huang X., Tanzi R. E., Bush A. I., Metal chelation as a potential therapy for Alzheimer's disease Annals of the New York Academy of Sciences 2000 920 292 304
-
(2000)
Annals of the New York Academy of Sciences
, vol.920
, pp. 292-304
-
-
Cuajungco, M.P.1
Fagt, K.Y.2
Huang, X.3
Tanzi, R.E.4
Bush, A.I.5
-
28
-
-
34447634140
-
The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease
-
Crouch P. J., White A. R., Bush A. I., The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease The FEBS Journal 2007 274 15 3775 3783
-
(2007)
The FEBS Journal
, vol.274
, Issue.15
, pp. 3775-3783
-
-
Crouch, P.J.1
White, A.R.2
Bush, A.I.3
-
29
-
-
67649803877
-
Chelation therapy for neurodegenerative diseases
-
Bolognin S., Drago D., Messori L., Zatta P., Chelation therapy for neurodegenerative diseases Medicinal Research Reviews 2009 29 4 547 570
-
(2009)
Medicinal Research Reviews
, vol.29
, Issue.4
, pp. 547-570
-
-
Bolognin, S.1
Drago, D.2
Messori, L.3
Zatta, P.4
-
30
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits -amyloid accumulation in Alzheimer's disease transgenic mice
-
Cherny R. A., Atwood C. S., Xilinas M. E., Gray D. N., Jones W. D., McLean C. A., Barnham K. J., Volitakis I., Fraser F. W., Kim Y.-S., Huang X., Goldstein L. E., Moir R. D., Lim J. T., Beyreuther K., Zheng H., Tanzi R. E., Masters C. L., Bush A. I., Treatment with a copper-zinc chelator markedly and rapidly inhibits -amyloid accumulation in Alzheimer's disease transgenic mice Neuron 2001 30 3 665 676
-
(2001)
Neuron
, vol.30
, Issue.3
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
Gray, D.N.4
Jones, W.D.5
McLean, C.A.6
Barnham, K.J.7
Volitakis, I.8
Fraser, F.W.9
Kim, Y.-S.10
Huang, X.11
Goldstein, L.E.12
Moir, R.D.13
Lim, J.T.14
Beyreuther, K.15
Zheng, H.16
Tanzi, R.E.17
Masters, C.L.18
Bush, A.I.19
-
31
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting A amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial
-
Ritchie C. W., Bush A. I., Mackinnon A., Macfarlane S., Mastwyk M., MacGregor L., Kiers L., Cherny R., Li Q.-X., Tammer A., Carrington D., Mavros C., Volitakis I., Xilinas M., Ames D., Davis S., Beyreuther K., Tanzi R. E., Masters C. L., Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting A amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial Archives of Neurology 2003 60 12 1685 1691
-
(2003)
Archives of Neurology
, vol.60
, Issue.12
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
MacKinnon, A.3
MacFarlane, S.4
Mastwyk, M.5
MacGregor, L.6
Kiers, L.7
Cherny, R.8
Li, Q.-X.9
Tammer, A.10
Carrington, D.11
Mavros, C.12
Volitakis, I.13
Xilinas, M.14
Ames, D.15
Davis, S.16
Beyreuther, K.17
Tanzi, R.E.18
Masters, C.L.19
-
32
-
-
46149107512
-
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial A
-
Adlard P. A., Cherny R. A., Finkelstein D. I., Gautier E., Robb E., Cortes M., Volitakis I., Liu X., Smith J. P., Perez K., Laughton K., Li Q.-X., Charman S. A., Nicolazzo J. A., Wilkins S., Deleva K., Lynch T., Kok G., Ritchie C. W., Tanzi R. E., Cappai R., Masters C. L., Barnham K. J., Bush A. I., Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial A Neuron 2008 59 1 43 55
-
(2008)
Neuron
, vol.59
, Issue.1
, pp. 43-55
-
-
Adlard, P.A.1
Cherny, R.A.2
Finkelstein, D.I.3
Gautier, E.4
Robb, E.5
Cortes, M.6
Volitakis, I.7
Liu, X.8
Smith, J.P.9
Perez, K.10
Laughton, K.11
Li, Q.-X.12
Charman, S.A.13
Nicolazzo, J.A.14
Wilkins, S.15
Deleva, K.16
Lynch, T.17
Kok, G.18
Ritchie, C.W.19
Tanzi, R.E.20
Cappai, R.21
Masters, C.L.22
Barnham, K.J.23
Bush, A.I.24
more..
