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Volumn 190, Issue 4, 2012, Pages 1325-1339

TORC2 signaling is antagonized by protein phosphatase 2A and the far complex in saccharomyces cerevisiae

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE 2A; TARGET OF RAPAMYCIN KINASE; TARGET OF RAPAMYCIN KINASE C2; UNCLASSIFIED DRUG;

EID: 84859445077     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.111.138305     Document Type: Article
Times cited : (36)

References (58)
  • 3
    • 29544435434 scopus 로고    scopus 로고
    • LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast
    • Araki, T., Y. Uesono, T. Oguchi, and E. A. Toh, 2005 LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast. Genes Genet. Syst. 80: 325-343.
    • (2005) Genes Genet. Syst , vol.80 , pp. 325-343
    • Araki, T.1    Uesono, Y.2    Oguchi, T.3    Toh, E.A.4
  • 5
    • 6344265083 scopus 로고    scopus 로고
    • Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton
    • Audhya, A., R. Loewith, A. B. Parsons, L. Gao, M. Tabuchi et al., 2004 Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. EMBO J. 23: 3747-3757.
    • (2004) EMBO J , vol.23 , pp. 3747-3757
    • Audhya, A.1    Loewith, R.2    Parsons, A.B.3    Gao, L.4    Tabuchi, M.5
  • 6
    • 78649705725 scopus 로고    scopus 로고
    • Quantitative analysis of fitness and genetic interactions in yeast on a genome scale
    • Baryshnikova, A., M. Costanzo, Y. Kim, H. Ding, J. Koh et al., 2010 Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat. Methods 7: 1017-1024.
    • (2010) Nat. Methods , vol.7 , pp. 1017-1024
    • Baryshnikova, A.1    Costanzo, M.2    Kim, Y.3    Ding, H.4    Koh, J.5
  • 7
    • 0033540030 scopus 로고    scopus 로고
    • The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
    • Beck, T., and M. N. Hall, 1999 The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402: 689-692.
    • (1999) Nature , vol.402 , pp. 689-692
    • Beck, T.1    Hall, M.N.2
  • 8
    • 63749117393 scopus 로고    scopus 로고
    • TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain
    • Berchtold, D., and T. C. Walther, 2009 TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain. Mol. Biol. Cell 20: 1565-1575.
    • (2009) Mol. Biol. Cell , vol.20 , pp. 1565-1575
    • Berchtold, D.1    Walther, T.C.2
  • 10
    • 78649808070 scopus 로고    scopus 로고
    • A mutant defective in sexual development produces aseptate ascogonia
    • Bloemendal, S., K. M. Lord, C. Rech, B. Hoff, I. Engh et al., 2010 A mutant defective in sexual development produces aseptate ascogonia. Eukaryot. Cell 9: 1856-1866.
    • (2010) Eukaryot. Cell , vol.9 , pp. 1856-1866
    • Bloemendal, S.1    Lord, K.M.2    Rech, C.3    Hoff, B.4    Engh, I.5
  • 11
    • 0036320668 scopus 로고    scopus 로고
    • Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae
    • Bonangelino, C. J., E.M. Chavez, and J. S. Bonifacino, 2002 Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol. Biol. Cell 13: 2486-2501.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2486-2501
    • Bonangelino, C.J.1    Chavez, E.M.2    Bonifacino, J.S.3
  • 12
    • 33745049690 scopus 로고    scopus 로고
    • Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease
    • Bultynck, G., V. L. Heath, A. P. Majeed, J. M. Galan, R. Haguenauer- Tsapis et al., 2006 Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease. Mol. Cell. Biol. 26: 4729-4745.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 4729-4745
    • Bultynck, G.1    Heath, V.L.2    Majeed, A.P.3    Galan, J.M.4    Haguenauer- Tsapis, R.5
  • 13
    • 0028215472 scopus 로고
    • Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae
    • Burns, N., B. Grimwade, P. B. Ross-Macdonald, E. Y. Choi, K. Finberg et al., 1994 Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae. Genes Dev. 8: 1087-1105.
    • (1994) Genes Dev , vol.8 , pp. 1087-1105
    • Burns, N.1    Grimwade, B.2    Ross-Macdonald, P.B.3    Choi, E.Y.4    Finberg, K.5
  • 14
    • 0033573016 scopus 로고    scopus 로고
    • The TOR signaling cascade regulates gene expression in response to nutrients
    • Cardenas, M. E., N. S. Cutler, M. C. Lorenz, C. J. Di Como, and J. Heitman, 1999 The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev. 13: 3271-3279.
