Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds

Immunity

Volumn 27, Issue 6, 2007, Pages 941-951

  Santiago, César ^a   Ballesteros, Angela ^a   Martínez Muñoz, Laura ^a   Mellado, Mario ^a   Kaplan, Gerardo G ^b   Freeman, Gordon J ^c   Casasnovas, José M ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

MOLIMMUNO

Indexed keywords

FATTY ACID; GLYCOPROTEIN; METAL ION; PHOSPHATIDYLSERINE; T CELL IMMUNOGLOBULIN MUCIN PROTEIN 4; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; C57BL 6 MOUSE; CELL LINE; CELL STRAIN 293T; CELL SURFACE; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIGAND BINDING; LIPID BILAYER; METAL ION LIGAND BINDING SITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; BINDING SITES; CELL LINE; CRYSTALLIZATION; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; LIGANDS; MEMBRANE PROTEINS; METALS; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLSERINES; PROTEIN TRANSPORT;

EID: 37049039277     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2007.11.008     Document Type: Article

References (36)

1. Bratton D.L., Fadok V.A., Richter D.A., Kailey J.M., Guthrie L.A., and Henson P.M. Appearance of phosphatidylserine on apoptotic cells requires calcium-mediated nonspecific flip-flop and is enhanced by loss of the aminophospholipid translocase. J. Biol. Chem. 272 (1997) 26159-26165
2. Brünger A.T., Adams P.D., Clore G.M., DeLano W.L., Gros P., Grosse-Kunstleve R.W., Jiang J.-S., Kuszewski J., Nilges N., Pannu N.S., et al. Crystallography and NMR system (CNS): a new software system for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54 (1998) 905-921
3. Cao E., Zang X., Ramagopal U.A., Mukhopadhaya A., Fedorov A., Fedorov E., Zencheck W.D., Lary J.W., Cole J.L., Deng H., et al. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Immunity 26 (2007) 311-321
4. Carson M. Ribbon models of macromolecules. J. Mol. Graph. 5 (1987) 103-106
5. Chakravarti S., Sabatos C.A., Xiao S., Illes Z., Cha E.K., Sobel R.A., Zheng X.X., Strom T.B., and Kuchroo V.K. Tim-2 regulates T helper type 2 responses and autoimmunity. J. Exp. Med. 202 (2005) 437-444
6. Chen T.T., Li L., Chung D.H., Allen C.D., Torti S.V., Torti F.M., Cyster J.G., Chen C.Y., Brodsky F.M., Niemi E.C., et al. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J. Exp. Med. 202 (2005) 955-965
7. Collaborative Computational Project, Number 4. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50 (1994) 760-763
8. Feigelstock D., Thompson P., Mattoo P., Zhang Y., and Kaplan G.G. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72 (1998) 6621-6628
9. Han W.K., and Bonventre J.V. Biologic markers for the early detection of acute kidney injury. Curr. Opin. Crit. Care 10 (2004) 476-482
10. Harding M. Metal-ligand geometry relevant to proteins and in proteins: sodium and potassium. Acta Crystallogr. D Biol.Crystallogr. 58 (2002) 872-874
11. Harrison S.C. Mechanism of membrane fusion by viral envelope proteins. Adv. Virus Res. 64 (2005) 231-261
12. Kaplan G., Totsuka A., Thompson P., Akatsuka T., Moritsugu Y., and Feinstone S.M. Identification of a surface glycoprotein on african green monkey kidney cells as a receptor for hepatitis A virus. EMBO J. 15 (1996) 4282-4296
13. Kobayashi N., Karisola P., Peña-Cruz V., Dorfman D.M., Jinushi M., Umetsu S.E., Butte M.J., Nagumo H., Chernova I., Zhu B., et al. TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity 27 (2007) 927-940 this issue
14. Kuchroo V.K., Umetsu D.T., DeKruyff R.H., and Freeman G.J. The TIM gene family: emerging roles in immunity and disease. Nat. Rev. Immunol. 3 (2003) 454-462
15. Kuchroo V.K., Meyers J.H., Umetsu D.T., and DeKruyff R.H. TIM family of genes in immunity and tolerance. Adv. Immunol. 91 (2006) 227-249