-
33
-
-
48949098573
-
Safety, efficacy, and biomarker findings of PBT2 in targeting A as a modifying therapy for Alzheimer's disease: A phase IIa, double-blind, randomised, placebo-controlled trial
-
Lannfelt L., Blennow K., Zetterberg H., Safety, efficacy, and biomarker findings of PBT2 in targeting A as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial The Lancet Neurology 2008 7 9 779 786
-
(2008)
The Lancet Neurology
, vol.7
, Issue.9
, pp. 779-786
-
-
Lannfelt, L.1
Blennow, K.2
Zetterberg, H.3
-
34
-
-
0022261647
-
Chelation therapy. Unproved modality in the treatment of Alzheimer-type dementia
-
Cardelli M. B., Russell M., Bagne C. A., Pomara N., Chelation therapy. Unproved modality in the treatment of Alzheimer-type dementia Journal of the American Geriatrics Society 1985 33 8 548 551
-
(1985)
Journal of the American Geriatrics Society
, vol.33
, Issue.8
, pp. 548-551
-
-
Cardelli, M.B.1
Russell, M.2
Bagne, C.A.3
Pomara, N.4
-
35
-
-
4644238758
-
The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human -amyloid precursor protein transgenic mice
-
Lee J.-Y., Friedman J. E., Angel I., Kozak A., Koh J.-Y., The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human -amyloid precursor protein transgenic mice Neurobiology of Aging 2004 25 10 1315 1321
-
(2004)
Neurobiology of Aging
, vol.25
, Issue.10
, pp. 1315-1321
-
-
Lee, J.-Y.1
Friedman, J.E.2
Angel, I.3
Kozak, A.4
Koh, J.-Y.5
-
36
-
-
0031761894
-
Clioquinol-zinc chelate: A candidate causative agent of subacute myelo- optic neuropathy
-
Arbiser J. L., Kraeft S.-K., van Leeuwen R., Hurwitz S. J., Selig M., Dickersin G. R., Flint A., Byers H. R., Chen L. B., Clioquinol-zinc chelate: a candidate causative agent of subacute myelo- optic neuropathy Molecular Medicine 1998 4 10 665 670
-
(1998)
Molecular Medicine
, vol.4
, Issue.10
, pp. 665-670
-
-
Arbiser, J.L.1
Kraeft, S.-K.2
Van Leeuwen, R.3
Hurwitz, S.J.4
Selig, M.5
Dickersin, G.R.6
Flint, A.7
Byers, H.R.8
Chen, L.B.9
-
37
-
-
77951714977
-
Two functions, one molecule: A metal-binding and a targeting moiety to combat Alzheimer's disease
-
Hureau C., Sasaki I., Gras E., Faller P., Two functions, one molecule: a metal-binding and a targeting moiety to combat Alzheimer's disease ChemBioChem 2010 11 7 950 953
-
(2010)
ChemBioChem
, vol.11
, Issue.7
, pp. 950-953
-
-
Hureau, C.1
Sasaki, I.2
Gras, E.3
Faller, P.4
-
38
-
-
77149144132
-
Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease
-
Perez L. R., Franz K. J., Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease Dalton Transactions 2010 39 9 2177 2187
-
(2010)
Dalton Transactions
, vol.39
, Issue.9
, pp. 2177-2187
-
-
Perez, L.R.1
Franz, K.J.2
-
39
-
-
9744219638
-
Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis
-
Dedeoglu A., Cormier K., Payton S., Tseitlin K. A., Kremsky J. N., Lai L., Li X., Moir R. D., Tanzi R. E., Bush A. I., Kowall N. W., Rogers J. T., Huang X., Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis Experimental Gerontology 2004 39 11-12 1641 1649
-
(2004)
Experimental Gerontology
, vol.39
, Issue.1112
, pp. 1641-1649
