Tim-1 regulates Th2 responses in an airway hypersensitivity model

European Journal of Immunology

Volumn 42, Issue 3, 2012, Pages 651-661

  Curtiss, Miranda L ^a,b   Gorman, Jacob V ^b   Businga, Thomas R ^b   Traver, Geri ^b   Singh, Melody ^b   Meyerholz, David K ^b   Kline, Joel N ^b   Murphy, Andrew J ^c   Valenzuela, David M ^c   Colgan, John D ^b   Rothman, Paul B ^b   Cassel, Suzanne L ^b  

^a The University of Iowa   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c VelociGene Division   (United States)

Author keywords

Allergy; Asthma; Th2; Tim 1

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 5; KIDNEY INJURY MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT ALLERGY; SPLEEN CELL; TH17 CELL; TH2 CELL;

ANIMALS; BRONCHIAL HYPERREACTIVITY; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; INTERLEUKIN-13; INTERLEUKIN-17; INTERLEUKIN-5; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; TH2 CELLS;

EID: 84859487590     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201141581     Document Type: Article

References (32)

1. Masoli, M., Fabian, D., Holt, S. and Beasley, R., The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004. 59: 469-478.
2. Mannino, D. M., Homa, D. M., Pertowski, C. A., Ashizawa, A., Nixon, L. L., Johnson, C. A., Ball, L. B. et al., Surveillance for asthma - United States, 1960-1995. MMWR CDC Surveill. Summ. 1998. 47: 1-27.
3. McIntire, J. J., Umetsu, S. E., Akbari, O., Potter, M., Kuchroo, V. K., Barsh, G. S., Freeman, G. J. et al., Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat. Immunol. 2001. 2: 1109-1116.
4. Wong S. H., Barlow J. L., Nabarro S., Fallon P. G. and McKenzie A. N., Tim-1 is induced on germinal centre B cells through B-cell receptor signalling but is not essential for the germinal centre response. Immunology 2010. 131: 77-88.
5. Sonar S. S., Hsu Y. M., Conrad M. L., Majeau G. R., Kilic A., Garber E., Gao Y. et al., Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma. J. Clin. Invest. 2010. 120: 2767-2781.
6. Freeman G. J., Casasnovas J. M., Umetsu D. T. and DeKruyff R. H., TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol. Rev. 2010. 235: 172-189.
7. Nakajima T., Wooding S., Satta Y., Jinnai N., Goto S., Hayasaka I., Saitou N. et al., Evidence for natural selection in the HAVCR1 gene: high degree of amino-acid variability in the mucin domain of human HAVCR1 protein. Genes Immun. 2005. 6: 398-406.
8. Encinas J. A., Janssen E. M., Weiner D. B., Calarota S. A., Nieto D., Moll T., Carlo D. J. and Moss R. B., Anti-T-cell Ig and mucin domain-containing protein 1 antibody decreases TH2 airway inflammation in a mouse model of asthma. J. Allergy Clin. Immunol. 2005. 116: 1343-1349.
9. Sizing I. D., Bailly V., McCoon P., Chang W., Rao S., Pablo L., Rennard R. et al., Epitope-dependent effect of anti-murine TIM-1 monoclonal antibodies on T-cell activity and lung immune responses. J. Immunol. 2007. 178: 2249-2261.
10. Umetsu S. E., Lee W. L., McIntire J. J., Downey L., Sanjanwala B., Akbari O., Berry G. J. et al., TIM-1 induces T-cell activation and inhibits the development of peripheral tolerance. Nat. Immunol. 2005. 6: 447-454.
11. Xiao S., Najafian N., Reddy J., Albin M., Zhu C., Jensen E., Imitola J. et al., Differential engagement of Tim-1 during activation can positively or negatively costimulate T-cell expansion and effector function. J. Exp. Med. 2007. 204: 1691-1702.
12. Ueno T., Habicht A., Clarkson M. R., Albin M. J., Yamaura K., Boenisch O., Popoola J. et al., The emerging role of T-cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J. Clin. Invest. 2008. 118: 742-751.
