CPU86017-RS attenuate hypoxia-induced testicular dysfunction in mice by normalizing androgen biosynthesis genes and pro-inflammatory cytokines

Acta Pharmacologica Sinica

Volumn 33, Issue 4, 2012, Pages 470-478

  Zhang, Guo Lin ^a   Yu, Feng ^a   Dai, De Zai ^a   Cheng, Yu Si ^a   Zhang, Can ^a   Dai, Yin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

3 hydroxysteroid dehydrogenase; connexin 43; CPU86017 RS; endothelin receptor A; intermittent hypoxia; matrix metalloprotease 9; nifedipine; OBRb; StAR; testicular injury

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ACID PHOSPHATASE; CALCIUM CHANNEL BLOCKING AGENT; CONNEXIN 43; CPU 86017TS; ENDOTHELIN A RECEPTOR; GELATINASE B; LACTATE DEHYDROGENASE; LEPTIN RECEPTOR; MALONALDEHYDE; NIFEDIPINE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; SUCCINATE DEHYDROGENASE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HYPOXIA; IMMUNOFLUORESCENCE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTIS DISEASE; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS; TISSUE STRUCTURE; WESTERN BLOTTING;

3-HYDROXYSTEROID DEHYDROGENASES; ANDROGENS; ANIMALS; ANOXIA; BERBERINE; CALCIUM CHANNEL BLOCKERS; CONNEXIN 43; GENE EXPRESSION REGULATION; MALE; MATRIX METALLOPROTEINASE 9; MICE; NIFEDIPINE; OXIDATIVE STRESS; PHOSPHOPROTEINS; RECEPTORS, LEPTIN; TESTICULAR DISEASES; TESTIS; TESTOSTERONE;

EID: 84859575900     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.175     Document Type: Article

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