Matrix effect elimination during LC - MS/MS bioanalytical method development

Bioanalysis

Volumn 1, Issue 7, 2009, Pages 1243-1257

  Côté, Cynthia ^a   Bergeron, Annik ^a   Mess, Jean Nicholas ^a   Furtado, Milton ^a   Garofolo, Fabio ^a  

^a Algorithme Pharma Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN;

ANIMAL; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; EVALUATION; HIGH THROUGHPUT SCREENING; HUMAN; INSTRUMENTATION; LIQUID CHROMATOGRAPHY; METHODOLOGY; REPRODUCIBILITY; REVIEW; SENSITIVITY AND SPECIFICITY;

ANIMALS; CHROMATOGRAPHY, LIQUID; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PROTEINS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 79952020424     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.09.117     Document Type: Review

References (70)

1. Ikonomou MG, Blades AT, Kebarle P. Investigations of the electrospray interface for liquid chromatography/mass spectrometry. Anal. Chem. 62, 957-967 (1990).
2. Kebarle P, Tang L. From ions in solution to ions in the gas phase -the mechanism of electrospray mass spectrometry. Anal. Chem. 65(22), 972A-986A (1993).
3. Buhrman DL, Price PI, Rudewicz PJ. Quantification of SR 27417 in human plasma using electrospray liquid chromatography-tandem mass spectrometry. A study of ion suppression. J. Am. Soc. Mass. Spectrom. 7, 1099-1105 (1996).
4. Matuszewski BK, Constanzer ML, Chavez-Eng CM. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 75(13), 3019-3030 (2003).
5. Taylor PJ. Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. Clin. Biochem. 38(4), 328-334 (2005).
6. Van Eeckhaut A, Lanckmans K, Sarre S, Smolders I, Michotte Y. Validation of bioanalytical LC-MS/MS assays. Evaluation of matrix effects. J. Chromatogr. B 877(23), 2198-2207 (2009).
7. Cai S-S, Karl A. Hanold KA, Syage JA. Comparison of atmospheric pressure photoionization and atmospheric pressure chemical ionization for normal-phase LC/MS chiral analysis of pharmaceuticals. Anal. Chem. 79, 2491-2498 (2007).
8. Chen J, Korfmacher WA, Hsieh Y. Chiral liquid chromatography-tandem mass spectrometric methods for stereoisomeric pharmaceutical determinations. J. Chromatogr. B 820, 1-8 (2005).
9. Dole M, Mack LL, Hines RL, Mobley RC, Ferguson LD, Alice MB. Molecular beams of macroions. J. Chem. Phys. 49(5), 2240-2249 (1968).
10. Iribarne JV, Thomson BA. On the evaporation of small ions from charged droplets. J. Chem. Phys. 64(6), 2287-2294 (1976).
11. King R, Bonfiglio R, Fernandez-Metzler C, Miller-Stein C, Olah T. Mechanistic investigation of ionization suppression in electrospray ionization. J. Am. Soc. Mass Spectrom. 11(11), 942-950 (2000).
12. Robb DB, Blades MW. State-of-the-art in atmospheric pressure photoionization for LC/MS. Analytica Chimica Acta 627, 34-49 (2008).
13. Marchi I, Rudaz S, Veuthey J-L. Atmospheric pressure photoionization for coupling liquid-chromatography to mass spectrometry. A review. Talanta 78, 1-18 (2009).
14. Syage J. Mechanism of [M+H]+ formation in photoionization mass spectrometry. J. Am. Soc. Mass Spectrom. 15, 1521-1533 (2004).
15. Bruins AP, Covey TR, Henion JD. Ion spray interface for combined liquid chromatography/atmospheric pressure ionization mass spectrometry. Anal. Chem. 59, 2642-2646 (1967).
16. Robb DB, Covey TR, Bruins AP. Atmospheric pressure photoionization. an ionization method for liquid chromatography-mass spectrometry. Anal. Chem. 72(15), 3653-3659 (2000).
17. Bonfiglio R, King RC, Olah TV, Merkle K. The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds. Rapid Commun. Mass Spectrom. 13(12), 1175-1185 (1999).
18. Matuszewski BK. Standard line slopes as a measure of a relative matrix effect in quantitative HPLC-MS bioanalysis. J. Chromatogr. B 830(2), 293-300 (2006).
