T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 19, 2010, Pages 8706-8711

  Rodriguez Manzanet, Roselynn ^a   Sanjuan, Miguel A ^b   Wu, Henry Y ^a   Quintana, Francisco J ^a   Xiao, Sheng ^a   Anderson, Ana C ^a   Weiner, Howard L ^a   Green, Douglas R ^b   Kuchrooa, Vijay K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Apoptosis; Autoantibody; Phagocytosis; Phosphatidylserine receptor

Indexed keywords

DOUBLE STRANDED DNA; IMMUNOGLOBULIN; PROTEIN; PROTEIN TIM 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELL ACTIVITY; LYMPH NODE CELL; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; THYMUS;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIGEN-PRESENTING CELLS; APOPTOSIS; AUTOIMMUNITY; B-LYMPHOCYTES; CELL COMPARTMENTATION; FEMALE; LYMPHOCYTE ACTIVATION; MACROPHAGES, PERITONEAL; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PHAGOCYTOSIS; PHENOTYPE; RECOMBINATION, GENETIC; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND;

MUS;

EID: 77952687335     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0910359107     Document Type: Article

References (25)

1. Kuchroo VK, Dardalhon V, Xiao S, Anderson AC (2008) New roles for TIM family members in immune regulation. Nat Rev Immunol 8:577-580.
2. Kuchroo VK, Meyers JH, Umetsu DT, DeKruyff RH (2006) TIM family of genes in immunity and tolerance. Adv Immunol 91:227-249.
3. Kuchroo VK, Umetsu DT, DeKruyff RH, Freeman GJ (2003) The TIM gene family: Emerging roles in immunity and disease. Nat Rev Immunol 3:454-462.
4. Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK (2005) The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med 11:362-369. (Pubitemid 41080577)
5. Rodriguez-Manzanet R, et al. (2008) TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol 180:4706-4713.
6. Mizui M, et al. (2008) Bimodal regulation of T cell-mediated immune responses by TIM-4. Int Immunol 20:695-708. (Pubitemid 351619237)
7. Meyers JH, et al. (2005) TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol 6:455-464.
8. Kobayashi N, et al. (2007) TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity 27:927-940. (Pubitemid 50014866)
9. Miyanishi M, et al. (2007) Identification of Tim4 as a phosphatidylserine receptor. Nature 450:435-439.
10. Park D, et al. (2007) BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature 450:430-434. (Pubitemid 350126756)
11. Park SY, et al. (2008) Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Cell Death Differ 15:192-201.
12. Schulze C, et al. (2008) Clearance deficiency - a potential link between infections and autoimmunity. Autoimmun Rev 8:5-8.
13. Janko C, et al. (2008) Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE). Autoimmun Rev 8:9-12.
14. Munoz LE, et al. (2008) Apoptosis in the pathogenesis of systemic lupus erythematosus. Lupus 17:371-375. (Pubitemid 351798710)
15. Yasutomo K (2003) Pathological lymphocyte activation by defective clearance of self-ligands in systemic lupus erythematosus. Rheumatology (Oxford) 42:214-222.
16. Santiago C, et al. (2007) Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds. Immunity 27:941-951. (Pubitemid 50013979)
17. Cumano A, Paige CJ, Iscove NN, Brady G (1992) Bipotential precursors of B cells and macrophages in murine fetal liver. Nature 356:612-615.
18. Montecino-Rodriguez E, Leathers H, Dorshkind K (2006) Identification of a B-1 B cellspecified progenitor. Nat Immunol 7:293-301.
19. Li J, et al. (2006) B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities. Nat Immunol 7:1116-1124. (Pubitemid 44420657)
20. Popi AF, et al. (2009) Co-ordinated expression of lymphoid and myeloid specific transcription factors during B-1b cell differentiation into mononuclear phagocytes in vitro. Immunology 126:114-122.
21. Falkowski M, Schledzewski K, Hansen B, Goerdt S (2003) Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfaces. Histochem Cell Biol 120:361-369. (Pubitemid 38005355)
22. Fairhurst AM, Wandstrat AE, Wakeland EK (2006) Systemic lupus erythematosus: Multiple immunological phenotypes in a complex genetic disease. Adv Immunol 92:1-69. (Pubitemid 44828118)
23. Gaipl US, et al. (2007) Clearance deficiency and systemic lupus erythematosus (SLE). J Autoimmun 28:114-121. (Pubitemid 46680499)
24. Liossis SN, Kovacs B, Dennis G, Kammer GM, Tsokos GC (1996) B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events. J Clin Invest 98:2549-2557. (Pubitemid 26415075)
25. Cohen-Solal JF, et al. (2008) Hormonal regulation of B-cell function and systemic lupus erythematosus. Lupus 17:528-532. (Pubitemid 351955427)