-
-
Dedeoglu, A.1
Cormier, K.2
Payton, S.3
Tseitlin, K.A.4
Kremsky, J.N.5
Lai, L.6
Li, X.7
Moir, R.D.8
Tanzi, R.E.9
Bush, A.I.10
Kowall, N.W.11
Rogers, J.T.12
Huang, X.13
-
40
-
-
57649130599
-
Sequestration of copper from -amyloid promotes selective lysis by cyclen-hybrid cleavage agents
-
Wu W.-h., Lei P., Liu Q., Hu J., Gunn A. P., Chen M.-S., Rui Y.-F., Su X.-Y., Xie Z.-P., Zhao Y.-F., Bush A. I., Li Y.-M., Sequestration of copper from -amyloid promotes selective lysis by cyclen-hybrid cleavage agents Journal of Biological Chemistry 2008 283 46 31657 31664
-
(2008)
Journal of Biological Chemistry
, vol.283
, Issue.46
, pp. 31657-31664
-
-
Wu, W.-H.1
Lei, P.2
Liu, Q.3
Hu, J.4
Gunn, A.P.5
Chen, M.-S.6
Rui, Y.-F.7
Su, X.-Y.8
Xie, Z.-P.9
Zhao, Y.-F.10
Bush, A.I.11
Li, Y.-M.12
-
41
-
-
63149091152
-
Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease
-
Rodrguez-Rodrguez C., de Groot N. Snchez, Rimola A., lvarez-Larena., Lloveras V., Vidal-Gancedo J., Ventura S., Vendrell J., Sodupe M., Gonzlez-Duarte P., Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease Journal of the American Chemical Society 2009 131 4 1436 1451
-
(2009)
Journal of the American Chemical Society
, vol.131
, Issue.4
, pp. 1436-1451
-
-
Rodrguez-Rodrguez, C.1
De Groot, N.S.2
Rimola, A.3
Lvarez-Larena, .4
Lloveras, V.5
Vidal-Gancedo, J.6
Ventura, S.7
Vendrell, J.8
Sodupe, M.9
Gonzlez-Duarte, P.10
-
42
-
-
70450202390
-
Small molecule modulators of copper-induced A aggregation
-
Hindo S. S., Mancino A. M., Braymer J. J., Liu Y., Vivekanandan S., Ramamoorthy A., Lim M. H., Small molecule modulators of copper-induced A aggregation Journal of the American Chemical Society 2009 131 46 16663 16665
-
(2009)
Journal of the American Chemical Society
, vol.131
, Issue.46
, pp. 16663-16665
-
-
Hindo, S.S.1
Mancino, A.M.2
Braymer, J.J.3
Liu, Y.4
Vivekanandan, S.5
Ramamoorthy, A.6
Lim, M.H.7
-
43
-
-
0000464103
-
Fluorescent stains, with special reference to amyloid and connective tissues
-
Vassar P. S., Culling C. F. A., Fluorescent stains, with special reference to amyloid and connective tissues Archives of Pathology 1959 68 5 487 498
-
(1959)
Archives of Pathology
, vol.68
, Issue.5
, pp. 487-498
-
-
Vassar, P.S.1
Culling, C.F.A.2
-
44
-
-
0027502784
-
Thioflavine T interaction with synthetic Alzheimer's disease -amyloid peptides: Detection of amyloid aggregation in solution
-
LeVine H. III, Thioflavine T interaction with synthetic Alzheimer's disease -amyloid peptides: detection of amyloid aggregation in solution Protein Science 1993 2 3 404 410
-
(1993)
Protein Science
, vol.2
, Issue.3
, pp. 404-410
-
-
Levine III, H.1
-
45
-
-
48149107920
-
Thioflavin derivatives as markers for amyloid- fibrils: Insights into structural features important for high-affinity binding
-
Leuma Yona R., Mazres S., Faller P., Gras E., Thioflavin derivatives as markers for amyloid- fibrils: insights into structural features important for high-affinity binding ChemMedChem 2008 3 1 63 66
-
(2008)
ChemMedChem
, vol.3
, Issue.1
, pp. 63-66
-
-
Leuma Yona, R.1
Mazres, S.2
Faller, P.3