19. Bennett PK, Van Horne KC. Identification of the major endogenous and persistent compounds in plasma, serum and tissue that cause matrix effects with electrospray LC/MS techniques. Presented at: American Association of Pharmaceutical Scientists Conference. Salt Lake City, UT, USA, 26-30 October 2003.
20. Little JL, Wempe MF, Buchanan CM. Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies. Examining lipid matrix ionization effects in plasma. J. Chromatogr. B 833(2), 219-230 (2006).
21. Xia YQ, Jemal M. Phospholipids in liquid chromatography/mass spectrometry bioanalysis. Comparison of three tandem mass spectrometric techniques for monitoring plasma phospholipids, the effect of mobile phase composition on phospholipids elution and the association of phospholipids with the matrix effects. Rapid Commun. Mass Spectrom. 23, 2125-2138 (2009).
22. Matuszewski BK, Constanzer ML, Chavez-Eng CM. Matrix effect in quantitative LC/MS/MS analyses of biological fluids. A method for determination of finasteride in human plasma at picogram per milliliter concentrations. Anal. Chem. 70(5), 882-889 (1998).
23. Souverain S, Rudaz S, Veuthey JL. Matrix effect in LC-ESI-MS and LC-APCI-MS with off-line and on-line extraction procedures. J. Chromatogr. A 1058(1-2), 61-66 (2004).
24. Dams R, Huestis MA, Lambert WE, Murphy CM. Matrix effect in bio-analysis of illicit drugs with LC-MS/MS. influence of ionization type, sample preparation, and biofluid. J. Am. Soc. Mass Spectrom. 14(11), 1290-1294 (2003).
25. Mei H, Hsieh Y, Nardo C et al. Investigation of matrix effects in bioanalytical highperformance liquid chromatography-tandem mass spectrometric assays. application to drug discovery. Rapid Commun. Mass Spectrom. 17(1), 97-103 (2003).
26. Xu X, Mei H, Wang S et al. A study of common discovery dosing formulation components and their potential for causing time-dependent matrix effects in highperformance liquid chromatography-tandem mass spectrometry assays. Rapid Commun. Mass Spectrom. 19(18), 2643-2650 (2005).
27. Yang C, Henion J. Atmospheric pressure photoionization liquid chromatographic-mass spectrometric determination of idoxifene and its metabolites in human plasma. J. Chromatogr. A 970(1-2), 155-165 (2002).
28. Fu I, Woolf EJ, Matuszewski BK. Effect of the sample matrix on the determination of indinavir in human urine by HPLC with turbo ion spray tandem mass spectrometric detection. J. Pharm. Biomed. Anal. 18(3), 347-357 (1998).
29. De Nardi C, Bonelli F. Moving from fast to ballistic gradient in liquid chromatography/tandem mass spectrometry pharmaceutical bioanalysis. Matrix effect and chromatographic evaluations. Rapid Commun. Mass Spectrom. 20(18), 2709-2716 (2006).
30. Shou WZ, Naidong W. Post-column infusion study of the 'dosing vehicle effect' in the liquid chromatography/tandem mass spectrometric analysis of discovery pharmacokinetic samples. Rapid Commun. Mass Spectrom. 17(6), 589-597 (2003).
31. Ismaiel OA, Halquist MS, Elmamly MY, Shalaby A, Karnes HT. Monitoring phospholipids for assessment of matrix effects in a liquid chromatography-tandem mass spectrometry method for hydrocodone and pseudoephedrine in human plasma. J. Chromatogr. B 859(1), 84-93 (2007).
32. Chambers E, Wagrowski-Diehl DM, Lu Z, Mazzeo JR. Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses. J. Chromatogr. B 852(1-2), 22-34 (2007).
33. Farkas T, Peng L. Effect of pH on the quantification and ion suppression of basic drugs in samples of biological origin by RP LC-ESI+-MS/MS. Presented at: 56th American Society for Mass Spectrometry Conference. Denver, CO, USA, 1-5 June 2008.
34. Van de Steene JC, Lambert WE. Comparison of matrix effects in HPLC-MS/MS and UPLC-MS/MS analysis of nine basic pharmaceuticals in surface waters. J. Am. Soc. Mass Spectrom. 19(5), 713-718 (2008).
35. Gibb I, Sprake E, Preece S. Effect of sample preparation and chromatographic separation on matrix effects in quantitative bioanalysis. Presented at: British Mass Spectrometry Society 28th Annual Meeting. York, UK, 4-7 September 2005.