16. Kumanogoh A., Marukawa S., Suzuki K., Takegahara N., Watanabe C., Ch'ng E., Ishida I., Fujimura H., Sakoda S., Yoshida K., and Kikutani H. Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2. Nature 419 (2002) 629-633
17. Linsley P.S., Bradshaw J., Greene J., Peach R., Bennett K., and Mittler R.S. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 4 (1996) 535-543
18. McIntire J.J., Umetsu S.E., Akbari O., Potter M., Kuchroo V.K., Barsh G.S., Freeman G.J., Umetsu D.T., and DeKruyff R.H. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat. Immunol. 2 (2001) 1109-1116
19. McIntire J.J., Umetsu S.E., Macaubas C., Hoyte E.G., Cinnioglu C., Cavalli-Sforza L.L., Barsh G.S., Hallmayer J.F., Underhill P.A., Risch N.J., et al. Hepatitis A virus link to atopic disease. Nature 425 (2003) 576
20. Meyers J.H., Chakravarti S., Schlesinger D., Illes Z., Waldner H., Umetsu S.E., Kenny J., Zheng X.X., Umetsu D.T., DeKruyff R.H., et al. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat. Immunol. 6 (2005) 455-464
21. + binding sites. J. Mol. Biol. 256 (1996) 228-234
22. Read R.J. Pushing the boundaries of molecular replacement with maximum likelihood. Acta Crystallogr. D Biol. Crystallogr. 57 (2001) 1373-1382
23. Rennert P.D., Ichimura T., Sizing I.D., Bailly V., Li Z., Rennard R., McCoon P., Pablo L., Miklasz S., Tarilonte L., and Bonventre J.V. T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation. J. Immunol. 177 (2006) 4311-4321
24. Sabatos C.A., Chakravarti S., Cha E., Schubart A., Sanchez-Fueyo A., Zheng X.X., Coyle A.J., Strom T.B., Freeman G.J., and Kuchroo V.K. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat. Immunol. 4 (2003) 1102-1110
25. Sanchez-Fueyo A., Tian J., Picarella D., Domenig C., Zheng X.X., Sabatos C.A., Manlongat N., Bender O., Kamradt T., Kuchroo V.K., et al. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat. Immunol. 4 (2003) 1093-1101
26. Santiago C., Ballesteros A., Tami C., Martinez-Munoz L., Kaplan G.G., and Casasnovas J.M. Structures of T cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family. Immunity 26 (2007) 299-310
27. Silberstein E., Xing L., van de Beek W., Lu J., Cheng H., and Kaplan G.G. Alteration of hepatitis A virus (HAV) particles by a soluble form of HAV cellular receptor 1 containing the immunoglobin-and mucin-like regions. J. Virol. 77 (2003) 8765-8774
28. 2+-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V. Nat. Struct. Mol. Biol. 2 (1995) 968-974
29. Umetsu S.E., Lee W.L., McIntire J.J., Downey L., Sanjanwala B., Akbari O., Berry G.J., Nagumo H., Freeman G.J., Umetsu D.T., and DeKruyff R.H. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat. Immunol. 6 (2005) 447-454
30. 2+ bridges the C2 membrane-binding domain of protein kinase C directly to phosphatidylserine. EMBO J. 18 (1999) 6329-6338
31. Verhoven B., Schlegel R.A., and Williamson P. Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes. J. Exp. Med. 182 (1995) 1597-1601
32. Vila M.R., Kaplan G.G., Feigelstock D., Nadal M., Morote J., Porta R., Bellmunt J., and Meseguer A. Hepatitis A virus receptor blocks cell differentiation and is overexpressed in clear cell renal cell carcinoma. Kidney Int. 65 (2004) 1761-1773
33. Wilker P.R., Sedy J.R., Grigura V., Murphy T.L., and Murphy K.M. Evidence for carbohydrate recognition and homotypic and heterotypic binding by the TIM family. Int. Immunol. 19 (2007) 763-773
34. 2+ induces transbilayer redistribution of all major phospholipids in human erythrocytes. Biochemistry 31 (1992) 6355-6360
35. Zhu C., Anderson A.C., Schubart A., Xiong H., Imitola J., Khoury S.J., Zheng X.X., Strom T.B., and Kuchroo V.K. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat. Immunol. 6 (2005) 1245-1252
36. Zwaal R.F.A., and Schroit A.J. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 89 (1997) 1121-1132