Gras, E.4
-
46
-
-
76249096197
-
Crystal structure of thioflavin-T and its binding to amyloid fibrils: Insights at the molecular level
-
Rodrguez-Rodrguez C., Rimola A., Rodrguez-Santiago L., Ugliengo P., lvarez-Larena A., Gutirrez-De-Tern H., Sodupe M., Gonzlez-Duarte P., Crystal structure of thioflavin-T and its binding to amyloid fibrils: insights at the molecular level Chemical Communications 2010 46 7 1156 1158
-
(2010)
Chemical Communications
, vol.46
, Issue.7
, pp. 1156-1158
-
-
Rodrguez-Rodrguez, C.1
Rimola, A.2
Rodrguez-Santiago, L.3
Ugliengo, P.4
Lvarez-Larena, A.5
Gutirrez-De-Tern, H.6
Sodupe, M.7
Gonzlez-Duarte, P.8
-
47
-
-
0035902875
-
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain
-
Klunk W. E., Wang Y., Huang G.-f., Debnath M. L., Holt D. P., Mathis C. A., Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain Life Sciences 2001 69 13 1471 1484
-
(2001)
Life Sciences
, vol.69
, Issue.13
, pp. 1471-1484
-
-
Klunk, W.E.1
Wang, Y.2
Huang, G.-F.3
Debnath, M.L.4
Holt, D.P.5
Mathis, C.A.6
-
48
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski C. A., Lombardo F., Dominy B. W., Feeney P. J., Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Advanced Drug Delivery Reviews 2001 46 13 3 26
-
(2001)
Advanced Drug Delivery Reviews
, vol.46
, Issue.13
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
49
-
-
0033981358
-
Computational methods for the prediction of drug-likeness
-
Clark D. E., Pickett S. D., Computational methods for the prediction of drug-likeness Drug Discovery Today 2000 5 2 49 58
-
(2000)
Drug Discovery Today
, vol.5
, Issue.2
, pp. 49-58
-
-
Clark, D.E.1
Pickett, S.D.2
-
50
-
-
10744232413
-
Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B
-
Klunk W. E., Engler H., Nordberg A., Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B Annals of Neurology 2004 55 3 306 319
-
(2004)
Annals of Neurology
, vol.55
, Issue.3
, pp. 306-319
-
-
Klunk, W.E.1
Engler, H.2
Nordberg, A.3
-
51
-
-
68449090629
-
Update on amyloid imaging: From healthy aging to Alzheimers disease
-
Wolk D. A., Klunk W. E., Update on amyloid imaging: from healthy aging to Alzheimers disease Current Neurology and Neuroscience Reports 2009 9 5 345 352
-
(2009)
Current Neurology and Neuroscience Reports
, vol.9
, Issue.5
, pp. 345-352
-
-
Wolk, D.A.1
Klunk, W.E.2
-
52
-
-
0031873102
-
Sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy
-
Soto C., Sigurdsson E. M., Morelli L., Kumar R. A., Castao E. M., Frangione B., -sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy Nature Medicine 1998 4 7 822 826
-
(1998)
Nature Medicine
, vol.4
, Issue.7
, pp. 822-826
-
-
Soto, C.1
Sigurdsson, E.M.2
Morelli, L.3
Kumar, R.A.4
Castao, E.M.5
Frangione, B.6
-
53
-
-
0033526553
-
Sheet breaker peptide inhibitor of Alzheimer's amyloidogenesis with increased blood-brain barrier permeability and resistance to proteolytic degradation in plasma
-
Poduslo J. F., Curran G. L., Kumar A., Frangione B., Soto C., -Sheet breaker peptide inhibitor of Alzheimer's amyloidogenesis with increased blood-brain barrier permeability and resistance to proteolytic degradation in plasma Journal of Neurobiology 1999 39 3 371 382