    • (1999) Genes Dev , vol.13 , pp. 3271-3279
    • Cardenas, M.E.1    Cutler, N.S.2    Lorenz, M.C.3    di Como, C.J.4    Heitman, J.5
  • 15
    • 0037732600 scopus 로고    scopus 로고
    • LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway
    • Chen, E. J., and C. A. Kaiser, 2003 LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J. Cell Biol. 161: 333-347.
    • (2003) J. Cell Biol , vol.161 , pp. 333-347
    • Chen, E.J.1    Kaiser, C.A.2
  • 16
    • 0036024577 scopus 로고    scopus 로고
    • Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: Connecting the dots
    • Cooper, T. G., 2002 Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: connecting the dots. FEMS Microbiol. Rev. 26: 223-238.
    • (2002) FEMS Microbiol. Rev , vol.26 , pp. 223-238
    • Cooper, T.G.1
  • 17
    • 70449900928 scopus 로고    scopus 로고
    • TOR complex 2: A signaling pathway of its own
    • Cybulski, N., and M. N. Hall, 2009 TOR complex 2: a signaling pathway of its own. Trends Biochem. Sci. 34: 620-627.
    • (2009) Trends Biochem. Sci , vol.34 , pp. 620-627
    • Cybulski, N.1    Hall, M.N.2
  • 18
    • 33846147991 scopus 로고    scopus 로고
    • The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress
    • Daquinag, A., M. Fadri, S. Y. Jung, J. Qin, and J. Kunz, 2007 The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress. Mol. Cell. Biol. 27: 633-650.
    • (2007) Mol. Cell. Biol , vol.27 , pp. 633-650
    • Daquinag, A.1    Fadri, M.2    Jung, S.Y.3    Qin, J.4    Kunz, J.5
  • 20
    • 0041320898 scopus 로고    scopus 로고
    • The role of phosphatases in TOR signaling in yeast
    • Duvel, K., and J. R. Broach, 2004 The role of phosphatases in TOR signaling in yeast. Curr. Top. Microbiol. Immunol. 279: 19-38.
    • (2004) Curr. Top. Microbiol. Immunol , vol.279 , pp. 19-38
    • Duvel, K.1    Broach, J.R.2
  • 21
    • 77957343158 scopus 로고    scopus 로고
    • Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation
    • Fabrizio, P., S. Hoon, M. Shamalnasab, A. Galbani, M. Wei et al., 2010 Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS Genet. 6: e1001024.
    • (2010) PLoS Genet , vol.e1001024 , pp. 6
    • Fabrizio, P.1    Hoon, S.2    Shamalnasab, M.3    Galbani, A.4    Wei, M.5
  • 22
    • 16344385976 scopus 로고    scopus 로고
    • The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2
    • Fadri, M., A. Daquinag, S. Wang, T. Xue, and J. Kunz, 2005 The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol. Biol. Cell 16: 1883-1900.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 1883-1900
    • Fadri, M.1    Daquinag, A.2    Wang, S.3    Xue, T.4    Kunz, J.5
  • 23
    • 30044443639 scopus 로고    scopus 로고
    • Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression
    • Giannattasio, S., Z. Liu, J. Thornton, and R. A. Butow, 2005 Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression. J. Biol. Chem. 280: 42528-42535.
    • (2005) J. Biol. Chem , vol.280 , pp. 42528-42535
    • Giannattasio, S.1    Liu, Z.2    Thornton, J.3    Butow, R.A.4
  • 24
    • 59149096171 scopus 로고    scopus 로고
    • A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein
    • Goudreault, M., L. M. D'Ambrosio, M. J. Kean, M. J. Mullin, B. G. Larsen et al., 2009 A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol. Cell. Proteomics 8: 157-171.
    • (2009) Mol. Cell. Proteomics , vol.8 , pp. 157-171
    • Goudreault, M.1    D'ambrosio, L.M.2    Kean, M.J.3    Mullin, M.J.4    Larsen, B.G.5
  • 25
    • 33751348056 scopus 로고    scopus 로고
    • Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
    • Guertin, D. A., D. M. Stevens, C. C. Thoreen, A. A. Burds, N. Y. Kalaany et al., 2006 Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev. Cell 11: 859-871.
