Hypoxia-selective, enzymatic conversion of 6-nitroquinoline into a fluorescent helicene: Pyrido[3,2- f ]quinolino[6,5- c ]cinnoline 3-oxide

Journal of Organic Chemistry

Volumn 77, Issue 7, 2012, Pages 3531-3537

  Rajapakse, Anuruddha ^a   Gates, Kent S ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6-NITROQUINOLINE; BOND FORMATION; CHEMICAL COMPLEXITY; CINNOLINE; CYTOTOXIC AGENTS; DIRECT IMAGING; ENZYMATIC CONVERSIONS; FLUORESCENCE EMISSION; FLUORESCENCE SPECTRA; FLUORESCENT MARKERS; FLUORESCENT PROBES; FLUORESCENT PRODUCTS; HELICENES; HUMAN PHYSIOLOGY; HYPOXIC CONDITION; HYPOXIC TISSUES; IMMUNOHISTOCHEMICAL STAINING; INTRAMOLECULAR CONDENSATION; LC-MS ANALYSIS; LOW OXYGEN; NITROSO; ONE-ELECTRON REDUCTIONS; PATHOPHYSIOLOGICAL; RADICAL ANIONS; REACTION MIXTURE; TAUTOMERIZATIONS;

CHEMICAL BONDS; CHEMICAL COMPOUNDS; FUNCTIONAL GROUPS; METABOLISM; PHYSIOLOGY; PROBES; TISSUE;

FLUORESCENCE;

6 NITROQUINOLINE; CYCLOALKENE; FLUORESCENT DYE; FUNCTIONAL GROUP; HYDROXYLAMINE; NITROQUINOLINE DERIVATIVE; NITROSO DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRIDINE DERIVATIVE; PYRIDO[3,2 F]QUINOLINO[6,5 C]CINNOLINE 3 OXIDE; QUINOLINE DERIVATIVE; RADICAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CELL HYPOXIA; FLUORESCENCE; HYPOXIA; IMMUNOHISTOCHEMISTRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; POLYMERIZATION; RADIOCHEMISTRY; REDUCTION; TAUTOMERIZATION;

AMINOQUINOLINES; ANOXIA; CELL HYPOXIA; ELECTRONS; FLUORESCENT DYES; HUMANS; MOLECULAR STRUCTURE; NADPH-FERRIHEMOPROTEIN REDUCTASE; NITROPHENOLS; OXIDATION-REDUCTION; POLYCYCLIC COMPOUNDS; PYRIDINES; QUINOLINES;

EID: 84859619372     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo3004748     Document Type: Article

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