-
(1999)
Journal of Neurobiology
, vol.39
, Issue.3
, pp. 371-382
-
-
Poduslo, J.F.1
Curran, G.L.2
Kumar, A.3
Frangione, B.4
Soto, C.5
-
54
-
-
0029994633
-
Arrest of -amyloid fibril formation by a pentapeptide ligand
-
Tjernberg L. O., Nslund J., Lindqvist F., Johansson J., Karlstrm A. R., Thyberg J., Tereniust L., Nordstedt C., Arrest of -amyloid fibril formation by a pentapeptide ligand Journal of Biological Chemistry 1996 271 15 8545 8548
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.15
, pp. 8545-8548
-
-
Tjernberg, L.O.1
Nslund, J.2
Lindqvist, F.3
Johansson, J.4
Karlstrm, A.R.5
Thyberg, J.6
Tereniust, L.7
Nordstedt, C.8
-
55
-
-
0029910347
-
A strategy for designing inhibitors of -amyloid toxicity
-
Ghanta J., Shen C.-L., Kiessling L. L., Murphy R. M., A strategy for designing inhibitors of -amyloid toxicity Journal of Biological Chemistry 1996 271 47 29525 29528
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.47
, pp. 29525-29528
-
-
Ghanta, J.1
Shen, C.-L.2
Kiessling, L.L.3
Murphy, R.M.4
-
56
-
-
0033596944
-
Recognition sequence design for peptidyl modulators of -amyloid aggregation and toxicity
-
Pallitto M. M., Ghanta J., Heinzelman P., Kiessling L. L., Murphy R. M., Recognition sequence design for peptidyl modulators of -amyloid aggregation and toxicity Biochemistry 1999 38 12 3570 3578
-
(1999)
Biochemistry
, vol.38
, Issue.12
, pp. 3570-3578
-
-
Pallitto, M.M.1
Ghanta, J.2
Heinzelman, P.3
Kiessling, L.L.4
Murphy, R.M.5
-
57
-
-
67649880982
-
Effects of cyclen and cyclam on zinc(II)- and copper(II)-induced amyloid -peptide aggregation and neurotoxicity
-
Chen T., Wang X., He Y., Zhang C., Wu Z., Liao K., Wang J., Guo Z., Effects of cyclen and cyclam on zinc(II)- and copper(II)-induced amyloid -peptide aggregation and neurotoxicity Inorganic Chemistry 2009 48 13 5801 5809
-
(2009)
Inorganic Chemistry
, vol.48
, Issue.13
, pp. 5801-5809
-
-
Chen, T.1
Wang, X.2
He, Y.3
Zhang, C.4
Wu, Z.5
Liao, K.6
Wang, J.7
Guo, Z.8
-
58
-
-
43049120207
-
Metal complexes as artificial proteases: Toward catalytic drugs
-
Suh J., Chei W. S., Metal complexes as artificial proteases: toward catalytic drugs Current Opinion in Chemical Biology 2008 12 2 207 213
-
(2008)
Current Opinion in Chemical Biology
, vol.12
, Issue.2
, pp. 207-213
-
-
Suh, J.1
Chei, W.S.2
-
59
-
-
1542364225
-
Curcumin has potent anti-amyloidogenic effects for Alzheimer's -amyloid fibrils in vitro
-
Ono K., Hasegawa K., Naiki H., Yamada M., Curcumin has potent anti-amyloidogenic effects for Alzheimer's -amyloid fibrils in vitro Journal of Neuroscience Research 2004 75 6 742 750
-
(2004)
Journal of Neuroscience Research
, vol.75
, Issue.6
, pp. 742-750
-
-
Ono, K.1
Hasegawa, K.2
Naiki, H.3
Yamada, M.4
-
60
-
-
33749265462
-
Curcumin and dehydrozingerone derivatives: Synthesis, radiolabeling, and evaluation for -amyloid plaque imaging
-
Ryu E. K., Choe Y. S., Lee K.-H., Choi Y., Kim B.-T., Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for -amyloid plaque imaging Journal of Medicinal Chemistry 2006 49 20 6111 6119
