Effect of disease state on ionization during bioanalysis of MK-7009, a selective HCV NS3/NS4 protease inhibitor, in human plasma and human Tween-treated urine by high-performance liquid chromatography with tandem mass spectrometric detection

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 11-12, 2009, Pages 1047-1056

  Anderson, M D G ^a   Breidinger, S A ^a   Woolf, E J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

LC MS MS; MK 7009; NS3 NS4 protease inhibitor; Plasma and urine quantitation; Signal suppression

Indexed keywords

96 WELLS; ANALYTE; ANALYTES; BIO-ANALYSIS; CLINICAL STUDIES; CONCENTRATION RANGES; DISEASE STATE; HEPATITIS C; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIES; HPLC-MS/MS; HUMAN PLASMAS; INTERNAL STANDARDS; ION PAIRS; LC-MS/MS; LIQUID-LIQUID EXTRACTIONS; MK-7009; MULTIPLE-REACTION MONITORING; NS3/NS4 PROTEASE INHIBITOR; PH ADJUSTMENTS; PLASMA SAMPLES; POSITIVE MODES; RE-ANALYSIS; REPRODUCIBILITY; REVERSED-PHASE HPLC; SIGNAL SUPPRESSION; STABLE ISOTOPE LABELED INTERNAL STANDARDS; TANDEM MASS SPECTROMETRIC DETECTIONS;

BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION; LIQUIDS; PLASMA (HUMAN); PLASMAS; POLARIZATION; SOLVENT EXTRACTION;

PLASMA DIAGNOSTICS;

MK 7009; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BLOOD ANALYSIS; BLOOD PH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DILUTION; DRUG DETERMINATION; DRUG ISOLATION; ELECTROSPRAY; HEPATITIS C; HEPATITIS C VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IONIZATION; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REPRODUCIBILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; URINALYSIS;

ANTIVIRAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; HUMANS; HYDROGEN-ION CONCENTRATION; INDOLES; POLYSORBATES; QUALITY CONTROL; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SURFACE-ACTIVE AGENTS; TANDEM MASS SPECTROMETRY; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 63449103687     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.02.069     Document Type: Article

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