Global DNA hypomethylation in peripheral blood leukocytes as a biomarker for cancer risk: A meta-analysis

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Woo, Hae Dong ^a   Kim, Jeongseon ^a  

^a National Cancer Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DNA;

ARTICLE; BLADDER CANCER; CANCER INVASION; CANCER PROGNOSIS; CANCER RISK; CANCER SCREENING; DNA METHYLATION; GENE SEQUENCE; GENETIC HETEROGENEITY; HUMAN; LEUKOCYTE; META ANALYSIS; PROMOTER REGION; BLOOD; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; METABOLISM; MONONUCLEAR CELL; NEOPLASM;

BIOLOGICAL MARKERS; DNA METHYLATION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; NEOPLASMS;

EID: 84859620860     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034615     Document Type: Article

References (60)

1. Issa J, (2000) CpG-island methylation in aging and cancer. Curr Top Microbiol Immunol 249: 101-118.
2. Jaenisch R, Bird A, (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33: 245-254.
3. Laird PW, Jaenisch R, (1994) DNA methylation and cancer. Hum Mol Genet 3: 1487-1496.
4. Jones PA, (1996) DNA methylation errors and cancer. Cancer Res 56: 2463-2467.
5. Liu L, Wylie RC, Andrews LG, Tollefsbol TO, (2003) Aging, cancer and nutrition: the DNA methylation connection. Mech Ageing Dev 124: 989-998.
6. Davis CD, Uthus EO, (2004) DNA methylation, cancer susceptibility, and nutrient interactions. Exp Biol Med 229: 988-995.
7. Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M, (1988) Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res 48: 1159-1161.
8. Cravo M, Pinto R, Fidalgo P, Chaves P, Gloria L, et al. (1996) Global DNA hypomethylation occurs in the early stages of intestinal type gastric carcinoma. Gut 39: 434-438.
9. Kondo Y, Issa JPJ, (2004) Epigenetic changes in colorectal cancer. Cancer Metastasis Rev 23: 29-39.
10. Lengauer C, Kinzler K, Vogelstein B, (1997) Genetic instability in colorectal cancers. Nature 386: 623-627.
11. Eden A, Gaudet F, Waghmare A, Jaenisch R, (2003) Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300: 455.
12. Jones PA, Baylin SB, (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428.
13. Laird PW, (2003) The power and the promise of DNA methylation markers. Nat Rev Cancer 3: 253-266.
14. Okano M, Bell DW, Haber DA, Li E, (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247-257.
15. Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, et al. (2002) DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat Genet 33: 61-65.
16. Li E, Bestor TH, Jaenisch R, (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915-926.
17. Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M, (1999) A mammalian protein with specific demethylase activity for mCpG DNA. Nature 397: 579-583.
18. Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, et al. (1999) MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet 23: 58-61.
19. Santos F, Hendrich B, Reik W, Dean W, (2002) Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev Biol 241: 172-182.
20. Barreto G, Schafer A, Marhold J, Stach D, Swaminathan SK, et al. (2007) Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 445: 671-675.
21. Jin SG, Guo C, Pfeifer GP, (2008) GADD45A does not promote DNA demethylation. PLoS Genet 4: e1000013.
22. Gehring M, Reik W, Henikoff S, (2009) DNA demethylation by DNA repair. Trends Genet 25: 82-90.
23. Rai K, Huggins IJ, James SR, Karpf AR, Jones DA, et al. (2008) DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell 135: 1201-1212.
24. Vatolin S, Abdullaev Z, Pack SD, Flanagan PT, Custer M, et al. (2005) Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes. Cancer Res 65: 7751-7762.
25. Woloszynska-Read A, Zhang W, Yu J, Link PA, Mhawech-Fauceglia P, et al. (2011) Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage. Clin Cancer Res 17: 2170-2180.
26. Ehrlich M, (2002) DNA methylation in cancer: too much, but also too little. Oncogene 21: 5400-5413.
27. Kim YI, Giuliano A, Hatch KD, Schneider A, Nour MA, et al. (1994) Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma. Cancer 74: 893-899.
28. Soares J, Pinto AE, Cunha CV, Andre S, Barao I, et al. (1999) Global DNA hypomethylation in breast carcinoma. Cancer 85: 112-118.
29. Lin CH, Hsieh SY, Sheen I, (2001) Genome-wide hypomethylation in hepatocellular carcinogenesis. Cancer Res 61: 4238-4243.
30. Cho NY, Kim JH, Moon KC, Kang GH, (2009) Genomic hypomethylation and CpG island hypermethylation in prostatic intraepithelial neoplasm. Virchows Archiv 454: 17-23.
31. Suter CM, Martin DI, Ward RL, (2004) Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int J Colorectal Dis 19: 95-101.
