T cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis

Journal of Immunology

Volumn 172, Issue 11, 2004, Pages 7169-7176

  Khademi, Mohsen ^a,c   Illés, Zsolt ^b   Gielen, Alexander W ^a   Marta, Monica ^a   Takazawa, Naruhiko ^b   Baecher Allan, Claire ^b   Brundin, Lou ^a,c   Hannerz, Jan ^c   Martin, Claes ^d   Harris, Robert A ^a   Hafler, David A ^b   Kuchroo, Vijay K ^b   Olsson, Tomas ^a,c   Piehl, Fredrik ^a,c   Wallström, Erik ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d DANDERYD HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GENOMIC DNA; IMMUNOGLOBULIN; INTERLEUKIN 13; MESSENGER RNA; MUCIN; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING MOLECULE 1; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING MOLECULE 3; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CEREBROSPINAL FLUID; DEMYELINATING DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH1 CELL; TH2 CELL; TIM1 GENE; TIM3 GENE;

EID: 2442704124     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.11.7169     Document Type: Article

References (22)

1. Kaplan, G., A. Totsuka, P. Thompson, T. Akatsuka, Y. Moritsugu, and S. M. Feinstone. 1996. Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus. EMBO J. 15:4282.
2. Ichimura, T., J. V. Bonventre, V. Bailly, H. Wei, C. A. Hession, R. L. Cate, and M. Sanicola. 1998. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J. Biol. Chem. 273:4135.
3. Feigelstock, D., P. Thompson, P. Mattoo, Y. Zhang, and G. G. Kaplan. 1998. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72:6621.
4. McIntire, J. J., S. E. Umetsu, O. Akbari, M. Potter, V. K. Kuchroo, G. S. Barsh, G. J. Freeman, D. T. Umetsu, and R. H. DeKruyff. 2001. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat. Immunol. 2:1109.
5. Monney, L., C. A. Sabatos, J. L. Gaglia, A. Ryu, H. Waldner, T. Chernova, S. Manning, E. A. Greenfield, A. J. Coyle, R. A. Sobel, et al. 2002. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415:536.
6. Kuchroo, V. K., D. T. Umetsu, R. H. DeKruyff, and G. J. Freeman. 2003. The TIM gene family: emerging roles in immunity and disease. Nat. Rev. Immunol. 3:454.
7. Bailly, V., Z. Zhang, W. Meier, R. Cate, M. Sanicola, and J. V. Bonventre. 2002. Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. J. Biol. Chem. 277:39739.
8. Noguchi, E., J. Nakayama, M. Kamioka, K. Ichikawa, M. Shibasaki, and T. Arinami. 2003. Insertion/Deletion coding polymorphisms in hHAVcr-1 are not associated with atopic asthma in the Japanese population. Genes Immun. 4:170.
9. McIntire, J. J., S. E. Umetsu, C. Macaubas, E. G. Hoyte, C. Cinnioglu, L. L. Cavalli-Sforza, G. S. Barsh, J. F. Hallmayer, P. A. Underhill, N. J. Risch, et al. 2003. Immunology: hepatitis A virus link to atopic disease. Nature 425:576.
10. McDonald, W. I., A. Compston, G. Edan, D. Goodkin, H. P. Hartung, F. D. Lublin, H. F. McFarland, D. W. Paty, C. H. Polman, S. C. Reingold, et al. 2001. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 50:121.
11. Windhagen, A., L. B. Nicholson, H. L. Weiner, V. K. Kuchroo, and D. A. Hafler. 1996. Role of Th1 and Th2 cells in neurologic disorders. Chem. Immunol. 63:171.
12. Calabresi, P. A., L. R. Tranquill, H. F. McFarland, and E. P. Cowan. 1998. Cytokine gene expression in cells derived from CSF of multiple sclerosis patients. J. Neuroimmunol. 89:198.
13. Lu, C. Z., M. A. Jensen, and B. G. Arnason. 1993. Interferon γ- and interleukin-4-secreting cells in multiple sclerosis. J. Neuroimmunol. 46:123.
14. Wang, T., and M. J. Brown. 1999. mRNA quantification by real time TaqMan polymerase chain reaction: validation and comparison with RNase protection. Anal. Biochem. 269:198.
15. Reue, K. 1998. mRNA quantitation techniques: considerations for experimental design and application. J. Nutr. 128:2038.
16. Bjartmar, C., and B. D. Trapp. 2001. Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Curr. Opin. Neurol. 14:271.
17. Varadhachary, A. S., S. N. Perdow, C. Hu, M. Ramanarayanan, and P. Salgame, 1997. Differential ability of T cell subsets to undergo activation-induced, cell death. Proc. Natl. Acad. Sci. USA 94:5778.
18. Schmied, M., H. Breitschopf, R. Gold, H. Zischler, G. Rothe, H. Wekerle, and H. Lassmann. 1993. Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis: evidence for programmed cell death as a mechanism to control inflammation in the brain. Am. J. Pathol. 143:446.
19. Pender, M. P., and M. J. Rist. 2001. Apoptosis of inflammatory cells in immune control of the nervous system: role of glia. Glia 36:137.
20. Sabatos, C. A., S. Chakravarti, E. Cha, A. Schubart, A. Sanchez-Fueyo, X. X. Zheng, A. J. Coyle, T. B. Strom, G. J. Freeman, and V. K. Kuchroo. 2003. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat. Immunol. 4:1102.
21. + T cell clones and peripheral blood T cells. J. Immunol. 149:2378.
22. Del Prete, G., M. De Carli, F. Almerigogna, M. G. Giudizi, R. Biagiotti, and S. Romagnani. 1993. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J. Immunol. 150:353.