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.20
, pp. 6111-6119
-
-
Ryu, E.K.1
Choe, Y.S.2
Lee, K.-H.3
Choi, Y.4
Kim, B.-T.5
-
61
-
-
77349084360
-
Naturally occurring phytochemicals for the prevention of Alzheimer's disease
-
Kim J., Lee H. J., Lee K. W., Naturally occurring phytochemicals for the prevention of Alzheimer's disease Journal of Neurochemistry 2010 112 6 1415 1430
-
(2010)
Journal of Neurochemistry
, vol.112
, Issue.6
, pp. 1415-1430
-
-
Kim, J.1
Lee, H.J.2
Lee, K.W.3
-
62
-
-
34548182307
-
Structure-activity relationships of amyloid beta-aggregation inhibitors based on curcumin: Influence of linker length and flexibility
-
Reinke A. A., Gestwicki J. E., Structure-activity relationships of amyloid beta-aggregation inhibitors based on curcumin: influence of linker length and flexibility Chemical Biology and Drug Design 2007 70 3 206 215
-
(2007)
Chemical Biology and Drug Design
, vol.70
, Issue.3
, pp. 206-215
-
-
Reinke, A.A.1
Gestwicki, J.E.2
-
63
-
-
0037195577
-
IMPY: An improved thioflavin-T derivative for in vivo labeling of -amyloid plaques
-
Kung M.-P., Hou C., Zhuang Z.-P., Zhang B., Skovronsky D., Trojanowski J. Q., Lee V. M.-Y., Kung H. F., IMPY: an improved thioflavin-T derivative for in vivo labeling of -amyloid plaques Brain Research 2002 956 2 202 210
-
(2002)
Brain Research
, vol.956
, Issue.2
, pp. 202-210
-
-
Kung, M.-P.1
Hou, C.2
Zhuang, Z.-P.3
Zhang, B.4
Skovronsky, D.5
Trojanowski, J.Q.6
Lee, V.M.-Y.7
Kung, H.F.8
-
64
-
-
5444264488
-
Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease
-
Kung M.-P., Hou C., Zhuang Z.-P., Skovronsky D., Kung H. F., Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease Brain Research 2004 1025 1-2 98 105
-
(2004)
Brain Research
, vol.1025
, Issue.12
, pp. 98-105
-
-
Kung, M.-P.1
Hou, C.2
Zhuang, Z.-P.3
Skovronsky, D.4
Kung, H.F.5
-
65
-
-
3943100779
-
Characterization of IMPY as a potential imaging agent for -amyloid plaques in double transgenic PSAPP mice
-
Kung M.-P., Hou C., Zhuang Z.-P., Cross A. J., Maier D. L., Kung H. F., Characterization of IMPY as a potential imaging agent for -amyloid plaques in double transgenic PSAPP mice European Journal of Nuclear Medicine and Molecular Imaging 2004 31 8 1136 1145
-
(2004)
European Journal of Nuclear Medicine and Molecular Imaging
, vol.31
, Issue.8
, pp. 1136-1145
-
-
Kung, M.-P.1
Hou, C.2
Zhuang, Z.-P.3
Cross, A.J.4
Maier, D.L.5
Kung, H.F.6
-
66
-
-
33745534523
-
Safety, biodistribution, and dosimetry of 123 I-IMPY: A novel amyloid plaque-imaging agent for the diagnosis of Alzheimer's disease
-
Newberg A. B., Wintering N. A., Plssl K., Hochold J., Stabin M. G., Watson M., Skovronsky D., Clark C. M., Kung M.-P., Kung H. F., Safety, biodistribution, and dosimetry of 123 I-IMPY: a novel amyloid plaque-imaging agent for the diagnosis of Alzheimer's disease Journal of Nuclear Medicine 2006 47 5 748 754
-
(2006)
Journal of Nuclear Medicine
, vol.47
, Issue.5
, pp. 748-754
-
-
Newberg, A.B.1
Wintering, N.A.2
Plssl, K.3
Hochold, J.4
Stabin, M.G.5
