HPLC-MS/MS determination of a hardly soluble drug in human urine through drug-albumin binding assisted dissolution

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 872, Issue 1-2, 2008, Pages 128-132

  Rodila, Ramona ^a   Kim, Grace E ^a   Fan, Leimin ^a   Chang, Min S ^a   Zhang, Jun ^a   Wu, Huaiqin ^a   El Shourbagy, Tawakol A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

ABT 263; Albumin; Determination; Hardly soluble drug; Hydrophobic drug; Liquid chromatography; Plasma protein binding; Tandem mass spectrometry; Urine

Indexed keywords

ARSENIC COMPOUNDS; BIOCHEMISTRY; CHEMOTHERAPY; CHLORINE COMPOUNDS; DISSOLUTION; DRUG DELIVERY; DRUG DOSAGE; ORGANIC COMPOUNDS; ORGANIC SOLVENTS; POWDERS; SOLUBILITY; TERNARY SYSTEMS;

ABT-263; ALBUMIN; ANALYTICAL METHODS; CANCER.; CLINICAL TRIALS; DETERMINATION; HARDLY SOLUBLE DRUG; HPLC-MS/MS DETERMINATION; HUMAN URINE; HYDROPHOBIC DRUG; LIQUID CHROMATOGRAPHY; PLASMA PROTEIN BINDING; PROTEIN BINDINGS; TANDEM MASS SPECTROMETRY; UNIVERSAL APPROACH; URINE; URINE MATRIX; URINE SAMPLES;

BODY FLUIDS;

ALBUMIN;

ARTICLE; DRUG PROTEIN BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN BINDING; URINALYSIS; URINE;

ALBUMINS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLUBILITY; TANDEM MASS SPECTROMETRY;

EID: 49849086893     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.07.027     Document Type: Article

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