36. Grant RP, Wagner AD. Ultra low level endogenous peptide quantitation using two-dimensional reverse-phase/normal-phase LC-LC-MS/MS. Presented at: 8th Land O'Lakes Bioanalytical Conference. Merrimac, WI, USA, 9-13 July 2007.
37. Sancho JV, Pozo OJ, López FJ, Hernández F. Different quantitation approaches for xenobiotics in human urine samples by liquid chromatography/electrospray tandem mass spectrometry. Rapid Commun. Mass Spectrom. 16(7), 639-645 (2002).
38. Choi BK, Hercules DM, Gusev AI. LC-MS/MS signal suppression effects in the analysis of pesticides in complex environmental matrices. Fresenius J. Anal. Chem. 369, 370-377 (2001).
39. Mess JN, Côté C, Bergeron A, Furtado M, Garofolo F. Selection of HILIC columns to handle matrix effect due to phospholipids. Bioanalysis. 1(1), 57-62 (2009).
40. Brus TS. Comparison of diatomaceous earth liquid extraction versus liquid-liquid extraction for plasma assays using LC-MS/MS. Presented at: 56th American Society for Mass Spectrometry Conference. Denver, CO, USA, 1-5 June 2008.
41. Capka V, Carter SJ. Minimizing matrix effects in the development of a method for the determination of salmeterol in human plasma by LC-MS/MS at low pg/ml concentration levels. J. Chromatogr. B 856(1-2), 285-293 (2007).
42. Lahaie M, Mess JN, Furtado M, Bradley T, Garofolo F. Elimination of LC-MS/MS matrix effect due to phospholipids using specific SPE elution conditions. Presented at: 56th American Society for Mass Spectrometry Conference. Denver, CO, USA, 1-5 June 2008.
43. Bergeron M, Lahaie M, Furtado M, Garofolo F. Selection of buffer additives for liquid-liquid extraction (LLE) procedure to remove matrix effect due to phospholipids. Presented at: 57th American Society for Mass Spectrometry Conference. Philadelphy, PA, USA, 31 May-4 June 2009.
44. Espourteille FA, LaFontaine C. Impact of ion suppression by eliminating phospholipids interferences using a generic Turboflow method. Presented at: 55th American Society for Mass Spectrometry Conference. Indianapolis, IN, USA, 3-7 June 2007.
45. Zhou S, Zhou H, Larson M et al. Highthroughput biological sample analysis using on-line turbulent flow extraction combined with monolithic column liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 19(15), 2144-2150 (2005).
46. Xu RN, Fan L, Rieser MJ, El-Shourbagy TA. Recent advances in high-throughput quantitative bioanalysis by LC-MS/MS. J. Pharm. Biomed. Anal. 44(2), 342-355 (2007).
47. Boos K-S, Grimm C-H. High-performance liquid chromatography integrated solid-phase extraction in bioanalysis using restricted access precolumn packings. Trends Anal. Chem. 18(3), 175-180 (1999).
48. Boos K-S, Fleisher CT. Multidimensional on-line solid-phase extraction (SPE) using restricted access materials (RAM) in combination with molecular imprinted polymers (MIP). Fresenius J. Anal. Chem. 371, 16-20 (2001).
49. Schoener D, Noren M, Lehman J, Lin P. Reduction of phospholipid matrix effects in electrospray ionization by adding colloidal silica and manganese(II) chloride. Presented at: 54th American Society for Mass Spectrometry Conference. Seattle, WA, USA, 28 May-1 June 2006.
50. Grant RP, Holland P, Rappold B, Katz B, Norris J. Eliminating chromatography using high-throuphput electrophoretic sample preparation in quantitative bioanalysis. Presented at: 56th American Society for Mass Spectrometry Conference. Denver, CO, USA, 1-5 June 2008.
51. Pucci V, Di Palma S, Alfieri A, Bonelli F, Monteagudo E. A novel strategy for reducing phospholipids-based matrix effect in LC-ESI-MS bioanalysis by means of HybridSPE. J. Pharm. Biomed. Anal. DOI: 10.1016/j.jpba.2009.05.037 (2009) (Epub ahead of print).
52. Jones D, Stubbs R. A unique filtration device for matrix interference removal and reduction of ion-suppression in protein precipitated plasma samples. Presented at: Pittcon Conference. New Orleans, LA, USA, 1-7 March 2008.
