Stabilization and determination of a PPAR agonist in human urine using automated 96-well liquid-liquid extraction and liquid chromatography/tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 842, Issue 2 SPEC. ISS., 2006, Pages 122-130

  Groff, Michelle ^a   Riffel, Kerry ^a   Song, Hengchang ^a   Lo, Man Wai ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Automated liquid liquid extraction; Bovine serum albumin; LC MS MS; Stabilization of acylglucuronide metabolite; Urine

Indexed keywords

CARBOXYLIC ACIDS; DRUG PRODUCTS; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; STABILIZATION;

ACYLGLUCURONIDE METABOLITES; AUTOMATED LIQUID-LIQUID EXTRACTION; BOVINE SERUM ALBUMIN; URINE;

METABOLITES;

2 [[5,7 DIPROPYL 3 (TRIFLUOROMETHYL) 1,2 BENZISOXAZOL 6 YL]OXY] 2 METHYLPROPIONIC ACID; ACETIC ACID ETHYL ESTER; ACYLGLUCURONIDE; BOVINE SERUM ALBUMIN; DRUG METABOLITE; GLUCURONIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG STABILITY; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REACTION TIME; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY; URINALYSIS; URINE; URINE VOLUME;

BOS TAURUS;

EID: 33748778735     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.05.004     Document Type: Article

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