Watson, M.6
Skovronsky, D.7
Clark, C.M.8
Kung, M.-P.9
Kung, H.F.10
-
67
-
-
0642341172
-
Characterization of radioiodinated ligand binding to amyloid plaques
-
Kung M.-P., Zhuang Z.-P., Hou C., Jin L.-W., Kung H. F., Characterization of radioiodinated ligand binding to amyloid plaques Journal of Molecular Neuroscience 2003 20 3 249 253
-
(2003)
Journal of Molecular Neuroscience
, vol.20
, Issue.3
, pp. 249-253
-
-
Kung, M.-P.1
Zhuang, Z.-P.2
Hou, C.3
Jin, L.-W.4
Kung, H.F.5
-
68
-
-
34648822430
-
Synthesis and structure-affinity relationships of new 4-(6-iodo- H -imidazo[1,2- a ]pyridin-2-yl)- N -dimethylbenzeneamine derivatives as ligands for human -amyloid plaques
-
Cai L., Cuevas J., Temme S., Herman M. M., Dagostin C., Widdowson D. A., Innis R. B., Pike V. W., Synthesis and structure-affinity relationships of new 4-(6-iodo- H -imidazo[1,2- a ]pyridin-2-yl)- N -dimethylbenzeneamine derivatives as ligands for human -amyloid plaques Journal of Medicinal Chemistry 2007 50 19 4746 4758
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.19
, pp. 4746-4758
-
-
Cai, L.1
Cuevas, J.2
Temme, S.3
Herman, M.M.4
Dagostin, C.5
Widdowson, D.A.6
Innis, R.B.7
Pike, V.W.8
-
69
-
-
0035915387
-
Novel stilbenes as probes for amyloid plaques
-
Kung H. F., Lee C.-W., Zhuang Z.-P., Kung M.-P., Hou C., Plssl K., Novel stilbenes as probes for amyloid plaques Journal of the American Chemical Society 2001 123 50 12740 12741
-
(2001)
Journal of the American Chemical Society
, vol.123
, Issue.50
, pp. 12740-12741
-
-
Kung, H.F.1
Lee, C.-W.2
Zhuang, Z.-P.3
Kung, M.-P.4
Hou, C.5
Plssl, K.6
-
70
-
-
24944586305
-
F-18 stilbenes as PET imaging agents for detecting -amyloid plaques in the brain
-
Zhang W., Oya S., Kung M.-P., Hou C., Maier D. L., Kung H. F., F-18 stilbenes as PET imaging agents for detecting -amyloid plaques in the brain Journal of Medicinal Chemistry 2005 48 19 5980 5988
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.19
, pp. 5980-5988
-
-
Zhang, W.1
Oya, S.2
Kung, M.-P.3
Hou, C.4
Maier, D.L.5
Kung, H.F.6
-
71
-
-
77249145936
-
18 F stilbenes and styrylpyridines for PET imaging of A plaques in Alzheimers disease: A miniperspective
-
Kung H. F., Choi S. R., Qu W., Zhang W., Skovronsky D., 18 F stilbenes and styrylpyridines for PET imaging of A plaques in Alzheimers disease: a miniperspective Journal of Medicinal Chemistry 2010 53 3 933 941
-
(2010)
Journal of Medicinal Chemistry
, vol.53
, Issue.3
, pp. 933-941
-
-
Kung, H.F.1
Choi, S.R.2
Qu, W.3
Zhang, W.4
Skovronsky, D.5
-
72
-
-
78650669293
-
Design of small molecules that target metal-A species and regulate metal-induced A aggregation and neurotoxicity
-
Choi J.-S., Braymer J. J., Nanga R. P. R., Ramamoorthy A., Lim M. H., Design of small molecules that target metal-A species and regulate metal-induced A aggregation and neurotoxicity 2010. Proceedings of the National Academy of Sciences of the United States of America. In press
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America. in Press
-
-
Choi, J.-S.1
Braymer, J.J.2
Nanga, R.P.R.3
Ramamoorthy, A.4
Lim, M.H.5
|