    • (2006) Dev. Cell , vol.11 , pp. 859-871
    • Guertin, D.A.1    Stevens, D.M.2    Thoreen, C.C.3    Burds, A.A.4    Kalaany, N.Y.5
  • 26
    • 0031882240 scopus 로고    scopus 로고
    • TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae
    • Helliwell, S. B., I. Howald, N. Barbet, and M. N. Hall, 1998a TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics 148: 99-112.
    • (1998) Genetics , vol.148 , pp. 99-112
    • Helliwell, S.B.1    Howald, I.2    Barbet, N.3    Hall, M.N.4
  • 27
    • 0032488042 scopus 로고    scopus 로고
    • The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton
    • Helliwell, S. B., A. Schmidt, Y. Ohya, and M. N. Hall, 1998b The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton. Curr. Biol. 8: 1211-1214.
    • (1998) Curr. Biol , vol.8 , pp. 1211-1214
    • Helliwell, S.B.1    Schmidt, A.2    Ohya, Y.3    Hall, M.N.4
  • 28
    • 0029861939 scopus 로고    scopus 로고
    • Identification and characterization of FAR3 a gene required for pheromone-mediated G1 arrest in Saccharomyces cerevisiae
    • Horecka, J., and G. F. Sprague Jr., 1996 Identification and characterization of FAR3 a gene required for pheromone-mediated G1 arrest in Saccharomyces cerevisiae. Genetics 144: 905-921.
    • (1996) Genetics , vol.144 , pp. 905-921
    • Horecka, J.1    Sprague Jr, G.F.2
  • 29
    • 69249240179 scopus 로고    scopus 로고
    • Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
    • Huber, A., B. Bodenmiller, A. Uotila, M. Stahl, S. Wanka et al., 2009 Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev. 23: 1929-1943.
    • (2009) Genes Dev , vol.23 , pp. 1929-1943
    • Huber, A.1    Bodenmiller, B.2    Uotila, A.3    Stahl, M.4    Wanka, S.5
  • 30
    • 14844363721 scopus 로고    scopus 로고
    • Signaling by target of rapamycin proteins in cell growth control
    • Inoki, K., H. Ouyang, Y. Li, and K. L. Guan, 2005 Signaling by target of rapamycin proteins in cell growth control. Microbiol. Mol. Biol. Rev. 69: 79-100.
    • (2005) Microbiol. Mol. Biol. Rev , vol.69 , pp. 79-100
    • Inoki, K.1    Ouyang, H.2    Li, Y.3    Guan, K.L.4
  • 31
    • 23344448223 scopus 로고    scopus 로고
    • Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization
    • Kamada, Y., Y. Fujioka, N. N. Suzuki, F. Inagaki, S. Wullschleger et al., 2005 Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Mol. Cell. Biol. 25: 7239-7248.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 7239-7248
    • Kamada, Y.1    Fujioka, Y.2    Suzuki, N.N.3    Inagaki, F.4    Wullschleger, S.5
  • 32
    • 0037370059 scopus 로고    scopus 로고
    • Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae
    • Kemp, H. A., and G. F. Sprague Jr., 2003 Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 23: 1750-1763.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 1750-1763
    • Kemp, H.A.1    Sprague Jr, G.F.2
  • 33
    • 0037623417 scopus 로고    scopus 로고
    • GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
    • Kim, D. H., D. D. Sarbassov, S. M. Ali, R. R. Latek, K. V. Guntur et al., 2003 GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell 11: 895-904.
    • (2003) Mol. Cell , vol.11 , pp. 895-904
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3    Latek, R.R.4    Guntur, K.V.5
  • 34
    • 78651441537 scopus 로고    scopus 로고
    • Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast
    • Lai, F., R. Wu, J. Wang, C. Li, L. Zou et al., 2011 Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast. FEMS Yeast Res. 11: 72-79.
    • (2011) FEMS Yeast Res , vol.11 , pp. 72-79
    • Lai, F.1    Wu, R.2    Wang, J.3    Li, C.4    Zou, L.5
  • 35
    • 0037126596 scopus 로고    scopus 로고
    • RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p
    • Liu, Z., T. Sekito, C. B. Epstein, and R. A. Butow, 2001 RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO J. 20: 7209-7219.