53. Jones D, Chang M, Arora R, Mahmoud SB. Simplified lipid and protein depletion in bioanalysis. Presented at: 9th Land O'Lakes Bioanalytical Conference. Merrimac, WI, USA, 14-18 July 2008.
54. Dicaire C, Furtado M, Garofolo F. Efficiency, reproducibility, accuracy and linearity evaluation of filtration plates during protein precipitation to remove phospholipids in bioanalysis by LC-MS/MS. Presented at: 57th American Society for Mass Spectrometry Conference. Philadelphia, PA, USA, 31 May-4 June 2009.
55. Bouchard D, Belanger P, Arcand P, Vallée F. Evalutation of the Variantm Captiva ND™ lipids filtration plate using five different analytes on narrow-bore columns. Presented at: 2008 Annual Meeting and Exposition of the American Pharmaceutical Scientists Conference. Atlanta, GA, USA, 16-20 November, 2008.
56. Wu ST, Schoener D, Jemal M. Plasma phospholipids implicated in the matrix effect observed in liquid chromatography/tandem mass spectrometry bioanalysis: evaluation of the use of colloidal silica in combination with divalent or trivalent cations for the selective removal of phospholipids from plasma. Rapid Commun. Mass Spectrom. 22, 2873-2881 (2008).
57. Shi G. Application of co-eluting structural analog internal standards for expanded linear dynamic range in liquid chromatography/electrospray mass spectrometry. Rapid Commun. Mass Spectrom. 17(3), 202-206 (2003).
58. Stokvis E, Rosing H, Beijnen JH. Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not? Rapid Commun. Mass Spectrom. 19(3), 401-407 (2005).
59. Lanckmans K, Sarre S, Smolders I, Michotte Y. Use of a structural analogue versus a stable isotope labeled internal standard for the quantification of angiotensin IV in rat brain dialysates using nano-liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 21(7), 1187-1195 (2007).
60. Jemal M, Schuster A, Whigan DB. Liquid chromatography/tandem mass spectrometry methods for quantitation of mevalonic acid in human plasma and urine: method validation, demonstration of using a surrogate analyte, and demonstration of unacceptable matrix effect in spite of use of a stable isotope analog internal standard. Rapid Commun. Mass Spectrom. 17(15), 1723-1734 (2003).
61. Chin C, Zhang ZP, Karnes HT. A study of matrix effects on an LC-MS/MS assay for olanzapine and desmethyl olanzapine. J. Pharm. Biomed. Anal. 35(5), 1149-1167 (2004).
62. Wang S, Cyronak M, Yang E. Does a stable isotopically labeled internal standard always correct analyte response? A matrix effect study on a LC-MS/MS method for the determination of carvedilol enantiomers in human plasma. J. Pharm. Biomed. Anal. 43(2), 701-707 (2007).
63. Lindegardh N, Annerberg A, White NJ, Day NP. Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of piperaquine in plasma stable isotope labeled internal standard does not always compensate for matrix effects. J. Chromatogr. B. 862(1-2), 227-236 (2008).
64. Chavez-Eng CM, Constanzer ML, Matuszewski BK. High-performance liquid chromatographic-tandem mass spectrometric evaluation and determination of stable isotope labeled analogs of rofecoxib in human plasma samples from oral bioavailability studies. J. Chromatogr. B 767(1), 117-129 (2002).
65. Bennett PK, Meng M, Capka V. Managing phospholipid-based matrix effects in bioanalysis. Presented at: 17th International Mass Spectrometry Conference. Prague, Czech Republic, 27 August-1 September 2006.
66. AAPS workshop/conference report -quantitative bioanalytical methods validation and implementation. Best practices for chromatographic and ligand binding assays 2007 www.aapsj.org/articles/aapsj0901/aapsj0901004/aapsj0901004. pdf
67. Applied Biosystems www.appliedbiosystems.com
68. Thermo Fisher Scientific Inc. www.thermo.com
69. Sigma-Aldrich Inc. www.sigma-aldrich.com
70. Varian Inc. www.varianinc.com