13. Yuan X., Ansari M. J., D'Addio F., Paez-Cortez J., Schmitt I., Donnarumma M., Boenisch O., Zhao X. et al., Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc. Natl. Acad. Sci. USA 2009. 106: 10734-10739.
14. Rennert P. D., Novel roles for TIM-1 in immunity and infection. Immunol. Lett. 2011 141: 28-35.
15. Gelb A. F., Schein A., Nussbaum E., Shinar C. M., Aelony Y., Aharonian H. and Zamel N., Risk factors for near-fatal asthma. Chest 2004. 126: 1138-1146.
16. Ding Q., Yeung M., Camirand G., Zeng Q., Akiba H., Yagita H., Chalasani G. et al., Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. J. Clin. Invest. 2011. 121: 3645-3656.
17. Ma J., Usui Y., Takeda K., Harada N., Yagita H., Okumura K. and Akiba H., TIM-1 signaling in B cells regulates antibody production. Biochem. Biophys. Res. Commun. 2011. 406: 223-228.
18. Kobayashi N., Karisola P., Pena-Cruz V., Dorfman D. M., Jinushi M., Umetsu S. E., Butte M. J. et al., TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity 2007. 27: 927-940.
19. Santiago C., Ballesteros A., Tami C., Martinez-Munoz L., Kaplan G. G. and Casasnovas J. M., Structures of T-cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family. Immunity 2007. 26: 299-310.
20. Meyers J. H., Chakravarti S., Schlesinger D., Illes Z., Waldner H., Umetsu S. E., Kenny J. et al., TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T-cell proliferation. Nat. Immunol. 2005. 6: 455-464.
21. Miyanishi M., Tada K., Koike M., Uchiyama Y., Kitamura T. and Nagata S., Identification of Tim4 as a phosphatidylserine receptor. Nature 2007. 450: 435-439.
22. Santiago C., Ballesteros A., Martinez-Munoz L., Mellado M., Kaplan G. G., Freeman G. J. and Casasnovas J. M., Structures of T-cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds. Immunity 2007. 27: 941-951.
23. Yamanishi Y., Kitaura J., Izawa K., Kaitani A., Komeno Y., Nakamura M., Yamazaki S. et al., TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J. Exp. Med. 2010. 207: 1501-1511.
24. Wilker P. R., Sedy J. R., Grigura V., Murphy T. L. and Murphy K. M., Evidence for carbohydrate recognition and homotypic and heterotypic binding by the TIM family Int. Immunol. 2007. 19: 763-773.
25. Silberstein E., Xing L., van de Beek W., Lu, L., Cheng H. and Kaplan G. G., Alteration of hepatitis A virus (HAV) particles by a soluble form of HAV cellular receptor 1 containing the immunoglobin-and mucin-like regions. J. Virol. 2003. 77: 8765-8774.
26. de Souza A. L., Oriss T. B., O'Malley K. J., Ray A. and Kane L. R., T-cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T-cell activation. Proc. Natl. Acad. Sci. USA 2005. 102: 17113-17118.
27. Khademi M., Illes Z., Gielen A. W., Marta M., Takazawa N., Baecher-Allan G., Brundin L. et al., T-cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mono-nuclear cells in multiple sclerosis.J. Immunol. 2004. 172: 7169-7176.
28. Rodriguez-Manzanet R., Sanjuan M. A., Wu H. Y., Quintana, R. L., Xiao S., Anderson A. G., Weiner H. L. et al., T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc. Natl. Acad. Sci. USA 2010. 107: 8706-8711.
29. Lu P., Hankel I. L., Knisz, L., Marquardt A., Chiang M. Y., Grosse, L., Gonstien R., Meyer T. et al., The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis. J. Exp. Med. 2010. 207: 1359-1367.
30. Rennert P. D., Ichimura T., Sizing I. D., Bailly V., Li Z., Rennard R., McGoon P., Pablo L. et al., T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation. J. Immunol. 2006. 177: 4311-4321.
31. + T cells via a proline-directed conformational switch in Itk. Immunity 2004. 21: 189-201.
32. Baniyash M. and Eshhar Z., Inhibition of IgE binding to mast cells and basophils by monoclonal antibodies to murine IgE. Eur. J. Immunol. 1984. 14: 799-807.