    • (2001) EMBO J , vol.20 , pp. 7209-7219
    • Liu, Z.1    Sekito, T.2    Epstein, C.B.3    Butow, R.A.4
  • 36
    • 37849030140 scopus 로고    scopus 로고
    • Activation of the SPS amino acid-sensing pathway in Saccharomyces cerevisiae correlates with the phosphorylation state of a sensor component, Ptr3
    • Liu, Z., J. Thornton, M. Spirek, and R. A. Butow, 2008 Activation of the SPS amino acid-sensing pathway in Saccharomyces cerevisiae correlates with the phosphorylation state of a sensor component, Ptr3. Mol. Cell. Biol. 28: 551-563.
    • (2008) Mol. Cell. Biol , vol.28 , pp. 551-563
    • Liu, Z.1    Thornton, J.2    Spirek, M.3    Butow, R.A.4
  • 37
    • 0036753494 scopus 로고    scopus 로고
    • Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    • Loewith, R., E. Jacinto, S. Wullschleger, A. Lorberg, J. L. Crespo et al., 2002 Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10: 457-468.
    • (2002) Mol. Cell , vol.10 , pp. 457-468
    • Loewith, R.1    Jacinto, E.2    Wullschleger, S.3    Lorberg, A.4    Crespo, J.L.5
  • 38
    • 5144229125 scopus 로고    scopus 로고
    • Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression
    • Marion, R. M., A. Regev, E. Segal, Y. Barash, D. Koller et al., 2004 Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression. Proc. Natl. Acad. Sci. USA 101: 14315-14322.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 14315-14322
    • Marion, R.M.1    Regev, A.2    Segal, E.3    Barash, Y.4    Koller, D.5
  • 39
    • 11144273952 scopus 로고    scopus 로고
    • TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1
    • Martin, D. E., A. Soulard, and M. N. Hall, 2004 TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell 119: 969-979.
    • (2004) Cell , vol.119 , pp. 969-979
    • Martin, D.E.1    Soulard, A.2    Hall, M.N.3
  • 40
    • 33845609865 scopus 로고    scopus 로고
    • Mutual antagonism of target of rapamycin and calcineurin signaling
    • Mulet, J. M., D. E. Martin, R. Loewith, and M. N. Hall, 2006 Mutual antagonism of target of rapamycin and calcineurin signaling. J. Biol. Chem. 281: 33000-33007.
    • (2006) J. Biol. Chem , vol.281 , pp. 33000-33007
    • Mulet, J.M.1    Martin, D.E.2    Loewith, R.3    Hall, M.N.4
  • 41
    • 2442605728 scopus 로고    scopus 로고
    • TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae
    • Reinke, A., S. Anderson, J. M. McCaffery, J. Yates III., S. Aronova et al., 2004 TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J. Biol. Chem. 279: 14752-14762.
    • (2004) J. Biol. Chem , vol.279 , pp. 14752-14762
    • Reinke, A.1    Anderson, S.2    McCaffery, J.M.3    Yates, J.4    Aronova, S.5
  • 42
    • 77955988806 scopus 로고    scopus 로고
    • Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling
    • Ribeiro, P. S., F. Josue, A. Wepf, M. C. Wehr, O. Rinner et al., 2010 Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling. Mol. Cell 39: 521-534.
    • (2010) Mol. Cell , vol.39 , pp. 521-534
    • Ribeiro, P.S.1    Josue, F.2    Wepf, A.3    Wehr, M.C.4    Rinner, O.5
  • 43
    • 0030809956 scopus 로고    scopus 로고
    • Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8
    • Roberg, K. J., S. Bickel, N. Rowley, and C. A. Kaiser, 1997 Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8. Genetics 147: 1569-1584.
    • (1997) Genetics , vol.147 , pp. 1569-1584
    • Roberg, K.J.1    Bickel, S.2    Rowley, N.3    Kaiser, C.A.4
  • 44
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle, T., and M. N. Hall, 2000 TOR, a central controller of cell growth. Cell 103: 253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 45
    • 0030906569 scopus 로고    scopus 로고
    • The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
    • Schmidt, A., M. Bickle, T. Beck, and M. N. Hall, 1997 The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88: 531-542.
    • (1997) Cell , vol.88 , pp. 531-542
    • Schmidt, A.1    Bickle, M.2    Beck, T.3    Hall, M.N.4
  • 46
    • 0034649569 scopus 로고    scopus 로고
    • Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins
    • Shamji, A. F., F. G. Kuruvilla, and S. L. Schreiber, 2000 Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. Curr. Biol. 10: 1574-1581.
