Overcoming non-specific adsorption issues for AZD9164 in human urine samples: Consideration of bioanalytical and metabolite identification procedures

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 893-894, Issue , 2012, Pages 134-143

  Silvester, Steve ^a   Zang, Frank ^b  

^a ASTRAZENECA   (United Kingdom)

^b LOUGHBOROUGH UNIVERSITY   (United Kingdom)

Author keywords

Analyte adsorption; Bioanalysis; LC MS MS; Metabolite identification; Phospholipid; Surfactant

Indexed keywords

ADSORPTION EXPERIMENT; ANALYTE LOSS; ANALYTES; BIOANALYSIS; BIOANALYTICAL; BIOANALYTICAL METHODS; CHROMATOGRAPHIC PEAKS; CLINICAL PHARMACOLOGY; DIMETHYLACETAMIDE; HUMAN URINE; IN-HOUSE DEVELOPMENT; INTERNAL STANDARDS; ION SUPPRESSION; LC-MS/MS; METABOLITE IDENTIFICATION; METABOLITE PROFILING; MINIMAL SAMPLE; NONSPECIFIC ADSORPTION; RETENTION TIME; TWEEN 80; URINE SAMPLE; VOID VOLUME;

ADDITIVES; BIOMOLECULES; BODY FLUIDS; CONTAINERS; METABOLISM; METABOLITES; PHOSPHOLIPIDS; SURFACE ACTIVE AGENTS;

ADSORPTION;

3 [(3 CHOLAMIDOPROPYL)DIMETHYLAMMONIO] 1 PROPANESULFONIC ACID; AMINE; AZD 9164; BETA CYCLODEXTRIN; DODECYLBENZENESULFONATE SODIUM; LYSOPHOSPHATIDYLCHOLINE; N,N DIMETHYLACETAMIDE; PHOSPHATIDYLCHOLINE; POLYSORBATE 80; UNCLASSIFIED DRUG;

ACCURACY; ADSORPTION; ADSORPTION KINETICS; ARTICLE; CHEMICAL INTERACTION; CONCENTRATION (PARAMETERS); ELUTION; HUMAN; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SURFACE PROPERTY; TANDEM MASS SPECTROMETRY; URINALYSIS; URINE LEVEL;

ADSORPTION; CHOLIC ACIDS; CHROMATOGRAPHY, LIQUID; HUMANS; PIPERIDINES; QUINUCLIDINES; REPRODUCIBILITY OF RESULTS; SURFACE-ACTIVE AGENTS; TANDEM MASS SPECTROMETRY;

EID: 84859439264     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.03.004     Document Type: Article

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