32. Cho YH, Yazici H, Wu H, Terry MB, Gonzalez K, et al. (2010) Aberrant promoter hypermethylation and genomic hypomethylation in tumor, adjacent normal tissues and blood from breast cancer patients. Anticancer res 30: 2489-2496.
33. Sterne JAC, Bradburn MJ, Egger M, (2008) Meta-analysis in STATA. In: Egger M, Davey Smith G, Altman DG, editors. Systematic reviews in health care: meta-analysis in context. 2nd ed London BMJ Publications pp. 347-369.
34. Higgins J, Thompson SG, Deeks JJ, Altman DG, (2003) Measuring inconsistency in meta-analyses. BMJ 327: 557-560.
35. Poole C, Greenland S, (1999) Random-effects meta-analyses are not always conservative. Am J Epidemiol 150: 469-475.
36. Kjaergard LL, Villumsen J, Gluud C, (2001) Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med 135: 982-989.
37. Pufulete M, Al-Ghnaniem R, Leather AJM, Appleby P, Gout S, et al. (2003) Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology 124: 1240-1248.
38. Hsiung DT, Marsit C, Houseman E, Eddy K, Furniss C, et al. (2007) Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 16: 108-114.
39. Lim U, Flood A, Choi SW, Albanes D, Cross AJ, et al. (2008) Genomic methylation of leukocyte DNA in relation to colorectal adenoma among asymptomatic women. Gastroenterology 134: 47-55.
40. Moore LE, Pfeiffer RM, Poscablo C, Real FX, Kogevinas M, et al. (2008) Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study. Lancet Oncol 9: 359-366.
41. Choi JY, James SR, Link PA, McCann SE, Hong CC, et al. (2009) Association between global DNA hypomethylation in leukocytes and risk of breast cancer. Carcinogenesis 30: 1889-1897.
42. Hou L, Wang H, Sartori S, Gawron A, Lissowska J, et al. (2010) Blood leukocyte DNA hypomethylation and gastric cancer risk in a high risk Polish population. Int J Cancer 127: 1866-1874.
43. Wilhelm CS, Kelsey KT, Butler R, Plaza S, Gagne L, et al. (2010) Implications of LINE1 methylation for bladder cancer risk in women. Clin Cancer Res 16: 1682-1689.
44. Cash HL, Tao L, Yuan JM, Marsit CJ, Houseman EA, et al. (2012) LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese. Int J Cancer 130: 1151-1159.
45. Liao LM, Brennan P, van Bemmel DM, Zaridze D, Matveev V, et al. (2011) LINE-1 Methylation Levels in Leukocyte DNA and Risk of Renal Cell Cancer. PloS One 6: e27361.
46. Gao Y, Baccarelli A, Shu X, Ji B, Yu K, et al. (2012) Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women's Health Study. Br J Cancer 106: 585-591.
47. Zhu ZZ, Sparrow D, Hou L, Tarantini L, Bollati V, et al. (2011) Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study. Cancer Causes Control 22: 437-447.
48. Xiong Z, Laird PW, (1997) COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res 25: 2532-2534.
49. Eads CA, Danenberg KD, Kawakami K, Saltz LB, Blake C, et al. (2000) MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res 28: e32.
50. Fraga MF, Uriol E, Diego LB, Berdasco M, Esteller M, et al. (2002) High performance capillary electrophoretic method for the quantification of 5 methyl 2′ deoxycytidine in genomic DNA: Application to plant, animal and human cancer tissues. Electrophoresis 23: 1677-1681.
51. Colella S, Shen L, Baggerly K, Issa J, Krahe R, (2003) Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. Biotechniques 35: 146-151.
52. Dahl C, Guldberg P, (2003) DNA methylation analysis techniques. Biogerontology 4: 233-250.
53. Jordan IK, Rogozin IB, Glazko GV, Koonin EV, (2003) Origin of a substantial fraction of human regulatory sequences from transposable elements. Trends Genet 19: 68-72.
54. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, et al. (2001) Initial sequencing and analysis of the human genome. Nature 409: 860-921.
55. Qu G, Dubeau L, Narayan A, Yu MC, Ehrlich M, (1999) Satellite DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial tumors of different malignant potential. Mutat Res 423: 91-101.
56. Nelson H, Marsit C, Kelsey K, (2011) Global Methylation in Exposure Biology and Translational Medical Science. Environ Health Perspect 119: 1528-1533.
57. Phokaew C, Kowudtitham S, Subbalekha K, Shuangshoti S, Mutirangura A, (2008) LINE-1 methylation patterns of different loci in normal and cancerous cells. Nucleic Acids Res 36: 5704-5712.
58. Bollati V, Baccarelli A, Hou L, Bonzini M, Fustinoni S, et al. (2007) Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res 67: 876-880.
59. Gama-Sosa MA, Slagel VA, Trewyn RW, Oxenhandler R, Kuo KC, et al. (1983) The 5-methylcytosine content of DNA from human tumors. Nucleic Acids Res 11: 6883-6894.
60. Widschwendter M, Menon U, (2006) Circulating methylated DNA: a new generation of tumor markers. Clin Cancer Res 12: 7205-7208.