    • (2000) Curr. Biol , vol.10 , pp. 1574-1581
    • Shamji, A.F.1    Kuruvilla, F.G.2    Schreiber, S.L.3
  • 48
    • 33746506061 scopus 로고    scopus 로고
    • The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation
    • Tabuchi, M., A. Audhya, A. B. Parsons, C. Boone, and S. D. Emr, 2006 The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Mol. Cell. Biol. 26: 5861-5875.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 5861-5875
    • Tabuchi, M.1    Audhya, A.2    Parsons, A.B.3    Boone, C.4    Emr, S.D.5
  • 49
    • 0034628508 scopus 로고    scopus 로고
    • A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
    • Uetz, P., L. Giot, G. Cagney, T. A. Mansfield, R. S. Judson et al., 2000 A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403: 623-627.
    • (2000) Nature , vol.403 , pp. 623-627
    • Uetz, P.1    Giot, L.2    Cagney, G.3    Mansfield, T.A.4    Judson, R.S.5
  • 50
    • 0037345059 scopus 로고    scopus 로고
    • Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae
    • Wedaman, K. P., A. Reinke, S. Anderson, J. Yates III., J. M. McCaffery et al., 2003 Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol. Biol. Cell 14: 1204-1220.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1204-1220
    • Wedaman, K.P.1    Reinke, A.2    Anderson, S.3    Yates, J.4    McCaffery, J.M.5
  • 51
    • 0035846951 scopus 로고    scopus 로고
    • Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p
    • Wei, H., D. G. Ashby, C. S. Moreno, E. Ogris, F. M. Yeong et al., 2001 Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p. J. Biol. Chem. 276: 1570-1577.
    • (2001) J. Biol. Chem , vol.276 , pp. 1570-1577
    • Wei, H.1    Ashby, D.G.2    Moreno, C.S.3    Ogris, E.4    Yeong, F.M.5
  • 52
    • 24744439255 scopus 로고    scopus 로고
    • Molecular organization of target of rapamycin complex 2
    • Wullschleger, S., R. Loewith, W. Oppliger, and M. N. Hall, 2005 Molecular organization of target of rapamycin complex 2. J. Biol. Chem. 280: 30697-30704.
    • (2005) J. Biol. Chem , vol.280 , pp. 30697-30704
    • Wullschleger, S.1    Loewith, R.2    Oppliger, W.3    Hall, M.N.4
  • 53
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., R. Loewith, and M. N. Hall, 2006 TOR signaling in growth and metabolism. Cell 124: 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 54
    • 0036160639 scopus 로고    scopus 로고
    • The ham-2 locus, encoding a putative transmembrane protein, is required for hyphal fusion in Neurospora crassa
    • Xiang, Q., C. Rasmussen, and N. L. Glass, 2002 The ham-2 locus, encoding a putative transmembrane protein, is required for hyphal fusion in Neurospora crassa. Genetics 160: 169-180.
    • (2002) Genetics , vol.160 , pp. 169-180
    • Xiang, Q.1    Rasmussen, C.2    Glass, N.L.3
  • 55
    • 18844446425 scopus 로고    scopus 로고
    • Insights into TOR function and rapamycin response: Chemical genomic profiling by using a high-density cell array method
    • Xie, M. W., F. Jin, H. Hwang, S. Hwang, V. Anand et al., 2005 Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method. Proc. Natl. Acad. Sci. USA 102: 7215-7220.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 7215-7220
    • Xie, M.W.1    Jin, F.2    Hwang, H.3    Hwang, S.4    Anand, V.5
  • 56
    • 0000856498 scopus 로고
    • Two nuclear mutations that block mitochondrial protein import in yeast
    • Yaffe, M. P., and G. Schatz, 1984 Two nuclear mutations that block mitochondrial protein import in yeast. Proc. Natl. Acad. Sci. USA 81: 4819-4823.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 4819-4823
    • Yaffe, M.P.1    Schatz, G.2
  • 57
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu, R., A. Efeyan, and D. M. Sabatini, 2011 mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12: 21-35.
    • (2011) Nat. Rev. Mol. Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 58
    • 13744258110 scopus 로고    scopus 로고
    • Tor and cyclic AMP-protein kinase A: Two parallel pathways regulating expression of genes required for cell growth
    • Zurita-Martinez, S. A., and M. E. Cardenas, 2005 Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth. Eukaryot. Cell 4: 63-71.
    • (2005) Eukaryot. Cell , vol.4 , pp. 63-71
    • Zurita-Martinez, S.A.1    Cardenas, M.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.